Published in J Biol Chem on November 30, 2005
Activation of innate immune antiviral responses by Nod2. Nat Immunol (2009) 4.19
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol (2008) 3.22
Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
Macrophage activation by endogenous danger signals. J Pathol (2008) 2.38
Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A (2007) 2.20
Alterations in intestinal permeability. Gut (2006) 2.17
Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol (2007) 2.12
A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy (2009) 1.81
Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis (2010) 1.79
Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem (2009) 1.68
Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J Physiol (2012) 1.56
Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun (2007) 1.48
Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front Immunol (2013) 1.41
TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30
Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun (2006) 1.27
Irritable bowel syndrome, gut microbiota and probiotics. J Neurogastroenterol Motil (2011) 1.23
NOD1 and NOD2 Signaling in Infection and Inflammation. Front Immunol (2012) 1.22
The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol (2007) 1.21
Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases. Biosci Rep (2012) 1.17
Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury. J Immunol (2010) 1.13
Nod-like receptors: cytosolic watchdogs for immunity against pathogens. PLoS Pathog (2007) 1.12
A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses. J Biol Chem (2010) 1.11
Functions of NOD-Like Receptors in Human Diseases. Front Immunol (2013) 1.08
Pathogen recognition and activation of the innate immune response in zebrafish. Adv Hematol (2012) 1.07
RNase 7 contributes to the cutaneous defense against Enterococcus faecium. PLoS One (2009) 1.06
Specific-sized hyaluronan fragments promote expression of human β-defensin 2 in intestinal epithelium. J Biol Chem (2012) 1.05
Changes in salivary proteome following allogeneic hematopoietic stem cell transplantation. Exp Hematol (2007) 1.04
Host- and microbe determinants that may influence the success of S. aureus colonization. Front Cell Infect Microbiol (2012) 1.03
Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers (2015) 1.02
Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease. PLoS One (2009) 1.01
Nod2: a key regulator linking microbiota to intestinal mucosal immunity. J Mol Med (Berl) (2011) 1.01
RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition. Proc Natl Acad Sci U S A (2012) 0.99
Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid Redox Signal (2013) 0.99
MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury. EMBO Mol Med (2012) 0.99
Intestinal epithelial cells in inflammatory bowel diseases. World J Gastroenterol (2010) 0.97
The blood-epididymis barrier and inflammation. Spermatogenesis (2014) 0.94
Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease. World J Gastroenterol (2006) 0.92
Cationic host defence peptides: potential as antiviral therapeutics. BioDrugs (2013) 0.92
Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance. PLoS One (2011) 0.91
The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. J Autoimmun (2015) 0.91
Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg (2012) 0.91
Sepsis: links between pathogen sensing and organ damage. Curr Pharm Des (2008) 0.90
Antimicrobial peptides in gastrointestinal inflammation. Int J Inflam (2010) 0.86
MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function. Inflamm Bowel Dis (2010) 0.86
Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol (2016) 0.86
Microbial sensing by the intestinal epithelium in the pathogenesis of inflammatory bowel disease. Int J Inflam (2010) 0.85
Gatekeepers of intestinal inflammation. Inflamm Res (2010) 0.85
The pattern recognition receptor NOD2 mediates Staphylococcus aureus-induced IL-17C expression in keratinocytes. J Invest Dermatol (2013) 0.85
Regulation of Dendritic Cell Function by Vitamin D. Nutrients (2015) 0.84
The role of immunostimulatory nucleic acids in septic shock. Int J Clin Exp Med (2012) 0.84
Functional characterization of the NF-kappaB binding site in the human NOD2 promoter. Cell Mol Immunol (2010) 0.84
Fecal calprotectin, MMP-9, and human beta-defensin-2 levels in pediatric inflammatory bowel disease. Int J Colorectal Dis (2014) 0.83
The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self. Semin Immunopathol (2007) 0.83
The role of innate immunity in donor organ procurement. Semin Immunopathol (2011) 0.83
