Published in JAMA on March 21, 2007
Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ (2008) 9.98
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01
Varenicline versus transdermal nicotine patch for smoking cessation: results from a randomised open-label trial. Thorax (2008) 4.79
Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med (2014) 4.22
Formal representation of eligibility criteria: a literature review. J Biomed Inform (2009) 3.16
Analysis of eligibility criteria complexity in clinical trials. AMIA Jt Summits Transl Sci Proc (2010) 2.37
Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med (2011) 1.92
Drug-disease and drug-drug interactions: systematic examination of recommendations in 12 UK national clinical guidelines. BMJ (2015) 1.85
Differences in clinical trial patient attributes and outcomes according to enrollment setting. J Clin Oncol (2009) 1.74
Estimating the population impact of preventive interventions from randomized trials. Am J Prev Med (2011) 1.72
Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med (2010) 1.71
Interpreting treatment effects from clinical trials in the context of real-world risk information: end-stage renal disease prevention in older adults. JAMA Intern Med (2014) 1.68
CONSORT 2010 statement: extension to randomised pilot and feasibility trials. BMJ (2016) 1.60
Prevalence of comorbidity of chronic diseases in Australia. BMC Public Health (2008) 1.57
Learning and caring in communities of practice: using relationships and collective learning to improve primary care for patients with multimorbidity. Ann Fam Med (2010) 1.48
A framework for crafting clinical practice guidelines that are relevant to the care and management of people with multimorbidity. J Gen Intern Med (2014) 1.46
Frailty Intervention Trial (FIT). BMC Geriatr (2008) 1.33
Managing older adults with CKD: individualized versus disease-based approaches. Am J Kidney Dis (2011) 1.31
A distribution-based method for assessing the differences between clinical trial target populations and patient populations in electronic health records. Appl Clin Inform (2014) 1.26
Generalizability of clinical trials for alcohol dependence to community samples. Drug Alcohol Depend (2008) 1.25
Exclusion of older adults and women from recent trials of acute coronary syndromes. J Am Geriatr Soc (2011) 1.23
Reporting of eligibility criteria of randomised trials: cohort study comparing trial protocols with subsequent articles. BMJ (2011) 1.19
Multimorbidity and evidence generation. J Gen Intern Med (2014) 1.17
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev (2010) 1.15
Informing clinical practice guideline development and implementation: prevalence of coexisting conditions among adults with coronary heart disease. J Am Geriatr Soc (2011) 1.15
The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995-2010. BMC Med (2015) 1.14
The external validity of published randomized controlled trials in primary care. BMC Fam Pract (2009) 1.09
Adverse drug reactions in special populations - the elderly. Br J Clin Pharmacol (2015) 1.07
Medication prescribing in frail older people. Eur J Clin Pharmacol (2012) 1.07
A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results. Trials (2015) 1.06
Informing evidence-based decision-making for patients with comorbidity: availability of necessary information in clinical trials for chronic diseases. PLoS One (2012) 1.05
Underrepresentation of elderly people in randomised controlled trials. The example of trials of 4 widely prescribed drugs. PLoS One (2012) 1.04
Subject eligibility criteria can substantially influence the results of alcohol-treatment outcome research. J Stud Alcohol Drugs (2008) 1.03
Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process. Br J Clin Pharmacol (2014) 1.03
CONSORT 2010 statement: extension to randomised pilot and feasibility trials. Pilot Feasibility Stud (2016) 0.99
Temporal Trends and Predictors for Cancer Clinical Trial Availability for Medically Underserved Populations. Oncologist (2015) 0.99
Adoption of clinical decision support in multimorbidity: a systematic review. JMIR Med Inform (2015) 0.99
IOM and DHHS meeting on making clinical practice guidelines appropriate for patients with multiple chronic conditions. Ann Fam Med (2014) 0.99
Addressing multimorbidity in evidence integration and synthesis. J Gen Intern Med (2014) 0.98
Impact of prior cancer on eligibility for lung cancer clinical trials. J Natl Cancer Inst (2014) 0.97
Generalizability of clinical trials for cannabis dependence to community samples. Drug Alcohol Depend (2010) 0.97
Understanding and Avoiding Immortal-Time Bias in Gastrointestinal Observational Research. Am J Gastroenterol (2015) 0.96
A method for analyzing commonalities in clinical trial target populations. AMIA Annu Symp Proc (2014) 0.95
