Published in Obesity (Silver Spring) on April 09, 2009
Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy. Am J Kidney Dis (2011) 1.19
The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children. Biomed Res Int (2014) 0.84
Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age. Metabolism (2009) 0.84
INSIG2 variants, dietary patterns and metabolic risk in Samoa. Eur J Clin Nutr (2012) 0.83
Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. Eur J Hum Genet (2014) 0.82
Exploring differences in adiposity in two U.S. Hispanic populations of Mexican origin using social, behavioral, physiologic and genetic markers: the IRAS Family Study. Ethn Dis (2012) 0.78
The Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India Iran Biomed J (2017) 0.75
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A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Protein sensors for membrane sterols. Cell (2006) 8.62
Problems of reporting genetic associations with complex outcomes. Lancet (2003) 8.11
Using linkage genome scans to improve power of association in genome scans. Am J Hum Genet (2006) 5.67
A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genet Epidemiol (2008) 5.07
Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet (2006) 4.78
MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther (2003) 4.34
High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A (2001) 4.31
MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed (1986) 3.54
Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods. Ann Epidemiol (2003) 2.51
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
Improving power in genome-wide association studies: weights tip the scale. Genet Epidemiol (2007) 2.20
Comment on "A common genetic variant is associated with adult and childhood obesity". Science (2007) 2.04
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest (2005) 2.03
Zero-recombinant haplotyping: applications to fine mapping using SNPs. Genet Epidemiol (2000) 1.93
Comment on "A common genetic variant is associated with adult and childhood obesity". Science (2007) 1.93
Comment on "A common genetic variant is associated with adult and childhood obesity". Science (2007) 1.86
Genetic and nongenetic determinants of regional fat distribution. Endocr Rev (1993) 1.63
INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families. BMC Med Genet (2006) 1.39
Why are we shaped differently, and why does it matter? Am J Physiol Endocrinol Metab (2008) 1.35
Association of morbid obesity with FTO and INSIG2 allelic variants. Arch Surg (2008) 1.34
INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects. Int J Obes (Lond) (2007) 1.28
Controlling false discoveries in genetic studies. Am J Med Genet B Neuropsychiatr Genet (2008) 1.27
INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism. Obesity (Silver Spring) (2008) 1.24
The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population. Clin Genet (2007) 1.20
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS One (2008) 1.17
Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes. J Clin Endocrinol Metab (2004) 1.16
Validity of body composition methods across ethnic population groups. Forum Nutr (2003) 1.14
INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet (2008) 1.10
Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family study. Int J Obes (Lond) (2005) 1.06
No association between rs7566605 variant and being overweight in Japanese. Obesity (Silver Spring) (2007) 1.01
No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population. Obesity (Silver Spring) (2008) 1.01
The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women. Br J Nutr (2008) 0.98
Obesity and polymorphisms in genes regulating human adipose tissue. Int J Obes (Lond) (2007) 0.97
Test of association for quantitative traits in general pedigrees: the quantitative pedigree disequilibrium test. Genet Epidemiol (2001) 0.95
Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation. J Clin Endocrinol Metab (2008) 0.95
Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation. Eur J Hum Genet (2008) 0.93
Lack of association between rs7566605 and obesity in a Chinese population. Hum Genet (2006) 0.93
A common polymorphism is associated with body mass index in Uyghur population. Diabetes Res Clin Pract (2008) 0.91
Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration. Diabetologia (2006) 0.82
Is rs7566605, a SNP near INSIG2, associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia? Mol Psychiatry (2007) 0.81
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med (2006) 19.09
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med (2006) 18.25
Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science (2010) 16.00
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51
Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials (2003) 9.97
Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med (2012) 9.46
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet (2008) 9.00
The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol (2004) 6.53
Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation (2003) 5.70
Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med (2010) 5.46
The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study. Diabetes Care (2003) 5.27
NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes (2003) 5.11
Identification of persons at high risk for type 2 diabetes mellitus: do we need the oral glucose tolerance test? Ann Intern Med (2002) 5.10
Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA (2006) 4.90
Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. Diabetes (2005) 4.81
Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes (2002) 4.58
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet (2004) 4.46
Effect of nateglinide on the incidence of diabetes and cardiovascular events. N Engl J Med (2010) 4.38
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int (2009) 3.58
Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol (2006) 3.55
Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care (2004) 3.51
Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int (2012) 3.46
Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT). Diabetes Care (2008) 3.45
Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol (2008) 3.16
The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol (2010) 3.15
JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Kidney Int (2013) 3.09
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries. Circulation (2007) 3.01
Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes Care (2002) 3.00
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol (2007) 2.99
Ordered subset analysis in genetic linkage mapping of complex traits. Genet Epidemiol (2004) 2.92
Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care (2002) 2.92
Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY). JAMA Pediatr (2013) 2.92
Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD. Nephrol Dial Transplant (2009) 2.88
Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab (2008) 2.87
Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies. Diabetes (2003) 2.76
Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis Rheum (2011) 2.74
Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. Am J Respir Crit Care Med (2007) 2.66
Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study. Circulation (2005) 2.63
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet (2011) 2.54
Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study. Diabetes Care (2005) 2.53
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes (2009) 2.51
Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods. Ann Epidemiol (2003) 2.51
Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. Hum Mol Genet (2010) 2.51
A prospective study of the incidence of childhood celiac disease. J Pediatr (2003) 2.50
Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus. Circulation (2005) 2.46
Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet (2009) 2.46
Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes (2005) 2.42
Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program. Diabetes Care (2007) 2.42
Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes (2008) 2.41
The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. Diabetes (2006) 2.40
Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth. Diabetes Care (2007) 2.38
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A (2009) 2.31
The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 2.27
Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Nephrol Dial Transplant (2011) 2.26
Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes (2003) 2.22
Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab (2004) 2.19
Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS One (2012) 2.18
Elevated risk of cardiovascular disease prior to clinical diagnosis of type 2 diabetes. Diabetes Care (2002) 2.16
Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis study. Arterioscler Thromb Vasc Biol (2003) 2.12
Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study. Circulation (2005) 2.08
Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes (2004) 2.08
Sleep duration as a risk factor for incident type 2 diabetes in a multiethnic cohort. Ann Epidemiol (2009) 2.07
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
Genetic factors in diabetic nephropathy. Clin J Am Soc Nephrol (2007) 2.03
Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant (2009) 2.02
A genome scan for diabetic nephropathy in African Americans. Kidney Int (2004) 2.00
Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum (2010) 1.99
Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women. Endocr Rev (2007) 1.98
A genome-wide association study for diabetic nephropathy genes in African Americans. Kidney Int (2010) 1.98
Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families. Invest Radiol (2005) 1.98
The impact of in utero exposure to diabetes on childhood body mass index growth trajectories: the EPOCH study. J Pediatr (2011) 1.95
Heritability of body composition measured by DXA in the diabetes heart study. Obes Res (2005) 1.94
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet (2002) 1.93