Published in J Biol Chem on December 13, 2006
Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest (2008) 3.02
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Mol Cell Biol (2007) 2.43
Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood (2008) 2.18
Molecular and therapeutic potential and toxicity of valproic acid. J Biomed Biotechnol (2010) 2.13
E2F-associated chromatin modifiers and cell cycle control. Curr Opin Cell Biol (2007) 2.04
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. Nucleic Acids Res (2011) 1.49
Dynamic protein methylation in chromatin biology. Cell Mol Life Sci (2009) 1.48
Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation. J Biol Chem (2009) 1.44
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet (2011) 1.43
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell (2013) 1.38
Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases. Mol Pharmacol (2010) 1.30
Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest (2011) 1.22
Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation. Drug Discov Today (2011) 1.18
Epigenetic responses to environmental change and their evolutionary implications. Philos Trans R Soc Lond B Biol Sci (2009) 1.14
On WD40 proteins: propelling our knowledge of transcriptional control? Epigenetics (2012) 1.03
Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulation. Epigenetics (2011) 1.03
Dietary manipulation of histone structure and function. Annu Rev Nutr (2008) 1.02
Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. PLoS One (2012) 1.02
Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination. EMBO J (2013) 1.01
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol (2014) 1.00
Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One (2009) 1.00
Histone deacetylase activity is necessary for left-right patterning during vertebrate development. BMC Dev Biol (2011) 1.00
Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns. Cell Cycle (2008) 0.99
Large scale analysis of co-existing post-translational modifications in histone tails reveals global fine structure of cross-talk. Mol Cell Proteomics (2014) 0.97
Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons. Neuropharmacology (2010) 0.92
The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing. Epigenetics Chromatin (2013) 0.91
Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS One (2012) 0.90
Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. BMC Genomics (2012) 0.90
Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes. Oncotarget (2016) 0.89
HDAC activity is required during Xenopus tail regeneration. PLoS One (2011) 0.89
HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. Epigenetics (2015) 0.89
Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J Virol (2014) 0.87
Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Nucleic Acids Res (2007) 0.87
Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry. J Biol Chem (2010) 0.86
Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. Physiol Genomics (2011) 0.84
A Genome-Wide Chronological Study of Gene Expression and Two Histone Modifications, H3K4me3 and H3K9ac, during Developmental Leaf Senescence. Plant Physiol (2015) 0.83
An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors. Mol Psychiatry (2013) 0.83
Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation. Epigenetics Chromatin (2010) 0.83
Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis. Elife (2014) 0.83
A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression(1,2,3). eNeuro (2015) 0.83
Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response. Epigenetics Chromatin (2015) 0.82
Histone methylation patterns in astrocytes are influenced by age following ischemia. Epigenetics (2015) 0.82
Cross-talk between DNA methylation and active histone modifications regulates aberrant expression of ZAP70 in CLL. J Cell Mol Med (2012) 0.82
Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. J Cell Mol Med (2012) 0.82
Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes. Mol Cell Pharmacol (2011) 0.82
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLoS One (2013) 0.81
Histone cleavage as a mechanism for epigenetic regulation: current insights and perspectives. Curr Mol Med (2014) 0.81
Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod. PLoS One (2012) 0.81
Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene. Transl Psychiatry (2015) 0.80
All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: role of histone modification. Mol Pharmacol (2014) 0.80
Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo. Exp Hematol Oncol (2015) 0.79
Applicability of histone deacetylase inhibition for the treatment of spinal muscular atrophy. Neurotherapeutics (2013) 0.78
A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types. PLoS One (2013) 0.77
RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes. J Neurochem (2009) 0.77
The histone deacetylase inhibitor valproic acid sensitizes diffuse large B-cell lymphoma cell lines to CHOP-induced cell death. Am J Transl Res (2013) 0.77
The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells. BMC Cancer (2015) 0.76
The Nuclear Protein IκBζ Forms a Transcriptionally Active Complex with Nuclear Factor-κB (NF-κB) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs. J Biol Chem (2016) 0.76
Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation. Stem Cell Rev (2016) 0.76
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics Chromatin (2015) 0.75
Targeting histone methylation for colorectal cancer. Therap Adv Gastroenterol (2016) 0.75
Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes. Epigenetics Chromatin (2016) 0.75
UHRF2 decreases H3K9ac expression by interacting with it through the PHD and SRA/YDG domain in HepG2 hepatocellular carcinoma cells. Int J Mol Med (2016) 0.75
Crop epigenetics and the molecular hardware of genotype × environment interactions. Front Plant Sci (2015) 0.75
Chromatin Switches during Neural Cell Differentiation and Their Dysregulation by Prenatal Alcohol Exposure. Genes (Basel) (2017) 0.75
Lysine deacetylase inhibition attenuates hypertension and is accompanied by acetylation of mineralocorticoid receptor instead of histone acetylation in spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev (2004) 7.57
A general method for the covalent labeling of fusion proteins with small molecules in vivo. Nat Biotechnol (2002) 6.77
Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations. Nat Genet (2006) 3.44
Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. Angew Chem Int Ed Engl (2010) 2.61
Microdroplets: a sea of applications? Lab Chip (2008) 2.55
Histone modifications: signalling receptors and potential elements of a heritable epigenetic code. Curr Opin Genet Dev (2006) 2.49
Immunoprecipitation of native chromatin: NChIP. Methods (2003) 2.27
Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes. PLoS Biol (2007) 2.06
Picoliter cell lysate assays in microfluidic droplet compartments for directed enzyme evolution. Chem Biol (2012) 1.87
Stress-induced transcription of satellite III repeats. J Cell Biol (2003) 1.86
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo. Chem Biol (2003) 1.76
Histone modifications in Arabidopsis- high methylation of H3 lysine 9 is dispensable for constitutive heterochromatin. Plant J (2003) 1.69
Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. Lab Chip (2008) 1.59
Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro. Methods (2004) 1.46
Directed evolution of a gatekeeper domain in nonribosomal peptide synthesis. Chem Biol (2011) 1.45
Investigating an incidental finding of thrombocytopenia. BMJ (2013) 1.38
Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70. J Biol Chem (2002) 1.35
Molecular and cytogenetic analysis of the spreading of X inactivation in X;autosome translocations. Hum Mol Genet (2002) 1.32
Development of quantitative cell-based enzyme assays in microdroplets. Anal Chem (2008) 1.29
Epigenome changes in active and inactive polycomb-group-controlled regions. EMBO Rep (2004) 1.25
Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis. Nat Genet (2011) 1.22
Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. Clin Cancer Res (2006) 1.22
Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells. Oncogene (2004) 1.20
Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets. Anal Chem (2009) 1.19
What makes an enzyme promiscuous? Curr Opin Chem Biol (2010) 1.17
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase. Dev Biol (2006) 1.15
An increasingly complex code. J Clin Invest (2002) 1.13
Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays. Anal Chem (2009) 1.13
Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments. J Am Chem Soc (2009) 1.11
The potential of microfluidic water-in-oil droplets in experimental biology. Mol Biosyst (2009) 1.08
An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily. Proc Natl Acad Sci U S A (2010) 1.07
Immunostaining of modified histones defines high-level features of the human metaphase epigenome. Genome Biol (2010) 1.07
An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets. Chembiochem (2008) 1.06
A double droplet trap system for studying mass transport across a droplet-droplet interface. Lab Chip (2010) 1.04
Microfluidic droplets: new integrated workflows for biological experiments. Curr Opin Chem Biol (2010) 1.03
Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function. J Cell Sci (2012) 1.03
Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells. Nucleic Acids Res (2010) 1.03
Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. PLoS One (2012) 1.02
X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum Mol Genet (2003) 1.00
A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site. Proc Natl Acad Sci U S A (2006) 1.00
Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One (2009) 1.00
Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. ACS Nano (2013) 0.99
New genotype-phenotype linkages for directed evolution of functional proteins. Curr Opin Struct Biol (2005) 0.98
An efficient method to assemble linear DNA templates for in vitro screening and selection systems. Nucleic Acids Res (2009) 0.98
One in a million: flow cytometric sorting of single cell-lysate assays in monodisperse picolitre double emulsion droplets for directed evolution. Anal Chem (2014) 0.98
The human histone acetyltransferase P/CAF is a promiscuous histone propionyltransferase. Chembiochem (2008) 0.98
Efficient catalytic promiscuity in an enzyme superfamily: an arylsulfatase shows a rate acceleration of 10(13) for phosphate monoester hydrolysis. J Am Chem Soc (2008) 0.98
Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes. J Am Chem Soc (2008) 0.97
