Published in Mol Biol Evol on December 20, 2006
Signals of recent positive selection in a worldwide sample of human populations. Genome Res (2009) 8.38
The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Curr Biol (2010) 4.25
The role of geography in human adaptation. PLoS Genet (2009) 3.41
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet (2010) 3.11
The African Genome Variation Project shapes medical genetics in Africa. Nature (2014) 3.11
Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet (2008) 2.68
A genomewide association study of skin pigmentation in a South Asian population. Am J Hum Genet (2007) 2.58
Using environmental correlations to identify loci underlying local adaptation. Genetics (2010) 2.52
Analysis of genomic admixture in Uyghur and its implication in mapping strategy. Am J Hum Genet (2008) 2.30
Spatial patterns of variation due to natural selection in humans. Nat Rev Genet (2009) 2.18
Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics (2009) 2.18
25-Hydroxyvitamin D in African-origin populations at varying latitudes challenges the construct of a physiologic norm. Am J Clin Nutr (2014) 2.16
Adaptations to climate-mediated selective pressures in humans. PLoS Genet (2011) 2.15
Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature (2014) 2.09
Genome-wide patterns of selection in 230 ancient Eurasians. Nature (2015) 2.09
Colloquium paper: human skin pigmentation as an adaptation to UV radiation. Proc Natl Acad Sci U S A (2010) 1.83
The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort. J Allergy Clin Immunol (2012) 1.52
A population genetic signal of polygenic adaptation. PLoS Genet (2014) 1.46
Adaptations to new environments in humans: the role of subtle allele frequency shifts. Philos Trans R Soc Lond B Biol Sci (2010) 1.40
Parallel adaptation: one or many waves of advance of an advantageous allele? Genetics (2010) 1.39
Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago. Sci Adv (2017) 1.39
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. Am J Hum Genet (2011) 1.35
Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the last 5,000 y. Proc Natl Acad Sci U S A (2014) 1.34
Genome-wide association studies of pigmentation and skin cancer: a review and meta-analysis. Pigment Cell Melanoma Res (2010) 1.28
Genetic architecture of skin and eye color in an African-European admixed population. PLoS Genet (2013) 1.28
Integrating evolutionary and functional approaches to infer adaptation at specific loci. Evolution (2010) 1.21
Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation. PLoS Genet (2010) 1.17
Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations? PLoS Genet (2011) 1.17
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Positive selection in East Asians for an EDAR allele that enhances NF-kappaB activation. PLoS One (2008) 1.14
The timing of pigmentation lightening in Europeans. Mol Biol Evol (2012) 1.13
Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics (2009) 1.12
Human pigmentation genes under environmental selection. Genome Biol (2012) 1.11
A global view of the OCA2-HERC2 region and pigmentation. Hum Genet (2011) 1.08
Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations. PLoS One (2012) 1.07
Toward a new history and geography of human genes informed by ancient DNA. Trends Genet (2014) 1.07
Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor. Pigment Cell Melanoma Res (2008) 1.07
Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 function. Mol Biol Cell (2008) 1.07
Cuba: exploring the history of admixture and the genetic basis of pigmentation using autosomal and uniparental markers. PLoS Genet (2014) 1.02
Human skin pigmentation, migration and disease susceptibility. Philos Trans R Soc Lond B Biol Sci (2012) 1.01
Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. Proc Natl Acad Sci U S A (2009) 1.00
Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry. BMC Evol Biol (2013) 0.99
Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans. Hum Genet (2012) 0.95
Association of genetic variants with self-assessed color categories in Brazilians. PLoS One (2014) 0.95
Genomic ancestry, self-reported "color" and quantitative measures of skin pigmentation in Brazilian admixed siblings. PLoS One (2011) 0.94
Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol Biol Cell (2012) 0.94
Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans. BMC Evol Biol (2008) 0.93
The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent. PLoS Genet (2013) 0.93
