Published in Proc Natl Acad Sci U S A on January 01, 1984
Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol (1987) 7.23
Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions. J Virol (1987) 6.20
T-cell antigenic sites tend to be amphipathic structures. Proc Natl Acad Sci U S A (1985) 5.05
Molecular model of the action potential sodium channel. Proc Natl Acad Sci U S A (1986) 4.61
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proc Natl Acad Sci U S A (1988) 4.32
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A (1990) 3.90
Anatomy of the herpes simplex virus 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody-resistant mutants. J Virol (1985) 3.67
The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene. Nucleic Acids Res (1985) 3.59
Kinetic states and modes of single large-conductance calcium-activated potassium channels in cultured rat skeletal muscle. J Physiol (1988) 3.48
Two anthranilate synthase genes in Arabidopsis: defense-related regulation of the tryptophan pathway. Plant Cell (1992) 3.32
Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton. Proc Natl Acad Sci U S A (1986) 3.22
Ion-channel entrances influence permeation. Net charge, size, shape, and binding considerations. Biophys J (1986) 3.19
Hypothesis about the function of membrane-buried proline residues in transport proteins. Proc Natl Acad Sci U S A (1986) 2.90
Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. J Cell Biol (1992) 2.72
Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. EMBO J (1987) 2.46
Characterization of a halobacterial gene affecting bacterio-opsin gene expression. Nucleic Acids Res (1984) 2.37
Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus. J Virol (1990) 2.36
Lipid-alamethicin interactions influence alamethicin orientation. Biophys J (1991) 2.33
Monovalent and divalent cation permeation in acetylcholine receptor channels. Ion transport related to structure. J Gen Physiol (1987) 2.20
Fractal models are inadequate for the kinetics of four different ion channels. Biophys J (1988) 2.06
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine. Proc Natl Acad Sci U S A (1986) 2.06
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol (1988) 1.97
Evolutionary relationship between the TonB-dependent outer membrane transport proteins: nucleotide and amino acid sequences of the Escherichia coli colicin I receptor gene. J Bacteriol (1989) 1.92
Amino acid side-chain partition energies and distribution of residues in soluble proteins. Biophys J (1985) 1.92
Two major outer envelope glycoproteins of Epstein-Barr virus are encoded by the same gene. J Virol (1985) 1.82
Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase. Proc Natl Acad Sci U S A (1984) 1.82
The structure of the lactose permease derived from Raman spectroscopy and prediction methods. EMBO J (1985) 1.79
Topogenic analysis of the human immunodeficiency virus type 1 envelope glycoprotein, gp160, in microsomal membranes. J Cell Biol (1988) 1.71
Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor. Proc Natl Acad Sci U S A (1984) 1.65
Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth. J Cell Biol (1989) 1.62
Structural conservation of ion conduction pathways in K channels and glutamate receptors. Proc Natl Acad Sci U S A (1995) 1.57
Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains. EMBO J (1988) 1.57
cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. Proc Natl Acad Sci U S A (1987) 1.56
Anomalous interaction of the acetylcholine receptor protein with the nonionic detergent Triton X-114. Proc Natl Acad Sci U S A (1985) 1.54
A charged amino acid substitution within the transmembrane anchor of the Rous sarcoma virus envelope glycoprotein affects surface expression but not intracellular transport. J Cell Biol (1987) 1.50
Determination of intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides in the absence of nearest-neighbor or conformational effects. Biopolymers (2006) 1.46
Conservation of neural nicotinic acetylcholine receptors from Drosophila to vertebrate central nervous systems. EMBO J (1988) 1.45
Evidence for unpredicted transmembrane domains in acetylcholine receptor subunits. Proc Natl Acad Sci U S A (1985) 1.45
Characterization of a second gene involved in bacterio-opsin gene expression in a halophilic archaebacterium. J Bacteriol (1988) 1.44
Conformational analysis of apolipoprotein A-I and E-3 based on primary sequence and circular dichroism. Biophys J (1992) 1.43
M2 delta, a candidate for the structure lining the ionic channel of the nicotinic cholinergic receptor. Proc Natl Acad Sci U S A (1988) 1.42
Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila. EMBO J (1986) 1.40
