Published in Mol Cell on March 26, 2010
Driving the cell cycle with a minimal CDK control network. Nature (2010) 2.79
Ultrasensitivity in the Regulation of Cdc25C by Cdk1. Mol Cell (2011) 2.27
A link between mitotic entry and membrane growth suggests a novel model for cell size control. J Cell Biol (2012) 1.70
Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules (2012) 1.44
Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development (2011) 1.42
The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell (2010) 1.29
Spatial positive feedback at the onset of mitosis. Cell (2012) 1.26
Multisite phosphorylation networks as signal processors for Cdk1. Nat Struct Mol Biol (2013) 1.19
A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast. Mol Biol Cell (2011) 1.17
Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation. Dev Cell (2012) 1.03
Cks confers specificity to phosphorylation-dependent CDK signaling pathways. Nat Struct Mol Biol (2013) 0.99
A Wee1 checkpoint inhibits anaphase onset. J Cell Biol (2013) 0.98
The Zds proteins control entry into mitosis and target protein phosphatase 2A to the Cdc25 phosphatase. Mol Biol Cell (2010) 0.98
Spatiotemporal regulations of Wee1 at the G2/M transition. Mol Biol Cell (2011) 0.96
Rising cyclin-CDK levels order cell cycle events. PLoS One (2011) 0.95
Meiotic progression in Arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM. Plant Cell (2010) 0.94
Regulated protein kinases and phosphatases in cell cycle decisions. Curr Opin Cell Biol (2010) 0.91
Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation. Mol Biol Cell (2011) 0.89
In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation? Nat Rev Cancer (2013) 0.89
Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells. Dev Cell (2015) 0.88
Wee1 and Cdc25 are controlled by conserved PP2A-dependent mechanisms in fission yeast. Cell Cycle (2017) 0.84
A nontranscriptional role for Oct4 in the regulation of mitotic entry. Proc Natl Acad Sci U S A (2014) 0.82
Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry. Cell Div (2010) 0.82
Transcriptional regulation is a major controller of cell cycle transition dynamics. PLoS One (2012) 0.81
The kinetics of G2 and M transitions regulated by B cyclins. PLoS One (2013) 0.81
Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategies. Mol Cell Biochem (2016) 0.80
Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch. Front Physiol (2012) 0.80
Erroneous Silencing of the Mitotic Checkpoint by Aberrant Spindle Pole-Kinetochore Coordination. Biophys J (2015) 0.80
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun (2015) 0.80
AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta (2014) 0.79
Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae. Genetics (2015) 0.78
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. Cell Discov (2015) 0.77
Flavonoids as CDK1 Inhibitors: Insights in Their Binding Orientations and Structure-Activity Relationship. PLoS One (2016) 0.75
14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression. Sci Rep (2016) 0.75
The G2 checkpoint-a node-based molecular switch. FEBS Open Bio (2017) 0.75
Protein Phosphatases Involved in Regulating Mitosis: Facts and Hypotheses. Mol Cells (2016) 0.75
Cyclin A is required at two points in the human cell cycle. EMBO J (1992) 7.96
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18
Cyclin activation of p34cdc2. Cell (1990) 6.87
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol (2003) 5.86
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell (1993) 4.37
Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol (2003) 4.31
The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle. EMBO J (1990) 4.25
Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat Struct Biol (1996) 3.81
Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell (2005) 3.10
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J (1995) 2.96
Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell (2007) 2.88
Activation of human cyclin-dependent kinases in vitro. Mol Biol Cell (1992) 2.68
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell (2007) 2.35
Human cyclin A is required for mitosis until mid prophase. J Cell Biol (1999) 2.31
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell (2007) 2.22
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell (2009) 2.05
Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. PLoS Biol (2007) 1.64
Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome. J Cell Biol (2005) 1.63
Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol (2007) 1.63
Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis. J Cell Biol (1999) 1.59
Role for cyclin A in the dependence of mitosis on completion of DNA replication. Nature (1991) 1.58
Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor. Mol Biol Cell (2007) 1.44
Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2. J Cell Biol (1992) 1.43
Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. EMBO J (1992) 1.41
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem (2006) 1.39
Multisite M-phase phosphorylation of Xenopus Wee1A. Mol Cell Biol (2005) 1.37
Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events. Oncogene (2008) 1.35
Modeling M-phase control in Xenopus oocyte extracts: the surveillance mechanism for unreplicated DNA. Biophys Chem (1998) 1.29
Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene (2001) 1.29
Timing of events in mitosis. Curr Biol (2002) 1.20
An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts. Proc Natl Acad Sci U S A (1996) 1.15
Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase. Proc Natl Acad Sci U S A (2007) 1.13
The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle. EMBO J (2002) 1.12
Different thresholds of MPF inactivation are responsible for controlling different mitotic events in mammalian cell division. Cell Cycle (2007) 0.90
Cyclin B1 expression in HeLa S3 cells studied by flow cytometry. Exp Cell Res (1994) 0.89
A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer Res (2004) 0.83
Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A (2014) 14.78
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature (2004) 3.62
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell (2006) 2.91
Using buoyant mass to measure the growth of single cells. Nat Methods (2010) 2.67
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36
Direct observation of mammalian cell growth and size regulation. Nat Methods (2012) 2.34
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Mol Cell Proteomics (2005) 2.12
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol (2004) 2.11
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell (2009) 2.08
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell (2005) 2.05
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature (2013) 2.02
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol (2004) 1.99
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
Self-assembly of filopodia-like structures on supported lipid bilayers. Science (2010) 1.87
Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proc Natl Acad Sci U S A (2005) 1.83
Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A (2003) 1.77
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Dev Cell (2011) 1.76
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell (2003) 1.56
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem (2002) 1.40
Optimizing optical flow cytometry for cell volume-based sorting and analysis. PLoS One (2011) 1.39
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol (2004) 1.39
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development (2003) 1.35
Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A (2008) 1.34
Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol (2010) 1.24
Kinetic responses of β-catenin specify the sites of Wnt control. Science (2012) 1.23
Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci U S A (2009) 1.23
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development (2005) 1.20
Timing of events in mitosis. Curr Biol (2002) 1.20
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (2009) 1.15
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res (2009) 1.15
Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.15
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol (2006) 1.12
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
Remodeling of the metabolome during early frog development. PLoS One (2011) 1.12
Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell (2013) 1.12
Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A (2011) 1.11
Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A (2013) 1.07
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. Nat Cell Biol (2013) 1.06
Graded positional information: interpretation for both fate and guidance. Cell (2003) 1.05
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci (2007) 1.04
Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development (2003) 1.02
Anaphase specific auto-cleavage of separase. FEBS Lett (2002) 1.01
The relationship between evolutionary and physiological variation in hemoglobin. Proc Natl Acad Sci U S A (2007) 1.01
Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Anal Chem (2012) 0.98
Domain structure of separase and its binding to securin as determined by EM. Nat Struct Mol Biol (2005) 0.98
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proc Natl Acad Sci U S A (2013) 0.96
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep (2013) 0.93
Exploiting polypharmacology for drug target deconvolution. Proc Natl Acad Sci U S A (2014) 0.93
Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol (2005) 0.89
Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell (2005) 0.88
In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods Enzymol (2006) 0.87
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods Enzymol (2006) 0.87
Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc (2014) 0.84
Protein microarrays for genome-wide posttranslational modification analysis. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A (2013) 0.83
Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Res (2002) 0.80
Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Curr Protoc Protein Sci (2014) 0.76