Published in Biochem J on January 01, 2007
ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab (2009) 2.49
The transcription factor network associated with the amino acid response in mammalian cells. Adv Nutr (2012) 1.27
Asparagine synthetase: regulation by cell stress and involvement in tumor biology. Am J Physiol Endocrinol Metab (2013) 1.26
Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription. Biochem J (2008) 1.18
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells. Physiol Genomics (2010) 1.15
The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res (2007) 1.14
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell (2013) 1.13
ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation. Nucleic Acids Res (2007) 1.09
Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway. PLoS One (2010) 1.07
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. J Biol Chem (2008) 1.06
Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells. Nucleic Acids Res (2009) 1.06
Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements. J Biol Chem (2009) 1.04
Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer. Breast Cancer Res (2015) 1.04
NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3. Carcinogenesis (2010) 1.02
Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals. Mol Cell Biol (2009) 1.01
Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium. Amino Acids (2010) 0.99
FGF21 mediates the lipid metabolism response to amino acid starvation. J Lipid Res (2013) 0.99
Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153. PLoS One (2012) 0.95
Acrolein induces endoplasmic reticulum stress and causes airspace enlargement. PLoS One (2012) 0.92
Remodeling of lipid metabolism by dietary restriction of essential amino acids. Diabetes (2013) 0.92
A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha). J Biol Chem (2009) 0.92
ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. J Biol Chem (2012) 0.91
Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochim Biophys Acta (2015) 0.88
Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs. Nucleic Acids Res (2012) 0.87
Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response. Physiol Genomics (2012) 0.85
Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex. Nucleic Acids Res (2008) 0.84
Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress. Nucleic Acids Res (2014) 0.83
Short-term cuprizone feeding induces selective amino acid deprivation with concomitant activation of an integrated stress response in oligodendrocytes. Cell Mol Neurobiol (2013) 0.82
Expression and clinical significance of activating transcription factor 3 in human breast cancer. Iran J Basic Med Sci (2013) 0.81
Functional genomic analysis of variation on beef tenderness induced by acute stress in angus cattle. Comp Funct Genomics (2012) 0.81
A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation. J Biol Chem (2014) 0.78
A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant. Cell Stress Chaperones (2013) 0.78
Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation. Biochim Biophys Acta (2011) 0.77
Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation. Biochem J (2013) 0.76
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Histone modifications in transcriptional regulation. Curr Opin Genet Dev (2002) 8.10
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A (2004) 4.39
Transcriptional coactivator complexes. Annu Rev Biochem (2001) 3.97
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
ATF3 and stress responses. Gene Expr (1999) 3.31
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell (2003) 2.50
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol Cell Biol (1996) 2.41
Acetylation and chromosomal functions. Curr Opin Cell Biol (2000) 2.33
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2002) 2.04
Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J Biol Chem (2003) 2.04
Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr (2005) 1.97
RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription. Nucleic Acids Res (2004) 1.86
ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. J Biol Chem (1994) 1.83
Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. J Biol Chem (1997) 1.82
Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem (2001) 1.82
ATF3 gene. Genomic organization, promoter, and regulation. J Biol Chem (1996) 1.77
gadd153/Chop10, a potential target gene of the transcriptional repressor ATF3. Mol Cell Biol (1997) 1.65
Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR. J Biol Chem (2002) 1.61
Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. J Biol Chem (2000) 1.51
Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. J Biol Chem (2002) 1.31
Transcriptional autorepression of the stress-inducible gene ATF3. J Biol Chem (2000) 1.29
Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. J Biol Chem (2005) 1.28
Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Mol Cell Biol (2002) 1.28
Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem (2003) 1.27
C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. FEBS Lett (2003) 1.19
Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization. Biochem J (2004) 1.17
Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter. Biochem J (2003) 1.08
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature (2002) 6.22
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol (2013) 3.84
CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci U S A (2008) 3.04
Maternal exposure to magnetic fields during pregnancy in relation to the risk of asthma in offspring. Arch Pediatr Adolesc Med (2011) 2.90
Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med (2014) 2.90
Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong Kong. Clin Infect Dis (2009) 2.60
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09
A case-control study of long-term exposure to ambient volatile organic compounds and lung cancer in Toronto, Ontario, Canada. Am J Epidemiol (2013) 2.05
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2002) 2.04
Genetic diversity and multiple infections of Plasmodium vivax malaria in Western Thailand. Am J Trop Med Hyg (2003) 1.98
Tumor necrosis factor receptor levels are associated with carotid atherosclerosis. Stroke (2002) 1.94
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity. Arthritis Rheum (2009) 1.87
Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives. Chem Pharm Bull (Tokyo) (2008) 1.83
Asparagine synthetase chemotherapy. Annu Rev Biochem (2006) 1.82
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J Biol Chem (2002) 1.68
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol (2005) 1.68
Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal (2010) 1.68