Endorsement of the CONSORT statement by high-impact medical journals in China: a survey of instructions for authors and published papers. PLoS One (2012) 0.94
The impact of concomitant medication use on patient eligibility for phase I cancer clinical trials. J Cancer (2012) 0.94
Effect of prior cancer on outcomes in advanced lung cancer: implications for clinical trial eligibility and accrual. J Natl Cancer Inst (2015) 0.94
Characteristics of opioid-using pregnant women who accept or refuse participation in a clinical trial: screening results from the MOTHER study. Am J Drug Alcohol Abuse (2009) 0.93
Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. CMAJ (2014) 0.91
Neglected external validity in reports of randomized trials: the example of hip and knee osteoarthritis. Arthritis Rheum (2009) 0.90
Challenges of managing people with multimorbidity in today's healthcare systems. BMC Fam Pract (2015) 0.89
Reporting of participant flow diagrams in published reports of randomized trials. Trials (2011) 0.89
Should criteria for inclusion in cancer clinical trials be expanded? J Comp Eff Res (2015) 0.88
Update on pharmacologic and nonpharmacologic therapies for smoking cessation. Can Fam Physician (2008) 0.87
Optimizing Clinical Research Participant Selection with Informatics. Trends Pharmacol Sci (2015) 0.86
Making general internal medicine research relevant to the older patient with multiple chronic comorbidities. J Gen Intern Med (2014) 0.86
Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years. Circ Cardiovasc Qual Outcomes (2015) 0.85
Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study. Can Geriatr J (2015) 0.85
Comorbidity in older adults with cancer. J Geriatr Oncol (2015) 0.85
Hypertension and aging. Ageing Res Rev (2016) 0.84
Effectiveness of the physical activity promotion programme on the quality of life and the cardiopulmonary function for inactive people: randomized controlled trial. BMC Public Health (2013) 0.83
Are statin trials in diabetes representative of real-world diabetes care: a population-based study on statin initiators in Finland. BMJ Open (2014) 0.83
Age, exclusion criteria, and generalizability of randomized trials enrolling kidney transplant recipients. Transplantation (2011) 0.83
Routinely collected data and comparative effectiveness evidence: promises and limitations. CMAJ (2016) 0.82
Effectiveness of inhaler types for real-world asthma management: retrospective observational study using the GPRD. J Asthma Allergy (2011) 0.82
The effectiveness of critical time intervention for abused women and homeless people leaving Dutch shelters: study protocol of two randomised controlled trials. BMC Public Health (2013) 0.82
Clinical research methodology I: introduction to randomized trials. J Am Coll Surg (2008) 0.82
Systematic reviews of observational studies of risk of thrombosis and bleeding in urological surgery (ROTBUS): introduction and methodology. Syst Rev (2014) 0.81
Generalizability of pharmacological and psychotherapy clinical trial results for borderline personality disorder to community samples. Personal Disord (2015) 0.81
Identifying the appropriate comparison group for HIV-infected individuals. Curr Opin HIV AIDS (2014) 0.81
Actual Use of Medications Prescribed During Pregnancy: A Cross-Sectional Study Using Data from a Population-Based Congenital Anomaly Registry. Drug Saf (2015) 0.81
A weight-loss intervention program designed for Mexican-American women: cultural adaptations and results. J Immigr Minor Health (2012) 0.81
Representativeness of patients enrolled in influential clinical trials: a comparison of substance dependence with other medical disorders. J Stud Alcohol Drugs (2013) 0.81
Caring for patients with kidney disease: shifting the paradigm from evidence-based medicine to patient-centered care. Nephrol Dial Transplant (2015) 0.81
How GPs value guidelines applied to patients with multimorbidity: a qualitative study. BMJ Open (2015) 0.81
Research priorities in geriatric palliative care: multimorbidity. J Palliat Med (2013) 0.80
Prevalence of diabetes treatment effect modifiers: the external validity of trials to older adults. Aging Clin Exp Res (2012) 0.80
Palliative radiation therapy in patients with metastasized pancreatic cancer - description of a rare patient group. Eur J Med Res (2014) 0.80
The association between use of cardiovascular drugs and antidepressants: a nationwide register-based study. Eur J Clin Pharmacol (2008) 0.79
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev (2015) 0.79
Effects of group metacognitive training (MCT) on mental capacity and functioning in patients with psychosis in a secure forensic psychiatric hospital: a prospective-cohort waiting list controlled study. BMC Res Notes (2012) 0.79
