Published in Annu Rev Biophys on January 01, 2015
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Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. Proc Natl Acad Sci U S A (2016) 0.82
Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork. Mol Cell (2017) 0.80
Characterization of human translesion DNA synthesis across a UV-induced DNA lesion. Elife (2016) 0.77
Ubc13: the Lys63 ubiquitin chain building machine. Oncotarget (2016) 0.76
PARP10 deficiency manifests by severe developmental delay and DNA repair defect. Neurogenetics (2016) 0.76
Expansion of Interstitial Telomeric Sequences in Yeast. Cell Rep (2015) 0.76
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. Elife (2016) 0.75
Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks. Nucleic Acids Res (2016) 0.75
Pathological trans-lesion synthesis in cancer. Cell Cycle (2016) 0.75
Bacterial and Eukaryotic Replisome Machines. JSM Biochem Mol Biol (2016) 0.75
Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA. Biochemistry (2017) 0.75
Cancer cells activate damage-tolerant and error-prone DNA synthesis. Mol Cell Oncol (2016) 0.75
DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress. J Cell Biol (2017) 0.75
Both RAD5-dependent and independent pathways are involved in DNA damage-associated sister chromatid exchange in budding yeast. AIMS Genet (2017) 0.75
Differential expression profile analysis of DNA damage repair genes in CD133(+)/CD133(-) colorectal cancer cells. Oncol Lett (2017) 0.75
Relating protein motion to catalysis. Annu Rev Biochem (2006) 4.50
Network of coupled promoting motions in enzyme catalysis. Proc Natl Acad Sci U S A (2002) 3.98
DNA polymerase fidelity: kinetics, structure, and checkpoints. Biochemistry (2004) 3.71
Allosteric regulation and catalysis emerge via a common route. Nat Chem Biol (2008) 3.62
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science (2008) 2.98
On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves. Proc Natl Acad Sci U S A (2012) 2.91
Surface sites for engineering allosteric control in proteins. Science (2008) 2.82
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science (2007) 2.82
Design and evolution of new catalytic activity with an existing protein scaffold. Science (2006) 2.71
Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase. Proc Natl Acad Sci U S A (2006) 2.37
Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis. J Am Chem Soc (2004) 2.21
Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry (2002) 2.09
Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase. Proc Natl Acad Sci U S A (2005) 2.05
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proc Natl Acad Sci U S A (2007) 1.76
The dynamic processivity of the T4 DNA polymerase during replication. Proc Natl Acad Sci U S A (2004) 1.76
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71
Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase. Biochemistry (2005) 1.68
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome. Nat Chem Biol (2009) 1.68
Flexibility, diversity, and cooperativity: pillars of enzyme catalysis. Biochemistry (2011) 1.60
Effects of a distal mutation on active site chemistry. Biochemistry (2006) 1.59
Coupled motions in enzyme catalysis. Curr Opin Chem Biol (2010) 1.49
Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proc Natl Acad Sci U S A (2002) 1.43
The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philos Trans R Soc Lond B Biol Sci (2006) 1.39
Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction. J Am Chem Soc (2012) 1.37
Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem (2010) 1.36
The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication. Mol Cell (2006) 1.35
Boron-containing inhibitors of synthetases. Chem Soc Rev (2011) 1.32
Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli. Nat Protoc (2007) 1.31
The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. Proc Natl Acad Sci U S A (2006) 1.29
Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction. ACS Chem Biol (2008) 1.23
Microtubule-assisted mechanism for functional metabolic macromolecular complex formation. Proc Natl Acad Sci U S A (2010) 1.23
Evolution of cyclic peptide protease inhibitors. Proc Natl Acad Sci U S A (2011) 1.20
Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. Bioorg Med Chem Lett (2006) 1.16
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nat Chem Biol (2011) 1.15
Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. Proc Natl Acad Sci U S A (2004) 1.14
Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles. Lab Chip (2013) 1.13
Replication clamps and clamp loaders. Cold Spring Harb Perspect Biol (2013) 1.10
Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proc Natl Acad Sci U S A (2013) 1.09
The application of a minicircle substrate in the study of the coordinated T4 DNA replication. J Biol Chem (2003) 1.08
Preorganization and protein dynamics in enzyme catalysis. Chem Rec (2002) 1.08
Collaborative coupling between polymerase and helicase for leading-strand synthesis. Nucleic Acids Res (2012) 1.08
Evolution of highly active enzymes by homology-independent recombination. Proc Natl Acad Sci U S A (2005) 1.08
Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase. J Am Chem Soc (2014) 1.07
A systematic method for identifying small-molecule modulators of protein-protein interactions. Proc Natl Acad Sci U S A (2004) 1.07
