Published in Science on March 27, 2009
Multifaceted roles of tunneling nanotubes in intercellular communication. Front Physiol (2012) 1.21
Prison break: pathogens' strategies to egress from host cells. Microbiol Mol Biol Rev (2012) 0.97
Tuberculosis: new aspects of an old disease. Int J Cell Biol (2011) 0.83
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02
A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol (2004) 3.53
Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol (2004) 3.20
C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science (2006) 2.72
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. J Exp Med (2003) 2.30
ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. Cell Microbiol (2008) 2.01
A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathog (2007) 2.00
Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog (2009) 1.96
Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy. Mol Microbiol (2003) 1.91
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep (2009) 1.89
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A (2006) 1.67
Macrophage complement receptors and pathogen clearance. Cell Microbiol (2007) 1.65
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A (2009) 1.59
Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival. Infect Immun (2003) 1.59
Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathog (2009) 1.55
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet (2009) 1.51
Interactions between CD47 and thrombospondin reduce inflammation. J Immunol (2007) 1.46
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR. J Clin Invest (2011) 1.46
Mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium. Microbes Infect (2004) 1.43
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. Mol Cell Biol (2008) 1.37
Polar localization of virulence-related Esx-1 secretion in mycobacteria. PLoS Pathog (2009) 1.32
Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. PLoS Pathog (2010) 1.31
A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages. Infect Immun (2006) 1.31
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature (2010) 1.29
Role of the WASP family proteins for Mycobacterium marinum actin tail formation. Proc Natl Acad Sci U S A (2005) 1.25
Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity (2003) 1.21
Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47. Blood (2002) 1.20
Aberrant Epstein-Barr viral infection in systemic lupus erythematosus. Autoimmun Rev (2009) 1.20
CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol (2008) 1.19
Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood (2002) 1.19
A delicate dance: host response to mycobacteria. Curr Opin Immunol (2011) 1.18
A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells. Cell Microbiol (2002) 1.18
RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. Genes Dev (2013) 1.17
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J Cell Biol (2009) 1.15
Replicative stress, stem cells and aging. Mech Ageing Dev (2008) 1.14
Actin-based motility of intracellular bacteria, and polarized surface distribution of the bacterial effector molecules. J Cell Physiol (2006) 1.14
Cytosol as battleground: ubiquitin as a weapon for both host and pathogen. Trends Cell Biol (2010) 1.13
The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbetagamma. J Cell Biol (2003) 1.09
Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection. Proc Natl Acad Sci U S A (2008) 1.08
Dual regulation of SIRPalpha phosphorylation by integrins and CD47. J Biol Chem (2007) 1.08
Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol (2011) 1.07
Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection. J Infect Dis (2013) 1.07
ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. Am J Physiol Gastrointest Liver Physiol (2006) 1.03
Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. Genesis (2007) 1.03
Actin-bundling protein L-plastin regulates T cell activation. J Immunol (2010) 1.01
ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing. Genes Dev (2013) 1.01
Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication. J Biol Chem (2008) 1.00
ATR maintains select progenitors during nervous system development. EMBO J (2012) 1.00
The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis. Mol Biol Cell (2008) 0.99
Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. PLoS Pathog (2013) 0.98
The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol (2010) 0.97
Removing all obstacles: a critical role for p53 in promoting tissue renewal. Cell Cycle (2010) 0.94
Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J Biol Chem (2005) 0.93
Ubiquilins in the crosstalk among proteolytic pathways. Biol Chem (2012) 0.93
Transmembrane mutations to FcgammaRIIA alter its association with lipid rafts: implications for receptor signaling. J Immunol (2007) 0.91
Novel CD47-dependent intercellular adhesion modulates cell migration. J Cell Physiol (2005) 0.90
Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect. Neuropsychopharmacology (2011) 0.89
In vivo bioimaging tracks conditionally replicative adenoviral replication and provides an early indication of viral antitumor efficacy. Cancer Sci (2009) 0.89
Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase. J Leukoc Biol (2010) 0.88
Coxiella burnetii avoids macrophage phagocytosis by interfering with spatial distribution of complement receptor 3. J Immunol (2003) 0.87
EccA1, a component of the Mycobacterium marinum ESX-1 protein virulence factor secretion pathway, regulates mycolic acid lipid synthesis. Chem Biol (2012) 0.86
Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow. Blood (2003) 0.86
Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation. Autophagy (2009) 0.85
Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis. J Infect Dis (2013) 0.85
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery. EMBO Rep (2013) 0.84
Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res (2004) 0.82
Chk'ing p53-deficient breast cancers. J Clin Invest (2012) 0.81
Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in vivo. Infect Immun (2012) 0.80
Chemotaxis of non-compressed blood polymorphonuclear leukocytes from an adolescent with severe leukocyte adhesion deficiency. Am J Hematol (2003) 0.80
Impaired FcεRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins. Blood (2011) 0.75