Assessment of solid cancer treatment feasibility in older patients: a prospective cohort study. Oncologist (2014) 0.79
The promotion of data sharing in pharmacoepidemiology. Eur J Health Law (2014) 0.79
Who enrolls in the Medicare Part D prescription drug benefit program? Medication use among patients with heart failure. J Am Heart Assoc (2013) 0.79
Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry. Crit Care (2013) 0.79
Comparing a marginal structural model with a Cox proportional hazard model to estimate the effect of time-dependent drug use in observational studies: statin use for primary prevention of cardiovascular disease as an example from the Rotterdam Study. Eur J Epidemiol (2014) 0.78
Cellulite and extracorporeal Shockwave therapy (CelluShock-2009)--a randomized trial. BMC Womens Health (2010) 0.78
Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial. BMC Gastroenterol (2015) 0.78
Registry-Based Pragmatic Trials in Heart Failure: Current Experience and Future Directions. Curr Heart Fail Rep (2017) 0.78
Cardiovascular toxicity of multi-tyrosine kinase inhibitors in advanced solid tumors: a population-based observational study. PLoS One (2015) 0.77
Assessing the external validity of a randomized controlled trial of anthelminthics in mothers and their children in Entebbe, Uganda. Trials (2014) 0.77
Mitigating the Effects of Nonadherence in Clinical Trials. J Clin Pharmacol (2016) 0.77
Prescribing for Australians living with dementia: study protocol using the Delphi technique. BMJ Open (2015) 0.77
The impact of cardiovascular disease prevalence on women's enrollment in landmark randomized cardiovascular trials: a systematic review. J Gen Intern Med (2011) 0.77
Storage duration of red blood cell transfusion and Clostridium difficile infection: a within person comparison. PLoS One (2014) 0.77
Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria. Trials (2015) 0.77
The value of structured data elements from electronic health records for identifying subjects for primary care clinical trials. BMC Med Inform Decis Mak (2016) 0.77
Risk of Stroke in Patients with ESRD. Clin J Am Soc Nephrol (2015) 0.77
The relationship between eligibility criteria and adverse events in randomized controlled trials of hematologic malignancies. Leukemia (2016) 0.77
Co-enrollment of critically ill patients into multiple studies: patterns, predictors and consequences. Crit Care (2013) 0.76
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
Critically Ill patients with 2009 influenza A(H1N1) in Mexico. JAMA (2009) 9.41
Validation of a rule for termination of resuscitation in out-of-hospital cardiac arrest. N Engl J Med (2006) 7.38
Critical care and the global burden of critical illness in adults. Lancet (2010) 5.55
Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Lancet Infect Dis (2013) 5.37
Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med (2014) 5.17
Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review. Am J Respir Crit Care Med (2008) 5.06
Clinical presentation of patients with Ebola virus disease in Conakry, Guinea. N Engl J Med (2014) 4.79
Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis (2006) 3.80
A multifaceted intervention for quality improvement in a network of intensive care units: a cluster randomized trial. JAMA (2011) 3.08
Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review. Crit Care Med (2011) 3.07
Pan-Canadian evaluation of irreversible compression ratios ("lossy" compression) for development of national guidelines. J Digit Imaging (2008) 2.81
Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years. Neurology (2005) 2.45
A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry. Crit Care Med (2009) 2.17
Ebola virus disease among children in West Africa. N Engl J Med (2015) 2.17
The effect of low-complexity patients on emergency department waiting times. Ann Emerg Med (2006) 2.14
Internal fixation of mandibular angle fractures: a meta-analysis. Plast Reconstr Surg (2010) 2.10
The incidence of hematoma formation in patients with continuous femoral catheters following total knee arthroplasty while receiving rivaroxaban as thromboprophylaxis: an observational study. Reg Anesth Pain Med (2014) 2.02
Is a mass immunization program for pandemic (H1N1) 2009 good value for money? Evidence from the Canadian Experience. Vaccine (2010) 1.91
Universal health insurance and health care access for homeless persons. Am J Public Health (2010) 1.85
Risk factors for harm in cognitively impaired seniors who live alone: a prospective study. J Am Geriatr Soc (2004) 1.84
Significant regional variation in adequacy of lymph node assessment and survival in gastric cancer. Cancer (2006) 1.78
Stage-specific effect of adjuvant therapy following gastric cancer resection: a population-based analysis of 4,041 patients. Ann Surg Oncol (2007) 1.78
