Published in Mol Biol Evol on April 12, 2006
Detection of large numbers of novel sequences in the metatranscriptomes of complex marine microbial communities. PLoS One (2008) 3.83
Enigmatic, ultrasmall, uncultivated Archaea. Proc Natl Acad Sci U S A (2010) 2.12
Quantitative analysis of a deeply sequenced marine microbial metatranscriptome. ISME J (2010) 1.90
Prokaryotic genomes and diversity in surface ocean waters: interrogating the global ocean sampling metagenome. Appl Environ Microbiol (2009) 1.76
Distinct gene number-genome size relationships for eukaryotes and non-eukaryotes: gene content estimation for dinoflagellate genomes. PLoS One (2009) 1.46
Sizing up metatranscriptomics. ISME J (2012) 1.45
Development of an artificial cell, from self-organization to computation and self-reproduction. Proc Natl Acad Sci U S A (2011) 1.43
A method for multiplex gene synthesis employing error correction based on expression. PLoS One (2015) 1.38
Biology by design: reduction and synthesis of cellular components and behaviour. J R Soc Interface (2007) 1.33
The conversion of 3' UTRs into coding regions. Mol Biol Evol (2006) 1.24
Functional assignment of metagenomic data: challenges and applications. Brief Bioinform (2012) 1.13
Combining gene prediction methods to improve metagenomic gene annotation. BMC Bioinformatics (2011) 1.06
Aquilegia as a model system for the evolution and ecology of petals. Philos Trans R Soc Lond B Biol Sci (2010) 1.05
Comparing patterns of natural selection across species using selective signatures. PLoS Genet (2008) 0.96
Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange. Nat Protoc (2015) 0.94
In with the old, in with the new: the promiscuity of the duplication process engenders diverse pathways for novel gene creation. Int J Evol Biol (2012) 0.91
De novo assembly and characterization of tissue specific transcriptomes in the emerald notothen, Trematomus bernacchii. BMC Genomics (2013) 0.89
A comparison of next generation sequencing technologies for transcriptome assembly and utility for RNA-Seq in a non-model bird. PLoS One (2014) 0.88
Creation of a type IIS restriction endonuclease with a long recognition sequence. Nucleic Acids Res (2009) 0.87
The calculation of information and organismal complexity. Biol Direct (2010) 0.85
Evolutionary tradeoffs in cellular composition across diverse bacteria. ISME J (2016) 0.85
Strong genome-wide selection early in the evolution of Prochlorococcus resulted in a reduced genome through the loss of a large number of small effect genes. PLoS One (2014) 0.84
Endogenous mechanisms for the origins of spliceosomal introns. J Hered (2009) 0.84
A catalogue of putative unique transcripts from Douglas-fir (Pseudotsuga menziesii) based on 454 transcriptome sequencing of genetically diverse, drought stressed seedlings. BMC Genomics (2012) 0.83
De novo assembly and characterization of the transcriptome of the toxic dinoflagellate Karenia brevis. BMC Genomics (2014) 0.81
Comparative transcriptome analysis of four prymnesiophyte algae. PLoS One (2014) 0.81
GWAS-based pathway analysis differentiates between fluid and crystallized intelligence. Genes Brain Behav (2014) 0.81
Genome desertification in eutherians: can gene deserts explain the uneven distribution of genes in placental mammalian genomes? J Mol Evol (2009) 0.78
Expression of heterologous sigma factors enables functional screening of metagenomic and heterologous genomic libraries. Nat Commun (2015) 0.77
Drivers of Bacterial Maintenance and Minimal Energy Requirements. Front Microbiol (2017) 0.76
Eukaryotic transcriptomics in silico: optimizing cDNA-AFLP efficiency. BMC Genomics (2009) 0.76
Inside Out: Archaeal Ectosymbionts Suggest a Second Model of Reduced-Genome Evolution. Front Microbiol (2017) 0.75
Protein structure and evolution: are they constrained globally by a principle derived from information theory? PLoS One (2015) 0.75
Using Dendritic Heat Maps to Simultaneously Display Genotype Divergence with Phenotype Divergence. PLoS One (2016) 0.75
A single molecule view on Dbp5 and mRNA at the nuclear pore. Nucleus (2013) 0.75
Comparative metagenomics unveils functions and genome features of microbialite-associated communities along a depth gradient. Environ Microbiol (2016) 0.75
Degradation and half-life of DNA present in biomass from a genetically-modified organism during land application. J Ind Microbiol Biotechnol (2016) 0.75
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature (2002) 6.22
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol (2008) 5.55
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
Rationally designed, polymeric, extended metal-ciprofloxacin complexes. Chemistry (2005) 3.56
Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest (2008) 3.53
CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci U S A (2008) 3.04
Maternal exposure to magnetic fields during pregnancy in relation to the risk of asthma in offspring. Arch Pediatr Adolesc Med (2011) 2.90
Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med (2014) 2.90
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong Kong. Clin Infect Dis (2009) 2.60
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
A transforming metal nanocomposite with large elastic strain, low modulus, and high strength. Science (2013) 2.28
Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol (2007) 2.21
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09
Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. Neuroreport (2006) 2.08
Long noncoding RNA: an emerging paradigm of cancer research. Tumour Biol (2013) 2.07
Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron (2005) 2.07
A case-control study of long-term exposure to ambient volatile organic compounds and lung cancer in Toronto, Ontario, Canada. Am J Epidemiol (2013) 2.05
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2002) 2.04
A branched, balloon-deployable, Aortomonoiliac stent-graft for treatment of AAA in a patient with a solitary intrapelvic kidney. J Endovasc Ther (2010) 2.04
Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis. Int J Cancer (2011) 2.01
Genetic diversity and multiple infections of Plasmodium vivax malaria in Western Thailand. Am J Trop Med Hyg (2003) 1.98
Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology (2008) 1.94
Tumor necrosis factor receptor levels are associated with carotid atherosclerosis. Stroke (2002) 1.94
