Published in Mol Cell Biol on February 05, 2007
Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell (2011) 2.34
Altered DNA methylation in leukocytes with trisomy 21. PLoS Genet (2010) 1.44
Cherubism: best clinical practice. Orphanet J Rare Dis (2012) 1.42
Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT. J Biol Chem (2009) 1.02
3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions. J Clin Invest (2011) 0.99
The role of SH3BP2 in the pathophysiology of cherubism. Orphanet J Rare Dis (2012) 0.95
3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells. J Biol Chem (2010) 0.92
Body mass index is associated with gene methylation in estrogen receptor-positive breast tumors. Cancer Epidemiol Biomarkers Prev (2015) 0.85
Cherubism gene Sh3bp2 is important for optimal bone formation, osteoblast differentiation, and function. Am J Orthod Dentofacial Orthop (2010) 0.83
A concerted HIF-1α/MT1-MMP signalling axis regulates the expression of the 3BP2 adaptor protein in hypoxic mesenchymal stromal cells. PLoS One (2011) 0.82
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest (2016) 0.80
Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Rep (2014) 0.80
The adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells. J Immunol (2012) 0.80
Decreased SH3BP2 inhibits osteoclast differentiation and function. J Orthop Res (2011) 0.79
SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss. J Bone Miner Res (2014) 0.79
Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. PLoS One (2012) 0.78
Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages. J Clin Invest (2015) 0.77
Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice. Arthritis Rheumatol (2015) 0.77
Bone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism mice. Bone (2014) 0.76
SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model. PLoS One (2014) 0.76
The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K. Self Nonself (2010) 0.75
SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation. HSS J (2008) 0.75
The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival. J Immunol (2015) 0.75
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Identification of a ten-amino acid proline-rich SH3 binding site. Science (1993) 8.05
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol (2002) 6.85
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature (2003) 6.78
An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science (2001) 5.73
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02
T cell-independent antigens type 2. Annu Rev Immunol (1995) 4.62
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science (1992) 4.57
C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science (1996) 4.35
Defective B cell development and function in Btk-deficient mice. Immunity (1995) 4.20
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity (2003) 3.73
Regulation of the T-independent humoral response by TACI. Immunity (2001) 3.43
Marginal zone B cells. Annu Rev Immunol (2005) 3.32
Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev (1999) 2.82
Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur J Immunol (1997) 2.77
T-Independent immune response: new aspects of B cell biology. Science (2000) 2.63
B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory". Immunol Rev (2000) 2.55
Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Nat Genet (2001) 2.43
BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity (2003) 2.02
Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol (2000) 1.95
Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF. Blood (2003) 1.91
Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity (1999) 1.84
CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science (1993) 1.80
The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J (2000) 1.79
Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. J Immunol (1989) 1.78
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J Exp Med (2001) 1.57
Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. Immunity (1996) 1.54
Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. Am J Pathol (1995) 1.53
Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. J Exp Med (1993) 1.44
Differences in the recruitment of virgin B cells into antibody responses to thymus-dependent and thymus-independent type-2 antigens. Eur J Immunol (1986) 1.31
The physiologic role of CD19 cytoplasmic tyrosines. Immunity (2002) 1.25
Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity (1998) 1.25
CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. Immunity (1998) 1.25
The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor. Blood (2004) 1.22
The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex. J Immunol (1991) 1.17
Antigen-dependent B-cell development. Curr Opin Immunol (2002) 1.14
CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. J Immunol (1999) 1.13
3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol (2006) 1.13
Study of the cell biology and biochemistry of cherubism. J Clin Pathol (1998) 1.09
Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood (2002) 1.04
Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2. J Immunol (2001) 1.00
The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing. J Immunol (2005) 0.99
The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. J Immunol (2000) 0.93
The CR2/CD19 complex on human B cells contains the src-family kinase Lyn. Int Immunol (1993) 0.93
Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig. J Immunol (1997) 0.84
Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J Biol Chem (2005) 0.82
Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains. Eur J Immunol (1995) 0.81
Contribution of the membrane-distal tyrosine in intracellular signaling by the granulocyte colony-stimulating factor receptor. J Biol Chem (2003) 0.80
BCR activation of PI3K is Vav-independent in murine B cells. Biochem Soc Trans (2004) 0.76
Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24
microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72
LPS/TLR4 signal transduction pathway. Cytokine (2008) 6.60
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell (2003) 4.37
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A (2009) 3.39
Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet (2004) 2.96
