NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL.

PubWeight™: 1.76‹?› | Rank: Top 3%

🔗 View Article (PMC 2579276)

Published in Biochemistry on January 16, 2007

Authors

Thomas J Malia1, Gerhard Wagner

Author Affiliations

1: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science (2008) 3.38

Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69

Direct control of mitochondrial function by mTOR. Proc Natl Acad Sci U S A (2009) 1.85

Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr (2008) 1.73

Biogenesis of beta-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence. Cell Mol Life Sci (2009) 1.62

Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell (2009) 1.58

Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. Channels (Austin) (2009) 1.57

Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Prog Nucl Magn Reson Spectrosc (2009) 1.57

Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J Am Chem Soc (2009) 1.55

Membrane protein structure and dynamics from NMR spectroscopy. Annu Rev Phys Chem (2011) 1.43

Uncovering the role of VDAC in the regulation of cell life and death. J Bioenerg Biomembr (2008) 1.34

Coupled decomposition of four-dimensional NOESY spectra. J Am Chem Soc (2009) 1.31

The rheostat in the membrane: BCL-2 family proteins and apoptosis. Cell Death Differ (2013) 1.29

Solution NMR of membrane proteins in bilayer mimics: small is beautiful, but sometimes bigger is better. Biochim Biophys Acta (2007) 1.21

VDAC1: from structure to cancer therapy. Front Oncol (2012) 1.16

The 3D structures of VDAC represent a native conformation. Trends Biochem Sci (2010) 1.13

Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity. J Biol Chem (2009) 1.13

Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein. J Biol Chem (2012) 1.11

1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins. J Biomol NMR (2007) 1.10

Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Biochim Biophys Acta (2011) 1.01

Structure of the voltage dependent anion channel: state of the art. J Bioenerg Biomembr (2008) 1.01

The role of solution NMR in the structure determinations of VDAC-1 and other membrane proteins. Curr Opin Struct Biol (2009) 1.00

The role of VDAC in cell death: friend or foe? Biochim Biophys Acta (2011) 0.99

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor. Biochim Biophys Acta (2008) 0.98

Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation. Cell Death Dis (2014) 0.98

Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J Biol Chem (2008) 0.97

The role of lipids in VDAC oligomerization. Biophys J (2012) 0.96

An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake. J Biol Chem (2013) 0.95

Lipid dynamics and protein-lipid interactions in 2D crystals formed with the β-barrel integral membrane protein VDAC1. J Am Chem Soc (2012) 0.95

Determination of multicomponent protein structures in solution using global orientation and shape restraints. J Am Chem Soc (2009) 0.93

Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames. J Biomol NMR (2013) 0.91

Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem (2011) 0.90

Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein. J Biol Chem (2009) 0.85

Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins. J Am Chem Soc (2011) 0.85

The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria. J Biol Chem (2015) 0.83

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8. BMC Cancer (2010) 0.83

Approaching the structure of human VDAC1, a key molecule in mitochondrial cross-talk. J Bioenerg Biomembr (2008) 0.82

Bcl-2 proteins and calcium signaling: complexity beneath the surface. Oncogene (2016) 0.81

Structure, dynamics, lipid binding, and physiological relevance of the putative GTPase-binding domain of Dictyostelium formin C. J Biol Chem (2011) 0.81

Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins. Trends Endocrinol Metab (2015) 0.80

Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2. PLoS One (2014) 0.80

Improving the resistance of a eukaryotic β-barrel protein to thermal and chemical perturbations. J Mol Biol (2011) 0.80

Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR. J Biomol NMR (2015) 0.80

Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold. ACS Chem Biol (2015) 0.78

Structural basis of efficient electron transport between photosynthetic membrane proteins and plastocyanin in spinach revealed using nuclear magnetic resonance. Plant Cell (2012) 0.78

A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells. J Biol Chem (2015) 0.78

Two-step folding of recombinant mitochondrial porin in detergent. Biophys J (2007) 0.78

Magic angle spinning nuclear magnetic resonance characterization of voltage-dependent anion channel gating in two-dimensional lipid crystalline bilayers. Biochemistry (2015) 0.78

Visiting order on membrane proteins by using nanotechnology. Proc Natl Acad Sci U S A (2007) 0.76

Backbone and ILV side chain methyl group assignments of the integral human membrane protein VDAC-1. Biomol NMR Assign (2009) 0.75

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca(2+) Transport, Apoptosis, and Their Regulation. Front Oncol (2017) 0.75

Proteomic profiling of mitochondria: what does it tell us about the ageing brain? Aging (Albany NY) (2016) 0.75

Yeast mitochondrial interactosome model: metabolon membrane proteins complex involved in the channeling of ADP/ATP. Int J Mol Sci (2012) 0.75

Articles cited by this

Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR (1999) 26.99

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell (2006) 10.29

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature (1999) 8.70

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A (1997) 7.25

BH3-Only proteins-essential initiators of apoptotic cell death. Cell (2000) 7.04

Structure of Bax: coregulation of dimer formation and intracellular localization. Cell (2000) 7.00

Mitochondria as the central control point of apoptosis. Trends Cell Biol (2000) 5.91

Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol (2001) 3.63

Estimation of the number of alpha-helical and beta-strand segments in proteins using circular dichroism spectroscopy. Protein Sci (1999) 3.41

Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol (1998) 3.32

VDAC: the channel at the interface between mitochondria and the cytosol. Mol Cell Biochem (2004) 3.26

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol (1999) 3.17

Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. J Biol Chem (2001) 2.76

Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci U S A (2001) 2.60

Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell (1999) 2.58

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists. Cell (1999) 2.51

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem (2004) 2.12

VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function. Biophys J (1997) 2.09

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A (2000) 2.06

Regulation of metabolite flux through voltage-gating of VDAC channels. J Membr Biol (1997) 1.94

The voltage-dependent anion channel: an essential player in apoptosis. Biochimie (2002) 1.75

Properties of the permeability transition in VDAC1(-/-) mitochondria. Biochim Biophys Acta (2006) 1.74

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria. Mol Cell (2004) 1.71

On the role of VDAC in apoptosis: fact and fiction. J Bioenerg Biomembr (2005) 1.68

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. EMBO J (2003) 1.59

Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol (2001) 1.57

Bid, but not Bax, regulates VDAC channels. J Biol Chem (2004) 1.57

Membrane-insertion fragments of Bcl-xL, Bax, and Bid. Biochemistry (2004) 1.56

Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc (2006) 1.45

Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria. Biochem J (2005) 1.43

The topology of VDAC as probed by biotin modification. J Biol Chem (1998) 1.39

Toward the molecular structure of the mitochondrial channel, VDAC. J Bioenerg Biomembr (1992) 1.39

Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. Oncogene (2000) 1.30

Beta-NADH decreases the permeability of the mitochondrial outer membrane to ADP by a factor of 6. J Biol Chem (1994) 1.30

Bacterial expression and characterization of the mitochondrial outer membrane channel. Effects of n-terminal modifications. J Biol Chem (1998) 1.26

Determination of the interface of a large protein complex by transferred cross-saturation measurements. J Mol Biol (2002) 1.20

Structural and functional evidence for multiple channel complexes in the outer membrane of Neurospora crassa mitochondria. Proc Natl Acad Sci U S A (1983) 1.14

Positive cooperativity without domains or subunits in a monomeric membrane channel. Proc Natl Acad Sci U S A (2000) 1.10

Collagen-binding mode of vWF-A3 domain determined by a transferred cross-saturation experiment. Nat Struct Biol (2003) 1.10

Dynamics of nucleotides in VDAC channels: structure-specific noise generation. Biophys J (2002) 1.08

NMR studies of the anti-apoptotic protein Bcl-xL in micelles. Biochemistry (2000) 1.07

Crystallization of the human, mitochondrial voltage-dependent anion-selective channel in the presence of phospholipids. J Struct Biol (1999) 1.07

Circular dichroism studies of the mitochondrial channel, VDAC, from Neurospora crassa. Biophys J (1996) 1.04

Structural studies of apoptosis and ion transport regulatory proteins in membranes. Magn Reson Chem (2004) 1.03

Structural basis of the KcsA K(+) channel and agitoxin2 pore-blocking toxin interaction by using the transferred cross-saturation method. Structure (2003) 0.98

One-step on-column affinity refolding purification and functional analysis of recombinant human VDAC1. Biochem Biophys Res Commun (2003) 0.96

The state of association of band 3 protein of the human erythrocyte membrane in solutions of nonionic detergents. Biochim Biophys Acta (1983) 0.94

Hydrodynamic properties of porin isolated from outer membranes of rat liver mitochondria. Biochim Biophys Acta (1983) 0.94

Determination of the number of polypeptide subunits in a functional VDAC channel from Saccharomyces cerevisiae. J Bioenerg Biomembr (1992) 0.93

Bead-linked proteoliposomes: a reconstitution method for nmr analyses of membrane protein-ligand interactions. J Am Chem Soc (2005) 0.81

Articles by these authors

(truncated to the top 100)

Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (2004) 7.63

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89

Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (2010) 5.44

Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol (2006) 3.89

Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell (2003) 3.46

Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science (2008) 3.38

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A (2002) 3.28

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature (2006) 3.23

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21

HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity (2008) 3.01

A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature (2008) 3.00

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98

Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. Genes Dev (2003) 2.77

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60

The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem (2009) 2.41

The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J (2002) 2.41

Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction. J Am Chem Soc (2007) 2.40

Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature (2008) 2.39

The mRNA cap-binding protein eIF4E in post-transcriptional gene expression. Nat Struct Mol Biol (2004) 2.37

Translation initiation: structures, mechanisms and evolution. Q Rev Biophys (2005) 2.31

Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction. J Magn Reson (2004) 2.30

Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. Biochemistry (2002) 2.29

Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol (2003) 2.23

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy. Nat Struct Mol Biol (2008) 2.23

A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. Biochemistry (2004) 2.20

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat Struct Mol Biol (2005) 2.17

Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Mol Cell (2005) 2.07

Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins. J Am Chem Soc (2013) 1.90

Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure (2005) 1.86

Structural basis for the enhancement of eIF4A helicase activity by eIF4G. Genes Dev (2005) 1.83

Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap scheduling. J Biomol NMR (2012) 1.81

Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc Natl Acad Sci U S A (2009) 1.79

Poisson-gap sampling and forward maximum entropy reconstruction for enhancing the resolution and sensitivity of protein NMR data. J Am Chem Soc (2010) 1.78

Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. J Biol Chem (2007) 1.72

RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem Biol (2006) 1.71

Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes. Proc Natl Acad Sci U S A (2006) 1.70

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature (2008) 1.66

Domain-swapped dimerization of the HIV-1 capsid C-terminal domain. Proc Natl Acad Sci U S A (2007) 1.66

Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. Mol Cell (2003) 1.61

Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing. Nucleic Acids Res (2009) 1.61

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A (2010) 1.61

Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J Am Chem Soc (2009) 1.55

The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev Cell (2012) 1.54

PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci U S A (2008) 1.52

FM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation. J Biomol NMR (2009) 1.52

Selective pharmacological targeting of a DEAD box RNA helicase. PLoS One (2008) 1.49

Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure (2004) 1.48

Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc (2006) 1.45

Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. Proc Natl Acad Sci U S A (2003) 1.41

Solution NMR structure determination of proteins revisited. J Biomol NMR (2008) 1.39

Is routine hysteroscopy during LLETZ a valuable additional procedure? Acta Obstet Gynecol Scand (2011) 1.39

Alternate 13C-12C labeling for complete mainchain resonance assignments using C alpha direct-detection with applicability toward fast relaxing protein systems. J Am Chem Soc (2008) 1.39

Applications of non-uniform sampling and processing. Top Curr Chem (2012) 1.37

Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A (2004) 1.37

Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selection. J Biol Chem (2007) 1.34

The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G. Proc Natl Acad Sci U S A (2005) 1.34

Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling. Proc Natl Acad Sci U S A (2004) 1.33

Coupled decomposition of four-dimensional NOESY spectra. J Am Chem Soc (2009) 1.31

Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing. EMBO J (2007) 1.31

A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem (2005) 1.31

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol (2011) 1.29

Exploring signal-to-noise ratio and sensitivity in non-uniformly sampled multi-dimensional NMR spectra. J Biomol NMR (2012) 1.29

eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G. Biochemistry (2005) 1.26

Nonmicellar systems for solution NMR spectroscopy of membrane proteins. Curr Opin Struct Biol (2010) 1.24

IBIS--a tool for automated sequential assignment of protein spectra from triple resonance experiments. J Biomol NMR (2003) 1.24

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA. EMBO J (2007) 1.23

Using codon optimization, chaperone co-expression, and rational mutagenesis for production and NMR assignments of human eIF2 alpha. J Biomol NMR (2004) 1.23

Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling. J Biomol NMR (2005) 1.22

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proc Natl Acad Sci U S A (2011) 1.22

Molecular framework for the activation of RNA-dependent protein kinase. J Biol Chem (2007) 1.21

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science (2003) 1.21

Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. J Biol Chem (2008) 1.20

Cell-free expressed bacteriorhodopsin in different soluble membrane mimetics: biophysical properties and NMR accessibility. Structure (2013) 1.19

NMR methods for studying protein-protein interactions involved in translation initiation. Methods Enzymol (2007) 1.19

Tumor suppression by small molecule inhibitors of translation initiation. Oncotarget (2012) 1.17

Structure of the VP16 transactivator target in the Mediator. Nat Struct Mol Biol (2011) 1.17

NMR studies of protein interactions. Curr Opin Struct Biol (2006) 1.16

Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. Nat Protoc (2006) 1.16

A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes. J Biomol NMR (2003) 1.16

Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies. J Biomol NMR (2010) 1.15

Looking into live cells with in-cell NMR spectroscopy. J Struct Biol (2007) 1.15

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β. Cell Rep (2012) 1.13

The 3D structures of VDAC represent a native conformation. Trends Biochem Sci (2010) 1.13

Unambiguous assignment of NMR protein backbone signals with a time-shared triple-resonance experiment. J Biomol NMR (2005) 1.12

1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins. J Biomol NMR (2007) 1.10

A molecular handoff between bacteriophage T7 DNA primase and T7 DNA polymerase initiates DNA synthesis. J Biol Chem (2004) 1.09

Broadband 13C-13C adiabatic mixing in solution optimized for high fields. J Magn Reson (2003) 1.07

Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface. Proc Natl Acad Sci U S A (2008) 1.06

Specificity and affinity of sialic acid binding by the rhesus rotavirus VP8* core. J Virol (2002) 1.06

Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol (2006) 1.04

Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. J Mol Biol (2005) 1.04

A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Mol Cell (2005) 1.03

Determination of all nOes in 1H-13C-Me-ILV-U-2H-15N proteins with two time-shared experiments. J Biomol NMR (2006) 1.03

Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. J Immunol (2010) 1.03

Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates. Structure (2007) 1.02

CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol (2007) 1.01

TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling. Front Immunol (2012) 1.01

Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Biochim Biophys Acta (2011) 1.01