Published in Crit Care Med on May 01, 2007
Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward. Crit Care Med (2007) 3.05
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA (2009) 5.61
New insights into atopic dermatitis. J Clin Invest (2004) 5.09
Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med (2006) 4.62
Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med (2005) 4.49
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med (2005) 3.80
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol (2003) 3.41
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg (2013) 3.14
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med (2006) 2.84
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med (2007) 2.52
Differences between early and late readmissions among patients: a cohort study. Ann Intern Med (2015) 2.41
Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32
Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med (2011) 2.30
Do outcomes of near syncope parallel syncope? Am J Emerg Med (2010) 2.23
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int (2013) 2.17
Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria. Crit Care Med (2011) 2.11
Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med (2007) 1.95
Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortality. Crit Care Med (2007) 1.94
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically ill. Intensive Care Med (2012) 1.86
Acid-suppressive medication use and the risk for nosocomial gastrointestinal tract bleeding. Arch Intern Med (2011) 1.81
When policy gets it right: variability in u.s. Hospitals' diagnosis of ventilator-associated pneumonia*. Crit Care Med (2014) 1.79
Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities. J Immunol (2005) 1.78
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol (2007) 1.77
International validation of the out-of-hospital cardiac arrest score in the United States. Crit Care Med (2011) 1.72
National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med (2006) 1.69
International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock (2011) 1.61
Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med (2008) 1.58
IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J Immunol (2007) 1.55
Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma (2009) 1.53
Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc (2009) 1.53
Predictors and correlates of dissatisfaction with intensive care. Crit Care Med (2012) 1.53
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J Immunol (2010) 1.49
Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study. Crit Care Med (2014) 1.48
Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation (2013) 1.48
Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med (2012) 1.48
Teamwork and leadership in cardiopulmonary resuscitation. J Am Coll Cardiol (2011) 1.48
Characteristics of out-of-hospital shock care. Crit Care Med (2011) 1.47
Predicting adverse outcomes in syncope. J Emerg Med (2007) 1.45
Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med (2007) 1.44
C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med (2014) 1.41
Opportunities and Challenges for Reducing Hospital Revisits. Ann Intern Med (2015) 1.38
The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care (2013) 1.34
The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3. J Invest Dermatol (2007) 1.32
Charlson Index is associated with one-year mortality in emergency department patients with suspected infection. Acad Emerg Med (2006) 1.32
Red cell distribution width improves the simplified acute physiology score for risk prediction in unselected critically ill patients. Crit Care (2012) 1.26
Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med (2012) 1.24
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A (2009) 1.23
The costs and cost-effectiveness of an integrated sepsis treatment protocol. Crit Care Med (2008) 1.22
Identifying patients for early discharge: performance of decision rules among patients with acute chest pain. Int J Cardiol (2012) 1.20
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response. J Allergy Clin Immunol (2011) 1.19
Biomarkers of endothelial cell activation in early sepsis. Shock (2013) 1.18
TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier. J Invest Dermatol (2011) 1.18
Opportunities for Emergency Medical Services care of sepsis. Resuscitation (2009) 1.17
Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med (2009) 1.16
Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med (2011) 1.16
Chronic medical conditions and risk of sepsis. PLoS One (2012) 1.16
Risk factors for nosocomial gastrointestinal bleeding and use of acid-suppressive medication in non-critically ill patients. J Gen Intern Med (2013) 1.13
Variation in Inpatient Consultation Among Older Adults in the United States. J Gen Intern Med (2015) 1.11
Performance of severity of illness scoring systems in emergency department patients with infection. Acad Emerg Med (2007) 1.10
Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus. J Allergy Clin Immunol (2006) 1.09
Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study. BMJ Open (2014) 1.08
Statin therapy is associated with decreased mortality in patients with infection. Acad Emerg Med (2009) 1.07
Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol (2007) 1.05
Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults. Crit Care (2014) 1.05
Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care (2011) 1.04
High-sensitivity C-reactive protein and risk of sepsis. PLoS One (2013) 0.98
Inflammatory and endothelial activation biomarkers and risk of sepsis: a nested case-control study. J Crit Care (2013) 0.97
Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department. Acad Emerg Med (2013) 0.97
Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency Department. J Emerg Med (2008) 0.96
Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection. Ann Emerg Med (2010) 0.96
Guillain-Barré syndrome in the emergency department. Ann Emerg Med (2005) 0.96
Strategies to prevent ventilator-associated pneumonia in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol (2014) 0.95
The value of cardiac enzymes in elderly patients presenting to the emergency department with syncope. J Gerontol A Biol Sci Med Sci (2003) 0.94
Vaccinia virus-specific molecular signature in atopic dermatitis skin. J Allergy Clin Immunol (2010) 0.94
Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer. Acad Emerg Med (2010) 0.94
Emergency department abnormal vital sign "triggers" program improves time to therapy. Acad Emerg Med (2011) 0.93
Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion (2012) 0.92
Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med (2011) 0.92
Obesity and risk of sepsis: a population-based cohort study. Obesity (Silver Spring) (2013) 0.91
Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock (2013) 0.91
Reducing admissions utilizing the Boston Syncope Criteria. J Emerg Med (2011) 0.91