Published in Nat Cell Biol on September 01, 2000
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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J (2003) 5.48
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C-terminal ubiquitination of p53 contributes to nuclear export. Mol Cell Biol (2001) 2.09
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Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Mol Cell Biol (2006) 1.76
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Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. Mol Cell Biol (2005) 1.35
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Mdm2 targets the p53 transcription cofactor JMY for degradation. EMBO Rep (2006) 1.33
Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Genes Dev (2001) 1.30
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Identification of p53 sequence elements that are required for MDM2-mediated nuclear export. Mol Cell Biol (2001) 1.26
c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination. Mol Cell Biol (2001) 1.19
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A novel function for p53: regulation of growth cone motility through interaction with Rho kinase. J Neurosci (2009) 1.05
Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts. Biochem J (2004) 1.05
The nucleolus directly regulates p53 export and degradation. J Cell Biol (2011) 1.04
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors. Proc Natl Acad Sci U S A (2002) 1.03
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Proc Natl Acad Sci U S A (2008) 1.02
Deacetylation of p53 induces autophagy by suppressing Bmf expression. J Cell Biol (2013) 1.01
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RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proc Natl Acad Sci U S A (2013) 0.97
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. Mol Cell Biol (2006) 0.96
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Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis. Proc Natl Acad Sci U S A (2002) 0.91
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Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination. FEBS J (2011) 0.89
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Involvement of nuclear export in human papillomavirus type 18 E6-mediated ubiquitination and degradation of p53. J Virol (2005) 0.88
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. J Biol Chem (2010) 0.88
An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biol (2002) 0.87
Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory. Genes Cancer (2010) 0.86
ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res (2011) 0.86
L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells. Cell Death Differ (2014) 0.85
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p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines. Cancer Chemother Pharmacol (2015) 0.78
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Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget (2016) 0.77
An unexpected inhibition of antiviral signaling by virus-encoded tumor suppressor p53 in pancreatic cancer cells. Virology (2015) 0.77
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p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling. J Biol Chem (2014) 0.76
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A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53. PLoS One (2016) 0.75
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