Published in Mol Cell Biol on April 23, 2007
Circadian organization of behavior and physiology in Drosophila. Annu Rev Physiol (2010) 2.36
Molecular genetic analysis of circadian timekeeping in Drosophila. Adv Genet (2011) 2.04
Post-translational modifications in circadian rhythms. Trends Biochem Sci (2009) 1.80
Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell (2009) 1.79
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock. Genes Dev (2008) 1.70
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. Genes Dev (2010) 1.57
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. Mol Cell Biol (2009) 1.57
Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. Genes Dev (2007) 1.43
NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed. Cell (2011) 1.41
Circadian transcription contributes to core period determination in Drosophila. PLoS Biol (2008) 1.40
G protein-coupled receptor kinase 2 is required for rhythmic olfactory responses in Drosophila. Curr Biol (2008) 1.32
DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock. Mol Cell Biol (2009) 1.27
A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks. J Neurosci (2010) 1.22
A role for O-GlcNAcylation in setting circadian clock speed. Genes Dev (2012) 1.21
Activating PER repressor through a DBT-directed phosphorylation switch. PLoS Biol (2008) 1.20
A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity. Mol Cell Biol (2007) 1.20
Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra. Curr Biol (2013) 1.17
Control of WHITE COLLAR localization by phosphorylation is a critical step in the circadian negative feedback process. EMBO J (2008) 1.13
Dominant-negative CK2alpha induces potent effects on circadian rhythmicity. PLoS Genet (2007) 1.09
Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFkappaB Relish. BMC Neurosci (2010) 1.07
The novel gene twenty-four defines a critical translational step in the Drosophila clock. Nature (2011) 1.06
Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration. Biophys J (2009) 0.93
Phosphorylation of the transcription activator CLOCK regulates progression through a ∼ 24-h feedback loop to influence the circadian period in Drosophila. J Biol Chem (2014) 0.91
TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo. J Neurosci (2008) 0.90
A master CLOCK hard at work brings rhythm to the transcriptome. Genes Dev (2011) 0.89
Two distinct modes of PERIOD recruitment onto dCLOCK reveal a novel role for TIMELESS in circadian transcription. J Neurosci (2010) 0.89
Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function. Genetics (2008) 0.88
CULLIN-3 controls TIMELESS oscillations in the Drosophila circadian clock. PLoS Biol (2012) 0.87
Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. PLoS Genet (2013) 0.87
Functional analysis of Casein Kinase 1 in a minimal circadian system. PLoS One (2013) 0.86
Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation. PLoS Genet (2014) 0.83
The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator. PLoS Biol (2013) 0.82
Of switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation. EMBO Rep (2010) 0.82
Modeling the Drosophila melanogaster circadian oscillator via phase optimization. J Biol Rhythms (2008) 0.81
Mechanism of the Neurospora circadian clock, a FREQUENCY-centric view. Biochemistry (2014) 0.81
A role for the PERIOD:PERIOD homodimer in the Drosophila circadian clock. PLoS Biol (2009) 0.81
Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment. PLoS Genet (2014) 0.80
Natural variation in the Drosophila melanogaster clock gene period modulates splicing of its 3'-terminal intron and mid-day siesta. PLoS One (2012) 0.80
A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein. Genetics (2011) 0.79
Casein kinase 1 promotes synchrony of the circadian clock network. Mol Cell Biol (2014) 0.79
The Catalytic and Non-catalytic Functions of the Brahma Chromatin-Remodeling Protein Collaborate to Fine-Tune Circadian Transcription in Drosophila. PLoS Genet (2015) 0.78
Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga. BMC Cell Biol (2013) 0.78
A role for timely nuclear translocation of clock repressor proteins in setting circadian clock speed. Exp Neurobiol (2014) 0.77
Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation. Proc Natl Acad Sci U S A (2016) 0.75
Circadian Rhythms and Sleep in Drosophila melanogaster. Genetics (2017) 0.75
Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila. Mol Cell Biol (2015) 0.75
Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD. Genes Dev (2016) 0.75
Rhythmic Behavior Is Controlled by the SRm160 Splicing Factor in Drosophila melanogaster. Genetics (2017) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Molecular bases for circadian clocks. Cell (1999) 13.96
Time zones: a comparative genetics of circadian clocks. Nat Rev Genet (2001) 8.98
Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A (1971) 8.63
Posttranslational mechanisms regulate the mammalian circadian clock. Cell (2001) 7.93
Molecular components of the mammalian circadian clock. Hum Mol Genet (2006) 7.51
Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science (2005) 7.28
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science (1998) 5.72
double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell (1998) 5.10
PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature (1993) 4.96
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell (1998) 4.59
Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature (2005) 4.39
