Published in Proc Natl Acad Sci U S A on November 06, 2006
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell (2008) 3.53
The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol (2008) 1.88
Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc Natl Acad Sci U S A (2008) 1.77
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J (2008) 1.44
Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell (2009) 1.27
REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions. Cell Cycle (2010) 1.24
Characterization and classification of zebrafish brain morphology mutants. Anat Rec (Hoboken) (2009) 1.12
Mediator and human disease. Semin Cell Dev Biol (2011) 1.10
Multiple roles for Med12 in vertebrate endoderm development. Dev Biol (2008) 1.06
Mediator kinase module and human tumorigenesis. Crit Rev Biochem Mol Biol (2015) 0.98
Mediator subunit 12 is required for neutrophil development in zebrafish. PLoS One (2011) 0.96
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling. EMBO Rep (2011) 0.94
Analysis of differential expression of Mediator subunit genes in Arabidopsis. Plant Signal Behav (2012) 0.88
Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Mol Autism (2013) 0.85
Identification of unstable network modules reveals disease modules associated with the progression of Alzheimer's disease. PLoS One (2013) 0.85
Mediator subunit Med12 contributes to the maintenance of neural stem cell identity. BMC Dev Biol (2016) 0.81
PHYTOCHROME AND FLOWERING TIME1/MEDIATOR25 Regulates Lateral Root Formation via Auxin Signaling in Arabidopsis. Plant Physiol (2014) 0.80
The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. J Biol Chem (2014) 0.79
The transcriptional mediator component Med12 is required for hindbrain boundary formation. PLoS One (2011) 0.78
Mediator: the missing link in amyloid precursor protein nuclear signalling. EMBO Rep (2011) 0.77
Transcriptional mediators Kto and Skd are involved in the regulation of the IMD pathway and anti-Plasmodium defense in Anopheles gambiae. PLoS One (2012) 0.77
MED12 in hematopoietic stem cells-cell specific function despite ubiquitous expression. Stem Cell Investig (2017) 0.75
Time dynamics of protein complexes in the AD11 transgenic mouse model for Alzheimer's disease like pathology. BMC Neurosci (2015) 0.75
MED12 mutations in human diseases. Protein Cell (2013) 0.75
Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci (2017) 0.75
The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent. eNeuro (2017) 0.75
Stages of embryonic development of the zebrafish. Dev Dyn (1995) 42.72
Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62
Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell (1994) 7.39
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature (1994) 7.30
Transcription of eukaryotic protein-coding genes. Annu Rev Genet (2000) 6.12
Vertebrate neural cell-fate determination: lessons from the retina. Nat Rev Neurosci (2001) 5.26
Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37
Mediator of transcriptional regulation. Annu Rev Biochem (2000) 3.51
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell (1999) 3.47
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42
Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends Biochem Sci (2000) 3.03
Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. J Neurosci (1994) 2.88
Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron (1997) 2.71
Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system. Cell (1999) 2.60
Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem (2006) 2.51
Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science (2002) 2.33
A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development (2005) 2.20
Specification of temporal identity in the developing nervous system. Annu Rev Cell Dev Biol (2004) 2.13
Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression. Development (2002) 2.10
A regulator of transcriptional elongation controls vertebrate neuronal development. Nature (2000) 1.87
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85
A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature (2002) 1.82
Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron (1999) 1.65
Two sox9 genes on duplicated zebrafish chromosomes: expression of similar transcription activators in distinct sites. Dev Biol (2001) 1.59
Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development (2001) 1.42
SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res (2002) 1.38
Two subunits of the Drosophila mediator complex act together to control cell affinity. Development (2003) 1.36
Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol (1999) 1.36
Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Development (2005) 1.35
Ascl1/Mash1 is required for the development of central serotonergic neurons. Nat Neurosci (2004) 1.35
Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development (1995) 1.32
The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci U S A (2005) 1.31
Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development. Dev Biol (2006) 1.23
A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene. Genes Dev (2000) 1.22
Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters. Mol Cell Biol (2001) 1.16
The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem (2004) 1.13
The expression pattern of two zebrafish achaete-scute homolog (ash) genes is altered in the embryonic brain of the cyclops mutant. Dev Biol (1994) 1.08
A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development (2003) 1.08
lessen encodes a zebrafish trap100 required for enteric nervous system development. Development (2006) 1.03
Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proc Natl Acad Sci U S A (2006) 1.02
Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism. Am J Med Genet (2001) 0.89
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46
Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell (2004) 5.30
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med (2008) 4.25
S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell (2003) 4.03
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell (2002) 3.99
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol (2004) 3.70
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55
A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol (2004) 3.53
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
Retracted GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2009) 3.10
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell (2003) 2.97
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet (2007) 2.96
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87
The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. Mol Cell (2005) 2.79
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70
30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol (2008) 2.62
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell (2003) 2.31
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell (2011) 2.30
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell (2010) 2.25
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell (2010) 2.20
Suppression of the antiviral response by an influenza histone mimic. Nature (2012) 2.18
Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A (2006) 2.16
GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev (2013) 2.07
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06
H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell (2013) 2.00
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A (2005) 1.97
E protein silencing by the leukemogenic AML1-ETO fusion protein. Science (2004) 1.89
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87
Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A (2008) 1.80
Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacol Biochem Behav (2004) 1.75
Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol (2006) 1.75
The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A (2002) 1.72
7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A (2009) 1.71
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc Natl Acad Sci U S A (2011) 1.65
An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. Hum Mol Genet (2008) 1.62
A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A (2006) 1.58
Peste des petits ruminants virus in Tibet, China. Emerg Infect Dis (2009) 1.54
Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates. Cell (2006) 1.54
PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol Cell Biol (2008) 1.53
Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol (2003) 1.53
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest (2015) 1.52
Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks. Eur J Hum Genet (2006) 1.51
Risk factors associated with fluoroquinolone-resistant tuberculosis in a Beijing tuberculosis referral hospital. Respirology (2011) 1.50
Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol (2007) 1.50
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science (2011) 1.49
Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J Biol Chem (2006) 1.46
Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin. Mol Cell (2002) 1.44
Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast. J Biol Chem (2009) 1.44
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet (2011) 1.44
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Am J Pathol (2002) 1.41
SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. J Biol Chem (2001) 1.40
Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. Mol Cell Biol (2003) 1.38
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J (2002) 1.38
SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res (2002) 1.38
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell (2013) 1.38
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov (2012) 1.33
MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein. J Biomed Sci (2002) 1.33
GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. Mol Cell Biol (2006) 1.32
TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol (2002) 1.31
Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study. Ann Allergy Asthma Immunol (2010) 1.31
Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol (2004) 1.31
The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A (2006) 1.30
Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol (2004) 1.30
Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220. Mol Cell (2005) 1.30
Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Altern Complement Med (2009) 1.30
Isolation and functional characterization of the TRAP/mediator complex. Methods Enzymol (2003) 1.28
A systematic approach to identify functional motifs within vertebrate developmental enhancers. Dev Biol (2009) 1.26
Reconstitution and transcriptional analysis of chromatin in vitro. Methods Enzymol (2004) 1.25
Characterization of the human beta-globin downstream promoter region. Nucleic Acids Res (2003) 1.24
Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A (2008) 1.23
SWI/SNF remodeling and p300-dependent transcription of histone variant H2ABbd nucleosomal arrays. EMBO J (2004) 1.23
RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Mol Cell (2011) 1.23
RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep (2013) 1.22
TIP30 deficiency increases susceptibility to tumorigenesis. Cancer Res (2003) 1.20
Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiol Dis (2010) 1.20
Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One (2008) 1.20
Limb-girdle muscular dystrophy: diagnostic evaluation, frequency and clues to pathogenesis. Neuromuscul Disord (2007) 1.19
The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol Cell (2013) 1.19