Published in Genes Dev on December 01, 1993
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol (1994) 4.36
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol (1995) 3.55
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol Cell Biol (1996) 3.50
E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol Cell Biol (1996) 3.40
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99
Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol Cell Biol (1994) 2.95
Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol (2000) 2.85
Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc Natl Acad Sci U S A (2000) 2.84
Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev (1999) 2.73
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A (1994) 2.63
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57
The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol (1996) 2.47
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol (1994) 2.44
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol Cell Biol (1996) 2.44
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A (2008) 2.42
A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A (1996) 2.36
E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol Cell Biol (1997) 2.33
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A (2003) 2.29
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A (1995) 2.27
E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol (1995) 2.26
Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol Cell Biol (1996) 2.23
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev (1998) 2.19
DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc Natl Acad Sci U S A (1994) 2.08
Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol Cell Biol (1997) 2.00
In vivo association of E2F and DP family proteins. Mol Cell Biol (1995) 1.99
c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol Cell Biol (1998) 1.97
In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol Cell Biol (1995) 1.93
Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proc Natl Acad Sci U S A (1995) 1.89
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol (1995) 1.87
Multiple members of the E2F transcription factor family are the products of oncogenes. Proc Natl Acad Sci U S A (1995) 1.86
Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol (1996) 1.81
Subunit composition determines E2F DNA-binding site specificity. Mol Cell Biol (1997) 1.75
Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. Proc Natl Acad Sci U S A (1996) 1.72
Plant cells contain a novel member of the retinoblastoma family of growth regulatory proteins. EMBO J (1996) 1.70
Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol Cell Biol (1999) 1.68
The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J (1995) 1.67
The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J Virol (1996) 1.63
Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Mol Cell Biol (1998) 1.63
Cyclin A expression is under negative transcriptional control during the cell cycle. Mol Cell Biol (1996) 1.63
Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol (1996) 1.62
Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells. Mol Cell Biol (1998) 1.52
Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc Natl Acad Sci U S A (1996) 1.51
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle. Cell Div (2012) 1.46
Cumulative effect of phosphorylation of pRB on regulation of E2F activity. Mol Cell Biol (1999) 1.42
p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol Cell Biol (1998) 1.39
Identification and analysis of a retinoblastoma binding motif in the replication protein of a plant DNA virus: requirement for efficient viral DNA replication. EMBO J (1995) 1.38
p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol Cell Biol (1997) 1.37
Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol (1996) 1.37
Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. EMBO J (1994) 1.37
Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells. EMBO J (1995) 1.33
Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms. Mol Cell Biol (1996) 1.33
Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription. Mol Cell Biol (1995) 1.32
p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol Cell Biol (1997) 1.31
Activation of the Epstein-Barr virus DNA polymerase promoter by the BRLF1 immediate-early protein is mediated through USF and E2F. J Virol (1996) 1.27
Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins. J Virol (2000) 1.25
Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc Natl Acad Sci U S A (1997) 1.23
Domains A and B in the Rb pocket interact to form a transcriptional repressor motif. Mol Cell Biol (1996) 1.23
The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen. J Virol (1994) 1.22
BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control. J Virol (1996) 1.22
Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters. J Virol (1994) 1.21
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis. Mol Cell Biol (1995) 1.20
Serum-induced expression of the cdc25A gene by relief of E2F-mediated repression. Mol Cell Biol (1999) 1.19
Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. J Virol (1994) 1.18
Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins. Mol Cell Biol (1997) 1.18
p21 Disrupts the interaction between cdk2 and the E2F-p130 complex. Mol Cell Biol (1996) 1.16
Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle. Mol Cell Biol (1996) 1.15
Pocket protein-independent repression of urokinase-type plasminogen activator and plasminogen activator inhibitor 1 gene expression by E2F1. Mol Cell Biol (2000) 1.14
Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor. Mol Cell Biol (1998) 1.14
Regulation of differentiation by HBP1, a target of the retinoblastoma protein. Mol Cell Biol (1998) 1.13
Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins. J Virol (1997) 1.10
Multiple change in E2F function and regulation occur upon muscle differentiation. Mol Cell Biol (1995) 1.10
E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis. Mol Cell Biol (1997) 1.09
Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains. Mol Cell Biol (1998) 1.09
Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest. Proc Natl Acad Sci U S A (1994) 1.08
Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters. J Biol Chem (2009) 1.07
Functional interaction between DP-1 and p53. Mol Cell Biol (1996) 1.06
Cell-context specific role of the E2F/Rb pathway in development and disease. Glia (2010) 1.04
Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins. Mol Cell Biol (1994) 1.03
Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1. J Virol (1994) 1.03
Inhibition of E2F-mediated transcription by p202. EMBO J (1996) 1.02
Retinal horizontal cells: challenging paradigms of neural development and cancer biology. Development (2009) 1.02
Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation. Biochem J (1998) 0.99
The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif. Mol Cell Biol (1996) 0.97
Deregulated E2F transcriptional activity in autonomously growing melanoma cells. J Exp Med (2000) 0.97
