Published in Curr Opin Gastroenterol on January 01, 2007
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NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis (2010) 1.84
Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun (2008) 1.77
Vitamin D3: a helpful immuno-modulator. Immunology (2011) 1.46
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol (2012) 1.19
Human immune responses in cryptosporidiosis. Future Microbiol (2010) 1.10
Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology (2011) 1.09
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The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut (2012) 1.02
Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. J Reprod Immunol (2011) 0.99
Susceptibility to infectious diseases based on antimicrobial peptide production. Infect Immun (2009) 0.94
Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections. Emerg Health Threats J (2009) 0.93
Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk. Interdiscip Perspect Infect Dis (2008) 0.92
Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway. Infect Immun (2010) 0.91
The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol (2009) 0.89
Differential changes in expression of intestinal antimicrobial peptide genes during Ascaris lumbricoides infection in Zambian adults do not respond to helminth eradication. J Infect Dis (2011) 0.84
Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial. Pediatrics (2013) 0.83
Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions. Int J Inflam (2010) 0.83
How important is vitamin D in preventing infections? Osteoporos Int (2012) 0.82
Identification of genetic loci that contribute to Campylobacter resistance to fowlicidin-1, a chicken host defense peptide. Front Cell Infect Microbiol (2012) 0.81
Immune-epithelial crosstalk at the intestinal surface. J Gastroenterol (2014) 0.81
The differential effects of 1,25-dihydroxyvitamin D3 on Salmonella-induced interleukin-8 and human beta-defensin-2 in intestinal epithelial cells. Clin Exp Immunol (2016) 0.79
Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk. PLoS One (2012) 0.78
Expression of antimicrobial peptides in cecal tonsils of chickens treated with probiotics and infected with Salmonella enterica serovar typhimurium. Clin Vaccine Immunol (2008) 0.77
Fecal biomarkers of intestinal health and disease in children. Front Pediatr (2014) 0.77
Alterations in content and localization of defensins in rat ileum and jejunum following ischemia-reperfusion. Specific peptides, in specific places, for specific jobs? Eplasty (2011) 0.76
Vitamin-D status is not a confounder of the relationship between zinc and diarrhoea: a study in 6-24-month-old underweight and normal-weight children of urban Bangladesh. Eur J Clin Nutr (2016) 0.76
Update on clinical and research application of fecal biomarkers for gastrointestinal diseases. World J Gastrointest Pharmacol Ther (2017) 0.75
Role of yqiC in the Pathogenicity of Salmonella and Innate Immune Responses of Human Intestinal Epithelium. Front Microbiol (2016) 0.75
Homeostasis of the Gut Barrier and Potential Biomarkers. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Effect of live Salmonella Ty21a in dextran sulfate sodium-induced colitis. Drug Target Insights (2007) 0.75
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun (2004) 2.47
Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J (2006) 2.33
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature (2011) 2.31
A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology (2002) 2.15
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis (2003) 2.06
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem (2005) 2.06
Response of refractory colitis to intravenous or oral tacrolimus (FK506). Inflamm Bowel Dis (2002) 1.80
Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Transl Med (2011) 1.74
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol (2007) 1.73
Extraintestinal manifestations and complications in inflammatory bowel diseases. World J Gastroenterol (2006) 1.73
Crohn's disease: a defensin deficiency syndrome? Eur J Gastroenterol Hepatol (2003) 1.72
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol (2002) 1.59
Inflammatory Bowel Disease. Dtsch Arztebl Int (2016) 1.56
Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun (2007) 1.48
Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. Hepatology (2012) 1.39
The expression patterns of peritoneal defensins. Perit Dial Int (2007) 1.39
[Suspected cases of severe side effects after infliximab (Remicade) in Germany]. Med Klin (Munich) (2003) 1.38
IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes. J Immunol (2008) 1.31
Antimicrobial peptides and proinflammatory cytokines in periprosthetic joint infection. J Bone Joint Surg Am (2013) 1.30
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29
Paneth's disease. J Crohns Colitis (2010) 1.29
Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol (2005) 1.27
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J Leukoc Biol (2004) 1.26
Defensins and other antimicrobial peptides in inflammatory bowel disease. Curr Opin Gastroenterol (2007) 1.25
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One (2009) 1.24
Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases. Eur J Gastroenterol Hepatol (2006) 1.21
Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. PLoS One (2009) 1.17
Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease. J Leukoc Biol (2007) 1.14
Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo. PLoS One (2013) 1.13
Butyrate-enhanced TNFalpha-induced apoptosis is associated with inhibition of NF-kappaB. Anticancer Res (2002) 1.11
Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut (2007) 1.11
New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol (2013) 1.06
Rosacea - S1 guideline. J Dtsch Dermatol Ges (2013) 1.06
A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts. J Microbiol Methods (2005) 1.05
The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth. J Immunol (2009) 1.04
Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3. Microbes Infect (2009) 1.03
Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. Ann Dermatol (2012) 1.03
Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD. J Crohns Colitis (2011) 1.03
Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis. Exp Dermatol (2012) 0.96
Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. J Lipid Res (2005) 0.96
Innate antimicrobial host defense in small intestinal Crohn's disease. Int J Med Microbiol (2009) 0.96
Vitamin D analog calcipotriol suppresses the Th17 cytokine-induced proinflammatory S100 "alarmins" psoriasin (S100A7) and koebnerisin (S100A15) in psoriasis. J Invest Dermatol (2012) 0.95
Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease. J Lipid Res (2008) 0.94
IL-36γ sustains a proinflammatory self-amplifying loop with IL-17C in anti-TNF-induced psoriasiform skin lesions of patients with Crohn's disease. Inflamm Bowel Dis (2014) 0.92
Paneth cells and the innate immune response. Curr Opin Gastroenterol (2006) 0.91
Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg (2012) 0.91
Treatment of striae distensae using an ablative Erbium: YAG fractional laser versus a 585-nm pulsed-dye laser. J Cosmet Laser Ther (2013) 0.89
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease. PLoS Genet (2012) 0.88
Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. J Invest Dermatol (2008) 0.88
Innate immunity in atopic dermatitis. Clin Rev Allergy Immunol (2011) 0.88
Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies? J Dermatol Sci (2010) 0.88
Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation. Digestion (2008) 0.88
VDR and MEK-ERK dependent induction of the antimicrobial peptide cathelicidin in keratinocytes by lithocholic acid. Mol Immunol (2009) 0.86
Human colonic mucus is a reservoir for antimicrobial peptides. J Crohns Colitis (2013) 0.86
Human defensins in Crohn's disease. Chem Immunol Allergy (2005) 0.86
A new look at Crohn's disease: breakdown of the mucosal antibacterial defense. Ann N Y Acad Sci (2006) 0.86
Antimicrobial peptides in gastrointestinal inflammation. Int J Inflam (2010) 0.86
Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease. Am J Gastroenterol (2006) 0.86
More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus. Int J Med Microbiol (2012) 0.86
Influence of protein kinase C on transcription of the tight junction elements ZO-1 and occludin. J Cell Physiol (2005) 0.86
Butyrate inhibits leukocyte adhesion to endothelial cells via modulation of VCAM-1. Inflamm Bowel Dis (2004) 0.85
Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identified variants linked to reduced expression. Hum Genet (2009) 0.85
Serum procalcitonin differentiates inflammatory bowel disease and self-limited colitis. Inflamm Bowel Dis (2004) 0.85
Fatal staphylococcal sepsis in Crohn's disease after infliximab. Inflamm Bowel Dis (2004) 0.85
Vitamin D deficiency and asthma: not a strong link--yet. J Allergy Clin Immunol (2008) 0.85
Waking the wimp: redox-modulation activates human beta-defensin 1. Gut Microbes (2011) 0.84
Cutaneous squamous cell carcinoma with perineural invasion: report on eight cases and review of the literature. Dermatology (2014) 0.84
Symptomatic or asymptomatic gallstone disease: is the gallbladder motility the clue? Hepatogastroenterology (2002) 0.84
Antimicrobial host defense in the upper gastrointestinal tract. Eur J Gastroenterol Hepatol (2008) 0.83
A variant of the SLC10A2 gene encoding the apical sodium-dependent bile acid transporter is a risk factor for gallstone disease. PLoS One (2009) 0.83
Control of cutaneous antimicrobial peptides by vitamin D3. Arch Dermatol Res (2010) 0.82
Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation. Acta Derm Venereol (2014) 0.82
Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice. Biochem J (2002) 0.81
Antimicrobial peptides (AMPs) from fish epidermis: perspectives for investigative dermatology. J Invest Dermatol (2013) 0.81
Gastrointestinal involvement in granulomatosis with polyangiitis and microscopic polyangiitis: histological features and outcome. Int J Rheum Dis (2013) 0.80
Vitamin d, the cutaneous barrier, antimicrobial peptides and allergies: is there a link? Allergy Asthma Immunol Res (2013) 0.80
Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease. Expert Rev Anti Infect Ther (2007) 0.80
Mesenteric pulsatility index analysis predicts response to azathioprine in patients with Crohn's disease. Inflamm Bowel Dis (2005) 0.80
Is there a role for defensins in IBD? Inflamm Bowel Dis (2008) 0.80
Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cells. Int J Cancer (2002) 0.79
Impact of vitamin D3 on cutaneous immunity and antimicrobial peptide expression. Dermatoendocrinol (2011) 0.79
Gastric antimicrobial peptides fail to eradicate Helicobacter pylori infection due to selective induction and resistance. PLoS One (2013) 0.78
Autoantibodies against the bactericidal/permeability-increasing protein from inflammatory bowel disease patients can impair the antibiotic activity of bactericidal/permeability-increasing protein. Inflamm Bowel Dis (2004) 0.78
Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice. Biochim Biophys Acta (2004) 0.78
Pathogenic DNA: cytosolic DNA promotes inflammation in psoriasis. Cell Cycle (2011) 0.78
Defective antibacterial barrier in inflammatory bowel disease. Dig Dis (2013) 0.78
Antimicrobial peptides in the skin. N Engl J Med (2003) 0.78
Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications. J Drugs Dermatol (2016) 0.77
Paneth cell function--implications in pediatric Crohn disease. Gut Microbes (2011) 0.77
Narrow-band ultraviolet B exposure increases serum vitamin D levels in haemodialysis patients. Nephrol Dial Transplant (2011) 0.77
UV-B-triggered induction of vitamin D3 metabolism differentially affects antimicrobial peptide expression in keratinocytes. J Allergy Clin Immunol (2010) 0.77
Innate antimicrobial immunity in inflammatory bowel diseases. Expert Rev Clin Immunol (2010) 0.77
NOD2 mutation and mice: no Crohn's disease but many lessons to learn. Trends Mol Med (2005) 0.77
SKY and genetic fingerprinting reveal a cross-contamination of the putative normal colon epithelial cell line NCOL-1. Cancer Genet Cytogenet (2005) 0.76
Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease. BMC Gastroenterol (2013) 0.76