Published in Acad Emerg Med on July 13, 2007
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
Factors associated with nonadherence to early goal-directed therapy in the ED. Chest (2010) 3.23
Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes. Chest (2011) 1.33
Meta-analysis of protocolized goal-directed hemodynamic optimization for the management of severe sepsis and septic shock in the Emergency Department. West J Emerg Med (2014) 0.87
Lactate clearance for assessing response to resuscitation in severe sepsis. Acad Emerg Med (2013) 0.84
A Qualitative Study Exploring Factors Associated with Provider Adherence to Severe Pediatric Traumatic Brain Injury Guidelines. J Neurotrauma (2016) 0.81
Early goal-directed therapy reduces mortality in adult patients with severe sepsis and septic shock: Systematic review and meta-analysis. Indian J Crit Care Med (2015) 0.77
The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock. Ann Intensive Care (2017) 0.75
Outcomes before and after the Implementation of a Critical Pathway for Patients with Acute Aortic Disease. Yonsei Med J (2016) 0.75
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
The quality of health care delivered to adults in the United States. N Engl J Med (2003) 50.33
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest (2006) 5.31
Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med (2006) 4.62
The paths from research to improved health outcomes. ACP J Club (2005) 2.61
Deaths: preliminary data for 2002. Natl Vital Stat Rep (2004) 2.07
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med (2006) 1.82
Knowledge translation: closing the evidence-to-practice gap. Ann Emerg Med (2006) 1.81
Using checklists and reminders in clinical pathways to improve hospital inpatient care. Med J Aust (2004) 1.32
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med (2005) 3.80
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg (2013) 3.14
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med (2009) 2.92
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med (2007) 2.52
Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32
Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med (2011) 2.30
Do outcomes of near syncope parallel syncope? Am J Emerg Med (2010) 2.23
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med (2006) 1.69
Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol. Crit Care Med (2011) 1.65
International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock (2011) 1.61
Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med (2008) 1.58
Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma (2009) 1.53
Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc (2009) 1.53
Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med (2012) 1.48
Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation (2013) 1.48
Characteristics of out-of-hospital shock care. Crit Care Med (2011) 1.47
Predicting adverse outcomes in syncope. J Emerg Med (2007) 1.45
Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med (2007) 1.44
C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med (2014) 1.41
The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care (2013) 1.34
Charlson Index is associated with one-year mortality in emergency department patients with suspected infection. Acad Emerg Med (2006) 1.32
Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med (2012) 1.24
Identifying patients for early discharge: performance of decision rules among patients with acute chest pain. Int J Cardiol (2012) 1.20
Biomarkers of endothelial cell activation in early sepsis. Shock (2013) 1.18
Opportunities for Emergency Medical Services care of sepsis. Resuscitation (2009) 1.17
Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med (2009) 1.16
Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med (2011) 1.16
Chronic medical conditions and risk of sepsis. PLoS One (2012) 1.16
Performance of severity of illness scoring systems in emergency department patients with infection. Acad Emerg Med (2007) 1.10
Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study. BMJ Open (2014) 1.08
Evidence-based emergency medicine/systematic review abstract. What vasopressors should be used to treat shock? Ann Emerg Med (2007) 1.08
Statin therapy is associated with decreased mortality in patients with infection. Acad Emerg Med (2009) 1.07
Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults. Crit Care (2014) 1.05
Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care (2011) 1.04
High-sensitivity C-reactive protein and risk of sepsis. PLoS One (2013) 0.98
Inflammatory and endothelial activation biomarkers and risk of sepsis: a nested case-control study. J Crit Care (2013) 0.97
Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department. Acad Emerg Med (2013) 0.97
Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency Department. J Emerg Med (2008) 0.96
Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection. Ann Emerg Med (2010) 0.96
Guillain-Barré syndrome in the emergency department. Ann Emerg Med (2005) 0.96
The value of cardiac enzymes in elderly patients presenting to the emergency department with syncope. J Gerontol A Biol Sci Med Sci (2003) 0.94
Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer. Acad Emerg Med (2010) 0.94
Emergency department abnormal vital sign "triggers" program improves time to therapy. Acad Emerg Med (2011) 0.93
Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion (2012) 0.92
Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med (2011) 0.92
Obesity and risk of sepsis: a population-based cohort study. Obesity (Silver Spring) (2013) 0.91
Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection. J Emerg Med (2010) 0.91
Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock (2013) 0.91
Reducing admissions utilizing the Boston Syncope Criteria. J Emerg Med (2011) 0.91
Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock (2012) 0.91
Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med (2012) 0.89
Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock (2012) 0.89
Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Acad Emerg Med (2011) 0.88
Diagnostic characteristics of a clinical screening tool in combination with measuring bedside lactate level in emergency department patients with suspected sepsis. Acad Emerg Med (2014) 0.87
Risk factors for radiocontrast nephropathy after emergency department contrast-enhanced computerized tomography. Acad Emerg Med (2013) 0.87
Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. J Am Geriatr Soc (2014) 0.86
Bench-to-bedside review: future novel diagnostics for sepsis - a systems biology approach. Crit Care (2013) 0.86
Identifying patients with cellulitis who are likely to require inpatient admission after a stay in an ED observation unit. Am J Emerg Med (2012) 0.85
Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection. J Emerg Med (2010) 0.85
Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability. J Crit Care (2012) 0.84
N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. Ann Emerg Med (2013) 0.84
Impact of older age and nursing home residence on clinical outcomes of US emergency department visits for severe sepsis. J Crit Care (2013) 0.83
Can benign etiologies predict benign outcomes in high-risk syncope patients? J Emerg Med (2009) 0.83
The microcirculation is preserved in emergency department low-acuity sepsis patients without hypotension. Acad Emerg Med (2014) 0.82
Derivation of Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis. Crit Care Med (2016) 0.81
The microcirculation as a diagnostic and therapeutic target in sepsis. Intern Emerg Med (2009) 0.81
Applying the Boston syncope criteria to near syncope. J Emerg Med (2012) 0.80
Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock (2014) 0.80
Goal-directed hemodynamic optimization in the post-cardiac arrest syndrome: a systematic review. Resuscitation (2007) 0.80
Multicenter, randomized trial of quantitative pretest probability to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Circ Cardiovasc Imaging (2013) 0.79
Sex differences in the emergency department evaluation of elderly patients with syncope. J Gerontol A Biol Sci Med Sci (2005) 0.79
RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. Am J Pathol (2010) 0.79
Is telemetry useful in evaluating chest pain patients in an observation unit? Intern Emerg Med (2011) 0.78
Association of body mass index with increased cost of care and length of stay for emergency department patients with chest pain and dyspnea. Circ Cardiovasc Qual Outcomes (2014) 0.78
Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients. Crit Care Res Pract (2012) 0.78
Transcriptomics may pave the biomarker road in sepsis*. Crit Care Med (2014) 0.77
A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation. Crit Care Med (2010) 0.77
The Utility of Inflammatory and Endothelial Markers to Identify Infection in Emergency Department Patients. Shock (2015) 0.77
Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis. Shock (2016) 0.77
Prediction of bacteremia in the emergency department: an external validation of a clinical decision rule. Eur J Emerg Med (2016) 0.77
The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock. Crit Care Med (2017) 0.77
Surviving sepsis outside the intensive care unit. Crit Care Med (2007) 0.76
End expiratory oxygen concentrations to predict central venous oxygen saturation: an observational pilot study. BMC Emerg Med (2006) 0.75