Average gene length is highly conserved in prokaryotes and eukaryotes and diverges only between the two kingdoms. Mol Biol Evol (2006) 1.67
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol (2011) 1.67
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum (2005) 1.65
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature (2013) 1.61
Time to disease-modifying antirheumatic drug treatment in rheumatoid arthritis and its predictors: a national, multicenter, retrospective cohort. J Rheumatol (2012) 1.60
Postmenopausal breast cancer is associated with exposure to traffic-related air pollution in Montreal, Canada: a case-control study. Environ Health Perspect (2010) 1.56
Topiramate use in pregnancy and the birth prevalence of oral clefts. Pharmacoepidemiol Drug Saf (2014) 1.52
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem (2008) 1.51
4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.51
Transurethral vapor enucleation and resection of the prostate with plasma vaporization button electrode for the treatment of benign prostatic hyperplasia: a feasibility study. J Endourol (2012) 1.50
Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. J Hypertens (2003) 1.49
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49
GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood (2005) 1.47
The ENTH domain. FEBS Lett (2002) 1.45
Early management of newly diagnosed rheumatoid arthritis by Canadian rheumatologists: a national, multicenter, retrospective cohort. J Rheumatol (2011) 1.43
Dental treatment intensity in frail older adults in the last year of life. J Am Dent Assoc (2013) 1.42
Analyses of 2-DEG characteristics in GaN HEMT with AlN/GaN super-lattice as barrier layer grown by MOCVD. Nanoscale Res Lett (2012) 1.41
Combination of balanced ultrafiltration with modified ultrafiltration attenuates pulmonary injury in patients undergoing open heart surgery. Chin Med J (Engl) (2003) 1.40
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. Clin Cancer Res (2004) 1.39
Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep (2013) 1.36
Short report: permethrin and DDT resistance in the malaria vector Anopheles arabiensis from eastern Sudan. Am J Trop Med Hyg (2007) 1.34
Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. J Biol Chem (2002) 1.31
4-Des-oxy-4β-(4-methoxy-carbonyl-1,2,3-triazol-1-yl)podophyllotoxin dichloro-methane solvate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.30
Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. J Biol Chem (2005) 1.28
Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells (2012) 1.28
A cohort study relating urban green space with mortality in Ontario, Canada. Environ Res (2012) 1.27
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem (2008) 1.27
Prevalence and costs of major depression among elderly claimants with diabetes. Diabetes Care (2003) 1.27
Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem (2003) 1.27
Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem (2003) 1.27
Asparagine synthetase: regulation by cell stress and involvement in tumor biology. Am J Physiol Endocrinol Metab (2013) 1.26
Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. Biochem J (2006) 1.25
AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation. Circ Res (2008) 1.23
MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem (2008) 1.23
The relationship between obesity and injuries among U.S. adults. Am J Health Promot (2007) 1.23
Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines. Pediatr Blood Cancer (2008) 1.23
Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol (2014) 1.23
Using teledentistry to improve access to dental care for the underserved. Dent Clin North Am (2009) 1.22
Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci (2010) 1.22
Retracted Synthesis of PS/Ag nanocomposite spheres with catalytic and antibacterial activities. ACS Appl Mater Interfaces (2012) 1.21
Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital. Chin J Cancer Res (2013) 1.21
Associations between cigarette smoking, obesity, sociodemographic characteristics and remote-sensing-derived estimates of ambient PM2.5: results from a Canadian population-based survey. Occup Environ Med (2011) 1.20
Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease. PLoS One (2013) 1.19
9-{[4-(Dimethyl-amino)-benz-yl]amino}-5-(3,4,5-trimeth-oxy-phen-yl)-5,5a,8a,9-tetra-hydro-furo[3',4':6,7]naphtho-[2,3-d][1,3]dioxol-6(8H)-one. Acta Crystallogr Sect E Struct Rep Online (2011) 1.19
Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. Blood (2006) 1.19
Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription. Biochem J (2008) 1.18
9-[(Furan-2-ylmeth-yl)amino]-5-(3,4,5-trimeth-oxy-phen-yl)-5,5a,8a,9-tetra-hydro-furo[3',4':6,7]naphtho-[2,3-d][1,3]dioxol-6(8H)-one. Acta Crystallogr Sect E Struct Rep Online (2011) 1.17
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. Proc Natl Acad Sci U S A (2010) 1.17
Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization. Biochem J (2004) 1.17
N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain. J Biol Chem (2012) 1.16
Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation. Epigenetics (2010) 1.16
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells. Physiol Genomics (2010) 1.15
Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence. J Biol Chem (2004) 1.15
The role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids. Diabetes (2008) 1.15
Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? Antioxid Redox Signal (2012) 1.15
MicroRNA-409-3p inhibits migration and invasion of bladder cancer cells via targeting c-Met. Mol Cells (2013) 1.14
mRNA expression of BRCA1, PIAS1, and PIAS4 and survival after second-line docetaxel in advanced gastric cancer. J Natl Cancer Inst (2011) 1.14
A comparison of the case-control and case-crossover designs for estimating medical costs of nonfatal fall-related injuries among older Americans. Med Care (2005) 1.14
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell (2013) 1.13
Variations and transmission of QTL alleles for yield and fiber qualities in upland cotton cultivars developed in China. PLoS One (2013) 1.12
Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells. FEBS Lett (2012) 1.12
miR-26a inhibits proliferation and motility in bladder cancer by targeting HMGA1. FEBS Lett (2013) 1.12
A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res (2013) 1.12
Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. Int J Mol Med (2013) 1.11
MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1. J Transl Med (2013) 1.11
Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. Nucleic Acids Res (2013) 1.11
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J Exp Med (2010) 1.10