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature (2002) 4.13
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev (2006) 3.78
Temporal phosphorylation of the Drosophila period protein. Proc Natl Acad Sci U S A (1994) 3.43
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci (2002) 3.34
The circadian timekeeping system of Drosophila. Curr Biol (2005) 3.26
Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science (1996) 3.11
A role for CK2 in the Drosophila circadian oscillator. Nat Neurosci (2003) 3.09
A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell (2001) 3.07
Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol (2005) 3.03
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell (2003) 3.01
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature (2002) 2.99
A role for casein kinase 2alpha in the Drosophila circadian clock. Nature (2002) 2.89
Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science (1995) 2.87
A light-entrainment mechanism for the Drosophila circadian clock. Nature (1996) 2.84
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem (2005) 2.68
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell (2004) 2.62
The F-box protein slimb controls the levels of clock proteins period and timeless. Nature (2002) 2.59
Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol Cell Biol (2000) 2.52
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J Biol Chem (2002) 2.48
PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science (2006) 2.37
Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor. Cell (2005) 2.37
Block in nuclear localization of period protein by a second clock mutation, timeless. Science (1994) 2.37
Regulation of nuclear entry of the Drosophila clock proteins period and timeless. Neuron (1996) 2.35
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria. Proc Natl Acad Sci U S A (2006) 2.34
PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev (2006) 2.31
PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science (2005) 2.29
PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol Cell Biol (1999) 2.29
The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron (1998) 2.20
Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. J Neurosci (2002) 2.16
RNA interference of gene expression (RNAi) in cultured Drosophila cells. Sci STKE (2001) 2.14
Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells. Mol Cell Biol (2002) 2.13
VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron (2003) 2.07
Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators. Mol Cell Biol (1998) 1.96
The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Mol Cell (2004) 1.94
Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron (2001) 1.87
CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop. Genes Dev (2006) 1.85
Interspecific comparison of the period gene of Drosophila reveals large blocks of non-conserved coding DNA. EMBO J (1988) 1.80
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78
dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex. J Neurosci (2000) 1.73
Circadian rhythms in a nutshell. Physiol Genomics (2000) 1.70
Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc Natl Acad Sci U S A (2006) 1.63
Transcription regulation within the circadian clock: the E-box and beyond. J Biol Rhythms (2004) 1.63
A TIMELESS-independent function for PERIOD proteins in the Drosophila clock. Neuron (2000) 1.57
The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J Neurosci (2005) 1.54
Splicing of the period gene 3'-terminal intron is regulated by light, circadian clock factors, and phospholipase C. Mol Cell Biol (2004) 1.51
Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr Biol (2006) 1.50
Differential effects of light and heat on the Drosophila circadian clock proteins PER and TIM. Mol Cell Biol (1998) 1.50
Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol (2004) 1.49
Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. Curr Biol (2000) 1.42
A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription. Curr Biol (2003) 1.37
The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. J Neurosci (2001) 1.35
Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. J Neurosci (2000) 1.33
Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells. J Biol Rhythms (2006) 1.25
In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J Neurosci (2005) 1.24
A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity. Mol Cell Biol (2007) 1.20
Regulating a circadian clock's period, phase and amplitude by phosphorylation: insights from Drosophila. J Biochem (2006) 1.19
Circadian cycling of a PERIOD-beta-galactosidase fusion protein in Drosophila: evidence for cyclical degradation. J Biol Rhythms (1997) 1.12
Casein kinase I in the mammalian circadian clock. Methods Enzymol (2005) 0.95
A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. FEBS Lett (2003) 0.89
Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat Rev Genet (2005) 6.87
A role for CK2 in the Drosophila circadian oscillator. Nat Neurosci (2003) 3.09
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell (2003) 3.01
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature (2002) 2.99
PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev (2006) 2.31
Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila. Curr Biol (2004) 2.20
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol (2007) 2.17
VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron (2003) 2.07
Natural variation in the splice site strength of a clock gene and species-specific thermal adaptation. Neuron (2008) 1.99
The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids. J Biol Chem (2006) 1.94
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock. Genes Dev (2008) 1.70
Regulation of gustatory physiology and appetitive behavior by the Drosophila circadian clock. Curr Biol (2010) 1.68
A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes Dev (2007) 1.66
Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc Natl Acad Sci U S A (2006) 1.63
Circadian oscillators of Drosophila and mammals. J Cell Sci (2006) 1.59
Splicing of the period gene 3'-terminal intron is regulated by light, circadian clock factors, and phospholipase C. Mol Cell Biol (2004) 1.51
Circadian regulation in the ability of Drosophila to combat pathogenic infections. Curr Biol (2008) 1.50
Leptin-promoted cilia assembly is critical for normal energy balance. J Clin Invest (2014) 1.49
Light and temperature control the contribution of specific DN1 neurons to Drosophila circadian behavior. Curr Biol (2010) 1.47
DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila. Curr Biol (2010) 1.47
A role for the adult fat body in Drosophila male courtship behavior. PLoS Genet (2007) 1.45
The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol (2005) 1.42
NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed. Cell (2011) 1.41
Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity. Neuron (2002) 1.38
Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK. Biophys J (2004) 1.38
Circadian regulation of a limited set of conserved microRNAs in Drosophila. BMC Genomics (2008) 1.36
G protein-coupled receptor kinase 2 is required for rhythmic olfactory responses in Drosophila. Curr Biol (2008) 1.32
Spike amplitude of single-unit responses in antennal sensillae is controlled by the Drosophila circadian clock. Curr Biol (2008) 1.30
Assaying locomotor activity to study circadian rhythms and sleep parameters in Drosophila. J Vis Exp (2010) 1.27
DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock. Mol Cell Biol (2009) 1.27
Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells. J Biol Rhythms (2006) 1.25
PDP1epsilon functions downstream of the circadian oscillator to mediate behavioral rhythms. J Neurosci (2007) 1.23
Central and peripheral circadian oscillator mechanisms in flies and mammals. J Cell Sci (2002) 1.22
A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks. J Neurosci (2010) 1.22
A role for O-GlcNAcylation in setting circadian clock speed. Genes Dev (2012) 1.21
Regulating a circadian clock's period, phase and amplitude by phosphorylation: insights from Drosophila. J Biochem (2006) 1.19
Rhythmic E-box binding by CLK-CYC controls daily cycles in per and tim transcription and chromatin modifications. Mol Cell Biol (2008) 1.13
The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB Rep (2010) 1.07
The blue-light photoreceptor CRYPTOCHROME is expressed in a subset of circadian oscillator neurons in the Drosophila CNS. J Biol Rhythms (2008) 1.05
CLOCK expression identifies developing circadian oscillator neurons in the brains of Drosophila embryos. BMC Neurosci (2008) 1.00
NEMO kinase contributes to core period determination by slowing the pace of the Drosophila circadian oscillator. Curr Biol (2011) 0.97
Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion. J Mol Cell Cardiol (2007) 0.95
Circadian transcription: passing the HAT to CLOCK. Cell (2006) 0.95
Circadian rhythm of temperature preference and its neural control in Drosophila. Curr Biol (2012) 0.95
The circadian output gene takeout is regulated by Pdp1epsilon. Proc Natl Acad Sci U S A (2010) 0.94
A Drosophila nonvisual arrestin is required for the maintenance of olfactory sensitivity. Chem Senses (2005) 0.90
Two distinct modes of PERIOD recruitment onto dCLOCK reveal a novel role for TIMELESS in circadian transcription. J Neurosci (2010) 0.89
Use of firefly luciferase activity assays to monitor circadian molecular rhythms in vivo and in vitro. Methods Mol Biol (2007) 0.88
Cis-combination of the classic per(S) and per(L) mutations results in arrhythmic Drosophila with ectopic accumulation of hyperphosphorylated PERIOD protein. J Biol Rhythms (2007) 0.87
Go contributes to olfactory reception in Drosophila melanogaster. BMC Physiol (2009) 0.87
Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila. J Biol Rhythms (2006) 0.84
Spatial and circadian regulation of cry in Drosophila. J Biol Rhythms (2008) 0.82
Analyzing the degradation of PERIOD protein by the ubiquitin-proteasome pathway in cultured Drosophila cells. Methods Enzymol (2005) 0.82
Time to taste: circadian clock function in the Drosophila gustatory system. Fly (Austin) (2010) 0.81
Measuring circadian rhythms in olfaction using electroantennograms. Methods Enzymol (2005) 0.81
Single-stranded DNA aptamer that specifically binds to the influenza virus NS1 protein suppresses interferon antagonism. Antiviral Res (2013) 0.81
Natural variation in the Drosophila melanogaster clock gene period modulates splicing of its 3'-terminal intron and mid-day siesta. PLoS One (2012) 0.80
Daidzein suppresses tumor necrosis factor-α induced migration and invasion by inhibiting hedgehog/Gli1 signaling in human breast cancer cells. J Agric Food Chem (2014) 0.76
Localization of primary cilia in mouse retina. Acta Histochem (2013) 0.75