Linking vitamin d deficiency to inflammatory bowel disease. Inflamm Bowel Dis (2013) 0.92
Detecting the Genetic Signature of Natural Selection in Human Populations: Models, Methods, and Data. Annu Rev Anthropol (2008) 0.92
Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans. BMC Genet (2009) 0.92
Functional assessment of human coding mutations affecting skin pigmentation using zebrafish. PLoS One (2012) 0.91
Adaptations to local environments in modern human populations. Curr Opin Genet Dev (2014) 0.90
OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and Europeans. Hum Genet (2011) 0.90
Human evolutionary genomics: ethical and interpretive issues. Trends Genet (2012) 0.89
Purifying selection modulates the estimates of population differentiation and confounds genome-wide comparisons across single-nucleotide polymorphisms. Mol Biol Evol (2012) 0.88
Skin cancer was not a potent selective force in the evolution of protective pigmentation in early hominins. Proc Biol Sci (2014) 0.87
Deciphering the genetic blueprint behind Holstein milk proteins and production. Genome Biol Evol (2014) 0.86
Ancestry, admixture and fitness in Colombian genomes. Sci Rep (2015) 0.85
Skin color variation in Orang Asli tribes of Peninsular Malaysia. PLoS One (2012) 0.84
Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits. Pigment Cell Melanoma Res (2014) 0.84
Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing. Investig Genet (2011) 0.83
Inferring positive selection in humans from genomic data. Investig Genet (2015) 0.83
Polymorphisms in vitamin D-related genes and risk of uterine leiomyomata. Fertil Steril (2014) 0.82
Evolutionary genetics as a tool to target genes involved in phenotypes of medical relevance. Evol Appl (2009) 0.82
Evolutionary forces shaping genomic islands of population differentiation in humans. BMC Genomics (2012) 0.82
Re-appraisal of current theories for the development and loss of epidermal pigmentation in hominins and modern humans. J Hum Evol (2013) 0.81
Tooth, skin, hair and eye colour interrelationships in Greek young adults. Odontology (2012) 0.81
The Role of Standing Variation in Geographic Convergent Adaptation. Am Nat (2015) 0.80
Skin color in fish and humans: impacts on science and society. Zebrafish (2008) 0.80
The impact of natural selection on health and disease: uses of the population genetics approach in humans. Evol Appl (2013) 0.80
Molecular phylogeography of a human autosomal skin color locus under natural selection. G3 (Bethesda) (2013) 0.79
Global patterns of diversity and selection in human tyrosinase gene. PLoS One (2013) 0.79
The colours of humanity: the evolution of pigmentation in the human lineage. Philos Trans R Soc Lond B Biol Sci (2017) 0.79
Circadian rhythms of European and African-Americans after a large delay of sleep as in jet lag and night work. Sci Rep (2016) 0.79
Tracing the peopling of the world through genomics. Nature (2017) 0.79
Haplotype differences for copy number variants in the 22q11.23 region among human populations: a pigmentation-based model for selective pressure. Eur J Hum Genet (2014) 0.78
Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production. Evol Biol (2014) 0.78
Skin pigmentation, sun exposure and vitamin D levels in children of the Avon Longitudinal Study of Parents and Children. BMC Public Health (2014) 0.78
A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution. Mol Biol Evol (2016) 0.78
Private haplotypes can reveal local adaptation. BMC Genet (2014) 0.78
Understanding rare and common diseases in the context of human evolution. Genome Biol (2016) 0.78
Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes. G3 (Bethesda) (2016) 0.78
No evidence of a Neanderthal contribution to modern human diversity. Genome Biol (2008) 0.77
Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations. Hum Genome Var (2015) 0.76
Human population admixture in Asia. Genomics Inform (2012) 0.76
Recent coselection in human populations revealed by protein-protein interaction network. Genome Biol Evol (2014) 0.76
The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population. PLoS One (2014) 0.76
Searching for signatures of cold adaptations in modern and archaic humans: hints from the brown adipose tissue genes. Heredity (Edinb) (2014) 0.76
Living in an adaptive world: Genomic dissection of the genus Homo and its immune response. J Exp Med (2017) 0.75
MC1R diversity in Northern Island Melanesia has not been constrained by strong purifying selection and cannot explain pigmentation phenotype variation in the region. BMC Genet (2015) 0.75
