Published in Infect Immun on August 24, 2009
Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes. Infect Immun (2010) 1.07
Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models. PLoS One (2013) 0.96
Defensins as anti-inflammatory compounds and mucosal adjuvants. Future Microbiol (2010) 0.95
P. gingivalis in Periodontal Disease and Atherosclerosis - Scenes of Action for Antimicrobial Peptides and Complement. Front Immunol (2015) 0.93
Variation in Streptococcus pneumoniae susceptibility to human antimicrobial peptides may mediate intraspecific competition. Proc Biol Sci (2012) 0.87
Understanding the roles of gingival beta-defensins. J Oral Microbiol (2012) 0.86
Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells. Proc Natl Acad Sci U S A (2012) 0.83
Current and potential applications of host-defense peptides and proteins in urology. Biomed Res Int (2015) 0.80
Microbial colonization and ureteral stent-associated storage lower urinary tract symptoms: the forgotten piece of the puzzle? World J Urol (2012) 0.77
Effect of recombinant prophenin 2 on the integrity and viability of Trichomonas vaginalis. Biomed Res Int (2015) 0.75
Influence of diabetes mellitus on the immunity to human tuberculosis. Immunology (2017) 0.75
Current insights into the role of human β-defensins in atopic dermatitis. Clin Exp Immunol (2017) 0.75
Heightened circulating levels of antimicrobial peptides in tuberculosis-Diabetes co-morbidity and reversal upon treatment. PLoS One (2017) 0.75
Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-ĸB-sensitive pathways. Immunol Res (2017) 0.75
Antimicrobial peptides of multicellular organisms. Nature (2002) 23.50
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol (2005) 13.69
Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med (2002) 9.01
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88
Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet (2007) 8.07
Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature (2001) 6.71
Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell (1997) 5.99
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med (2006) 5.20
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature (2003) 5.14
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol (2007) 4.44
Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest (1998) 3.78
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med (2007) 3.75
Alarmins: chemotactic activators of immune responses. Curr Opin Immunol (2005) 3.57
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest (1998) 3.51
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol (2003) 3.41
Defensins of vertebrate animals. Curr Opin Immunol (2002) 3.41
Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity (2006) 3.39
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol (1999) 3.39
Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med (2001) 3.11
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet (2002) 3.01
Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat Immunol (2001) 2.29
Chediak-Higashi syndrome. Curr Opin Hematol (2008) 2.23
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis (2003) 2.06
Cathelicidins--a family of multifunctional antimicrobial peptides. Cell Mol Life Sci (2003) 1.89
Cathelicidin deficiency predisposes to eczema herpeticum. J Allergy Clin Immunol (2006) 1.88
Antimicrobial peptides in health and disease. N Engl J Med (2002) 1.78
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A (2006) 1.75
Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression. Infect Immun (2003) 1.69
Cathelicidins, essential gene-encoded mammalian antibiotics. J Mol Med (Berl) (2002) 1.68
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J Clin Invest (1988) 1.63
A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children. AIDS (2004) 1.59
Antimicrobial peptides, innate immunity, and the normally sterile urinary tract. J Am Soc Nephrol (2007) 1.59
Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol (2006) 1.55
Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. J Clin Microbiol (2003) 1.55
Human NKT cells express granulysin and exhibit antimycobacterial activity. J Immunol (2003) 1.52
The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr HIV Res (2007) 1.50
Characterization of the mouse beta defensin 1, Defb1, mutant mouse model. Infect Immun (2002) 1.49
Antimicrobial peptide therapeutics for cystic fibrosis. Antimicrob Agents Chemother (2005) 1.44
Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol (2000) 1.39
Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells. Infect Immun (2007) 1.38
beta-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis. Clin Exp Immunol (2004) 1.35
Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression. J Exp Med (2008) 1.33
Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins. J Leukoc Biol (2005) 1.26
Chediak-Higashi syndrome: a clinical and molecular view of a rare lysosomal storage disorder. Curr Mol Med (2002) 1.24
Human {beta}-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells. Infect Immun (2005) 1.24
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One (2009) 1.24
Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease. Cell Microbiol (2008) 1.22
DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children. AIDS (2006) 1.22
Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection. BMC Infect Dis (2002) 1.20
beta-Defensin gene expression during the course of experimental tuberculosis infection. J Infect Dis (2006) 1.19
Impaired expression of perforin and granulysin in CD8+ T cells at the site of infection in human chronic pulmonary tuberculosis. Infect Immun (2007) 1.18
Defensins and cathelicidins in gastrointestinal infections. Curr Opin Gastroenterol (2007) 1.16
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. J Immunol (2005) 1.16
Multispecific myeloid defensins. Curr Opin Hematol (2007) 1.15
Alpha-defensins in the prevention of HIV transmission among breastfed infants. J Acquir Immune Defic Syndr (2005) 1.12
The potential role of lung epithelial cells and beta-defensins in experimental latent tuberculosis. Scand J Immunol (2008) 1.10
Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections. Gene Ther (2005) 1.10
Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease. Biochem Biophys Res Commun (2002) 1.09
Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection. Infect Immun (2004) 1.07
Human beta defensin is absent in burn blister fluid. Burns (2000) 1.01
Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults. J Infect Dis (2006) 0.99
Cytolytic T cells in the immune response to mycobacterium tuberculosis. Scand J Infect Dis (2001) 0.99
Expression and secretion of cathelicidin antimicrobial peptides in murine mammary glands and human milk. Pediatr Res (2004) 0.99
A cutaneous gene therapy approach to treat infection through keratinocyte-targeted overexpression of antimicrobial peptides. FASEB J (2004) 0.98
Oral antimicrobial peptides and biological control of caries. BMC Oral Health (2006) 0.97
DEFB-1 genetic polymorphism screening in HIV-1 positive pregnant women and their children. J Matern Fetal Neonatal Med (2006) 0.94
Human alpha defensin in HIV-exposed but uninfected individuals. J Acquir Immune Defic Syndr (2004) 0.93
Innate immunity, antimicrobial peptides, and protection of the oral cavity. Lancet (2002) 0.92
Association of beta-defensin 1 single nucleotide polymorphisms with atopic dermatitis. Int Arch Allergy Immunol (2006) 0.91
Copy number variation of defensin genes and HIV infection in Brazilian children. J Acquir Immune Defic Syndr (2009) 0.88
Chemokines and defensins as HIV suppressive factors: an evolving story. Curr Pharm Des (2007) 0.88
Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases. Curr Pharm Des (2007) 0.86
Salivary defensins and their importance in oral health and disease. Curr Pharm Des (2007) 0.85
Asthma and atopy are associated with DEFB1 polymorphisms in Chinese children. Genes Immun (2006) 0.83
[Antimicrobial peptides in the innate immunity of infectious diseases]. Salud Publica Mex (2006) 0.81
Localization of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) in the rat to chromosome 4 and implications for the evolution of mammalian chromosomes. Genomics (1992) 0.81
Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease. Expert Rev Anti Infect Ther (2007) 0.80
[Immunitary response in tuberculosis and the role of Mycobacterium tuberculosis secretion antigens in its protection, pathology and diagnosis. Review]. Invest Clin (2008) 0.76
TRPM8, a versatile channel in human sperm. PLoS One (2009) 1.05
Transient receptor potential (TRPC) channels in human sperm: expression, cellular localization and involvement in the regulation of flagellar motility. FEBS Lett (2003) 1.02
Genetic homogeneity of axenic isolates of Giardia intestinalis derived from acute and chronically infected individuals in Mexico. Parasitol Res (2003) 0.95
Identification of distinct K+ channels in mouse spermatogenic cells and sperm. Zygote (2002) 0.83
Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers. Arch Dermatol Res (2014) 0.80
Oxidative stress modulation by Rosmarinus officinalis in CCl4-induced liver cirrhosis. Phytother Res (2010) 0.80
Trifluoroacetylated adducts in spermatozoa, testes, liver and plasma and CYP2E1 induction in rats after subchronic inhalatory exposure to halothane. Toxicol Lett (2003) 0.78
Expression kinetics of metalloproteinases and their tissue inhibitors in experimental murine pulmonary tuberculosis. Exp Lung Res (2014) 0.75