Published in Bioorg Med Chem Lett on September 25, 2006
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An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science (2007) 2.82
Design and evolution of new catalytic activity with an existing protein scaffold. Science (2006) 2.71
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Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. J Med Chem (2006) 1.85
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proc Natl Acad Sci U S A (2007) 1.76
The dynamic processivity of the T4 DNA polymerase during replication. Proc Natl Acad Sci U S A (2004) 1.76
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71
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Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Nat Chem Biol (2009) 1.68
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Negl Trop Dis (2011) 1.66
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Effects of a distal mutation on active site chemistry. Biochemistry (2006) 1.59
Coupled motions in enzyme catalysis. Curr Opin Chem Biol (2010) 1.49
Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proc Natl Acad Sci U S A (2002) 1.43
The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philos Trans R Soc Lond B Biol Sci (2006) 1.39
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Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem (2010) 1.36
The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication. Mol Cell (2006) 1.35
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Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli. Nat Protoc (2007) 1.31
The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. Proc Natl Acad Sci U S A (2006) 1.29
Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria. Antimicrob Agents Chemother (2013) 1.27
Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction. ACS Chem Biol (2008) 1.23
Microtubule-assisted mechanism for functional metabolic macromolecular complex formation. Proc Natl Acad Sci U S A (2010) 1.23
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett (2009) 1.22
Evolution of cyclic peptide protease inhibitors. Proc Natl Acad Sci U S A (2011) 1.20
Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir). Bioorg Med Chem Lett (2002) 1.19
Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles. J Mol Biol (2009) 1.17
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nat Chem Biol (2011) 1.15
Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. Proc Natl Acad Sci U S A (2004) 1.14
Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles. Lab Chip (2013) 1.13
Translational research involving oxidative stress and diseases of aging. Free Radic Biol Med (2011) 1.10
Replication clamps and clamp loaders. Cold Spring Harb Perspect Biol (2013) 1.10
Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proc Natl Acad Sci U S A (2013) 1.09
The application of a minicircle substrate in the study of the coordinated T4 DNA replication. J Biol Chem (2003) 1.08
Preorganization and protein dynamics in enzyme catalysis. Chem Rec (2002) 1.08
Collaborative coupling between polymerase and helicase for leading-strand synthesis. Nucleic Acids Res (2012) 1.08
3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. J Med Chem (2006) 1.08
Evolution of highly active enzymes by homology-independent recombination. Proc Natl Acad Sci U S A (2005) 1.08
Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase. J Am Chem Soc (2014) 1.07
An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex. Biochemistry (2006) 1.07
A systematic method for identifying small-molecule modulators of protein-protein interactions. Proc Natl Acad Sci U S A (2004) 1.07
Mechanism of strand displacement synthesis by DNA replicative polymerases. Nucleic Acids Res (2012) 1.07
FamClash: a method for ranking the activity of engineered enzymes. Proc Natl Acad Sci U S A (2004) 1.06
Assembly of the bacteriophage T4 helicase: architecture and stoichiometry of the gp41-gp59 complex. J Biol Chem (2002) 1.06
Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. Annu Rev Biophys (2015) 1.06
Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. Biochemistry (2005) 1.05
Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation. Biochemistry (2006) 1.05
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry (2003) 1.05
Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme. J Mol Biol (2003) 1.04
Single-molecule mechanical identification and sequencing. Nat Methods (2012) 1.04
RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue. Nat Commun (2013) 1.03
IPRO: an iterative computational protein library redesign and optimization procedure. Biophys J (2006) 1.02
On the solution structure of the T4 sliding clamp (gp45). Biochemistry (2004) 1.02
RNA primer handoff in bacteriophage T4 DNA replication: the role of single-stranded DNA-binding protein and polymerase accessory proteins. J Biol Chem (2008) 1.02
First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. J Biol Chem (2012) 1.02
Acute and chronic animal models for the evaluation of anti-diabetic agents. Cardiovasc Diabetol (2012) 1.02
Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase. Protein Sci (2003) 1.01
Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. Proc Natl Acad Sci U S A (2005) 1.01
Therapeutic potential of boron-containing compounds. Future Med Chem (2009) 1.01
Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors. Bioorg Med Chem Lett (2006) 1.01
Direct observation of stalled fork restart via fork regression in the T4 replication system. Science (2012) 1.01
Is complementary and alternative medicine effective in job satisfaction among dentists with musculoskeletal disorders? A cross sectional study. Med Pr (2014) 1.00
Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci (2007) 1.00
Dissociative properties of the proteins within the bacteriophage T4 replisome. J Biol Chem (2003) 0.99
Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents. J Med Chem (2011) 0.99
The oligomeric T4 primase is the functional form during replication. J Biol Chem (2005) 0.99
A clamp-like biohybrid catalyst for DNA oxidation. Nat Chem (2013) 0.98
The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities. J Biol Chem (2006) 0.98
Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S. J Org Chem (2012) 0.97
Microstructured-core photonic-crystal fiber for ultra-sensitive refractive index sensing. Opt Express (2011) 0.97
Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH. J Med Chem (2005) 0.97
Enhanced crossover SCRATCHY: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers. Nucleic Acids Res (2003) 0.96
Mapping protein-protein proximity in the purinosome. J Biol Chem (2012) 0.96
Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization. Angew Chem Int Ed Engl (2005) 0.96