Does inclusion of a placebo arm influence response to active antidepressant treatment in randomized controlled trials? Results from pooled and meta-analyses. J Clin Psychiatry (2010) 1.76
Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study. Crit Care (2013) 1.66
Population-based assessment of the surgical management of locally advanced colorectal cancer. J Natl Cancer Inst (2006) 1.66
EUS for detection of the hepatocellular carcinoma: results of a prospective study. Gastrointest Endosc (2007) 1.65
Knowledge translation in critical care: factors associated with prescription of commonly recommended best practices for critically ill patients. Crit Care Med (2007) 1.62
Validation of a universal prehospital termination of resuscitation clinical prediction rule for advanced and basic life support providers. Resuscitation (2009) 1.60
Screening and prevention of venous thromboembolism in critically ill patients: a decision analysis and economic evaluation. Am J Respir Crit Care Med (2011) 1.58
The effect of traumatic brain injury on the health of homeless people. CMAJ (2008) 1.53
Predictors of functional outcome two years following revision hip arthroplasty. J Bone Joint Surg Am (2006) 1.49
The highs and lows of intensive insulin therapy. Am J Respir Crit Care Med (2006) 1.47
Patient preferences for oropharyngeal cancer treatment de-escalation. Head Neck (2012) 1.45
Immediate angioplasty after thrombolysis: a systematic review. CMAJ (2005) 1.45
Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients. Crit Care Med (2016) 1.44
Doing today's work superbly well--treating Ebola with current tools. N Engl J Med (2014) 1.43
Economic evaluation of decompressive craniectomy versus barbiturate coma for refractory intracranial hypertension following traumatic brain injury. Crit Care Med (2014) 1.42
Images in clinical medicine. Chylothorax and chyloperitoneum. N Engl J Med (2005) 1.41
Surgical management of intrahepatic cholangiocarcinoma--a population-based study. Ann Surg Oncol (2007) 1.39
Effects of clinical supervision on resident learning and patient care during simulated ICU scenarios. Crit Care Med (2013) 1.39
Multidimensional social support and the health of homeless individuals. J Urban Health (2009) 1.38
An official American Thoracic Society systematic review: the association between health insurance status and access, care delivery, and outcomes for patients who are critically ill. Am J Respir Crit Care Med (2010) 1.32
High utilizers of emergency health services in a population-based cohort of homeless adults. Am J Public Health (2013) 1.23
Tracheostomy timing in traumatic brain injury: a propensity-matched cohort study. J Trauma Acute Care Surg (2014) 1.22
Clinical and temporal patterns of severe pneumonia causing critical illness during Hajj. BMC Infect Dis (2012) 1.22
Understanding organ dysfunction in Ebola virus disease. Intensive Care Med (2014) 1.19
Adjuvant therapy for resected gastric cancer--rapid, yet incomplete adoption following results of intergroup 0116 trial. Int J Radiat Oncol Biol Phys (2007) 1.18
Just ask: discussing goals of care with patients in hospital with serious illness. CMAJ (2013) 1.14
Effectiveness of the P.A.R.T.Y. (Prevent Alcohol and Risk-related Trauma in Youth) program in preventing traumatic injuries: a 10-year analysis. J Trauma (2011) 1.12
A comprehensive assessment of health care utilization among homeless adults under a system of universal health insurance. Am J Public Health (2013) 1.12
Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis. Crit Care (2011) 1.10
Impact of interhospital transfer on outcomes for trauma patients: a systematic review. J Trauma (2011) 1.07
A meta-analysis of D1 versus D2 lymph node dissection. Gastric Cancer (2011) 1.06
A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause (2006) 1.05
Criterion and convergent validity of the Montreal cognitive assessment with screening and standardized neuropsychological testing. J Am Geriatr Soc (2013) 1.05
Feedback GAP: study protocol for a cluster-randomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary care. Implement Sci (2010) 1.05
Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care (2011) 1.02
2009 influenza A (H1N1): a clinical review. Hosp Pract (1995) (2010) 1.01
Informed decision-making in elective major vascular surgery: analysis of 145 surgeon-patient consultations. Can J Surg (2011) 1.00
Intracranial pressure monitoring in severe traumatic brain injury: results from the American College of Surgeons Trauma Quality Improvement Program. J Neurotrauma (2013) 0.99
Patient outcome study of concurrent chemoradiation, external beam radiotherapy, and high-dose rate brachytherapy in locally advanced carcinoma of the cervix. Int J Gynecol Cancer (2010) 0.99
