Published in J Med Chem on March 16, 2007
Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol (2009) 1.58
3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors. Int J Mol Sci (2011) 0.89
Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem (2008) 0.86
UV-photoelectron spectroscopy of BN indoles: experimental and computational electronic structure analysis. J Am Chem Soc (2014) 0.86
Synthesis of indole analogues of the natural schweinfurthins. J Org Chem (2013) 0.82
A combination of receptor-based pharmacophore modeling & QM techniques for identification of human chymase inhibitors. PLoS One (2013) 0.80
Molecular modeling study for inhibition mechanism of human chymase and its application in inhibitor design. PLoS One (2013) 0.76
Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor. J Synchrotron Radiat (2013) 0.75
Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris. Protein Expr Purif (2014) 0.75
High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery. Ann Neurol (2010) 2.79
Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies. J Clin Oncol (2005) 2.53
Evolution of enzyme cascades from embryonic development to blood coagulation. Trends Biochem Sci (2002) 1.96
Gaussian docking functions. Biopolymers (2003) 1.82
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol (2007) 1.80
Role of Na+ and K+ in enzyme function. Physiol Rev (2006) 1.80
Molecular dissection of Na+ binding to thrombin. J Biol Chem (2004) 1.72
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood (2011) 1.71
A phase I trial of depsipeptide (FR901228) in patients with advanced cancer. J Exp Ther Oncol (2002) 1.68
Mer receptor tyrosine kinase signaling participates in platelet function. Arterioscler Thromb Vasc Biol (2004) 1.67
Studies on the basis for the properties of fibrin produced from fibrinogen-containing gamma' chains. Blood (2005) 1.64
Delayed inflammatory response to primary pneumonic plague occurs in both outbred and inbred mice. Infect Immun (2006) 1.59
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem (2006) 1.58
Exposure of R169 controls protein C activation and autoactivation. Blood (2012) 1.52
Phase I study of prolonged infusion Bryostatin-1 in patients with advanced malignancies. Cancer Biol Ther (2002) 1.50
Randomized crossover pharmacokinetic study of solvent-based paclitaxel and nab-paclitaxel. Clin Cancer Res (2008) 1.48
Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor. Invest New Drugs (2005) 1.40
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism. Biochemistry (2012) 1.39
Phase I/II trial of weekly intravenous 130-nm albumin-bound paclitaxel as initial chemotherapy in patients with stage IV non-small-cell lung cancer. J Clin Oncol (2008) 1.39
Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A (2008) 1.31
Rapid kinetics of Na+ binding to thrombin. J Biol Chem (2006) 1.29
Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin. PLoS One (2009) 1.27
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc Natl Acad Sci U S A (2007) 1.23
Conformational selection in trypsin-like proteases. Curr Opin Struct Biol (2012) 1.20
Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates. J Pharmacol Exp Ther (2003) 1.20
The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo. J Biol Chem (2002) 1.19
Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions. Proc Natl Acad Sci U S A (2008) 1.18
Catalytic cycle of human glutathione reductase near 1 A resolution. J Mol Biol (2008) 1.16
Evolution of peptidase diversity. J Biol Chem (2008) 1.16
Phase I and pharmacokinetic trial of carboplatin and albumin-bound paclitaxel, ABI-007 (Abraxane) on three treatment schedules in patients with solid tumors. Cancer Chemother Pharmacol (2007) 1.13
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood (2007) 1.12
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. J Med Chem (2005) 1.12
Crystal structure of thrombin in a self-inhibited conformation. J Biol Chem (2006) 1.11
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem (2004) 1.10
Collagen-related peptides: self-assembly of short, single strands into a functional biomaterial of micrometer scale. J Am Chem Soc (2007) 1.09
Engineering thrombin for selective specificity toward protein C and PAR1. J Biol Chem (2010) 1.09
Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C. J Biol Chem (2004) 1.08