Further evidence for population specific differences in the effect of DNA markers and gender on eye colour prediction in forensics. Int J Legal Med (2016) 0.75
Investigating the case of human nose shape and climate adaptation. PLoS Genet (2017) 0.75
Relationship between CATSPERB, NR5A2 gene polymorphisms and Peak Bone Mineral Density in College Students in China. Iran J Public Health (2014) 0.75
Genetic Ancestry, Skin Reflectance and Pigmentation Genotypes in Association with Serum Vitamin D Metabolite Balance. Horm Mol Biol Clin Investig (2011) 0.75
Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin. Biol Sex Differ (2016) 0.75
Implications of the admixture process in skin color molecular assessment. PLoS One (2014) 0.75
Tanning predicts bone mass but not structure in adolescent females living in Hawaii. Am J Hum Biol (2011) 0.75
Adaptation of human skin color in various populations. Hereditas (2017) 0.75
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science (2005) 12.02
Interrogating a high-density SNP map for signatures of natural selection. Genome Res (2002) 10.33
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
Control of confounding of genetic associations in stratified populations. Am J Hum Genet (2003) 7.99
Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science (2009) 7.64
Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol (2004) 7.11
Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array. Genome Res (2004) 5.59
Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet (2003) 4.67
Measuring European population stratification with microarray genotype data. Am J Hum Genet (2007) 4.03
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet (2007) 3.94
A genomewide admixture mapping panel for Hispanic/Latino populations. Am J Hum Genet (2007) 3.85
Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation. Hum Genomics (2005) 3.77
cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans. Cell (2007) 3.72
African pastoralism: genetic imprints of origins and migrations. Science (2002) 3.66
Abundant pleiotropy in human complex diseases and traits. Am J Hum Genet (2011) 3.60
Ancient DNA, pig domestication, and the spread of the Neolithic into Europe. Proc Natl Acad Sci U S A (2007) 3.45
Documenting domestication: the intersection of genetics and archaeology. Trends Genet (2006) 3.27
Population stratification confounds genetic association studies among Latinos. Hum Genet (2005) 3.19
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet (2010) 3.11
DNA markers reveal the complexity of livestock domestication. Nat Rev Genet (2003) 3.07
The landscape of recombination in African Americans. Nature (2011) 3.06
Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study. Lancet Neurol (2012) 3.04
Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol (2005) 3.03
Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92
Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol (2006) 2.87
A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet (2007) 2.84
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet (2011) 2.70
Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochs. Proc Biol Sci (2007) 2.61
The protocols for the 10/66 dementia research group population-based research programme. BMC Public Health (2007) 2.54
Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nat Genet (2003) 2.35
Ancient hybridization and an Irish origin for the modern polar bear matriline. Curr Biol (2011) 2.33
Measuring and using admixture to study the genetics of complex diseases. Hum Genomics (2003) 2.31
Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics (2009) 2.18
Genetic ancestry and the search for personalized genetic histories. Nat Rev Genet (2004) 2.08
Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city. Hum Genet (2004) 2.00
The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. Hum Genet (2005) 1.97
Using genetic admixture to explain racial differences in insulin-related phenotypes. Diabetes (2003) 1.94
Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors. Hum Genet (2006) 1.93
The genetic architecture of normal variation in human pigmentation: an evolutionary perspective and model. Hum Mol Genet (2006) 1.90
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J Clin Invest (2013) 1.89
Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Am J Respir Cell Mol Biol (2006) 1.88
Association of African genetic admixture with resting metabolic rate and obesity among women. Obes Res (2003) 1.86
