Published in Cell on January 26, 2007
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Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat Struct Mol Biol (2013) 1.00
Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. ACS Chem Biol (2009) 0.99
The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS. Nucleic Acids Res (2010) 0.98
Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4. J Biomol Screen (2009) 0.98
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Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A (2014) 0.85
Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide. PLoS One (2013) 0.85
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4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget (2014) 0.84
Evolutionary conservation and diversification of the translation initiation apparatus in trypanosomatids. Comp Funct Genomics (2012) 0.84
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Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1. PLoS One (2011) 0.84
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Antisense oligonucleotide targeting eukaryotic translation initiation factor 4E reduces growth and enhances chemosensitivity of non-small-cell lung cancer cells. Cancer Gene Ther (2015) 0.83
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism. J Neurosci (2015) 0.83
Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem (2009) 0.83
Navigating traditional chinese medicine network pharmacology and computational tools. Evid Based Complement Alternat Med (2013) 0.83
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Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol (2014) 0.82
Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia. Oncogene (2014) 0.82
A collection of caged compounds for probing roles of local translation in neurobiology. Bioorg Med Chem (2010) 0.81
Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia. Cancer Biol Ther (2012) 0.81
Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress. Elife (2017) 0.81
Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation. Int J Mol Sci (2015) 0.80
Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis. J Biol Chem (2014) 0.79
Axonal cap-dependent translation regulates presynaptic p35. Dev Neurobiol (2013) 0.79
New insights into 4E-BP1-regulated translation in cancer progression and metastasis. Cancer Cell Microenviron (2015) 0.79
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Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
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Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol (2006) 3.89
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Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell (2003) 3.46
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science (2008) 3.38
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