Practical application of pharmacotherapy with long-acting risperidone for patients with schizophrenia. Psychiatr Serv (2004) 2.94
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A (2004) 2.89
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med (2004) 2.80
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med (2002) 2.68
The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol (2005) 2.57
cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol (2006) 2.53
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol (2009) 2.51
Toll-like receptors induce a phagocytic gene program through p38. J Exp Med (2003) 2.49
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell (2011) 2.34
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med (2005) 2.21
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature (2007) 2.06
T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity (2011) 2.00
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med (2004) 1.80
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol (2006) 1.76
Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Blood (2004) 1.66
Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol (2010) 1.63
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. Proc Natl Acad Sci U S A (2003) 1.60
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood (2007) 1.60
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat Immunol (2013) 1.60
Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunol Rev (2008) 1.53
Cellular FLICE-inhibitory protein is required for T cell survival and cycling. J Exp Med (2005) 1.52
Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol (2005) 1.51
Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques. J Virol (2005) 1.51
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol (2010) 1.49
IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol (2002) 1.48
Problems with co-funding in Canada. Science (2005) 1.48
MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol (2010) 1.47
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J Exp Med (2009) 1.46
The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood (2005) 1.46
Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity (2008) 1.43
Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septic shock. Shock (2005) 1.42
Reprogramming primordial germ cells into pluripotent stem cells. PLoS One (2008) 1.41
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem (2004) 1.40
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A (2005) 1.40
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol Cell Biol (2003) 1.40
Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. J Immunol (2009) 1.38
Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res (2002) 1.37
Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. J Immunol (2004) 1.36
IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses. J Exp Med (2006) 1.36
The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med (2004) 1.35
Calcineurin negatively regulates TLR-mediated activation pathways. J Immunol (2007) 1.33
Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood (2005) 1.31
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol (2002) 1.29
The tumor suppressor activity of SOCS-1. Oncogene (2002) 1.29
The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proc Natl Acad Sci U S A (2005) 1.28
Signaling for survival and apoptosis in the immune system. Arthritis Res (2002) 1.28
Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production. Circulation (2005) 1.28
The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J Immunol (2007) 1.27
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A (2008) 1.26
The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem (2004) 1.25
Regulation of the immune system by SOCS family adaptor proteins. Semin Immunol (2004) 1.22
CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J Exp Med (2002) 1.22
Signal transduction by several KIT juxtamembrane domain mutations. Oncogene (2003) 1.20
An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway. EMBO J (2006) 1.20
Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nat Neurosci (2009) 1.19
Immunological function in mice lacking the Rac-related GTPase RhoG. Mol Cell Biol (2004) 1.19
SOCS1 links cytokine signaling to p53 and senescence. Mol Cell (2009) 1.18
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood (2007) 1.18
The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn (2006) 1.17
Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. J Immunol (2008) 1.16
A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science (2006) 1.16
Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. Adv Exp Med Biol (2007) 1.15
Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood (2002) 1.15
IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes. J Immunol (2008) 1.14
Rac GTPases play critical roles in early T-cell development. Blood (2008) 1.13
HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL. J Immunol (2004) 1.13
IRAK-4 inhibitors for inflammation. Curr Top Med Chem (2009) 1.13
Nur77 as a survival factor in tumor necrosis factor signaling. Proc Natl Acad Sci U S A (2003) 1.12
Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1. Mol Cell Biol (2004) 1.12
Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation. Mol Cell Biol (2009) 1.12
Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. BMC Cell Biol (2006) 1.11
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo. J Immunol (2005) 1.08
CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes. BMC Bioinformatics (2012) 1.08
A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling. Blood (2003) 1.08
Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection. PLoS One (2012) 1.07
DNA damage- and stress-induced apoptosis occurs independently of PIDD. Apoptosis (2009) 1.05
Accessory protein-like is essential for IL-18-mediated signaling. J Immunol (2005) 1.05
The adapter 3BP2: how it plugs into leukocyte signaling. Adv Exp Med Biol (2006) 1.04
The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J Immunol (2008) 1.04
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Mol Syst Biol (2013) 1.03
Essential role for thymosin β4 in regulating vascular smooth muscle cell development and vessel wall stability. Circ Res (2012) 1.03