Prevalence of antibodies to type a influenza virus in wild avian species using two serologic assays. J Wildl Dis (2010) 1.07
Allostery in trypsin-like proteases suggests new therapeutic strategies. Trends Biotechnol (2011) 1.07
Molecular pharmacodynamics, clinical therapeutics, and pharmacokinetics of topiramate. CNS Neurosci Ther (2008) 1.06
Assessment of GS-9219 in a pet dog model of non-Hodgkin's lymphoma. Clin Cancer Res (2009) 1.06
Redesigning the monovalent cation specificity of an enzyme. Proc Natl Acad Sci U S A (2003) 1.05
Conformational selection is a dominant mechanism of ligand binding. Biochemistry (2013) 1.05
Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae. Genetics (2007) 1.04
Synthesis of macrocycles via cobalt-mediated [2 + 2 + 2] cycloadditions. J Am Chem Soc (2005) 1.02
Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics. Biophys Chem (2007) 1.01
Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney. Am J Physiol Renal Physiol (2003) 1.00
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases. Nat Rev Cancer (2012) 0.99
Crystal structure of thrombin in complex with fibrinogen gamma' peptide. Biophys Chem (2006) 0.99
Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis. J Med Chem (2013) 0.98
Crystallographic and kinetic evidence of allostery in a trypsin-like protease. Biochemistry (2011) 0.98
Mutant N143P reveals how Na+ activates thrombin. J Biol Chem (2009) 0.97
Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex. Blood (2011) 0.97
Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation. Biochemistry (2011) 0.97
Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery. J Biol Chem (2007) 0.96
Crystal structure of the anticoagulant slow form of thrombin. J Biol Chem (2002) 0.96
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem (2005) 0.96
Dissecting substrate recognition by thrombin using the inactive mutant S195A. Biophys Chem (2003) 0.96
Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA. Proc Natl Acad Sci U S A (2010) 0.96
Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone. J Med Chem (2003) 0.96
Crystal structure of prethrombin-1. Proc Natl Acad Sci U S A (2010) 0.96
Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. J Biol Chem (2010) 0.96
Monitoring of lead, cadmium, chromium and nickel in placenta from an e-waste recycling town in China. Sci Total Environ (2010) 0.95
Structural and mutagenesis studies on the cytochrome c peroxidase from Rhodobacter capsulatus provide new insights into structure-function relationships of bacterial di-heme peroxidases. J Biol Chem (2005) 0.95
Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases. J Biol Chem (2005) 0.95
Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem (2009) 0.95
Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3beta (GSK-3beta) inhibitors. Bioorg Med Chem (2004) 0.95
An age-old paradigm challenged: old baboons generate vigorous humoral immune responses to LcrV, a plague antigen. J Immunol (2008) 0.95
Mimicry of high-density lipoprotein: functional peptide-lipid nanoparticles based on multivalent peptide constructs. J Am Chem Soc (2013) 0.94
Suicide categories by patterns of known risk factors: a latent class analysis. Arch Gen Psychiatry (2011) 0.94
Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke (2011) 0.94
The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation. Res Microbiol (2009) 0.94
Susceptibility of greater sage-grouse to experimental infection with West Nile virus. J Wildl Dis (2006) 0.94
The "old" Euonymus europaeus agglutinin represents a novel family of ubiquitous plant proteins. Plant Physiol (2008) 0.94
Murine thrombin lacks Na+ activation but retains high catalytic activity. J Biol Chem (2006) 0.93
The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding. J Biol Chem (2004) 0.93
Ser(214) is crucial for substrate binding to serine proteases. J Biol Chem (2002) 0.92
Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation. J Biol Chem (2013) 0.92
Autoactivation of thrombin precursors. J Biol Chem (2013) 0.92
Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation. Am J Respir Crit Care Med (2009) 0.92
Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites. J Biol Chem (2002) 0.92
Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem (2010) 0.91