Published in Annu Rev Biophys Bioeng on January 01, 1977
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci U S A (1990) 4.46
A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue. Proc Natl Acad Sci U S A (1985) 1.55
Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol (2016) 1.44
Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate. EMBO J (2001) 1.43
A protease responsible for post-translational cleavage of a conserved Asn-Gly linkage in glycinin, the major seed storage protein of soybean. Proc Natl Acad Sci U S A (1992) 1.40
The ctpA gene encodes the C-terminal processing protease for the D1 protein of the photosystem II reaction center complex. Proc Natl Acad Sci U S A (1994) 1.39
Model for haptoglobin heavy chain based upon structural homology. Proc Natl Acad Sci U S A (1980) 1.26
Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D. EMBO J (1999) 1.07
Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J Biol Chem (2010) 1.00
Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation. Proc Natl Acad Sci U S A (2007) 0.97
Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem (2012) 0.97
Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S' subsites. Biochemistry (2012) 0.96
Molecular mechanism that induces activation of Spätzle, the ligand for the Drosophila Toll receptor. J Biol Chem (2010) 0.95
Architecture and function of metallopeptidase catalytic domains. Protein Sci (2014) 0.92
The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1. Mol Cell Biol (2010) 0.92
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci U S A (2013) 0.91
Variable production windows for porcine trypsinogen employing synthetic inducible promoter variants in Pichia pastoris. Syst Synth Biol (2010) 0.89
Functional expression of trypsin from Streptomyces griseus by Pichia pastoris. J Ind Microbiol Biotechnol (2012) 0.87
A single mutation in the activation site of bovine trypsinogen enhances its accumulation in the fermentation broth of the yeast Pichia pastoris. Appl Environ Microbiol (2003) 0.87
Amide H/2H exchange reveals a mechanism of thrombin activation. Biochemistry (2006) 0.86
Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product. Biochemistry (2014) 0.86
Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation. PLoS One (2016) 0.84
A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5. Mol Biol Cell (2011) 0.83
Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism. Proc Natl Acad Sci U S A (2011) 0.82
A novel mechanism of latency in matrix metalloproteinases. J Biol Chem (2015) 0.79
The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding. J Biol Chem (2014) 0.78
The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction. PLoS One (2013) 0.77
Biochemical and structural characterization of SplD protease from Staphylococcus aureus. PLoS One (2013) 0.76
Application of pulse radiolysis to the study of proteins: chymotrypsin and trypsin. Biophys J (1978) 0.75
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science (1992) 7.00
Structure of a glycerol-conducting channel and the basis for its selectivity. Science (2000) 6.64
Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies. J Immunol (1971) 5.06
Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. Proc Natl Acad Sci U S A (1984) 4.70
The signal recognition particle. Annu Rev Biochem (2001) 4.47
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A (2000) 3.26
Structure and function of an acetylcholine receptor. Biophys J (1982) 2.92
Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65
Site-directed ligand discovery. Proc Natl Acad Sci U S A (2000) 2.58
Crystal structure of colicin Ia. Nature (1997) 2.57
Structure of the conserved GTPase domain of the signal recognition particle. Nature (1997) 2.52
Atomic structure of thymidylate synthase: target for rational drug design. Science (1987) 2.48
Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell (1998) 2.44
Mechanism of action of the C3b inactivator: requirement for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b'). Immunochemistry (1978) 2.43
The X-ray structure of a growth hormone-prolactin receptor complex. Nature (1994) 2.39
C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a. Immunochemistry (1966) 2.37
Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq). Proc Natl Acad Sci U S A (1972) 2.32
Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin. Biochemistry (1981) 2.30
Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b. Proc Natl Acad Sci U S A (1977) 2.27
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. J Biol Chem (1985) 2.27
Cleavage products of C4b produced by enzymes in human serum. Immunochemistry (1975) 2.26
Regulation of an enzyme by phosphorylation at the active site. Science (1990) 2.25
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. Proc Natl Acad Sci U S A (1989) 2.20
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1977) 2.17
Rabbit C1q: purification, functional and structural studies. J Immunol Methods (1972) 2.15
Chemical studies of Clq; a modulator of immunoglobulin biology. Biochem Biophys Res Commun (1971) 2.05
Linking regions between helices in bacteriorhodopsin revealed. Biophys J (1982) 2.03
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry (1990) 1.98
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol (1988) 1.97
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. J Immunol (1980) 1.94
Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry (1991) 1.91
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (1987) 1.87
Structural studies on human Clq: non-covalent and covalent subunits. Immunochemistry (1972) 1.83
Structure of Cry2Aa suggests an unexpected receptor binding epitope. Structure (2001) 1.82
Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1979) 1.82
