Published in Science on September 17, 2004
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Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
Multicolor super-resolution imaging with photo-switchable fluorescent probes. Science (2007) 9.00
Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol (2009) 7.77
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol (2008) 5.87
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Lamellipodial actin mechanically links myosin activity with adhesion-site formation. Cell (2007) 4.59
Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol (2007) 4.37
Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
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Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow. Biophys J (2006) 3.83
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J Cell Biol (2008) 3.44
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A (2007) 3.11
Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS Biol (2007) 3.01
Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol (2005) 2.89
Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol (2005) 2.83
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82
A role for actin arcs in the leading-edge advance of migrating cells. Nat Cell Biol (2011) 2.68
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction. Proc Natl Acad Sci U S A (2009) 2.52
Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr Biol (2007) 2.44
Myosin II contributes to cell-scale actin network treadmilling through network disassembly. Nature (2010) 2.37
Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cell (2008) 2.28
Cortactin branches out: roles in regulating protrusive actin dynamics. Cell Motil Cytoskeleton (2008) 2.26
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Fluctuations of intracellular forces during cell protrusion. Nat Cell Biol (2008) 2.13
Cytoskeletal coherence requires myosin-IIA contractility. J Cell Sci (2010) 2.13
Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow. PLoS One (2008) 2.11
Periodic patterns of actin turnover in lamellipodia and lamellae of migrating epithelial cells analyzed by quantitative Fluorescent Speckle Microscopy. Biophys J (2005) 2.11
Electron tomography reveals unbranched networks of actin filaments in lamellipodia. Nat Cell Biol (2010) 2.02
Cell motility as persistent random motion: theories from experiments. Biophys J (2005) 2.00
The shape of motile cells. Curr Biol (2009) 2.00
Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev Cell (2007) 1.96
Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol (2008) 1.95
Myosin II motors and F-actin dynamics drive the coordinated movement of the centrosome and soma during CNS glial-guided neuronal migration. Neuron (2009) 1.94
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol (2008) 1.88
Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane. Biophys J (2007) 1.85
Mathematics of cell motility: have we got its number? J Math Biol (2008) 1.84
Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells. Mol Biol Cell (2012) 1.82
Microtubule function in fibroblast spreading is modulated according to the tension state of cell-matrix interactions. Proc Natl Acad Sci U S A (2007) 1.80
Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts. J Cell Sci (2009) 1.78
A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells. Proc Natl Acad Sci U S A (2010) 1.77
Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A (2005) 1.73
Spatial organization and signal transduction at intercellular junctions. Nat Rev Mol Cell Biol (2010) 1.72
Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Proc Natl Acad Sci U S A (2010) 1.68
Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses. Curr Opin Cell Biol (2007) 1.68
At the leading edge of three-dimensional cell migration. J Cell Sci (2013) 1.66
F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex. Proc Natl Acad Sci U S A (2012) 1.65
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation. J Cell Biol (2012) 1.64
United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction. J Cell Sci (2012) 1.63
Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol (2013) 1.63
Cyclooxygenase-2-derived prostaglandin E₂ promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor. Circ Res (2013) 1.61
Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J (2006) 1.58
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Understanding the structure and function of the immunological synapse. Cold Spring Harb Perspect Biol (2010) 1.54
Apical constriction: themes and variations on a cellular mechanism driving morphogenesis. Development (2014) 1.53
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A (2008) 1.50
Force generated by actomyosin contraction builds bridges between adhesive contacts. EMBO J (2010) 1.47
Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells. Mol Biol Cell (2005) 1.43
