PubRank

David J Chen

Author PubWeight™ 159.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 2004 6.48
2 Genomic instability in laminopathy-based premature aging. Nat Med 2005 4.54
3 Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev 2002 3.83
4 Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem 2005 3.19
5 The endless tale of non-homologous end-joining. Cell Res 2008 3.03
6 Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 2005 3.02
7 Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol 2007 2.92
8 Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) 2006 2.67
9 Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem 2006 2.66
10 Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol 2005 2.64
11 Two essential but distinct functions of the mammalian abasic endonuclease. Proc Natl Acad Sci U S A 2005 2.26
12 Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure 2008 2.17
13 Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell 2011 2.16
14 Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) 2004 2.13
15 MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol Cell Biol 2010 2.03
16 Ku recruits XLF to DNA double-strand breaks. EMBO Rep 2007 2.00
17 Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev 2005 1.97
18 Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation. J Biol Chem 2004 1.96
19 DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc Natl Acad Sci U S A 2002 1.92
20 Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem 2009 1.91
21 ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal 2010 1.86
22 A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest 2008 1.82
23 A human breast cell model of preinvasive to invasive transition. Cancer Res 2008 1.79
24 Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. Structure 2004 1.78
25 DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair (Amst) 2006 1.75
26 Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res 2009 1.73
27 Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. Cancer Res 2007 1.68
28 Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proc Natl Acad Sci U S A 2011 1.64
29 Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell Cycle 2011 1.63
30 DNA double strand break repair via non-homologous end-joining. Transl Cancer Res 2013 1.61
31 Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. J Biol Chem 2002 1.60
32 DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A 2004 1.60
33 Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev 2011 1.60
34 Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A 2011 1.58
35 WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol 2006 1.55
36 Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol 2009 1.55
37 DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol 2007 1.48
38 Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res 2005 1.48
39 Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle 2010 1.48
40 Room-temperature single-nucleotide polymorphism and multiallele DNA detection using fluorescent nanocrystals and microarrays. Anal Chem 2003 1.40
41 Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst) 2002 1.40
42 Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts. Radiat Res 2008 1.37
43 Retracted DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. Cell 2009 1.37
44 Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 2011 1.36
45 Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation. Nucleic Acids Res 2009 1.34
46 Phosphoproteome profiling of human skin fibroblast cells in response to low- and high-dose irradiation. J Proteome Res 2006 1.33
47 MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem 2004 1.32
48 Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer 2003 1.31
49 DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst) 2008 1.29
50 Human Rad51C deficiency destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells. J Biol Chem 2004 1.27
51 DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst) 2009 1.27
52 The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet 2013 1.27
53 Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer Res 2010 1.26
54 Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst) 2005 1.25
55 DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. EMBO J 2002 1.21
56 Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation. Mutat Res 2010 1.20
57 Engineered bacterial outer membrane vesicles with enhanced functionality. J Mol Biol 2008 1.20
58 Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. J Biol Chem 2005 1.19
59 Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway. Cell Cycle 2008 1.19
60 Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res 2005 1.16
61 Akt promotes post-irradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Res 2012 1.14
62 ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair. EMBO Rep 2011 1.12
63 Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice. Mol Cell Biol 2002 1.12
64 FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat Commun 2012 1.12
65 Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Res 2003 1.11
66 Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF. FEBS Lett 2011 1.11
67 Tumor cell radiosensitivity is a major determinant of tumor response to radiation. Cancer Res 2006 1.10
68 Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination. DNA Repair (Amst) 2012 1.10
69 hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Res 2010 1.08
70 CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. J Biol Chem 2012 1.08
71 Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat Res 2003 1.08
72 Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability. Carcinogenesis 2007 1.05
73 Spontaneous mutagenesis is enhanced in Apex heterozygous mice. Mol Cell Biol 2004 1.05
74 Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem 2011 1.04
75 The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep 2003 1.03
76 The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol Cell Biol 2008 1.03
77 Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis. DNA Repair (Amst) 2003 1.02
78 Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line. DNA Repair (Amst) 2002 1.01
79 Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. Cell Res 2007 1.00
80 Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts. Nucleic Acids Res 2009 0.99
81 Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway. PLoS One 2012 0.97
82 The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation. J Biol Chem 2013 0.97
83 Gene expression changes in normal human skin fibroblasts induced by HZE-particle radiation. Radiat Res 2005 0.96
84 Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment. Cancer Res 2002 0.95
85 A positive role for the Ku complex in DNA replication following strand break damage in mammals. J Biol Chem 2003 0.93
86 Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. J Biol Chem 2007 0.93
87 Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability. Radiat Res 2010 0.93
88 Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. J Biol Chem 2010 0.92
89 Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks. Cell Cycle 2010 0.91
90 The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. J Biol Chem 2004 0.90
91 In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex. Mol Biol Cell 2003 0.89
92 WRN participates in translesion synthesis pathway through interaction with NBS1. Mech Ageing Dev 2010 0.89
93 Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination. DNA Repair (Amst) 2008 0.89
94 Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1. Biochem Biophys Res Commun 2009 0.88
95 The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions. Radiat Res 2015 0.87
96 Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities. Oncol Rep 2010 0.85
97 ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating. J Radiat Res 2010 0.85
98 Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture. Nucleic Acids Res 2011 0.85
99 Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Mol Cancer Res 2012 0.84
100 ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A. J Biol Chem 2007 0.84
101 Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment. Nucleic Acids Res 2013 0.83
102 Construction of a novel expression system on a human artificial chromosome. Biochem Biophys Res Commun 2005 0.82
103 Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation. Radiother Oncol 2011 0.81
104 The ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors. J Thorac Oncol 2014 0.80
105 Ku affects the ATM-dependent S phase checkpoint following ionizing radiation. Oncogene 2002 0.78
106 Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate. Mutagenesis 2011 0.77
107 DNA-PK and ATM are required for radiation-enhanced integration. Radiat Res 2002 0.77
108 Complex DSBs: A need for resection. Cell Cycle 2014 0.76
109 Rapid assessment of two major repair activities against DNA double-strand breaks in vertebrate cells. Biochem Biophys Res Commun 2005 0.76
110 DNA-PKcs-dependent modulation of cellular radiosensitivity by a selective cyclooxygenase-2 inhibitor. Int J Radiat Oncol Biol Phys 2007 0.76
111 A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining. Cell Cycle 2010 0.75
112 A role for protein phosphatase 4 in regulating non-homologous end-joining. Cell Cycle 2012 0.75
113 Differing responses of Nijmegen breakage syndrome and ataxia telangiectasia cells to ionizing radiation. Radiat Res 2002 0.75
114 Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 2009 0.75
115 Amplification and overexpression of oncogene Mdm2 and orphan receptor gene Nr1h4 in immortal PRKDC knockout cells. Mol Biol Rep 2004 0.75