Regulation and functional impact of lipopolysaccharide induced Nod2 gene expression in the murine epididymal epithelial cell line PC1. Immunology (2008) 0.82
Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC. Int J Colorectal Dis (2010) 0.82
Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases. World J Gastroenterol (2013) 0.82
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism. Eur J Nutr (2012) 0.81
Immune-epithelial crosstalk at the intestinal surface. J Gastroenterol (2014) 0.81
Regulation of intestinal microbiota by the NLR protein family. Int Immunol (2013) 0.81
Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn's disease. Mucosal Immunol (2014) 0.81
Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases. Pathogens (2013) 0.80
Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response. Innate Immun (2013) 0.80
Debug Your Bugs - How NLRs Shape Intestinal Host-Microbe Interactions. Front Immunol (2013) 0.80
The differential effects of 1,25-dihydroxyvitamin D3 on Salmonella-induced interleukin-8 and human beta-defensin-2 in intestinal epithelial cells. Clin Exp Immunol (2016) 0.79
Prenatal human skin expresses the antimicrobial peptide RNase 7. Arch Dermatol Res (2013) 0.78
Activated innate immune system in irritable bowel syndrome? Gut (2007) 0.78
The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease. Clin Lab Med (2014) 0.78
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis. PLoS One (2013) 0.77
Fecal biomarkers of intestinal health and disease in children. Front Pediatr (2014) 0.77
Role of NOD2/CARD15 in coronary heart disease. BMC Genet (2007) 0.77
Crosstalk between Vitamin D Metabolism, VDR Signalling, and Innate Immunity. Biomed Res Int (2016) 0.77
Identification of MDP (muramyl dipeptide)-binding key domains in NOD2 (nucleotide-binding and oligomerization domain-2) receptor of Labeo rohita. Fish Physiol Biochem (2012) 0.76
NOD2/RICK-dependent β-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection. PLoS One (2014) 0.76
Muramyl dipeptide activates human beta defensin 2 and pro-inflammatory mediators through Toll-like receptors and NLRP3 inflammasomes in human dental pulp cells. Clin Oral Investig (2014) 0.76
A case of bilateral endophthalmitis and carriage of beta-defensin 1 44CC genotype. Br J Ophthalmol (2007) 0.76
Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses. J Diabetes Res (2016) 0.76
De Novo sphingolipid synthesis is essential for Salmonella-induced autophagy and human beta-defensin 2 expression in intestinal epithelial cells. Gut Pathog (2016) 0.76
Interrelatedness between dysbiosis in the gut microbiota due to immunodeficiency and disease penetrance of colitis. Immunology (2015) 0.76
Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease. BMC Gastroenterol (2013) 0.75
NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae. Sci Rep (2016) 0.75
The immunological landscape in necrotising enterocolitis. Expert Rev Mol Med (2016) 0.75
Potential roles of nucleotide-binding oligomerization domain 2 in the pathogenesis of systemic lupus erythematosus. Rheumatol Int (2014) 0.75
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat Immunol (2004) 3.19
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun (2004) 2.47
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science (2012) 2.44
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature (2011) 2.31
A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology (2002) 2.15
Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J Immunol (2008) 2.13
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis (2003) 2.06
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol (2007) 2.02
Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome. Am J Gastroenterol (2009) 1.88
Response of refractory colitis to intravenous or oral tacrolimus (FK506). Inflamm Bowel Dis (2002) 1.80
Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Transl Med (2011) 1.74
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol (2007) 1.73
Extraintestinal manifestations and complications in inflammatory bowel diseases. World J Gastroenterol (2006) 1.73
Crohn's disease: a defensin deficiency syndrome? Eur J Gastroenterol Hepatol (2003) 1.72
Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7. J Invest Dermatol (2009) 1.70
RNase 7 protects healthy skin from Staphylococcus aureus colonization. J Invest Dermatol (2010) 1.69
Epidermal EGFR controls cutaneous host defense and prevents inflammation. Sci Transl Med (2013) 1.69
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol (2002) 1.59
Inflammatory Bowel Disease. Dtsch Arztebl Int (2016) 1.56
Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol (2008) 1.55
Production of endogenous antibiotics in articular cartilage. Arthritis Rheum (2004) 1.55
Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun (2007) 1.48
The novel human beta-defensin-3 is widely expressed in oral tissues. Eur J Oral Sci (2002) 1.43
Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. Hepatology (2012) 1.39
The expression patterns of peritoneal defensins. Perit Dial Int (2007) 1.39
[Suspected cases of severe side effects after infliximab (Remicade) in Germany]. Med Klin (Munich) (2003) 1.38
Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid. J Invest Dermatol (2004) 1.35
UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo. J Allergy Clin Immunol (2009) 1.31
Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis. Differentiation (2008) 1.30
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29
Paneth's disease. J Crohns Colitis (2010) 1.29
Burkholderia is highly resistant to human Beta-defensin 3. Antimicrob Agents Chemother (2003) 1.29
Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol (2005) 1.27
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J Leukoc Biol (2004) 1.26
Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract. Kidney Int (2011) 1.25
Defensins and other antimicrobial peptides in inflammatory bowel disease. Curr Opin Gastroenterol (2007) 1.25
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS One (2009) 1.24
Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases. Eur J Gastroenterol Hepatol (2006) 1.21
Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection. BMC Infect Dis (2002) 1.20
The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption. J Invest Dermatol (2008) 1.18
Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol Med (2013) 1.17
Defensins and cathelicidins in gastrointestinal infections. Curr Opin Gastroenterol (2007) 1.16
Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours. J Cancer Res Clin Oncol (2006) 1.15
Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease. J Leukoc Biol (2007) 1.14
Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo. PLoS One (2013) 1.13
Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines. Eur Urol (2006) 1.12
Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut (2007) 1.11
Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3. Antimicrob Agents Chemother (2008) 1.07
RNase 7 contributes to the cutaneous defense against Enterococcus faecium. PLoS One (2009) 1.06
A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts. J Microbiol Methods (2005) 1.05
Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1. J Invest Dermatol (2006) 1.03
From intestinal stem cells to inflammatory bowel diseases. World J Gastroenterol (2011) 1.03
Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3. Microbes Infect (2009) 1.03
Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD. J Crohns Colitis (2011) 1.03
Mechanical and metabolic injury to the skin barrier leads to increased expression of murine β-defensin-1, -3, and -14. J Invest Dermatol (2010) 0.99
Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells. BMC Urol (2008) 0.98
Crohn's disease--defect in innate defence. World J Gastroenterol (2008) 0.97
Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease. Am J Gastroenterol (2009) 0.97
Innate antimicrobial host defense in small intestinal Crohn's disease. Int J Med Microbiol (2009) 0.96
Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. J Lipid Res (2005) 0.96
Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. J Invest Dermatol (2008) 0.95
Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease. J Lipid Res (2008) 0.94
Antimicrobial RNases in cutaneous defense. J Innate Immun (2012) 0.93
Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proc Natl Acad Sci U S A (2013) 0.93
Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors. Arthritis Rheum (2005) 0.92
Paneth cells and the innate immune response. Curr Opin Gastroenterol (2006) 0.91
Identification of RNase 8 as a novel human antimicrobial protein. Antimicrob Agents Chemother (2006) 0.91
Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg (2012) 0.91
In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues. BMC Genomics (2008) 0.90
The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions. J Invest Dermatol (2009) 0.90
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease. PLoS Genet (2012) 0.88
Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation. Digestion (2008) 0.88
Differential expression pattern of antimicrobial peptides in nasal mucosa and secretion. Rhinology (2011) 0.88