PubRank

Eric J Brown

Author PubWeight™ 150.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
2 Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 2002 17.71
3 The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 2005 7.18
4 Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 2007 6.02
5 A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol 2004 3.53
6 Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A 2007 3.51
7 Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004 3.20
8 C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006 2.72
9 Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J 2007 2.61
10 Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest 2005 2.38
11 Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. J Exp Med 2003 2.30
12 ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. Cell Microbiol 2008 2.01
13 A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog 2007 2.00
14 Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog 2009 1.96
15 Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy. Mol Microbiol 2003 1.91
16 PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep 2009 1.89
17 Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res 2010 1.82
18 The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A 2006 1.67
19 Macrophage complement receptors and pathogen clearance. Cell Microbiol 2007 1.65
20 HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A 2009 1.59
21 Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival. Infect Immun 2003 1.59
22 Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathog 2009 1.55
23 ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem 2008 1.55
24 RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep 2013 1.53
25 Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet 2009 1.51
26 Interactions between CD47 and thrombospondin reduce inflammation. J Immunol 2007 1.46
27 Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR. J Clin Invest 2011 1.46
28 Mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium. Microbes Infect 2004 1.43
29 Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. Mol Cell Biol 2008 1.37
30 Polar localization of virulence-related Esx-1 secretion in mycobacteria. PLoS Pathog 2009 1.32
31 A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages. Infect Immun 2006 1.31
32 Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. PLoS Pathog 2010 1.31
33 Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature 2010 1.29
34 Role of the WASP family proteins for Mycobacterium marinum actin tail formation. Proc Natl Acad Sci U S A 2005 1.25
35 Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity 2003 1.21
36 Aberrant Epstein-Barr viral infection in systemic lupus erythematosus. Autoimmun Rev 2009 1.20
37 Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47. Blood 2002 1.20
38 CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol 2008 1.19
39 Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood 2002 1.19
40 A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells. Cell Microbiol 2002 1.18
41 A delicate dance: host response to mycobacteria. Curr Opin Immunol 2011 1.18
42 RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. Genes Dev 2013 1.17
43 Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J Cell Biol 2009 1.15
44 Replicative stress, stem cells and aging. Mech Ageing Dev 2008 1.14
45 Actin-based motility of intracellular bacteria, and polarized surface distribution of the bacterial effector molecules. J Cell Physiol 2006 1.14
46 Cytosol as battleground: ubiquitin as a weapon for both host and pathogen. Trends Cell Biol 2010 1.13
47 The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbetagamma. J Cell Biol 2003 1.09
48 Dual regulation of SIRPalpha phosphorylation by integrins and CD47. J Biol Chem 2007 1.08
49 Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection. Proc Natl Acad Sci U S A 2008 1.08
50 Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol 2011 1.07
51 Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection. J Infect Dis 2013 1.07
52 ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. Am J Physiol Gastrointest Liver Physiol 2006 1.03
53 Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. Genesis 2007 1.03
54 Actin-bundling protein L-plastin regulates T cell activation. J Immunol 2010 1.01
55 ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing. Genes Dev 2013 1.01
56 Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication. J Biol Chem 2008 1.00
57 ATR maintains select progenitors during nervous system development. EMBO J 2012 1.00
58 The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis. Mol Biol Cell 2008 0.99
59 Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. PLoS Pathog 2013 0.98
60 The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol 2010 0.97
61 Removing all obstacles: a critical role for p53 in promoting tissue renewal. Cell Cycle 2010 0.94
62 Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J Biol Chem 2005 0.93
63 Ubiquilins in the crosstalk among proteolytic pathways. Biol Chem 2012 0.93
64 Transmembrane mutations to FcgammaRIIA alter its association with lipid rafts: implications for receptor signaling. J Immunol 2007 0.91
65 Novel CD47-dependent intercellular adhesion modulates cell migration. J Cell Physiol 2005 0.90
66 Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect. Neuropsychopharmacology 2011 0.89
67 In vivo bioimaging tracks conditionally replicative adenoviral replication and provides an early indication of viral antitumor efficacy. Cancer Sci 2009 0.89
68 Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase. J Leukoc Biol 2010 0.88
69 Coxiella burnetii avoids macrophage phagocytosis by interfering with spatial distribution of complement receptor 3. J Immunol 2003 0.87
70 Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow. Blood 2003 0.86
71 EccA1, a component of the Mycobacterium marinum ESX-1 protein virulence factor secretion pathway, regulates mycolic acid lipid synthesis. Chem Biol 2012 0.86
72 Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation. Autophagy 2009 0.85
73 Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis. J Infect Dis 2013 0.85
74 Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery. EMBO Rep 2013 0.84
75 Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res 2004 0.82
76 Chk'ing p53-deficient breast cancers. J Clin Invest 2012 0.81
77 Chemotaxis of non-compressed blood polymorphonuclear leukocytes from an adolescent with severe leukocyte adhesion deficiency. Am J Hematol 2003 0.80
78 Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in vivo. Infect Immun 2012 0.80
79 Cell biology. The art of making an exit. Science 2009 0.77
80 Impaired FcεRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins. Blood 2011 0.75