Published in Cancer Res on September 01, 2006
Mammalian heparanase: what is the message? J Cell Mol Med (2007) 1.91
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics. Front Oncol (2014) 1.08
Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nat Commun (2013) 0.93
Newly discovered angiogenesis inhibitors and their mechanisms of action. Acta Pharmacol Sin (2012) 0.91
Marine-derived angiogenesis inhibitors for cancer therapy. Mar Drugs (2013) 0.89
Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in heparanase over-expressing CHO-K1 cells. Acta Pharmacol Sin (2009) 0.86
Extracellular matrix as target for antitumor therapy. Onco Targets Ther (2015) 0.85
MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition. J Cell Mol Med (2010) 0.84
Oligomannurarate sulfate blocks tumor growth by inhibiting NF-kappaB activation. Acta Pharmacol Sin (2010) 0.82
Discovery of novel sulfonated small molecules that inhibit vascular tube formation. Bioorg Med Chem Lett (2012) 0.80
Effect of non-anticoagulant N-desulfated heparin on basic fibroblast growth factor expression, angiogenesis, and metastasis of gastric carcinoma in vitro and in vivo. Gastroenterol Res Pract (2012) 0.78
Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice. BMC Cancer (2011) 0.77
Synthesized multiple antigenic polypeptide vaccine based on B-cell epitopes of human heparanase could elicit a potent antimetastatic effect on human hepatocellular carcinoma in vivo. PLoS One (2013) 0.77
Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis. ACS Med Chem Lett (2012) 0.76
Antiangiogenic platinum through glycan targeting. Chem Sci (2016) 0.75
Cocculus hirsutus: Molecular Docking to Identify Suitable Targets for Hepatocellular Carcinoma by In silico Technique. Pharmacogn Mag (2016) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature (2003) 22.89
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol (2007) 11.14
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA (2003) 7.01
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35
Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell (2010) 5.77
Global diversity in the human salivary microbiome. Genome Res (2009) 5.16
Metabolite identification via the Madison Metabolomics Consortium Database. Nat Biotechnol (2008) 5.12
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol (2011) 4.09
Modification of kidney barrier function by the urokinase receptor. Nat Med (2007) 4.01
Exchange-coupled nanocomposite magnets by nanoparticle self-assembly. Nature (2002) 3.71
IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med (2007) 3.69
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med (2011) 3.19
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol (2004) 3.19
From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal. Nature (2009) 3.18
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet (2010) 3.15
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol (2012) 3.09
Circulating suPAR in two cohorts of primary FSGS. J Am Soc Nephrol (2012) 2.83
OpenIGTLink: an open network protocol for image-guided therapy environment. Int J Med Robot (2009) 2.80
Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol (2006) 2.76
Analysis of wave behavior in lossy dielectric samples at high field. Magn Reson Med (2002) 2.59
Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients. J Infect Dis (2012) 2.53
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol (2009) 2.39
N-Benzyl-2-(2,6-dichloro-phen-oxy)-acetamide. Acta Crystallogr Sect E Struct Rep Online (2008) 2.36
The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet (2012) 2.33
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol (2006) 2.32
TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain. Neuron (2009) 2.30
Control of the pattern-recognition receptor EFR by an ER protein complex in plant immunity. EMBO J (2009) 2.28
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22
Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A (2007) 2.20
Project management system for structural and functional proteomics: Sesame. J Struct Funct Genomics (2003) 2.19
New bioinformatics resources for metabolomics. Pac Symp Biocomput (2007) 2.19
Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol Lung Cell Mol Physiol (2002) 2.19
Effects of vacuum-assisted closure on wound microcirculation: an experimental study. Asian J Surg (2005) 2.14
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. Circ Res (2006) 2.12
CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol (2003) 2.11
Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol (2005) 2.08
The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res (2009) 2.08
An integrated genetic and cytogenetic map of the cucumber genome. PLoS One (2009) 2.08
Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica (2007) 2.07
Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis. Clin Cancer Res (2010) 2.07
Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect (2012) 2.05
Learning brain connectivity of Alzheimer's disease by sparse inverse covariance estimation. Neuroimage (2010) 2.04
A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem (2005) 2.03
Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem (2003) 2.01
Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles. APMIS (2010) 2.00
Effect of otitis media with effusion and its clinical intervention on the development of mastoid in children. Acta Otolaryngol (2014) 1.98
TRPC channel activation by extracellular thioredoxin. Nature (2008) 1.97
Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer. Eur J Radiol (2006) 1.95
Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2005) 1.95
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc Natl Acad Sci U S A (2009) 1.94
Thermal difference spectra: a specific signature for nucleic acid structures. Nucleic Acids Res (2005) 1.91
Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types. BMC Genomics (2010) 1.88
'Social evils' and harm reduction: the evolving policy environment for human immunodeficiency virus prevention among injection drug users in China and Vietnam. Addiction (2007) 1.85
Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors. J Clin Oncol (2008) 1.84
A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase. Biochemistry (2002) 1.81
Using spatial principles to optimize distributed computing for enabling the physical science discoveries. Proc Natl Acad Sci U S A (2011) 1.81
Chinese authors do need CONSORT: reporting quality assessment for five leading Chinese medical journals. Contemp Clin Trials (2008) 1.80
HIV incidence among men who have sex with men in China: a meta-analysis of published studies. PLoS One (2011) 1.79
Changes of functional connectivity of the motor network in the resting state in Parkinson's disease. Neurosci Lett (2009) 1.78
Chlorophyllase 1, a damage control enzyme, affects the balance between defense pathways in plants. Plant Cell (2004) 1.76
Acid rain in China. Environ Sci Technol (2006) 1.75
Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation. Blood (2013) 1.75
Chiral separation of tamsulosin isomers by HPLC using cellulose tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase. J Pharm Biomed Anal (2004) 1.75
EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One (2011) 1.73
Draft genome of the kiwifruit Actinidia chinensis. Nat Commun (2013) 1.72
Beta-AMYLASE4, a noncatalytic protein required for starch breakdown, acts upstream of three active beta-amylases in Arabidopsis chloroplasts. Plant Cell (2008) 1.72
mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res (2013) 1.72
Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions. Biochem Biophys Res Commun (2006) 1.72
Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma. Cancer Biol Ther (2006) 1.70
The WRKY family of transcription factors in rice and Arabidopsis and their origins. DNA Res (2005) 1.70
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat Neurosci (2006) 1.70
Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies. Int J Cancer (2011) 1.69
EEG and MEG coherence: measures of functional connectivity at distinct spatial scales of neocortical dynamics. J Neurosci Methods (2007) 1.68
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients. Cochrane Database Syst Rev (2015) 1.67
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nat Neurosci (2010) 1.67
Combined serum CA19-9 and miR-27a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancer. Cancer Prev Res (Phila) (2013) 1.66
The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol Cell Neurosci (2007) 1.66
Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Nat Neurosci (2011) 1.66
Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota. Nat Commun (2013) 1.65
Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR. RNA (2002) 1.65
A mixed-valence copper coordination polymer generated by hydrothermal metal/ligand redox reactions. Chem Commun (Camb) (2002) 1.65
A DNAzyme that walks processively and autonomously along a one-dimensional track. Angew Chem Int Ed Engl (2005) 1.65
Common variants in P2RY11 are associated with narcolepsy. Nat Genet (2010) 1.65
PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo. Cancer Biol Ther (2005) 1.64