E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression. Mol Cell Biol (2000) 0.96
Induction of DNA synthesis and apoptosis by regulated inactivation of a temperature-sensitive retinoblastoma protein. EMBO J (1998) 0.94
DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. Proc Natl Acad Sci U S A (1996) 0.93
Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc Natl Acad Sci U S A (1996) 0.92
Identification of a novel E1A response element in the mouse c-fos promoter. J Virol (1995) 0.92
Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo. Mol Cell Biol (2006) 0.92
Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107. J Virol (1996) 0.91
Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells. Mol Biol Cell (1994) 0.91
The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification. Cell Div (2011) 0.90
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci U S A (1995) 0.89
Tumor suppressors and cell-cycle proteins in lung cancer. Patholog Res Int (2011) 0.89
Molecular characterization of Xenopus laevis DP proteins. Mol Biol Cell (1994) 0.89
Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice. J Exp Med (1996) 0.89
Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. J Cell Biol (2000) 0.88
Regulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor protein. Mol Cell Biol (1998) 0.87
The hallmarks of cancer. Cell (2000) 113.05
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (1983) 19.76
Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60
Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (1986) 13.96
p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (1993) 13.46
Mechanism of activation of a human oncogene. Nature (1982) 12.09
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev (2001) 11.25
Effects of an Rb mutation in the mouse. Nature (1992) 11.06
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (1988) 10.98
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell (1992) 7.61
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (1993) 7.20
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature (1985) 7.07
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell (1986) 7.06
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell (1992) 7.06
Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression. Mol Cell Biol (1986) 7.06
Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell (1982) 6.93
p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72
Cellular oncogenes and multistep carcinogenesis. Science (1983) 6.52
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature (1985) 6.23
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature (1982) 6.09
Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (1985) 5.90
The integrated genome of murine leukemia virus. Cell (1978) 5.84
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature (1986) 5.77
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
The psychological consequences of predictive testing for Huntington's disease. Canadian Collaborative Study of Predictive Testing. N Engl J Med (1992) 5.51
Sunburn and p53 in the onset of skin cancer. Nature (1995) 5.35
Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci U S A (1979) 5.32
Physical interaction of the retinoblastoma protein with human D cyclins. Cell (1993) 5.31
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol (2000) 5.28
Acrylamide gel electrophoresis of HeLa cell nucleolar RNA. Proc Natl Acad Sci U S A (1967) 5.06
Small molecular weight monodisperse nuclear RNA. J Mol Biol (1968) 4.96
Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 4.96
Tumor induction and tissue atrophy in mice lacking E2F-1. Cell (1996) 4.80
Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature (1981) 4.72
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell (1992) 4.68
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol (1998) 4.54
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell (1994) 4.22
DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster. Proc Natl Acad Sci U S A (1981) 4.17
Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16
Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol Cell Biol (1986) 4.14
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11
NF1 tumor suppressor gene function: narrowing the GAP. Cell (2001) 4.11
Isolation and characterization of simian virus 40 ribonucleic acid. J Virol (1972) 4.09
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci U S A (1990) 4.06
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (1996) 4.05
Restriction endonuclease cleavage of linear and closed circular murine leukemia viral DNAs: discovery of a smaller circular form. Cell (1979) 4.04
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet (1994) 3.97
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol (1998) 3.88
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proc Natl Acad Sci U S A (1987) 3.84
Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature (2000) 3.83
A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection. Cell (1979) 3.74
Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc Natl Acad Sci U S A (1987) 3.72
p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell (1994) 3.69
Identification of DNA fragments carrying ecotropic proviruses of AKR mice. Proc Natl Acad Sci U S A (1979) 3.64
The action of oncogenes in the cytoplasm and nucleus. Science (1985) 3.62
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature (1997) 3.57
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res (2001) 3.48
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
Oncogene-induced cell senescence--halting on the road to cancer. N Engl J Med (2006) 3.39
Point mutational inactivation of the retinoblastoma antioncogene. Science (1989) 3.37
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene (2001) 3.36
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
Characterization of a human colon/lung carcinoma oncogene. Nature (1983) 3.26
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A (1998) 3.23
Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol (1981) 3.18
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev (1993) 3.10
Infectious viral DNA of murine leukemia virus. Proc Natl Acad Sci U S A (1975) 3.09
A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell (1989) 3.08
Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc Natl Acad Sci U S A (1995) 3.08
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet (1996) 3.08
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat Cell Biol (2000) 3.07
Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus. Proc Natl Acad Sci U S A (1975) 3.07
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell (1998) 3.05
The pathway to signal achievement. Nature (1993) 3.03
The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell (1983) 3.00
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99
The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell (1989) 2.98
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci U S A (1997) 2.97
Structure of the intermediates leading to the integrated provirus. Biochim Biophys Acta (1977) 2.96