PubRank

Hediye Erdjument-Bromage

Author PubWeight™ 397.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002 24.31
2 mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 18.22
3 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004 16.83
4 Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 2002 13.08
5 PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008 13.08
6 DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 2007 11.14
7 Histone demethylation by a family of JmjC domain-containing proteins. Nature 2005 10.36
8 Role of histone H2A ubiquitination in Polycomb silencing. Nature 2004 9.48
9 Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005 7.75
10 Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell 2007 5.78
11 Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 2007 5.62
12 PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell 2002 5.59
13 JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006 5.54
14 Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol 2002 5.53
15 The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 2006 5.51
16 Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev 2002 5.43
17 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 2004 5.37
18 GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 5.21
19 NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 2007 5.20
20 Histone deimination antagonizes arginine methylation. Cell 2004 5.19
21 Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest 2006 4.37
22 TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011 4.16
23 Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol 2002 4.12
24 Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 2002 4.08
25 Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 2002 4.07
26 Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell 2005 4.04
27 Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol 2004 3.90
28 Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 2008 3.90
29 P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 2002 3.80
30 The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 2007 3.79
31 Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 2004 3.77
32 L3MBTL1, a histone-methylation-dependent chromatin lock. Cell 2007 3.70
33 PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell 2007 3.68
34 Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell 2006 3.39
35 An iron delivery pathway mediated by a lipocalin. Mol Cell 2002 3.38
36 Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 2006 3.31
37 The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol 2002 3.13
38 mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell 2003 2.97
39 A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell 2006 2.95
40 Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol 2009 2.91
41 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 2008 2.86
42 Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev 2007 2.81
43 The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Nature 2002 2.77
44 MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 2007 2.76
45 SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 2007 2.76
46 mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol 2003 2.72
47 The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev 2005 2.70
48 Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol 2003 2.66
49 A new role for Nogo as a regulator of vascular remodeling. Nat Med 2004 2.63
50 Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature 2007 2.52
51 Isolation and mass spectrometry of transcription factor complexes. Methods 2002 2.46
52 Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14. EMBO J 2004 2.46
53 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 2009 2.45
54 PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell 2005 2.44
55 Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nat Chem Biol 2011 2.42
56 Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev 2004 2.39
57 Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 2010 2.38
58 Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev 2006 2.36
59 Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A 2002 2.27
60 The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases. Nat Struct Mol Biol 2008 2.26
61 Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol Cell Biol 2007 2.10
62 Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. PLoS Biol 2006 2.08
63 The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol 2007 1.99
64 A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell 2007 1.98
65 Purification and characterization of the human elongator complex. J Biol Chem 2001 1.97
66 BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism. J Exp Med 2006 1.93
67 Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell 2005 1.93
68 LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J 2011 1.89
69 S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense. Proc Natl Acad Sci U S A 2004 1.87
70 Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev 2006 1.85
71 A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. J Biol Chem 2002 1.84
72 The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 2004 1.80
73 A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage. Nature 2002 1.80
74 MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab 2011 1.68
75 Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 2005 1.68
76 Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood 2013 1.68
77 Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 2003 1.60
78 ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Cell 2005 1.55
79 The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev Cell 2005 1.55
80 A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chem Biol 2011 1.54
81 Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev 2008 1.51
82 The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol Cell Biol 2008 1.47
83 Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress. Cell 2013 1.46
84 Role of integrins in the assembly and function of hensin in intercalated cells. J Am Soc Nephrol 2008 1.46
85 Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol Microbiol 2005 1.38
86 PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells 2011 1.37
87 Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J Biol Chem 2004 1.36
88 ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol 2003 1.34
89 L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell 2011 1.32
90 Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proc Natl Acad Sci U S A 2011 1.30
91 NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int 2012 1.30
92 Architecture of the Mediator head module. Nature 2011 1.30
93 Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem 2009 1.28
94 A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination. Immunity 2005 1.27
95 The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles. Genetics 2005 1.25
96 CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol 2006 1.25
97 The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates. Mol Cell Biol 2005 1.20
98 Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem 2007 1.19
99 Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol Cell Biol 2002 1.18
100 Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles. J Cell Biol 2005 1.18
101 Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries. Mol Cell Biol 2007 1.18
102 Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 2007 1.15
103 Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD. Cell 2007 1.13
104 Catalytic properties of ADAM19. J Biol Chem 2003 1.09
105 MTERF2 is a nucleoid component in mammalian mitochondria. Biochim Biophys Acta 2009 1.09
106 Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3. Mol Cell 2008 1.08
107 The yeast capping enzyme represses RNA polymerase II transcription. Mol Cell 2002 1.07
108 Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proc Natl Acad Sci U S A 2012 1.05
109 Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. J Biol Chem 2004 1.04
110 Schizosaccharomyces pombe carboxyl-terminal domain (CTD) phosphatase Fcp1: distributive mechanism, minimal CTD substrate, and active site mapping. J Biol Chem 2003 1.04
111 Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes. Nucleic Acids Res 2011 1.03
112 Processing of autophagic protein LC3 by the 20S proteasome. Autophagy 2010 1.02
113 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. Genes Dev 2013 1.01
114 Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production. J Biol Chem 2010 0.99
115 Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells. Nucleic Acids Res 2011 0.97
116 Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem 2007 0.96
117 Parkinson's disease-associated alpha-synuclein is a calmodulin substrate. J Biol Chem 2003 0.96
118 Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH. J Biol Chem 2003 0.96
119 Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells. Protein Sci 2006 0.96
120 Mutual targeting of mediator and the TFIIH kinase Kin28. J Biol Chem 2004 0.95
121 Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. J Exp Med 2012 0.95
122 Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. FEBS Lett 2004 0.92
123 Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. ACS Chem Biol 2014 0.91
124 Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. EMBO J 2004 0.90
125 The overlapping host responses to bacterial cyclic dinucleotides. Microbes Infect 2011 0.90
126 Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression. Sci Signal 2011 0.89
127 JAMP optimizes ERAD to protect cells from unfolded proteins. Mol Biol Cell 2008 0.88
128 SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. PLoS One 2010 0.87
129 Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. J Biol Chem 2005 0.86
130 The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation. Proc Natl Acad Sci U S A 2003 0.85
131 Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding. J Immunol 2009 0.85
132 PU.1 and a TTTAAA element in the myeloid defensin-1 promoter create an operational TATA box that can impose cell specificity onto TFIID function. J Immunol 2006 0.83
133 The laminin receptor modulates granulocyte-macrophage colony-stimulating factor receptor complex formation and modulates its signaling. Proc Natl Acad Sci U S A 2003 0.83
134 The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function. EMBO Rep 2003 0.82
135 Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol 2013 0.78
136 The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. PLoS One 2013 0.77
137 High-level expression of a full-length Eph receptor. Protein Expr Purif 2013 0.77
138 Aminopeptidase activities as prospective urinary biomarkers for bladder cancer. Proteomics Clin Appl 2014 0.76