Structure linkage, and sequence of the two genes encoding the delta and gamma subunits of the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (1984) 1.40
Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]. Mol Cell Biol (1987) 1.39
Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors. EMBO J (1988) 1.39
Channel protein engineering: synthetic 22-mer peptide from the primary structure of the voltage-sensitive sodium channel forms ionic channels in lipid bilayers. Proc Natl Acad Sci U S A (1988) 1.35
Calcium channel activity of purified human synexin and structure of the human synexin gene. Proc Natl Acad Sci U S A (1989) 1.33
Peptide models for membrane channels. Biochem J (1996) 1.31
Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis. J Cell Biol (1988) 1.27
Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction. J Cell Biol (1990) 1.25
Mouse muscle nicotinic acetylcholine receptor gamma subunit: cDNA sequence and gene expression. Nucleic Acids Res (1986) 1.24
Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics. J Physiol (1986) 1.24
Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn. Proc Natl Acad Sci U S A (1998) 1.20
Expression and functional characterization of bluetongue virus VP5 protein: role in cellular permeabilization. J Virol (2001) 1.19
Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. J Physiol (2009) 1.19
Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome. J Gen Physiol (2000) 1.18
Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A. J Cell Biol (1989) 1.17
Alternative primary structures in the transmembrane domain of the chicken erythroid anion transporter. Mol Cell Biol (1988) 1.16
Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide. Proc Natl Acad Sci U S A (1985) 1.16
Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein. Proc Natl Acad Sci U S A (1989) 1.14
Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution. Proc Natl Acad Sci U S A (1989) 1.14
Cell membrane interaction of Bacillus thuringiensis subsp. israelensis cytolytic toxins. Infect Immun (1987) 1.11
A synaptic basis for T-lymphocyte activation. Ann Immunol (Paris) (1985) 1.11
Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation. Biophys J (1999) 1.08
The reaction site of a non-competitive antagonist in the delta-subunit of the nicotinic acetylcholine receptor. EMBO J (1986) 1.07
Tubular crystals of acetylcholine receptor. J Cell Biol (1984) 1.06
Independent mutations at the amino terminus of a protein act as surrogate signals for mitochondrial import. EMBO J (1987) 1.05
An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein function. J Virol (1999) 1.02
Mutation causing congenital myasthenia reveals acetylcholine receptor beta/delta subunit interaction essential for assembly. J Clin Invest (1999) 0.99
The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures. EMBO J (1994) 0.99
Positive charges in the cytoplasmic domain of Escherichia coli leader peptidase prevent an apolar domain from functioning as a signal. EMBO J (1989) 0.97
Favored and suppressed patterns of hydrophobic and nonhydrophobic amino acids in protein sequences. Proc Natl Acad Sci U S A (1993) 0.97
On the distribution of amino acid residues in transmembrane alpha-helix bundles. Proc Natl Acad Sci U S A (1995) 0.96
Characterization of regions within the N-terminal 6-kilodalton domain of phytochrome A that modulate its biological activity. Plant Physiol (1997) 0.95
Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk. J Clin Invest (1993) 0.94
Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs. Proc Natl Acad Sci U S A (1986) 0.94
Sequence and functional expression of a single alpha subunit of an insect nicotinic acetylcholine receptor. EMBO J (1990) 0.94
Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93
Electron microscopic observations of reconstituted proteoliposomes with the purified major intrinsic membrane protein of eye lens fibers. J Cell Biol (1987) 0.92
Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proc Natl Acad Sci U S A (1996) 0.92
Evaluation of methods for the prediction of membrane protein secondary structures. Proc Natl Acad Sci U S A (1986) 0.91
Conformation of cytoplasmic segments of acetylcholine receptor alpha- and beta-subunits probed by monoclonal antibodies: sensitivity of the antibody competition approach. EMBO J (1987) 0.89
Impact of intracellular domain flexibility upon properties of activated human 5-HT3 receptors. Br J Pharmacol (2014) 0.89
Genetic variants of C2 muscle cells that are defective in synthesis of the alpha-subunit of the acetylcholine receptor. J Cell Biol (1987) 0.89