Hypofractionated concomitant intensity-modulated radiotherapy boost for high-risk prostate cancer: late toxicity. Int J Radiat Oncol Biol Phys (2011) 0.99
Emergency department length of stay for patients requiring mechanical ventilation: a prospective observational study. Scand J Trauma Resusc Emerg Med (2012) 0.97
Protective effect of metformin in CD1 mice placed on a high carbohydrate-high fat diet. Biochem Biophys Res Commun (2010) 0.95
Risk factors associated with resistance to ciprofloxacin in clinical bacterial isolates from intensive care unit patients. Infect Control Hosp Epidemiol (2007) 0.94
A randomized clinical trial to assess the impact on an emergency response system on anxiety and health care use among older emergency patients after a fall. Acad Emerg Med (2007) 0.93
Dispersal of respiratory droplets with open vs closed oxygen delivery masks: implications for the transmission of severe acute respiratory syndrome. Chest (2004) 0.93
Blood conservation strategies to reduce the need for red blood cell transfusion in critically ill patients. CMAJ (2008) 0.93
Methicillin-resistant Staphylococcus aureus in Canadian aboriginal people. Infect Control Hosp Epidemiol (2006) 0.93
Drug problems among homeless individuals in Toronto, Canada: prevalence, drugs of choice, and relation to health status. BMC Public Health (2010) 0.92
Derivation and evaluation of a termination of resuscitation clinical prediction rule for advanced life support providers. Resuscitation (2007) 0.92
Robotically assisted ablation of atrial fibrillation: a systematic review and meta-analysis. Int J Cardiol (2013) 0.90
Approaches to empiric ablation of slow pathway: results from the Canadian EP web survey. J Interv Card Electrophysiol (2012) 0.89
Homelessness and the response to emerging infectious disease outbreaks: lessons from SARS. J Urban Health (2008) 0.89
Recombinant activated coagulation factor VII and bleeding trauma patients. J Trauma (2006) 0.89
Outcome after traumatic brain injury sustained in older adulthood: a one-year longitudinal study. Am J Geriatr Psychiatry (2006) 0.89
Cat naps: an elderly woman with recurrent syncope. CMAJ (2003) 0.89
An innovative telemedicine knowledge translation program to improve quality of care in intensive care units: protocol for a cluster randomized pragmatic trial. Implement Sci (2009) 0.89
Endoscopic ultrasound versus CT scan for detection of the metastases to the liver: results of a prospective comparative study. J Clin Gastroenterol (2009) 0.88
Predictors of medical or surgical and psychiatric hospitalizations among a population-based cohort of homeless adults. Am J Public Health (2013) 0.88
Randomized, double-blinded, placebo-controlled, trial of risedronate for the prevention of bone mineral density loss in nonmetastatic prostate cancer patients receiving radiation therapy plus androgen deprivation therapy. Int J Radiat Oncol Biol Phys (2012) 0.88
Complexity of MRI white matter hyperintensity assessments in relation to cognition in aging and dementia from the Sunnybrook Dementia Study. J Alzheimers Dis (2011) 0.87
A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care. Crit Care (2007) 0.87
The optimal timing of intestinal transplantation for children with intestinal failure: a Markov analysis. Ann Surg (2007) 0.86
Traumatic brain injury, Apolipoprotein E-epsilon4, and cognition in older adults: a two-year longitudinal study. J Neuropsychiatry Clin Neurosci (2008) 0.86
Postpartum assessment of the renin angiotensin system in women with previous severe, early-onset preeclampsia. J Clin Endocrinol Metab (2011) 0.86
The Toronto prehospital hypertonic resuscitation--head injury and multiorgan dysfunction trial: feasibility study of a randomized controlled trial. J Crit Care (2010) 0.86
The impact of treatment modality on infection-related hospitalization rates in peritoneal dialysis and hemodialysis patients. Perit Dial Int (2010) 0.86
Neuropsychological predictors of self-neglect in cognitively impaired older people who live alone. Am J Geriatr Psychiatry (2007) 0.86
Laser trabeculoplasty: an investigation into factors that might influence outcomes. Can J Ophthalmol (2011) 0.85
Lipid membrane composition influences drug release from dioleoylphosphatidylethanolamine-based liposomes on exposure to ultrasound. Int J Pharm (2010) 0.85
Perioperative vasopressors are associated with an increased risk of gastrointestinal anastomotic leakage. World J Surg (2007) 0.84
Personalized Surgery for Gastric Adenocarcinoma: A Meta-analysis of D1 versus D2 Lymphadenectomy. Ann Surg Oncol (2014) 0.84
Ebola care and research protocols. Intensive Care Med (2014) 0.84
Hypertension analysis of stress reduction using mindfulness meditation and yoga: results from the HARMONY randomized controlled trial. Am J Hypertens (2013) 0.83