Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.

PubWeight™: 3.87‹?› | Rank: Top 1%

🔗 View Article (PMID 17157260)

Published in Mol Cell on December 08, 2006

Authors

Sean D Taverna1, Serge Ilin, Richard S Rogers, Jason C Tanny, Heather Lavender, Haitao Li, Lindsey Baker, John Boyle, Lauren P Blair, Brian T Chait, Dinshaw J Patel, John D Aitchison, Alan J Tackett, C David Allis

Author Affiliations

1: Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA.

Articles citing this

(truncated to the top 100)

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98

Regulation of chromatin by histone modifications. Cell Res (2011) 8.44

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35

Genome-wide views of chromatin structure. Annu Rev Biochem (2009) 3.89

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J (2010) 3.25

Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23

The language of histone crosstalk. Cell (2010) 3.18

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13

Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription. Genes Dev (2007) 2.82

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev (2007) 2.81

ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol (2007) 2.69

Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders. Genome Res (2008) 2.62

Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions. Cell (2009) 2.62

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A (2007) 2.53

High throughput characterization of combinatorial histone codes. Mol Cell Proteomics (2009) 2.52

Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell (2007) 2.47

Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat Res (2008) 2.31

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Mol Cell (2008) 2.09

H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activation. EMBO J (2009) 2.02

The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem (2008) 2.00

ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Mol Cell (2009) 1.95

Influence of combinatorial histone modifications on antibody and effector protein recognition. Curr Biol (2010) 1.93

Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast. PLoS Genet (2008) 1.93

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol (2008) 1.89

Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z. Proc Natl Acad Sci U S A (2007) 1.85

Tissue-specific expression and post-translational modification of histone H3 variants. J Proteome Res (2008) 1.84

The PHD finger: a versatile epigenome reader. Trends Biochem Sci (2011) 1.81

Chromatin state maps: new technologies, new insights. Curr Opin Genet Dev (2008) 1.77

Handpicking epigenetic marks with PHD fingers. Nucleic Acids Res (2011) 1.69

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol (2009) 1.65

Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics. Cell (2012) 1.61

Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem J (2009) 1.59

Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol (2008) 1.57

Genome-wide function of H2B ubiquitylation in promoter and genic regions. Genes Dev (2011) 1.56

S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination. J Exp Med (2009) 1.54

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J (2011) 1.52

Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J (2007) 1.46

The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res (2009) 1.46

Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. EMBO J (2011) 1.44

H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet (2011) 1.43

ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus. Cell Rep (2012) 1.42

Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. Endocrinology (2016) 1.41

Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity. Mol Cell Biol (2008) 1.38

The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. Mol Cell Biol (2008) 1.33

The Sas3p and Gcn5p histone acetyltransferases are recruited to similar genes. Genome Biol (2007) 1.31

Keeping it in the family: diverse histone recognition by conserved structural folds. Crit Rev Biochem Mol Biol (2010) 1.29

Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.26

Protein modifications in transcription elongation. Biochim Biophys Acta (2008) 1.26

Mapping the local protein interactome of the NuA3 histone acetyltransferase. Protein Sci (2009) 1.25

Trans-generational epigenetic regulation of C. elegans primordial germ cells. Epigenetics Chromatin (2010) 1.22

Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes Dev (2012) 1.21

Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. PLoS Genet (2012) 1.21

Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory. PLoS Biol (2010) 1.20

Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem (2011) 1.17

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A (2010) 1.17

The interplay of histone modifications - writers that read. EMBO Rep (2015) 1.15

Structural insight into histone recognition by the ING PHD fingers. Curr Drug Targets (2009) 1.11

Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A. Mol Cell Biol (2010) 1.11

The role of cotranscriptional histone methylations. Cold Spring Harb Symp Quant Biol (2011) 1.11

Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem (2008) 1.09

Saccharomyces cerevisiae Yta7 regulates histone gene expression. Genetics (2008) 1.09

Unbiased proteomic screen for binding proteins to modified lysines on histone H3. Proteomics (2009) 1.08

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol (2011) 1.06

Nuclear receptor coactivators: structural and functional biochemistry. Biochemistry (2010) 1.06

H3 k36 methylation helps determine the timing of cdc45 association with replication origins. PLoS One (2009) 1.05

Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03

Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Mol Cell Biol (2011) 1.03

Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Dev Biol (2008) 1.03

Transcription and post-transcriptional regulation of spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.02

Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger. Cell Res (2011) 1.02

A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity. Mol Cell Biol (2009) 1.00

MYSTs mark chromatin for chromosomal functions. Curr Opin Cell Biol (2008) 0.99

A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans. PLoS Genet (2011) 0.99

Analysis of stable and transient protein-protein interactions. Methods Mol Biol (2012) 0.98

Multivalent recognition of histone tails by the PHD fingers of CHD5. Biochemistry (2012) 0.97

RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36. J Biol Chem (2011) 0.96

SAGA and Rpd3 chromatin modification complexes dynamically regulate heat shock gene structure and expression. J Biol Chem (2009) 0.96

Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast. Proc Natl Acad Sci U S A (2012) 0.95

Histone target selection within chromatin: an exemplary case of teamwork. Genes Dev (2014) 0.95

Identification of lysine 37 of histone H2B as a novel site of methylation. PLoS One (2011) 0.94

The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression . Biochemistry (2010) 0.94

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast. J Biol Chem (2011) 0.93

A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions. Mol Cell Proteomics (2014) 0.92

The role of Aire in clonal selection. Immunol Cell Biol (2010) 0.90

The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination. PLoS One (2011) 0.90