Multiple actions of substance P that regulate the functional properties of acetylcholine receptors of clonal rat PC12 cells. J Physiol (1987) 0.89
Evolutionary origin of cholinergic macromolecules and thyroglobulin. Proc Natl Acad Sci U S A (1987) 0.88
Rapsyn interacts with the muscle acetylcholine receptor via alpha-helical domains in the alpha, beta, and epsilon subunit intracellular loops. Neuroscience (2009) 0.87
Expression of fusion proteins of the nicotinic acetylcholine receptor from mammalian muscle identifies the membrane-spanning regions in the alpha and delta subunits. J Cell Biol (1992) 0.87
On the biology of prions. Acta Neuropathol (1987) 0.87
Structure, oligosaccharide structures, and posttranslationally modified sites of the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (1989) 0.87
Profile of the alpha-bungarotoxin-binding regions on the extracellular part of the alpha-chain of Torpedo californica acetylcholine receptor. Biochem J (1987) 0.86
Protein stability and interaction of the nicotinic acetylcholine receptor with cholinergic ligands studied by Fourier-transform infrared spectroscopy. Biochem J (1992) 0.84
A neural network model for the prediction of membrane-spanning amino acid sequences. Protein Sci (1994) 0.84
Immunochemical demonstration that amino acids 360-377 of the acetylcholine receptor gamma-subunit are cytoplasmic. J Cell Biol (1985) 0.84
Genetic study of the functional organization of the colicin E1 molecule. J Bacteriol (1985) 0.82
Transmembrane topography of the nicotinic acetylcholine receptor delta subunit. EMBO J (1987) 0.81
Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore. Biophys J (1997) 0.80
Single expressed glycine receptor domains reconstitute functional ion channels without subunit-specific desensitization behavior. J Biol Chem (2014) 0.79
The Ascaris suum nicotinic receptor, ACR-16, as a drug target: Four novel negative allosteric modulators from virtual screening. Int J Parasitol Drugs Drug Resist (2016) 0.78
Induction of human immunodeficiency virus (HIV-1) envelope specific cell-mediated immunity by a non-homologous synthetic peptide. PLoS One (2007) 0.77
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol (1978) 33.47
Tests for comparing related amino-acid sequences. Cytochrome c and cytochrome c 551 . J Mol Biol (1971) 12.21
Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol (1982) 9.67
Ion-concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction. J Physiol (1979) 6.95
The permeability of the endplate channel to organic cations in frog muscle. J Gen Physiol (1980) 5.00
Structural homology of Torpedo californica acetylcholine receptor subunits. Nature (1983) 4.70
beta-Sheet topology and the relatedness of proteins. Nature (1977) 4.04
Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature (1982) 3.69
Acetylcholine receptor: complex of homologous subunits. Science (1980) 3.45
Periodic features in the amino acid sequence of nematode myosin rod. J Mol Biol (1983) 3.25
The 14-fold periodicity in alpha-tropomyosin and the interaction with actin. J Mol Biol (1976) 3.23
Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit. Proc Natl Acad Sci U S A (1983) 3.01
Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain. Proc Natl Acad Sci U S A (1983) 2.98
Structure and function of an acetylcholine receptor. Biophys J (1982) 2.92
The beta bulge: a common small unit of nonrepetitive protein structure. Proc Natl Acad Sci U S A (1978) 2.72
Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature (1983) 2.55
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1977) 2.17
Selectivity of cations and nonelectrolytes for acetylcholine-activated channels in cultured muscle cells. J Gen Physiol (1978) 2.13
Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica. Biochemistry (1978) 2.08
Biochemical properties of acteylcholine receptor subunits from Torpedo californica. Biochemistry (1979) 1.94
In vitro synthesis, glycosylation, and membrane insertion of the four subunits of Torpedo acetylcholine receptor. Proc Natl Acad Sci U S A (1981) 1.83
Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1979) 1.82
The molecular cloning and characterisation of cDNA coding for the alpha subunit of the acetylcholine receptor. Nucleic Acids Res (1982) 1.80
Permeability of the endplate membrane activated by acetylcholine to some organic cations. J Neurobiol (1977) 1.72
Inhibition of glycosylation with tunicamycin blocks assembly of newly synthesized acetylcholine receptor subunits in muscle cells. J Biol Chem (1982) 1.72
Acetylcholine receptor subunits transit a precursor pool before acquiring alpha-bungarotoxin binding activity. J Biol Chem (1981) 1.50
