Published in PLoS Biol on November 01, 2006
Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell (2010) 1.52
Glycolipid transfer proteins. Biochim Biophys Acta (2007) 1.15
Glycosphingolipid functions. Cold Spring Harb Perspect Biol (2011) 1.02
Glycolipid acquisition by human glycolipid transfer protein dramatically alters intrinsic tryptophan fluorescence: insights into glycolipid binding affinity. J Biol Chem (2009) 0.96
Human GLTP: Three distinct functions for the three tryptophans in a novel peripheral amphitropic fold. Biophys J (2010) 0.91
Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution. BMC Genomics (2008) 0.87
Arabidopsis accelerated cell death 11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels. Cell Rep (2014) 0.87
Dynamic modulation of the glycosphingolipid content in supported lipid bilayers by glycolipid transfer protein. Biophys J (2010) 0.85
PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. Protein Sci (2011) 0.85
Human GLTP and mutant forms of ACD11 suppress cell death in the Arabidopsis acd11 mutant. FEBS J (2008) 0.84
Conformational folding and stability of the HET-C2 glycolipid transfer protein fold: does a molten globule-like state regulate activity? Biochemistry (2011) 0.84
The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): structure drives preference for simple neutral glycosphingolipids. Biochim Biophys Acta (2012) 0.83
Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide. J Biol Chem (2010) 0.83
Sphingolipid homeostasis in the endoplasmic reticulum and beyond. Cold Spring Harb Perspect Biol (2013) 0.82
Substrate efflux propensity plays a key role in the specificity of secretory A-type phospholipases. J Biol Chem (2009) 0.82
Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein. Structure (2011) 0.82
Gene expression profiling of oral squamous cell carcinoma by differential display rt-PCR and identification of tumor biomarkers. Indian J Surg Oncol (2011) 0.79
Human glycolipid transfer protein (GLTP) expression modulates cell shape. PLoS One (2011) 0.78
Structural insights into lipid-dependent reversible dimerization of human GLTP. Acta Crystallogr D Biol Crystallogr (2013) 0.78
GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine. J Lipid Res (2013) 0.78
Phosphatidylserine stimulates ceramide-1-phosphate (C1P) intermembrane transfer by C1P transfer proteins. J Biol Chem (2016) 0.75
Too long, too short, or just right: glycosphingolipid-protein binding varies with acyl chain length. PLoS Biol (2006) 0.75
Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD. Physiol Rep (2016) 0.75
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol (1995) 74.88
Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure. J Mol Biol (2001) 15.97
Automated refinement of protein models. Acta Crystallogr D Biol Crystallogr (1993) 7.88
Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques. Biophys J (1981) 5.57
Membrane-protein interactions in cell signaling and membrane trafficking. Annu Rev Biophys Biomol Struct (2005) 3.97
How proteins adapt to a membrane-water interface. Trends Biochem Sci (2000) 3.76
Hydrophobic interactions of peptides with membrane interfaces. Biochim Biophys Acta (1998) 2.79
Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains. Nat Immunol (2002) 2.70
Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense. Genes Dev (2002) 2.51
The glycosynapse. Proc Natl Acad Sci U S A (2002) 2.46
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat Immunol (2003) 2.20
A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci U S A (1999) 2.05
Structure of human phosphatidylcholine transfer protein in complex with its ligand. Nat Struct Biol (2002) 2.01
Targeting glycosylation as a therapeutic approach. Nat Rev Drug Discov (2002) 1.95
StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism. J Biol Chem (2003) 1.88
Crystal structure of the long-chain fatty acid transporter FadL. Science (2004) 1.74
Rapid boundary element solvation electrostatics calculations in folding simulations: successful folding of a 23-residue peptide. Biopolymers (2001) 1.72
Optimal docking area: a new method for predicting protein-protein interaction sites. Proteins (2005) 1.69
Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology. Structure (1997) 1.54
The interfacial elastic packing interactions of galactosylceramides, sphingomyelins, and phosphatidylcholines. Biophys J (1996) 1.53
Structural basis for glycosphingolipid transfer specificity. Nature (2004) 1.46
Prediction of the binding energy for small molecules, peptides and proteins. J Mol Recognit (2000) 1.46
Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine. J Biol Chem (2000) 1.44
Identification of common structural features of binding sites in galactose-specific proteins. Proteins (2004) 1.30
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. Proc Natl Acad Sci U S A (2004) 1.28