High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium. Genome Res (2005) 1.85
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet (2008) 1.81
A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. J Clin Invest (2006) 1.79
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas. PLoS Genet (2012) 1.74
Ancestral components of admixed genomes in a Mexican cohort. PLoS Genet (2011) 1.67
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res (2006) 1.63
The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: a population validation study. BMC Public Health (2008) 1.60
Confirmation of the type 2 myotonic dystrophy (CCTG)n expansion mutation in patients with proximal myotonic myopathy/proximal myotonic dystrophy of different European origins: a single shared haplotype indicates an ancestral founder effect. Am J Hum Genet (2003) 1.59
Genetic signatures of a Mediterranean influence in Iberian Peninsula sheep husbandry. Mol Biol Evol (2006) 1.55
Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. PLoS Genet (2011) 1.54
Human genetic diversity and the nonexistence of biological races. Hum Biol (2003) 1.53
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Hum Mol Genet (2010) 1.53
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. PLoS Genet (2013) 1.52
The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269. Proc Biol Sci (2011) 1.52
Human genetic diversity and the nonexistence of biological races. 2003. Hum Biol (2009) 1.51
Microsatellite diversity suggests different histories for Mediterranean and Northern European cattle populations. Proc Biol Sci (2005) 1.49
Differences in allergic sensitization by self-reported race and genetic ancestry. J Allergy Clin Immunol (2008) 1.47
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. PLoS Genet (2011) 1.47
Ancestry estimation and correction for population stratification in molecular epidemiologic association studies. Cancer Epidemiol Biomarkers Prev (2008) 1.43
KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST). Pharmacogenet Genomics (2007) 1.40
Runs of homozygosity and population history in cattle. BMC Genet (2012) 1.40
Long-term consequences of polycystic ovary syndrome: results of a 31 year follow-up study. Hum Fertil (Camb) (2000) 1.39
Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. Hum Genet (2003) 1.39
Microalbuminuria and coronary heart disease risk in an ethnically diverse UK population: a prospective cohort study. J Am Soc Nephrol (2005) 1.38
Genetic contributions to disparities in preterm birth. Pediatr Res (2009) 1.37
Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). Hum Mol Genet (2004) 1.35
Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth. Am J Physiol Regul Integr Comp Physiol (2009) 1.34
The Longue Durée of genetic ancestry: multiple genetic marker systems and Celtic origins on the Atlantic facade of Europe. Am J Hum Genet (2004) 1.33
Measurement of admixture proportions and description of admixture structure in different U.S. populations. Hum Mutat (2009) 1.33
Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. Prostate (2010) 1.32
A Y-chromosome signature of hegemony in Gaelic Ireland. Am J Hum Genet (2005) 1.31
Genetic heterogeneity in colorectal cancer associations between African and European americans. Gastroenterology (2010) 1.31
COX-2 gene promoter haplotypes and prostate cancer risk. Carcinogenesis (2004) 1.30
IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans. Carcinogenesis (2007) 1.28
Genetic architecture of skin and eye color in an African-European admixed population. PLoS Genet (2013) 1.28
A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans. Proc Natl Acad Sci U S A (2006) 1.27
Markers that discriminate between European and African ancestry show limited variation within Africa. Hum Genet (2002) 1.27
Genetic admixture, self-reported ethnicity, self-estimated admixture, and skin pigmentation among Hispanics and Native Americans. Am J Phys Anthropol (2009) 1.26
Mitochondrial DNA (mtDNA) haplotypes reveal maternal population genetic affinities of Sea Island Gullah-speaking African Americans. Am J Phys Anthropol (2005) 1.23
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing. J Med Genet (2013) 1.20
A complete mitochondrial genome sequence from a mesolithic wild aurochs (Bos primigenius). PLoS One (2010) 1.18
From Galton to GWAS: quantitative genetics of human height. Genet Res (Camb) (2010) 1.16
Spanish genetic admixture is associated with larger V(O2) max decrement from sea level to 4338 m in Peruvian Quechua. J Appl Physiol (1985) (2003) 1.16