A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese. Cancer Epidemiol Biomarkers Prev (2009) 1.93
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci (2008) 1.92
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity. Arthritis Rheum (2009) 1.87
Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development. Proc Natl Acad Sci U S A (2012) 1.83
Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives. Chem Pharm Bull (Tokyo) (2008) 1.83
Entangled coordination networks with inherent features of polycatenation, polythreading, and polyknotting. Angew Chem Int Ed Engl (2005) 1.81
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest (2013) 1.81
The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development. Plant Cell (2005) 1.80
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J Biol Chem (2002) 1.68
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol (2005) 1.68
Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal (2010) 1.68
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol (2011) 1.67
Genetic dissection of ethanol tolerance in the budding yeast Saccharomyces cerevisiae. Genetics (2006) 1.67
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum (2005) 1.65
Hospitalizations for pediatric stone disease in United States, 2002-2007. J Urol (2010) 1.62
Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2/microRNA-155 pathway. J Immunol (2013) 1.61
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature (2013) 1.61
Time to disease-modifying antirheumatic drug treatment in rheumatoid arthritis and its predictors: a national, multicenter, retrospective cohort. J Rheumatol (2012) 1.60
Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease. J Neurosci (2006) 1.59
Postmenopausal breast cancer is associated with exposure to traffic-related air pollution in Montreal, Canada: a case-control study. Environ Health Perspect (2010) 1.56
Genome of the Chinese tree shrew. Nat Commun (2013) 1.55
Microtubule-dependent distribution of mRNA in adult cardiocytes. Am J Physiol Heart Circ Physiol (2008) 1.55
Hierarchical MnMoO(4)/CoMoO(4) heterostructured nanowires with enhanced supercapacitor performance. Nat Commun (2011) 1.55
A LDA-based approach to promoting ranking diversity for genomics information retrieval. BMC Genomics (2012) 1.54
Smoking and mortality in a prospective cohort study of elderly Chinese in Hong Kong. Addiction (2014) 1.52
Topiramate use in pregnancy and the birth prevalence of oral clefts. Pharmacoepidemiol Drug Saf (2014) 1.52
4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.51
Transurethral vapor enucleation and resection of the prostate with plasma vaporization button electrode for the treatment of benign prostatic hyperplasia: a feasibility study. J Endourol (2012) 1.50
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49
Neurite outgrowth and in vivo sensory innervation mediated by a Ca(V)2.2-laminin beta 2 stop signal. J Neurosci (2008) 1.49
Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. J Hypertens (2003) 1.49
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49
Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population. Carcinogenesis (2009) 1.48
GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood (2005) 1.47
The ENTH domain. FEBS Lett (2002) 1.45
Ovarian torsion: diagnosis of inclusion mandates earlier intervention. J Pediatr Surg (2012) 1.43
FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. Neurobiol Dis (2008) 1.43
Early management of newly diagnosed rheumatoid arthritis by Canadian rheumatologists: a national, multicenter, retrospective cohort. J Rheumatol (2011) 1.43
White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder. Am J Psychiatry (2007) 1.43
An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research. Thromb Res (2005) 1.43
Consequences of dichotomization. Pharm Stat (2009) 1.43
Dental treatment intensity in frail older adults in the last year of life. J Am Dent Assoc (2013) 1.42
In situ observation of dislocation behavior in nanometer grains. Phys Rev Lett (2010) 1.42
Analyses of 2-DEG characteristics in GaN HEMT with AlN/GaN super-lattice as barrier layer grown by MOCVD. Nanoscale Res Lett (2012) 1.41
Approaching the theoretical elastic strain limit in copper nanowires. Nano Lett (2011) 1.41
Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection. Exp Neurol (2004) 1.40
Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14. Mol Cell Neurosci (2007) 1.40
Combination of balanced ultrafiltration with modified ultrafiltration attenuates pulmonary injury in patients undergoing open heart surgery. Chin Med J (Engl) (2003) 1.40
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. Clin Cancer Res (2004) 1.39
Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem (2004) 1.38
An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1. J Biol Chem (2002) 1.37
Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell (2012) 1.37
Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep (2013) 1.36
Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse model. Circ Res (2002) 1.35
Interlocked and interdigitated architectures from self-assembly of long flexible ligands and cadmium salts. Angew Chem Int Ed Engl (2004) 1.35
CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. Tumour Biol (2014) 1.34
In situ atomic-scale observation of continuous and reversible lattice deformation beyond the elastic limit. Nat Commun (2013) 1.34
Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14. Neurobiol Dis (2007) 1.34
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. Biochem J (2007) 1.34
Short report: permethrin and DDT resistance in the malaria vector Anopheles arabiensis from eastern Sudan. Am J Trop Med Hyg (2007) 1.34
Long-term effect of stent placement in 115 patients with Budd-Chiari syndrome. World J Gastroenterol (2003) 1.34
Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke. BMC Neurosci (2009) 1.33
Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma. Tumour Biol (2014) 1.32
Enhanced contextual fear memory in central serotonin-deficient mice. Proc Natl Acad Sci U S A (2008) 1.31
Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res (2006) 1.31
WOX11 and 12 are involved in the first-step cell fate transition during de novo root organogenesis in Arabidopsis. Plant Cell (2014) 1.30