An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex. Biochemistry (2006) 1.07
Mechanism of strand displacement synthesis by DNA replicative polymerases. Nucleic Acids Res (2012) 1.07
FamClash: a method for ranking the activity of engineered enzymes. Proc Natl Acad Sci U S A (2004) 1.06
Assembly of the bacteriophage T4 helicase: architecture and stoichiometry of the gp41-gp59 complex. J Biol Chem (2002) 1.06
Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. Biochemistry (2005) 1.05
Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation. Biochemistry (2006) 1.05
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry (2003) 1.05
Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme. J Mol Biol (2003) 1.04
Single-molecule mechanical identification and sequencing. Nat Methods (2012) 1.04
RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue. Nat Commun (2013) 1.03
On the solution structure of the T4 sliding clamp (gp45). Biochemistry (2004) 1.02
RNA primer handoff in bacteriophage T4 DNA replication: the role of single-stranded DNA-binding protein and polymerase accessory proteins. J Biol Chem (2008) 1.02
IPRO: an iterative computational protein library redesign and optimization procedure. Biophys J (2006) 1.02
Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase. Protein Sci (2003) 1.01
Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. Proc Natl Acad Sci U S A (2005) 1.01
Direct observation of stalled fork restart via fork regression in the T4 replication system. Science (2012) 1.01
Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci (2007) 1.00
The oligomeric T4 primase is the functional form during replication. J Biol Chem (2005) 0.99
Dissociative properties of the proteins within the bacteriophage T4 replisome. J Biol Chem (2003) 0.99
A clamp-like biohybrid catalyst for DNA oxidation. Nat Chem (2013) 0.98
The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities. J Biol Chem (2006) 0.98
Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S. J Org Chem (2012) 0.97
Enhanced crossover SCRATCHY: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers. Nucleic Acids Res (2003) 0.96
Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization. Angew Chem Int Ed Engl (2005) 0.96
Mapping protein-protein proximity in the purinosome. J Biol Chem (2012) 0.96
Probing cell-cell communication with microfluidic devices. Lab Chip (2013) 0.96
A universal, vector-based system for nucleic acid reading-frame selection. Protein Eng (2002) 0.96
Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. Biochemistry (2005) 0.95
Architecture of the bacteriophage T4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). Proc Natl Acad Sci U S A (2005) 0.95
Protein-protein interactions in the bacteriophage T4 replisome. The leading strand holoenzyme is physically linked to the lagging strand holoenzyme and the primosome. J Biol Chem (2002) 0.95
Biochemical characterization of bacteriophage T4 Mre11-Rad50 complex. J Biol Chem (2010) 0.95
PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site. J Biol Chem (2002) 0.94
LOVely enzymes - towards engineering light-controllable biocatalysts. Microb Biotechnol (2009) 0.94
Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome. Proc Natl Acad Sci U S A (2013) 0.94
Detection of dihydrofolate reductase conformational change by FRET using two fluorescent amino acids. J Am Chem Soc (2013) 0.93
Investigation of stoichiometry of T4 bacteriophage helicase loader protein (gp59). J Biol Chem (2009) 0.93
Stepwise loading of yeast clamp revealed by ensemble and single-molecule studies. Proc Natl Acad Sci U S A (2010) 0.93
The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer. Chem Commun (Camb) (2010) 0.93
Response of the bacteriophage T4 replisome to noncoding lesions and regression of a stalled replication fork. J Mol Biol (2010) 0.91
Use of inteins for the in vivo production of stable cyclic peptide libraries in E. coli. Methods Mol Biol (2003) 0.91
The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans. Chem Commun (Camb) (2013) 0.90
Structural and functional modularity of proteins in the de novo purine biosynthetic pathway. Protein Sci (2009) 0.90
Magnetic tweezers for the study of DNA tracking motors. Methods Enzymol (2010) 0.90
Site-directed mutations of T4 helicase loading protein (gp59) reveal multiple modes of DNA polymerase inhibition and the mechanism of unlocking by gp41 helicase. J Biol Chem (2006) 0.89
Processive and unidirectional translocation of monomeric UvsW helicase on single-stranded DNA. Biochemistry (2009) 0.89
Single-molecule studies of DNA replisome function. Biochim Biophys Acta (2009) 0.89
Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. J Med Chem (2003) 0.87
A nonradioactive DNA methyltransferase assay adaptable to high-throughput screening. Anal Biochem (2005) 0.87
How a holoenzyme for DNA replication is formed. Proc Natl Acad Sci U S A (2012) 0.87
Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics. J Am Chem Soc (2012) 0.87
Genetic selection of cyclic peptide Dam methyltransferase inhibitors. Chembiochem (2008) 0.86
Cyclic peptides, a chemical genetics tool for biologists. Cell Cycle (2005) 0.86
Engineering an affinity tag for genetically encoded cyclic peptides. Biotechnol Bioeng (2005) 0.86
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. Bioorg Med Chem (2002) 0.85