Effects of methyl- and ethyl-derivatives of NH4 on the neuromuscular junction. Jpn J Physiol (1959) 1.37
Acetylcholine receptor channel ionic selectivity: ions experience an aqueous environment. Proc Natl Acad Sci U S A (1983) 1.26
Conformational and geometrical properties of beta-sheets in proteins. II. Antiparallel and mixed beta-sheets. J Mol Biol (1981) 1.17
On the conformation of the acetylcholine receptor protein from Torpedo nobiliana. FEBS Lett (1974) 1.15
Partial tertiary structure assignment for the acetylcholine receptor on the basis of the hydrophobicity of amino acid sequences and channel location using single group rotation theory. Biochem Biophys Res Commun (1983) 0.97
Structural models of the nicotinic acetylcholine receptor and its toxin-binding sites. Cell Mol Neurobiol (1981) 0.88
Structure of a glycerol-conducting channel and the basis for its selectivity. Science (2000) 6.64
Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies. J Immunol (1971) 5.06
The signal recognition particle. Annu Rev Biochem (2001) 4.47
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A (2000) 3.26
Structure and function of an acetylcholine receptor. Biophys J (1982) 2.92
Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65
Site-directed ligand discovery. Proc Natl Acad Sci U S A (2000) 2.58
Crystal structure of colicin Ia. Nature (1997) 2.57
Structure of the conserved GTPase domain of the signal recognition particle. Nature (1997) 2.52
Atomic structure of thymidylate synthase: target for rational drug design. Science (1987) 2.48
Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell (1998) 2.44
Mechanism of action of the C3b inactivator: requirement for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b'). Immunochemistry (1978) 2.43
C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a. Immunochemistry (1966) 2.37
Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq). Proc Natl Acad Sci U S A (1972) 2.32
Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b. Proc Natl Acad Sci U S A (1977) 2.27
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. J Biol Chem (1985) 2.27
Cleavage products of C4b produced by enzymes in human serum. Immunochemistry (1975) 2.26
Regulation of an enzyme by phosphorylation at the active site. Science (1990) 2.25
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. Proc Natl Acad Sci U S A (1989) 2.20
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1977) 2.17
Rabbit C1q: purification, functional and structural studies. J Immunol Methods (1972) 2.15
Chemical studies of Clq; a modulator of immunoglobulin biology. Biochem Biophys Res Commun (1971) 2.05
Linking regions between helices in bacteriorhodopsin revealed. Biophys J (1982) 2.03
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry (1990) 1.98
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol (1988) 1.97
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. J Immunol (1980) 1.94
Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry (1991) 1.91
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (1987) 1.87
Structural studies on human Clq: non-covalent and covalent subunits. Immunochemistry (1972) 1.83
Structure of Cry2Aa suggests an unexpected receptor binding epitope. Structure (2001) 1.82
Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1979) 1.82
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc Natl Acad Sci U S A (2001) 1.80
Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins. Science (1993) 1.76
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng (1989) 1.76
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry (1998) 1.75
Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J (1979) 1.75
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins (1990) 1.75
Attachment site(s) of retinal in bacteriorhodopsin. Proc Natl Acad Sci U S A (1981) 1.73
Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy. J Mol Biol (1981) 1.71
Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding. J Mol Biol (1974) 1.62
Structure-based discovery of inhibitors of thymidylate synthase. Science (1993) 1.61
The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution. J Mol Biol (1974) 1.55
Mechanisms of zymogen activation. Annu Rev Biophys Bioeng (1977) 1.51
The molecular neurobiology of the acetylcholine receptor. Annu Rev Neurosci (1986) 1.50
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nat Struct Biol (1999) 1.47
The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution. Cold Spring Harb Symp Quant Biol (1972) 1.45
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. J Biol Chem (1991) 1.41