The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genet Res Int (2011) 0.90

WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition. EMBO J (2013) 0.89

Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex. FEBS Open Bio (2014) 0.89

Making sense of transcribing chromatin. Curr Opin Cell Biol (2012) 0.89

Epigenetic regulation of muscle phenotype and adaptation: a potential role in COPD muscle dysfunction. J Appl Physiol (1985) (2013) 0.88

Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation. Nucleic Acids Res (2009) 0.86

Processing mechanism and substrate selectivity of the core NuA4 histone acetyltransferase complex. Biochemistry (2011) 0.86

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease. Mol Cell Biol (2016) 0.86

CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes. DNA Cell Biol (2008) 0.85

DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae. Genetics (2012) 0.85

Acetylation of conserved lysines in bovine papillomavirus E2 by p300. J Virol (2012) 0.85

The Paf1 complex represses ARG1 transcription in Saccharomyces cerevisiae by promoting histone modifications. Eukaryot Cell (2011) 0.84

Articles cited by this

Translating the histone code. Science (2001) 56.77

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

The language of covalent histone modifications. Nature (2000) 44.92

Genome-wide location and function of DNA binding proteins. Science (2000) 31.25

Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68

Genome-wide map of nucleosome acetylation and methylation in yeast. Cell (2005) 15.08

Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30

Deciphering the transcriptional histone acetylation code for a human gene. Cell (2002) 8.96

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86

Histone acetylation and an epigenetic code. Bioessays (2000) 8.84

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev (1997) 8.35

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70

Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature (2006) 7.52

Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40

Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature (2005) 5.53

Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature (2005) 5.15

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01

Binary switches and modification cassettes in histone biology and beyond. Nature (2003) 4.75

Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31

Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20

The nucleosome: from genomic organization to genomic regulation. Cell (2004) 3.83

The PHD finger, a nuclear protein-interaction domain. Trends Biochem Sci (2005) 3.56

Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell (2002) 3.16

MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev (2005) 2.83

The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev (2000) 2.77

Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev (2001) 2.55

It takes a PHD to read the histone code. Cell (2006) 2.34

The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol (2006) 2.29

Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol (2000) 2.21

Proteomic and genomic characterization of chromatin complexes at a boundary. J Cell Biol (2005) 1.92

I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions. J Proteome Res (2005) 1.87

Identification and analysis of yeast nucleosomal histone acetyltransferase complexes. Methods (1998) 1.82

SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription. Proc Natl Acad Sci U S A (2002) 1.62

Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin. Mol Cell Biol (2006) 1.58

Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. PLoS Biol (2005) 1.53

A mass spectrometric "Western blot" to evaluate the correlations between histone methylation and histone acetylation. Proteomics (2004) 1.47

Anc1 interacts with the catalytic subunits of the general transcription factors TFIID and TFIIF, the chromatin remodeling complexes RSC and INO80, and the histone acetyltransferase complex NuA3. Biochem Biophys Res Commun (2005) 1.17

Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex. Mol Cell Biol (2002) 1.15

The yeast histone acetyltransferase A2 complex, but not free Gcn5p, binds stably to nucleosomal arrays. J Biol Chem (2000) 1.14

Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem (2003) 1.02

The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins. BMC Genomics (2006) 0.98

Histone modification patterns during gene activation. Methods Enzymol (2004) 0.90

Articles by these authors

X-ray structure of a voltage-dependent K+ channel. Nature (2003) 14.50

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73

Crystal structure and mechanism of a calcium-gated potassium channel. Nature (2002) 10.03

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature (2002) 9.96

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25

The open pore conformation of potassium channels. Nature (2002) 9.09

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science (2011) 9.00

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86

Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79

Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69

Epigenetics: a landscape takes shape. Cell (2007) 8.29

MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17

Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature (2002) 7.54

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12

The molecular architecture of the nuclear pore complex. Nature (2007) 6.93

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44

Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40

Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol (2002) 6.38

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27

Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12

Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell (2004) 6.10

Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol (2006) 5.99

Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature (2008) 5.78

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol (2002) 5.67

RNA meets chromatin. Genes Dev (2005) 5.66

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59

Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46

Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol (2004) 5.44

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43

Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42

Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol (2009) 5.27

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature (2009) 5.24

Determining the architectures of macromolecular assemblies. Nature (2007) 4.94

Binary switches and modification cassettes in histone biology and beyond. Nature (2003) 4.75

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50

Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J Bacteriol (2008) 4.42

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell (2002) 3.99

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A (2007) 3.92

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell (2013) 3.92

Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature (2006) 3.90

Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84

Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes Dev (2006) 3.77

Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77

Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J Am Chem Soc (2004) 3.74

Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet (2001) 3.63

Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37

Recognition of small interfering RNA by a viral suppressor of RNA silencing. Nature (2003) 3.36

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J (2007) 3.31

ABI5 acts downstream of ABI3 to execute an ABA-dependent growth arrest during germination. Plant J (2002) 3.28

Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28

Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. J Am Chem Soc (2006) 3.26

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev (2004) 3.25

Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23

Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell (2002) 3.16

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02

Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00

TRIM24 links a non-canonical histone signature to breast cancer. Nature (2010) 2.99

Fluorescent proteins as proteomic probes. Mol Cell Proteomics (2005) 2.98

Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science (2010) 2.98

Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system. Antimicrob Agents Chemother (2009) 2.96

Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology (2009) 2.96

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94

A data integration methodology for systems biology. Proc Natl Acad Sci U S A (2005) 2.93

Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol (2002) 2.93

Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol (2004) 2.90

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86