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc Natl Acad Sci U S A (2001) 1.80
Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins. Science (1993) 1.76
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng (1989) 1.76
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry (1998) 1.75
Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique. Nature (1982) 1.75
Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J (1979) 1.75
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins (1990) 1.75
Attachment site(s) of retinal in bacteriorhodopsin. Proc Natl Acad Sci U S A (1981) 1.73
Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy. J Mol Biol (1981) 1.71
Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding. J Mol Biol (1974) 1.62
Structure-based discovery of inhibitors of thymidylate synthase. Science (1993) 1.61
Simple bedside additive tool for prediction of in-hospital mortality after percutaneous coronary interventions. Circulation (2001) 1.55
The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution. J Mol Biol (1974) 1.55
X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J Mol Biol (1993) 1.52
The molecular neurobiology of the acetylcholine receptor. Annu Rev Neurosci (1986) 1.50
Reappraisal of duplex criteria to assess significant carotid stenosis with special reference to reports from the North American Symptomatic Carotid Endarterectomy Trial and the European Carotid Surgery Trial. J Vasc Surg (1994) 1.47
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nat Struct Biol (1999) 1.47
Congenital heart diseases associated with coronary artery anomalies. Cleve Clin J Med (1990) 1.47
The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution. Cold Spring Harb Symp Quant Biol (1972) 1.45
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. J Biol Chem (1991) 1.41
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat Struct Biol (2000) 1.41
Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency. Immunochemistry (1966) 1.41
Deficiency of C1r in human serum. Effects on the structure and function of macromolecular C1. J Exp Med (1970) 1.36
Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry (1977) 1.36
Human factor D of the alternative complement pathway: purification and characterization. J Immunol (1977) 1.33
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry (1995) 1.32
The relationship of the hemolytic activity of active C'1s to its TAMe esterase action: a new method of purification and assay. J Immunol (1969) 1.28
Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. J Biol Chem (1990) 1.27
Complement and host defense against infection. J Pediatr (1977) 1.26
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. Protein Eng (1989) 1.25
X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants. J Mol Biol (1991) 1.24
Neutron diffraction identifies His 57 as the catalytic base in trypsin. Nature (1980) 1.23
A family of protein-cutting proteins. Sci Am (1974) 1.22
Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J Cell Biol (1980) 1.21
Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates. Immunochemistry (1965) 1.20
Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--III. Inhibition of C4 and C2 binding site(s) on C1s by polyanions. Immunochemistry (1976) 1.20
Acetylcholine receptor structure, function, and evolution. Annu Rev Cell Biol (1985) 1.18
Crystalline arrays of membrane-bound acetylcholine receptor. Proc Natl Acad Sci U S A (1981) 1.18
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits. Biochemistry (1999) 1.18
Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A. J Cell Biol (1989) 1.17
Design of potent selective zinc-mediated serine protease inhibitors. Nature (1998) 1.17
A designed four helix bundle protein with native-like structure. Nat Struct Biol (1997) 1.17
Bacteriorhodopsin D85N: three spectroscopic species in equilibrium. Biochemistry (1993) 1.16
Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide. Proc Natl Acad Sci U S A (1985) 1.16
Assembly of bacteriophage T7. Dimensions of the bacteriophage and its capsids. Biophys J (1981) 1.16
Purification of bacteriorhodopsin and characterization of mature and partially processed forms. J Biol Chem (1989) 1.14
Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis. Proteins (1990) 1.14
pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin. Biochemistry (1976) 1.13
Interaction of Histoplasma capsulatum with human platelets. J Infect Dis (1980) 1.13
Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. Anal Biochem (1981) 1.13
Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. Biochemistry (2000) 1.12
Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A. Protein Eng (1990) 1.10
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase. Biochemistry (1990) 1.10
Mechanism of hydrolysis by serine proteases: direct determination of the pKa's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy. Biochemistry (1976) 1.09
Effects of detergent environments on the photocycle of purified monomeric bacteriorhodopsin. Biochemistry (1991) 1.08
Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry (1995) 1.07
Atomic structure of a glycerol channel and implications for substrate permeation in aqua(glycero)porins. FEBS Lett (2001) 1.07
Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--II. Effect of polyanions on the binding of C2 to EAC4b. Immunochemistry (1976) 1.07
Purification and characterization of a macromolecular weight cofactor for C3b-inactivator, C4bC3bINA-cofactor, of human plasma. Mol Immunol (1980) 1.06
Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin. Biochemistry (1991) 1.06
Food-induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk. Arthritis Rheum (1986) 1.06
Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction. Proteins (1992) 1.06