Published in Proc Natl Acad Sci U S A on February 22, 2005
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Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism. Nat Struct Mol Biol (2005) 3.04
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An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science (2007) 2.82
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The dynamic processivity of the T4 DNA polymerase during replication. Proc Natl Acad Sci U S A (2004) 1.76
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71
Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase. Biochemistry (2005) 1.68
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Nat Chem Biol (2009) 1.68
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Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proc Natl Acad Sci U S A (2002) 1.43
The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philos Trans R Soc Lond B Biol Sci (2006) 1.39
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Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem (2010) 1.36
The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication. Mol Cell (2006) 1.35
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Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli. Nat Protoc (2007) 1.31
The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. Proc Natl Acad Sci U S A (2006) 1.29
Single molecule studies of enzyme mechanisms. Chem Rev (2006) 1.26
Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction. ACS Chem Biol (2008) 1.23
Microtubule-assisted mechanism for functional metabolic macromolecular complex formation. Proc Natl Acad Sci U S A (2010) 1.23
Evolution of cyclic peptide protease inhibitors. Proc Natl Acad Sci U S A (2011) 1.20
Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. Bioorg Med Chem Lett (2006) 1.16
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nat Chem Biol (2011) 1.15
Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. Proc Natl Acad Sci U S A (2004) 1.14
Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles. Lab Chip (2013) 1.13
Identification and mapping of protein-protein interactions by a combination of cross-linking, cleavage, and proteomics. Bioconjug Chem (2005) 1.12
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Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding. Nucleic Acids Res (2011) 1.10
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Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proc Natl Acad Sci U S A (2013) 1.09
The application of a minicircle substrate in the study of the coordinated T4 DNA replication. J Biol Chem (2003) 1.08
Preorganization and protein dynamics in enzyme catalysis. Chem Rec (2002) 1.08
Collaborative coupling between polymerase and helicase for leading-strand synthesis. Nucleic Acids Res (2012) 1.08
Evolution of highly active enzymes by homology-independent recombination. Proc Natl Acad Sci U S A (2005) 1.08
Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase. J Am Chem Soc (2014) 1.07
A systematic method for identifying small-molecule modulators of protein-protein interactions. Proc Natl Acad Sci U S A (2004) 1.07
An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex. Biochemistry (2006) 1.07
Mechanism of strand displacement synthesis by DNA replicative polymerases. Nucleic Acids Res (2012) 1.07
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Assembly of the bacteriophage T4 helicase: architecture and stoichiometry of the gp41-gp59 complex. J Biol Chem (2002) 1.06
FamClash: a method for ranking the activity of engineered enzymes. Proc Natl Acad Sci U S A (2004) 1.06
Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. Annu Rev Biophys (2015) 1.06
Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. Biochemistry (2005) 1.05
Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation. Biochemistry (2006) 1.05
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry (2003) 1.05
Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme. J Mol Biol (2003) 1.04
Single-molecule mechanical identification and sequencing. Nat Methods (2012) 1.04
RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue. Nat Commun (2013) 1.03
RNA primer handoff in bacteriophage T4 DNA replication: the role of single-stranded DNA-binding protein and polymerase accessory proteins. J Biol Chem (2008) 1.02
IPRO: an iterative computational protein library redesign and optimization procedure. Biophys J (2006) 1.02
On the solution structure of the T4 sliding clamp (gp45). Biochemistry (2004) 1.02
Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II. Proc Natl Acad Sci U S A (2007) 1.01
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Direct observation of stalled fork restart via fork regression in the T4 replication system. Science (2012) 1.01
Differential microRNA epression in asthma and the role of miR-1248 in regulation of IL-5. Am J Clin Exp Immunol (2012) 1.01
Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci (2007) 1.00
Dissociative properties of the proteins within the bacteriophage T4 replisome. J Biol Chem (2003) 0.99
The oligomeric T4 primase is the functional form during replication. J Biol Chem (2005) 0.99
A clamp-like biohybrid catalyst for DNA oxidation. Nat Chem (2013) 0.98
The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities. J Biol Chem (2006) 0.98
Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S. J Org Chem (2012) 0.97
Enhanced crossover SCRATCHY: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers. Nucleic Acids Res (2003) 0.96
Mapping protein-protein proximity in the purinosome. J Biol Chem (2012) 0.96
Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization. Angew Chem Int Ed Engl (2005) 0.96