Published in Proc Natl Acad Sci U S A on May 06, 2013
Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol (2013) 1.68
A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Mol Cell Proteomics (2015) 0.97
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues. Cell Death Differ (2016) 0.87
Recombinant renewable polyclonal antibodies. MAbs (2015) 0.83
Turning on caspases with genetics and small molecules. Methods Enzymol (2014) 0.83
A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases. Methods Enzymol (2014) 0.79
An improved single-chain Fab platform for efficient display and recombinant expression. J Mol Biol (2014) 0.78
Modifying caspase-3 activity by altering allosteric networks. Biochemistry (2014) 0.78
Small Molecule Active Site Directed Tools for Studying Human Caspases. Chem Rev (2015) 0.77
Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc Natl Acad Sci U S A (2016) 0.75
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish. Protein Sci (2016) 0.75
Engineering a light-activated caspase-3 for precise ablation of neurons in vivo. Proc Natl Acad Sci U S A (2017) 0.75
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46
Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol (2008) 8.30
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem (2000) 3.85
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol (2006) 3.30
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol (2000) 3.20
Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci U S A (2001) 3.04
Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A (2008) 2.74
Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A (2004) 2.51
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell (2001) 2.39
Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A (2001) 2.14
Role of proteolytic enzymes in biological regulation (a review). Proc Natl Acad Sci U S A (1976) 2.12
A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A (2006) 2.12
Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination. Trends Cell Biol (2007) 2.05
Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell (2010) 1.85
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity. Chem Biol (2000) 1.82
Small-molecule activators of a proenzyme. Science (2009) 1.72
Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide. Proc Natl Acad Sci U S A (2001) 1.68
Mechanisms of zymogen activation. Annu Rev Biophys Bioeng (1977) 1.51
Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries. Nat Protoc (2007) 1.49
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem (2009) 1.44
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell (2006) 1.43
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. J Mol Biol (2009) 1.41
Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A (2009) 1.40
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proc Natl Acad Sci U S A (2012) 1.36
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis. Proc Natl Acad Sci U S A (2012) 1.23
Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure (2012) 1.20
The crystal structure of caspase-6, a selective effector of axonal degeneration. Biochem J (2009) 1.18
Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell (2006) 1.14
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. J Am Chem Soc (2011) 1.14
Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3. Biochemistry (2006) 1.12
Substrate-induced conformational changes occur in all cleaved forms of caspase-6. J Mol Biol (2010) 1.10
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J Mol Biol (2006) 1.08
Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel. Clin Cancer Res (2004) 1.00
An optimized activity-based probe for the study of caspase-6 activation. Chem Biol (2012) 0.97
Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem (2012) 0.97
Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell (2012) 0.97
Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays. J Biol Chem (2012) 0.81
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov (2004) 7.84
Repairing research integrity. Nature (2008) 5.91
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature (2013) 4.43
Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nat Biotechnol (2006) 4.12
Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell (2008) 4.00
Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A (2004) 2.51
Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell (2013) 2.41
Tethering: fragment-based drug discovery. Annu Rev Biophys Biomol Struct (2004) 2.37
Searching for new allosteric sites in enzymes. Curr Opin Struct Biol (2004) 2.31
A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A (2006) 2.12
Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell (2010) 1.85
Caspase substrates and cellular remodeling. Annu Rev Biochem (2011) 1.79
Binding of small molecules to an adaptive protein-protein interface. Proc Natl Acad Sci U S A (2003) 1.78
Small-molecule activators of a proenzyme. Science (2009) 1.72
Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol (2013) 1.68
Inflammatory stimuli regulate caspase substrate profiles. Mol Cell Proteomics (2010) 1.57
A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery. Bioconjug Chem (2003) 1.50
Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A (2006) 1.47
Turning enzymes ON with small molecules. Nat Chem Biol (2010) 1.47
Mechanistic diversity of cytokine receptor signaling across cell membranes. Sci STKE (2004) 1.42
Directed evolution of adeno-associated virus to an infectious respiratory virus. Proc Natl Acad Sci U S A (2009) 1.42
Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A (2009) 1.40
A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells. PLoS One (2009) 1.40
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proc Natl Acad Sci U S A (2012) 1.36
The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics (2012) 1.34
Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc Natl Acad Sci U S A (2011) 1.33
Sampling the N-terminal proteome of human blood. Proc Natl Acad Sci U S A (2010) 1.28
Molecular engineering of viral gene delivery vehicles. Annu Rev Biomed Eng (2008) 1.28
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.23
Global cellular response to chemotherapy-induced apoptosis. Elife (2013) 1.19
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. J Am Chem Soc (2011) 1.14
Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A (2003) 1.13
Malonate-assisted purification of human caspases. Protein Expr Purif (2005) 1.12
Methods for the proteomic identification of protease substrates. Curr Opin Chem Biol (2009) 1.07
Partial acetylation of polyethylenimine enhances in vitro gene delivery. Pharm Res (2004) 1.07
Prediction of protease substrates using sequence and structure features. Bioinformatics (2010) 1.04
Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc (2003) 1.02
Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis. Proc Natl Acad Sci U S A (2012) 1.02
Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem (2009) 1.00
Ordering a dynamic protein via a small-molecule stabilizer. J Am Chem Soc (2013) 0.97
Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem (2012) 0.97
Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell (2012) 0.97
Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. J Biol Chem (2004) 0.96
An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells. Mol Ther (2011) 0.95
Molecules that modulate Apaf-1 activity. Med Res Rev (2010) 0.92
Tags for labeling protein N-termini with subtiligase for proteomics. Bioorg Med Chem Lett (2008) 0.91
Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochem Biophys Res Commun (2004) 0.89
Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus. J Virol (2011) 0.84
Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. J Biol Chem (2013) 0.82
Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J Biol Chem (2011) 0.81
Computational approach to site-directed ligand discovery. Proteins (2007) 0.76
Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol (2016) 0.76
Identification of specific tethered inhibitors for caspase-5. Chem Biol Drug Des (2011) 0.76
Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. J Am Chem Soc (2017) 0.75
Warren L. DeLano 21 June 1972-3 November 2009. Nat Struct Mol Biol (2009) 0.75
Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface. Methods Enzymol (2014) 0.75
Regulated cell death part A: apoptotic mechanisms. Preface. Methods Enzymol (2014) 0.75
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. medRxiv (2020) 0.75
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. bioRxiv (2020) 0.75
Next generation therapeutics. Curr Opin Chem Biol (2013) 0.75