A translocated effector required for Bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors. PLoS Pathog (2014) 1.43
Building distinct actin filament networks in a common cytoplasm. Curr Biol (2011) 1.43
Arp2/3 complex-dependent actin networks constrain myosin II function in driving retrograde actin flow. J Cell Biol (2012) 1.42
Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. J Cell Biol (2009) 1.41
The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Mol Biol Cell (2007) 1.39
Dynein drives nuclear rotation during forward progression of motile fibroblasts. J Cell Sci (2008) 1.37
A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells. J Cell Biol (2014) 1.36
Comparative maps of motion and assembly of filamentous actin and myosin II in migrating cells. Mol Biol Cell (2007) 1.33
Quantitative time-lapse fluorescence microscopy in single cells. Annu Rev Cell Dev Biol (2009) 1.32
Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes. Cell Motil Cytoskeleton (2008) 1.31
Nonmuscle myosin-2: mix and match. Cell Mol Life Sci (2012) 1.30
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell (2011) 1.29
The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions. Cell Motil Cytoskeleton (2009) 1.29
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
New insights into the regulation of the actin cytoskeleton by tropomyosin. Int Rev Cell Mol Biol (2010) 1.28
Roles of type II myosin and a tropomyosin isoform in retrograde actin flow in budding yeast. J Cell Biol (2006) 1.27
Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proc Natl Acad Sci U S A (2011) 1.25
Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J Cell Biol (2008) 1.25
Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion. Nat Cell Biol (2012) 1.23
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Mol Cell (2011) 1.22
Investigating sub-spine actin dynamics in rat hippocampal neurons with super-resolution optical imaging. PLoS One (2009) 1.22
Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism. J Cell Biol (2012) 1.20
Force transmission during adhesion-independent migration. Nat Cell Biol (2015) 1.19
Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension. J Cell Biol (2011) 1.17
Cell biology of embryonic migration. Birth Defects Res C Embryo Today (2008) 1.14
Guiding cell migration by tugging. Curr Opin Cell Biol (2013) 1.14
Role of focal adhesions and mechanical stresses in the formation and progression of the lamellipodium-lamellum interface [corrected]. Biophys J (2009) 1.14
Adhesion dynamics at a glance. J Cell Sci (2011) 1.13
h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton. J Biol Chem (2005) 1.13
Protrusion and actin assembly are coupled to the organization of lamellar contractile structures. Exp Cell Res (2010) 1.12
Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity. J Cell Sci (2007) 1.11
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. Elife (2015) 1.10
Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell (2001) 4.23
Cell motility: can Rho GTPases and microtubules point the way? J Cell Sci (2001) 3.55
Morphodynamic profiling of protrusion phenotypes. Biophys J (2005) 3.00
Automatic fluorescent tag detection in 3D with super-resolution: application to the analysis of chromosome movement. J Microsc (2002) 2.53
Periodic patterns of actin turnover in lamellipodia and lamellae of migrating epithelial cells analyzed by quantitative Fluorescent Speckle Microscopy. Biophys J (2005) 2.11
Rapid dynamics of the microtubule binding of ensconsin in vivo. J Cell Sci (2001) 2.10
Tracking quasi-stationary flow of weak fluorescent signals by adaptive multi-frame correlation. J Microsc (2005) 2.06
Recovery, visualization, and analysis of actin and tubulin polymer flow in live cells: a fluorescent speckle microscopy study. Biophys J (2003) 1.80
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Computational analysis of F-actin turnover in cortical actin meshworks using fluorescent speckle microscopy. Biophys J (2003) 1.67
Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br J Dermatol (2013) 1.50
Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy. Biophys J (2005) 1.31
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Mechanism of lateral movement of filopodia and radial actin bundles across neuronal growth cones. Biophys J (2000) 1.04
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A regioselective Ru-catalyzed alkene-alkyne coupling. Org Lett (2000) 0.90
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Signal analysis of total internal reflection fluorescent speckle microscopy (TIR-FSM) and wide-field epi-fluorescence FSM of the actin cytoskeleton and focal adhesions in living cells. J Microsc (2004) 0.87
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients. Lab Chip (2015) 0.83
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Predicting intradialytic hypotension from experience, statistical models and artificial neural networks. J Nephrol (2005) 0.79