Published in Oncogene on November 20, 2006
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Clin Cancer Res (2008) 1.66
Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Mol Cells (2009) 1.28
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Res (2009) 1.21
Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integr Biol (Camb) (2010) 0.98
Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discov (2012) 0.96
Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis. Cancer Res (2013) 0.89
Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA. Biochem Biophys Res Commun (2013) 0.84
The role of wild type RAS isoforms in cancer. Semin Cell Dev Biol (2016) 0.81
Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras. Exp Cell Res (2011) 0.80
Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis. J Biol Chem (2013) 0.78
Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras. Biochim Biophys Acta (2008) 0.77
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (1993) 13.46
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology (1994) 8.79
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell (1992) 7.06
p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (1985) 5.90
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
Sunburn and p53 in the onset of skin cancer. Nature (1995) 5.35
Tumor induction and tissue atrophy in mice lacking E2F-1. Cell (1996) 4.80
The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res (2001) 4.63
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell (1994) 4.22
Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature (1987) 4.19
NF1 tumor suppressor gene function: narrowing the GAP. Cell (2001) 4.11
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol (1998) 3.88
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proc Natl Acad Sci U S A (1987) 3.84
Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature (2000) 3.83
p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell (1994) 3.69
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Trefoil peptides: less clandestine in the intestine. Science (1996) 3.60
Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev (1993) 3.41
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene (2001) 3.36
A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys (1994) 3.29
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet (1996) 3.08
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat Cell Biol (2000) 3.07
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell (1998) 3.05
Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest (1997) 2.99
Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology (2000) 2.99
The retinoblastoma gene family in differentiation and development. Oncogene (1999) 2.95
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat Genet (1994) 2.73
Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev (1996) 2.71
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol (1996) 2.71
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev (1998) 2.66
Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J (1996) 2.63
Overexpression of transforming growth factor alpha in psoriatic epidermis. Science (1989) 2.63
Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell (1990) 2.63
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A (1994) 2.63
The retinoblastoma gene family: cousins with overlapping interests. Trends Genet (1998) 2.59
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet (1998) 2.53
Stereotactic radiosurgery for arteriovenous malformations of the brain. J Neurosurg (1991) 2.41
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature (1995) 2.41
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A (1994) 2.37
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev (2000) 2.33
Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. Nat Med (1997) 2.32
Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest (2000) 2.17
A new type of transforming growth factor-beta, TGF-beta 3. EMBO J (1988) 2.12
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proc Natl Acad Sci U S A (1999) 2.10
Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc Natl Acad Sci U S A (1989) 2.09
Mammary tumor suppression by transforming growth factor beta 1 transgene expression. Proc Natl Acad Sci U S A (1995) 2.07
Anti-tumor immunoreactivity in patients with malignant melanoma. Med J Aust (1972) 2.05
Impaired folic acid absorption in inflammatory bowel disease: effects of salicylazosulfapyridine (Azulfidine). Gastroenterology (1973) 2.03
Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proc Natl Acad Sci U S A (1988) 2.03
Modeling human lung cancer in mice: similarities and shortcomings. Oncogene (1999) 1.98
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1999) 1.96
Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas. Mol Carcinog (1991) 1.95
Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev (1996) 1.89
Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology (1999) 1.88
Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion. J Clin Invest (1987) 1.88
Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol (2003) 1.86
Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev (1993) 1.84
Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. J Exp Med (1998) 1.82
A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer. J Natl Cancer Inst (1985) 1.79
Cholangiocarcinoma complicating primary sclerosing cholangitis. Ann Surg (1991) 1.78
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Proc Natl Acad Sci U S A (1991) 1.77
Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol Cell Biol (1989) 1.76
Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology (1995) 1.74
Production of transforming growth factors by human colon cancer lines. Cancer Res (1986) 1.74
The cell cycle and cancer. Proc Natl Acad Sci U S A (1997) 1.72
A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat Genet (1997) 1.71
Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J Clin Invest (1989) 1.69
Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells. J Cell Physiol (1987) 1.68
The role of p53 in tumour suppression: lessons from mouse models. Cell Mol Life Sci (1999) 1.68
The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev (1997) 1.67
Transforming growth factors and control of neoplastic cell growth. J Cell Biochem (1987) 1.67
Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J Clin Invest (1994) 1.64
Stereotactic gamma knife radiosurgery. Initial North American experience in 207 patients. Arch Neurol (1990) 1.64
RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol Biol Cell (1998) 1.62
Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model. Cancer Res (1987) 1.61
Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J (1996) 1.61
Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN. Oncogene (2001) 1.59
p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J Cell Biol (1998) 1.59
Nf1 and Gmcsf interact in myeloid leukemogenesis. Mol Cell (2000) 1.58
Gamma knife for glioma: selection factors and survival. Int J Radiat Oncol Biol Phys (1996) 1.56
Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J Biol Chem (1998) 1.54
A method for the isolation and culture of human colonic crypts in collagen gels. In Vitro Cell Dev Biol (1987) 1.54
Reversible drug-induced oxyntic atrophy in rats. Gastroenterology (2000) 1.53