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat Struct Biol (2000) 1.41
Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency. Immunochemistry (1966) 1.41
Deficiency of C1r in human serum. Effects on the structure and function of macromolecular C1. J Exp Med (1970) 1.36
Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry (1977) 1.36
Human factor D of the alternative complement pathway: purification and characterization. J Immunol (1977) 1.33
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry (1995) 1.32
The relationship of the hemolytic activity of active C'1s to its TAMe esterase action: a new method of purification and assay. J Immunol (1969) 1.28
Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. J Biol Chem (1990) 1.27
Complement and host defense against infection. J Pediatr (1977) 1.26
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. Protein Eng (1989) 1.25
A family of protein-cutting proteins. Sci Am (1974) 1.22
Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J Cell Biol (1980) 1.21
Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates. Immunochemistry (1965) 1.20
Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--III. Inhibition of C4 and C2 binding site(s) on C1s by polyanions. Immunochemistry (1976) 1.20
Crystalline arrays of membrane-bound acetylcholine receptor. Proc Natl Acad Sci U S A (1981) 1.18
Acetylcholine receptor structure, function, and evolution. Annu Rev Cell Biol (1985) 1.18
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits. Biochemistry (1999) 1.18
Design of potent selective zinc-mediated serine protease inhibitors. Nature (1998) 1.17
Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A. J Cell Biol (1989) 1.17
A designed four helix bundle protein with native-like structure. Nat Struct Biol (1997) 1.17
Bacteriorhodopsin D85N: three spectroscopic species in equilibrium. Biochemistry (1993) 1.16
Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide. Proc Natl Acad Sci U S A (1985) 1.16
Assembly of bacteriophage T7. Dimensions of the bacteriophage and its capsids. Biophys J (1981) 1.16
Purification of bacteriorhodopsin and characterization of mature and partially processed forms. J Biol Chem (1989) 1.14
pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin. Biochemistry (1976) 1.13
Interaction of Histoplasma capsulatum with human platelets. J Infect Dis (1980) 1.13
Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. Anal Biochem (1981) 1.13
Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. Biochemistry (2000) 1.12
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase. Biochemistry (1990) 1.10
Mechanism of hydrolysis by serine proteases: direct determination of the pKa's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy. Biochemistry (1976) 1.09
Effects of detergent environments on the photocycle of purified monomeric bacteriorhodopsin. Biochemistry (1991) 1.08
Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry (1995) 1.07
Atomic structure of a glycerol channel and implications for substrate permeation in aqua(glycero)porins. FEBS Lett (2001) 1.07
Mode of interaction of different polyanions with the first (C1, C1), the second (C2) and the fourth (C4) component of complement--II. Effect of polyanions on the binding of C2 to EAC4b. Immunochemistry (1976) 1.07
Purification and characterization of a macromolecular weight cofactor for C3b-inactivator, C4bC3bINA-cofactor, of human plasma. Mol Immunol (1980) 1.06
Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin. Biochemistry (1991) 1.06
Food-induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk. Arthritis Rheum (1986) 1.06
Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction. Proteins (1992) 1.06
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A. Biochemistry (1994) 1.05
Detection and quantitation in plasma and synovial fluid of a fragment of human C4 with alpha mobility generated during the activation of the complement system. J Immunol (1975) 1.04
C1 fixation and classical complement pathway activation by a fragment of the Cmu4 domain of IgM. J Exp Med (1975) 1.03
The structural basis for binding of complement by immunoglobulin M. J Exp Med (1974) 1.03
The additivity of substrate fragments in enzyme-ligand binding. Structure (1998) 1.02
C1r, subunit of the first complement component: purification, properties, and assay based on its linking role. J Clin Invest (1971) 1.02
Subunit organization and structure of an acetylcholine receptor. Cold Spring Harb Symp Quant Biol (1983) 1.01
Wild-type and mutant bacteriorhodopsins D85N, D96N, and R82Q: purification to homogeneity, pH dependence of pumping, and electron diffraction. Biochemistry (1991) 1.01