An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets. Lab Chip (2009) 0.97
Transcription factors, chromatin and cancer. Int J Biochem Cell Biol (2008) 0.97
Undifferentiated embryonic cell transcription factor 1 regulates ESC chromatin organization and gene expression. Stem Cells (2010) 0.95
Efficient catalytic promiscuity for chemically distinct reactions. Angew Chem Int Ed Engl (2009) 0.95
Removal of background signals from fluorescence thermometry measurements in PDMS microchannels using fluorescence lifetime imaging. Lab Chip (2009) 0.92
The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing. Epigenetics Chromatin (2013) 0.91
Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns. Carcinogenesis (2012) 0.91
Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. J Biol Chem (2002) 0.91
Memorable transcription. Nat Cell Biol (2003) 0.90
In vitro affinity screening of protein and peptide binders by megavalent bead surface display. Protein Eng Des Sel (2013) 0.89
A single mutation in the core domain of the lac repressor reduces leakiness. Microb Cell Fact (2013) 0.89
Efficient, crosswise catalytic promiscuity among enzymes that catalyze phosphoryl transfer. Biochim Biophys Acta (2012) 0.88
A simple method to evaluate the biochemical compatibility of oil/surfactant mixtures for experiments in microdroplets. Lab Chip (2012) 0.88
Simultaneous measurement of reactions in microdroplets filled by concentration gradients. Lab Chip (2009) 0.88
Altered histone modifications in cancer. Adv Exp Med Biol (2013) 0.87
Mapping the limits of substrate specificity of the adenylation domain of TycA. Chembiochem (2009) 0.86
A covalent chemical genotype-phenotype linkage for in vitro protein evolution. Chembiochem (2007) 0.86
A fully unsupervised compartment-on-demand platform for precise nanoliter assays of time-dependent steady-state enzyme kinetics and inhibition. Anal Chem (2013) 0.85
A new map for navigating the yeast epigenome. Cell (2005) 0.84
Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells. J Steroid Biochem Mol Biol (2012) 0.84
An optimized ATP/PP(i)-exchange assay in 96-well format for screening of adenylation domains for applications in combinatorial biosynthesis. Biotechnol J (2007) 0.83
Elevated FOSB-expression; a potential marker of valproate sensitivity in AML. Br J Haematol (2008) 0.83
Controlling the contents of microdroplets by exploiting the permeability of PDMS. Lab Chip (2011) 0.82
Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride. J Am Chem Soc (2009) 0.82
Droplets as reaction compartments for protein nanotechnology. Methods Mol Biol (2013) 0.82
Differential loss of histone H3 isoforms mono-, di- and tri-methylated at lysine 4 during X-inactivation in female embryonic stem cells. Biol Chem (2008) 0.81
Monitoring a reaction at submillisecond resolution in picoliter volumes. Anal Chem (2011) 0.81
Peptide dendrimer/lipid hybrid systems are efficient DNA transfection reagents: structure--activity relationships highlight the role of charge distribution across dendrimer generations. ACS Nano (2013) 0.81
Flexibility and reactivity in promiscuous enzymes. Chembiochem (2013) 0.81
One-pot deracemization of sec-alcohols: enantioconvergent enzymatic hydrolysis of alkyl sulfates using stereocomplementary sulfatases. Angew Chem Int Ed Engl (2013) 0.81
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLoS One (2013) 0.81
Interfacing microwells with nanoliter compartments: a sampler generating high-resolution concentration gradients for quantitative biochemical analyses in droplets. Anal Chem (2014) 0.81
SNAP display: in vitro protein evolution in microdroplets. Methods Mol Biol (2012) 0.81
Inducing and sensing protein--protein interactions in living cells by selective cross-linking. Angew Chem Int Ed Engl (2007) 0.80
Fluid phase endocytosis contributes to transfection of DNA by PEI-25. Mol Ther (2009) 0.80
Polyethylene imine derivatives ('synzymes') accelerate phosphate transfer in the absence of metal. J Am Chem Soc (2007) 0.80
Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells. Exp Cell Res (2010) 0.80
Relating chemical and biological diversity space: a tunable system for efficient gene transfection. Chembiochem (2008) 0.80
SNAP dendrimers: multivalent protein display on dendrimer-like DNA for directed evolution. Chembiochem (2011) 0.80
Combining medium effects and cofactor catalysis: metal-coordinated synzymes accelerate phosphate transfer by 10(8). Chemistry (2009) 0.79
Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification. Nucleic Acids Res (2010) 0.79
SNAP display - an in vitro method for the selection of protein binders. Curr Pharm Des (2013) 0.79
Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. Exp Cell Res (2002) 0.78
Biochemistry: Enzymes under the nanoscope. Nature (2008) 0.78
Simplifying a complex code. Nat Struct Mol Biol (2008) 0.77
Just (protein) engineering? Curr Opin Struct Biol (2013) 0.77
Molecular recognition of DNA by rigid [N]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties. J Med Chem (2007) 0.77
Kinetic and computational evidence for an intermediate in the hydrolysis of sulfonate esters. Org Biomol Chem (2012) 0.77
Hitting a moving target?--Understanding how conformational diversity impacts enzymatic catalysis. Curr Opin Chem Biol (2010) 0.76