Published in Expert Rev Anti Infect Ther on December 01, 2007
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Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing. BMC Genomics (2010) 0.93
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease. PLoS Genet (2012) 0.88
Copy number variation in the mouse genome: implications for the mouse as a model organism for human disease. Cytogenet Genome Res (2009) 0.85
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
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A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology (2002) 2.15
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis (2003) 2.06
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem (2005) 2.06
Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome. Am J Gastroenterol (2009) 1.88
Response of refractory colitis to intravenous or oral tacrolimus (FK506). Inflamm Bowel Dis (2002) 1.80
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol (2007) 1.73
Extraintestinal manifestations and complications in inflammatory bowel diseases. World J Gastroenterol (2006) 1.73
Crohn's disease: a defensin deficiency syndrome? Eur J Gastroenterol Hepatol (2003) 1.72
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol (2002) 1.59
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Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun (2007) 1.48
Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. Hepatology (2012) 1.39
The expression patterns of peritoneal defensins. Perit Dial Int (2007) 1.39
[Suspected cases of severe side effects after infliximab (Remicade) in Germany]. Med Klin (Munich) (2003) 1.38
Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis. Differentiation (2008) 1.30
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29
Paneth's disease. J Crohns Colitis (2010) 1.29
Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol (2005) 1.27
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J Leukoc Biol (2004) 1.26
Defensins and other antimicrobial peptides in inflammatory bowel disease. Curr Opin Gastroenterol (2007) 1.25
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One (2009) 1.24
Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases. Eur J Gastroenterol Hepatol (2006) 1.21
Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol Med (2013) 1.17
Defensins and cathelicidins in gastrointestinal infections. Curr Opin Gastroenterol (2007) 1.16
Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease. J Leukoc Biol (2007) 1.14
Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo. PLoS One (2013) 1.13
Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut (2007) 1.11
A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts. J Microbiol Methods (2005) 1.05
From intestinal stem cells to inflammatory bowel diseases. World J Gastroenterol (2011) 1.03
Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3. Microbes Infect (2009) 1.03
Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD. J Crohns Colitis (2011) 1.03
Crohn's disease--defect in innate defence. World J Gastroenterol (2008) 0.97
Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease. Am J Gastroenterol (2009) 0.97
Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. J Lipid Res (2005) 0.96
Innate antimicrobial host defense in small intestinal Crohn's disease. Int J Med Microbiol (2009) 0.96
Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease. J Lipid Res (2008) 0.94
Paneth cells and the innate immune response. Curr Opin Gastroenterol (2006) 0.91
Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg (2012) 0.91
In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues. BMC Genomics (2008) 0.90
Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation. Digestion (2008) 0.88
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease. PLoS Genet (2012) 0.88
Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease. Am J Gastroenterol (2006) 0.86
More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus. Int J Med Microbiol (2012) 0.86
Human defensins in Crohn's disease. Chem Immunol Allergy (2005) 0.86
Antimicrobial peptides in gastrointestinal inflammation. Int J Inflam (2010) 0.86
A new look at Crohn's disease: breakdown of the mucosal antibacterial defense. Ann N Y Acad Sci (2006) 0.86
Human colonic mucus is a reservoir for antimicrobial peptides. J Crohns Colitis (2013) 0.86
Serum procalcitonin differentiates inflammatory bowel disease and self-limited colitis. Inflamm Bowel Dis (2004) 0.85
Fatal staphylococcal sepsis in Crohn's disease after infliximab. Inflamm Bowel Dis (2004) 0.85
Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identified variants linked to reduced expression. Hum Genet (2009) 0.85
Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses. Pediatr Res (2012) 0.84
Waking the wimp: redox-modulation activates human beta-defensin 1. Gut Microbes (2011) 0.84
Symptomatic or asymptomatic gallstone disease: is the gallbladder motility the clue? Hepatogastroenterology (2002) 0.84
Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing. J Crohns Colitis (2011) 0.83
A variant of the SLC10A2 gene encoding the apical sodium-dependent bile acid transporter is a risk factor for gallstone disease. PLoS One (2009) 0.83
Antimicrobial host defense in the upper gastrointestinal tract. Eur J Gastroenterol Hepatol (2008) 0.83
Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice. Biochem J (2002) 0.81
Gastrointestinal involvement in granulomatosis with polyangiitis and microscopic polyangiitis: histological features and outcome. Int J Rheum Dis (2013) 0.80
Is there a role for defensins in IBD? Inflamm Bowel Dis (2008) 0.80
Mesenteric pulsatility index analysis predicts response to azathioprine in patients with Crohn's disease. Inflamm Bowel Dis (2005) 0.80
A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation. J Invest Dermatol (2012) 0.80
Defective antibacterial barrier in inflammatory bowel disease. Dig Dis (2013) 0.78
Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice. Biochim Biophys Acta (2004) 0.78
Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins. Int J Med Microbiol (2012) 0.78
Antimicrobial peptides in the skin. N Engl J Med (2003) 0.78
Gastric antimicrobial peptides fail to eradicate Helicobacter pylori infection due to selective induction and resistance. PLoS One (2013) 0.78