Published in Circ Res on September 23, 2010
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Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med (2011) 1.08
New insights into the therapeutic potential of Girk channels. Trends Neurosci (2013) 1.01
Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice. J Biol Chem (2012) 1.01
Regulator of G protein signaling 6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species-dependent mechanism. Cancer Res (2011) 1.01
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Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling. J Biol Chem (2011) 0.93
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G-protein inactivator RGS6 mediates myocardial cell apoptosis and cardiomyopathy caused by doxorubicin. Cancer Res (2013) 0.92
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Modern concepts concerning the origin of the heartbeat. Physiology (Bethesda) (2013) 0.88
RGS Proteins in Heart: Brakes on the Vagus. Front Physiol (2012) 0.86
RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. Elife (2014) 0.85
Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet (2014) 0.84
Regulator of G protein signaling 6 is a novel suppressor of breast tumor initiation and progression. Carcinogenesis (2013) 0.83
Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells. J Neurochem (2012) 0.82
Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol. Proc Natl Acad Sci U S A (2015) 0.82
Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB J (2014) 0.81
Association between regulator of G protein signaling 9-2 and body weight. PLoS One (2011) 0.80
Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node. Front Physiol (2012) 0.80
Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2. PLoS One (2012) 0.78
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Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling. J Biol Chem (2015) 0.77
Electrocardiogram characteristics prior to in-hospital cardiac arrest. J Clin Monit Comput (2014) 0.76
Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein. J Biol Chem (2016) 0.76
GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability. Am J Hum Genet (2016) 0.75
Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes. Front Physiol (2012) 0.75
RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation. Oncotarget (2016) 0.75
RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays (2016) 0.75
Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK-ERK1/2 signalling pathway. Basic Res Cardiol (2016) 0.75
Regulator of G Protein Signaling 6 Protects the Heart from Ischemic Injury. J Pharmacol Exp Ther (2016) 0.75
Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun (2017) 0.75
Regulator of G protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion. FASEB J (2017) 0.75
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Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res (2006) 2.15
RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity. J Biol Chem (2003) 1.91
RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res (2008) 1.61
Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh. J Biol Chem (2002) 1.34
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proc Natl Acad Sci U S A (2010) 1.30
Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block. Am J Physiol Heart Circ Physiol (2007) 1.21
Profile of RGS expression in single rat atrial myocytes. Biochim Biophys Acta (2001) 1.18
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Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature (2012) 6.37
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
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Unintended consequences of caps on Medicare drug benefits. N Engl J Med (2006) 5.67
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Requirements for high impact diagnostics in the developing world. Nature (2006) 4.73
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68
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T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res (2010) 3.57
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RGS expression rate-limits recovery of rod photoresponses. Neuron (2006) 3.48
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2002) 3.27
Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol (2003) 3.04
Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol (2006) 2.95
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Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science (2006) 2.86
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
Rapid discharge connects Antarctic subglacial lakes. Nature (2006) 2.72
CaMKII determines mitochondrial stress responses in heart. Nature (2012) 2.63
Retracted L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Mol Cell (2006) 2.49
Evidence for two apoptotic pathways in light-induced retinal degeneration. Nat Genet (2002) 2.49
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
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Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Medicare beneficiaries' knowledge of Part D prescription drug program benefits and responses to drug costs. JAMA (2008) 2.31
An ER-fMRI investigation of morphological inflection in German reveals that the brain makes a distinction between regular and irregular forms. Brain Lang (2003) 2.30
A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly. Cell (2012) 2.21
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm (2011) 2.21
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Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. Circulation (2008) 2.16
Pharmacotherapy plus endoscopic intervention is more effective than pharmacotherapy or endoscopy alone in the secondary prevention of esophageal variceal bleeding: a meta-analysis of randomized, controlled trials. Gastrointest Endosc (2009) 2.10
Transducin translocation in rods is triggered by saturation of the GTPase-activating complex. J Neurosci (2007) 2.09
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Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway. J Cell Biol (2008) 2.08
Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes. Am J Physiol Heart Circ Physiol (2007) 2.07
A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J Clin Invest (2010) 2.04
Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer. Clin Colorectal Cancer (2002) 2.02
Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome (2013) 1.98
SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell (2013) 1.97
Annotations and functional analyses of the rice WRKY gene superfamily reveal positive and negative regulators of abscisic acid signaling in aleurone cells. Plant Physiol (2004) 1.96
Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A (2009) 1.95
Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ Res (2006) 1.94
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm (2012) 1.91
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Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo. Am J Physiol Heart Circ Physiol (2006) 1.86
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A (2006) 1.85
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation (2006) 1.85
Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry (2010) 1.85
A calcium sensor in the sodium channel modulates cardiac excitability. Nature (2002) 1.83
Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein. J Biol Chem (2003) 1.80
CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Proc Natl Acad Sci U S A (2003) 1.78
Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst (2013) 1.78
Comparison of 3D free-breathing coronary MR angiography and 64-MDCT angiography for detection of coronary stenosis in patients with high calcium scores. AJR Am J Roentgenol (2007) 1.77
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci (2005) 1.74
Regulation of flowering time in Arabidopsis by K homology domain proteins. Proc Natl Acad Sci U S A (2004) 1.73
Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. J Biol Chem (2006) 1.72
Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci U S A (2008) 1.72
Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice. J Biol Chem (2007) 1.70
Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability. Neurotoxicology (2005) 1.70
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem (2006) 1.70
Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res (2005) 1.70
Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69
Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature (2009) 1.69
Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest (2011) 1.68
Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J Neurosci (2005) 1.68
CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67
Falling into the coverage gap: Part D drug costs and adherence for Medicare Advantage prescription drug plan beneficiaries with diabetes. Health Serv Res (2009) 1.66
Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues. Methods Enzymol (2004) 1.63