Structural analysis of lipid complexes of GM2-activator protein. J Mol Biol (2003) 1.27
GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. FASEB J (2000) 1.24
Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol. Structure (2004) 1.21
Fatty acid interactions with proteins: what X-ray crystal and NMR solution structures tell us. Prog Lipid Res (2004) 1.17
Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway. Proc Natl Acad Sci U S A (1994) 1.15
Cloning and expression of glycolipid transfer protein from bovine and porcine brain. J Biol Chem (2000) 1.14
Structural evidence for adaptive ligand binding of glycolipid transfer protein. J Mol Biol (2005) 1.14
Glycolipid transfer protein and intracellular traffic of glucosylceramide. Experientia (1990) 1.12
Properties of a specific glycolipid transfer protein from bovine brain. Chem Phys Lipids (1985) 1.09
Purification and characterization of glycolipid transfer protein from bovine brain. Biochim Biophys Acta (1990) 1.06
Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. J Biol Chem (2005) 1.04
Glycolipid intermembrane transfer is accelerated by HET-C2, a filamentous fungus gene product involved in the cell-cell incompatibility response. Biochemistry (2003) 1.03
Specificity of the glycolipid transfer protein from pig brain. J Biol Chem (1985) 1.03
Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. Biophys J (2005) 1.03
Purification and some properties of the glycolipid transfer protein from pig brain. J Biol Chem (1985) 1.00
Purification and properties of a cerebroside transfer protein. J Biol Chem (1982) 1.00
Glycosphingolipids and mitochondria: role in apoptosis and disease. Glycoconj J (2004) 0.98
Energetics of galactose- and glucose-aromatic amino acid interactions: implications for binding in galactose-specific proteins. Protein Sci (2004) 0.97
Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy. Biochemistry (2004) 0.97
Lactosylceramide: effect of acyl chain structure on phase behavior and molecular packing. Biophys J (2002) 0.90
Membrane interaction and activity of the glycolipid transfer protein. Biochim Biophys Acta (2006) 0.88
Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha. Biochim Biophys Acta (2004) 0.83
Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells. J Neurosci Res (1999) 0.83
Affinity of phosphatidylcholine molecular species for the bovine phosphatidylcholine and phosphatidylinositol transfer proteins. Properties of the sn-1 and sn-2 acyl binding sites. Biochemistry (1990) 0.82
Crystallization and X-ray analysis of bovine glycolipid transfer protein. Acta Crystallogr D Biol Crystallogr (2004) 0.81
XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem (2006) 15.00
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (2010) 10.30
METLIN: a metabolite mass spectral database. Ther Drug Monit (2005) 10.15
Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice. Science (2003) 8.65
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature (2008) 5.78
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (2007) 5.49
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol (2004) 5.44
Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature (2009) 5.24
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. Nature (2005) 4.71
H5N1 infection of the respiratory tract and beyond: a molecular pathology study. Lancet (2007) 4.62
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell (2013) 3.92
Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature (2006) 3.90
Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes Dev (2006) 3.77
Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J Am Chem Soc (2004) 3.74
Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1. J Virol (2002) 3.59
Structure of the human histamine H1 receptor complex with doxepin. Nature (2011) 3.48
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38
Recognition of small interfering RNA by a viral suppressor of RNA silencing. Nature (2003) 3.36
Comparative study of several algorithms for flexible ligand docking. J Comput Aided Mol Des (2003) 3.29
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. J Am Chem Soc (2006) 3.26
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med (2012) 3.21
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13
TRIM24 links a non-canonical histone signature to breast cancer. Nature (2010) 2.99
Safety and effectiveness of a 2009 H1N1 vaccine in Beijing. N Engl J Med (2010) 2.98
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science (2010) 2.98
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
Pocketome via comprehensive identification and classification of ligand binding envelopes. Mol Cell Proteomics (2005) 2.83
Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J (2002) 2.82
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature (2013) 2.67
Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother (2012) 2.65
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol Cell (2006) 2.63
Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. J Am Chem Soc (2010) 2.62
Ribozymes, riboswitches and beyond: regulation of gene expression without proteins. Nat Rev Genet (2007) 2.52
Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics. J Am Chem Soc (2003) 2.52
Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense. Genes Dev (2002) 2.51
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature (2011) 2.49
Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell (2007) 2.47
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell (2010) 2.44
Structural insights into amino acid binding and gene control by a lysine riboswitch. Nature (2008) 2.41
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
Flexible ligand docking to multiple receptor conformations: a practical alternative. Curr Opin Struct Biol (2008) 2.38
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29
Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes (2011) 2.28
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell (2011) 2.26
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25
Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell (2012) 2.19
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem (2010) 2.14
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol (2010) 2.13
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure (2011) 2.11
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution. Nucleic Acids Res (2007) 2.09
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature (2012) 2.07
Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoprotein. J Virol (2002) 2.06
Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes. J Mol Recognit (2009) 2.05
Nuclear hormone receptor targeted virtual screening. J Med Chem (2003) 2.05
Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma. Cancer Lett (2012) 2.04
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol (2008) 2.00
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nat Chem Biol (2005) 2.00
Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution. Nucleic Acids Res (2006) 1.98
DNA architecture: from G to Z. Curr Opin Struct Biol (2006) 1.97
Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature (2009) 1.90
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol (2006) 1.89
RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction. RNA (2012) 1.88
Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem (2010) 1.88
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proc Natl Acad Sci U S A (2009) 1.87
Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings. J Mol Biol (2002) 1.86
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell (2013) 1.82
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature (2013) 1.82
A poised chromatin platform for TGF-β access to master regulators. Cell (2011) 1.81
Identification of protein-protein interaction sites from docking energy landscapes. J Mol Biol (2004) 1.79
A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids. J Am Chem Soc (2002) 1.77
The signal peptide of the Junín arenavirus envelope glycoprotein is myristoylated and forms an essential subunit of the mature G1-G2 complex. J Virol (2004) 1.74
Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. J Am Chem Soc (2009) 1.74
An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase. Proc Natl Acad Sci U S A (2005) 1.71
Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells. Stem Cells (2008) 1.69
Optimal docking area: a new method for predicting protein-protein interaction sites. Proteins (2005) 1.69
ADP_EM: fast exhaustive multi-resolution docking for high-throughput coverage. Bioinformatics (2006) 1.68
Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1. Structure (2010) 1.67
Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitch. Mol Cell (2010) 1.66
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature (2012) 1.65
Optimal vaccination strategies for 2009 pandemic H1N1 and seasonal influenza vaccines in humans. Vaccine (2010) 1.65
Statistical analysis and prediction of protein-protein interfaces. Proteins (2005) 1.65
Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science (2012) 1.64
Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor. J Virol (2004) 1.64
Structure of the semaphorin-3A receptor binding module. Neuron (2003) 1.63
ICM-DISCO docking by global energy optimization with fully flexible side-chains. Proteins (2003) 1.63
Soft protein-protein docking in internal coordinates. Protein Sci (2002) 1.60
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure (2009) 1.59
An effective method for the discrimination of motional anisotropy and chemical exchange. J Am Chem Soc (2002) 1.59