Published in J Biol Chem on March 24, 2006
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
The many faces and functions of β-catenin. EMBO J (2012) 3.85
Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol (2009) 3.67
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell (2008) 3.53
The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci (2010) 3.38
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature (2008) 3.24
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc Natl Acad Sci U S A (2008) 2.10
The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene. J Med Genet (2007) 2.02
The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol (2015) 1.97
The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol (2008) 1.88
Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc Natl Acad Sci U S A (2008) 1.77
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol Cell Biol (2006) 1.58
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CDK8: a positive regulator of transcription. Transcription (2012) 1.53
Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril (2014) 1.45
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J (2008) 1.44
Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J (2007) 1.38
MED12 alterations in both human benign and malignant uterine soft tissue tumors. PLoS One (2012) 1.26
A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A (2006) 1.25
The Mediator complex and transcription elongation. Biochim Biophys Acta (2012) 1.24
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer. Br J Cancer (2012) 1.24
Mutations in MED12 cause X-linked Ohdo syndrome. Am J Hum Genet (2013) 1.20
Probing transcription-specific outputs of β-catenin in vivo. Genes Dev (2011) 1.18
Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin. Mol Cell Biol (2008) 1.17
Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity. Cell Rep (2014) 1.14
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J Biol Chem (2008) 1.13
Characterization and classification of zebrafish brain morphology mutants. Anat Rec (Hoboken) (2009) 1.12
CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. Int J Cancer (2010) 1.11
Mediator and human disease. Semin Cell Dev Biol (2011) 1.10
Revving the Throttle on an oncogene: CDK8 takes the driver seat. Cancer Res (2009) 1.09
Multiple roles for Med12 in vertebrate endoderm development. Dev Biol (2008) 1.06
Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J (2014) 1.05
A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila. Mol Cell Biol (2010) 1.01
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2012) 1.00
Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth. Proc Natl Acad Sci U S A (2013) 0.98
Mediator kinase module and human tumorigenesis. Crit Rev Biochem Mol Biol (2015) 0.98
Mediator subunit 12 is required for neutrophil development in zebrafish. PLoS One (2011) 0.96
MiRNA-26b inhibits cellular proliferation by targeting CDK8 in breast cancer. Int J Clin Exp Med (2014) 0.95
Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo. Proc Natl Acad Sci U S A (2008) 0.95
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling. EMBO Rep (2011) 0.94
Effects of cyclin-dependent kinase 8 specific siRNA on the proliferation and apoptosis of colon cancer cells. J Exp Clin Cancer Res (2011) 0.93
A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Mol Ther (2009) 0.93
Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids. Mol Genet Genomics (2014) 0.93
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. Nat Commun (2015) 0.92
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J Med Chem (2016) 0.91
Selective requirement for Mediator MED23 in Ras-active lung cancer. Proc Natl Acad Sci U S A (2012) 0.91
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat Chem Biol (2015) 0.90
Message in a nucleus: signaling to the transcriptional machinery. Curr Opin Genet Dev (2008) 0.89
Conserved versatile master regulators in signalling pathways in response to stress in plants. AoB Plants (2013) 0.88
Analysis of differential expression of Mediator subunit genes in Arabidopsis. Plant Signal Behav (2012) 0.88
MED12 exon 2 mutations in histopathological uterine leiomyoma variants. Eur J Hum Genet (2013) 0.87
Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction. Obstet Gynecol Int (2013) 0.87
Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications. Hum Reprod Update (2014) 0.87
Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev Dyn (2011) 0.86
Disordered proteinaceous machines. Chem Rev (2014) 0.86
Microarray characterization of gene expression changes in blood during acute ethanol exposure. BMC Med Genomics (2013) 0.86
A novel MED12 mutation associated with non-specific X-linked intellectual disability. Hum Genome Var (2015) 0.83
Tissue-specific stem cells in the myometrium and tumor-initiating cells in leiomyoma. Biol Reprod (2014) 0.83
MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8. J Transl Med (2015) 0.83
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs. Sci Adv (2015) 0.82
Mediator subunit Med12 contributes to the maintenance of neural stem cell identity. BMC Dev Biol (2016) 0.81
Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth. Hum Reprod Update (2015) 0.80
Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila. J Biol Chem (2014) 0.80
The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Mol Cell Biol (2015) 0.79
Role of GAC63 in transcriptional activation mediated by beta-catenin. Nucleic Acids Res (2007) 0.79
Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas. Br J Cancer (2014) 0.78
Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution. Curr Opin Obstet Gynecol (2015) 0.78
Somatic mutational analysis of MED12 exon 2 in uterine leiomyomas of Iranian women. Am J Cancer Res (2015) 0.78
A gene trap mutagenesis screen for genes underlying cellular response to the mood stabilizer lithium. J Cell Mol Med (2013) 0.77
Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator. J Biol Chem (2010) 0.77
Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells. J Clin Endocrinol Metab (2016) 0.76
MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways. Oncotarget (2016) 0.75
MED12 mutations in human diseases. Protein Cell (2013) 0.75
MED30 Regulates the Proliferation and Motility of Gastric Cancer Cells. PLoS One (2015) 0.75
Somatic Genetic Variation in Solid Pseudopapillary Tumor of the Pancreas by Whole Exome Sequencing. Int J Mol Sci (2017) 0.75
Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling. Genes (Basel) (2017) 0.75
Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Nucleic Acids Res (2016) 0.75
High-resolution melting analysis of MED12 mutations in uterine leiomyomas in Chinese patients. Genet Test Mol Biomarkers (2015) 0.75
Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms. Biochem J (2011) 0.75
Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway. Endocrinology (2016) 0.75
Aberrant expression of CDK8 regulates the malignant phenotype and associated with poor prognosis in human laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol (2017) 0.75
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell (2008) 3.53
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res (2002) 1.60
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A (2011) 1.59
Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol Cell Biol (2006) 1.58
Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res (2009) 1.52
Trans-repression of beta-catenin activity by nuclear receptors. J Biol Chem (2003) 1.37
Modulation of estrogen receptor alpha protein level and survival function by DBC-1. Mol Endocrinol (2007) 1.37
The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression. Mol Cell Biol (2006) 1.31
Mutations in MED12 cause X-linked Ohdo syndrome. Am J Hum Genet (2013) 1.20
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J Biol Chem (2008) 1.13
A role for BRCA1 in uterine leiomyosarcoma. Cancer Res (2009) 1.13
Mediator and human disease. Semin Cell Dev Biol (2011) 1.10
Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors. Mol Cell Biol (2007) 1.09
Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures. Exp Cell Res (2006) 1.06
Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis. Exp Cell Res (2007) 1.06
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2012) 1.00
E-cadherin intron 2 contains cis-regulatory elements essential for gene expression. Development (2005) 1.00
BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells. J Clin Endocrinol Metab (2006) 0.95
Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes. Stem Cells (2008) 0.95
Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes. Oncogene (2002) 0.94
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling. EMBO Rep (2011) 0.94
Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas. Hum Mutat (2014) 0.89
Basic helix-loop-helix transcription factor Twist1 inhibits transactivator function of master chondrogenic regulator Sox9. J Biol Chem (2012) 0.89
Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryos. Dev Dyn (2003) 0.88
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein. Gynecol Oncol (2009) 0.88
Poly[(acetato-κO,O')aqua-(μ(4)-1H-benzimidazole-5,6-dicarboxyl-ato-κN:O,O:O,O:O)praseodymium(III)]. Acta Crystallogr Sect E Struct Rep Online (2010) 0.87
17beta-estradiol inhibits angiotensin II-induced cardiac myofibroblast differentiation. Eur J Pharmacol (2009) 0.87
Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. J Biol Chem (2003) 0.87
Prediction of the baseline toxicity of non-polar narcotic chemical mixtures by QSAR approach. Chemosphere (2012) 0.87
Bis(2,2'-bipyridine)(2-hy-droxy-2,2-diphenyl-acetato)-copper(II) nitrate dihydrate. Acta Crystallogr Sect E Struct Rep Online (2010) 0.85
Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer. Epigenetics (2011) 0.84
Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions. Front Physiol (2013) 0.83
Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression. Nucleic Acids Res (2012) 0.83
Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics (2011) 0.83
Bovine foamy virus transactivator BTas interacts with cellular RelB to enhance viral transcription. J Virol (2010) 0.81
Effect of severe short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover. J Appl Physiol (1985) (2006) 0.81
DBC-1 mediates endocrine resistant breast cancer cell survival. Cell Cycle (2010) 0.81
Transcription factor GATA-4 is involved in erythropoietin-induced cardioprotection against myocardial ischemia/reperfusion injury. Int J Cardiol (2008) 0.80
A multifunctional organic-inorganic hybrid structure based on Mn(III)-porphyrin and polyoxometalate as a highly effective dye scavenger and heterogenous catalyst. J Am Chem Soc (2011) 0.80
Preparation of BFV Gag antiserum and preliminary study on cellular distribution of BFV. Virol Sin (2010) 0.79
Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1. J Biol Chem (2004) 0.79
Improved electrocatalytic activity for ethanol oxidation by Pd@N-doped carbon from biomass. Chem Commun (Camb) (2014) 0.79
Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. Proc Natl Acad Sci U S A (2014) 0.78
Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex. PLoS One (2013) 0.78
BRCA1 and estrogen signaling in breast cancer. Breast Dis (2003) 0.78
4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. J Cell Mol Med (2009) 0.77
From 1D to 3D single-crystal-to-single-crystal structural transformations based on linear polyanion [Mn4(H2O)18WZnMn2(H2O)2(ZnW9O34)2]4-. Inorg Chem (2011) 0.77
Quantitative detection of potassium ions and adenosine triphosphate via a nanochannel-based electrochemical platform coupled with G-quadruplex aptamers. Anal Chem (2014) 0.77
A single nucleotide polymorphism in 3' untranslated region of epithelial growth factor receptor confers risk for pulmonary hypertension in chronic obstructive pulmonary disease. Cell Physiol Biochem (2015) 0.76
Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics. FEBS J (2015) 0.76
A quantitative assay for measuring of bovine immunodeficiency virus using a luciferase-based indicator cell line. Virol Sin (2010) 0.76
Microbial and metabolic characterization of a denitrifying phosphorus-uptake/side stream phosphorus removal system for treating domestic sewage. Biodegradation (2014) 0.76
QSAR modeling for the antimalarial activity of 1,4-naphthoquinonyl derivatives as potential antimalarial agents. Curr Comput Aided Drug Des (2013) 0.76
Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β. Mol Cell (2016) 0.75
Enhancement of naked FIX minigene expression by chloroquine in mice. Acta Pharmacol Sin (2004) 0.75
17beta-estradiol attenuates cardiac dysfunction and decreases NF-kappaB binding activity in mechanically stretched rat hearts. Steroids (2008) 0.75
[The Influence of Runoff Pollution to DOM Features in an Urban Wastewater Treatment Plant]. Guang Pu Xue Yu Guang Pu Fen Xi (2015) 0.75
[Interpretation of the experts' consensus on continuous blood purification treatment of severe sepsis in children]. Zhonghua Er Ke Za Zhi (2012) 0.75
Nanocomposites of graphene and cytochrome P450 2D6 isozyme for electrochemical-driven tramadol metabolism. Langmuir (2014) 0.75
[Sinonasal-type hemangiopericytoma:reports of two cases and review of the literature]. Zhonghua Bing Li Xue Za Zhi (2015) 0.75
[Molecular mechanism of idiopathic basal ganglia calcification]. Yi Chuan (2015) 0.75
Determination and pharmacokinetics of linarin in rat plasma after intramuscular administration of linarin solution and Yejuhua injection by HPLC. Biomed Chromatogr (2014) 0.75
Influence of magnesia modification on the properties of copper oxide supported on gamma-alumina. J Colloid Interface Sci (2008) 0.75
Extracorporeal membrane oxygenation as a support for TGA/IVS with low cardiac output syndrome and pulmonary hemorrhage. Rev Bras Cir Cardiovasc (2013) 0.75
[The pediatrician and disaster preparedness]. Zhonghua Er Ke Za Zhi (2009) 0.75
[Pricking blood therapy for 30 cases of Chalazions in children]. Zhongguo Zhen Jiu (2014) 0.75
Two metal-organic frameworks based on a double azolium derivative: post-modification and catalytic activity. Chem Commun (Camb) (2011) 0.75
Validation of accumulation models for inorganic suspended solids of different particle size in an activated sludge system. Bioresour Technol (2013) 0.75
Platinum(II)-catalyzed asymmetric ring-opening addition of arylboronic acids to oxabenzonorbornadienes. J Org Chem (2013) 0.75
[Quality of life in children with short stature: an analysis using PedsQL]. Zhongguo Dang Dai Er Ke Za Zhi (2013) 0.75