Published in Proc Natl Acad Sci U S A on April 30, 2007
Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations. Proc Natl Acad Sci U S A (2007) 1.74
Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin. Proc Natl Acad Sci U S A (2009) 1.35
Mechanical biochemistry of proteins one molecule at a time. J Biol Chem (2008) 1.33
Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezers. Eur Biophys J (2008) 1.29
Single homopolypeptide chains collapse into mechanically rigid conformations. Proc Natl Acad Sci U S A (2009) 1.25
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Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA. RNA (2007) 1.17
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Retracted Solvent molecules bridge the mechanical unfolding transition state of a protein. Proc Natl Acad Sci U S A (2008) 1.14
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Osmolyte-induced separation of the mechanical folding phases of ubiquitin. Proc Natl Acad Sci U S A (2009) 0.89
Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations. J Biol Chem (2010) 0.86
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How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory. Proc Natl Acad Sci U S A (2015) 0.83
Minimum energy compact structures in force-quench polyubiquitin folding are domain swapped. Proc Natl Acad Sci U S A (2011) 0.79
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Titin PEVK segment: charge-driven elasticity of the open and flexible polyampholyte. J Muscle Res Cell Motil (2005) 0.99
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Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine. Cell (2003) 3.33
The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques. Proc Natl Acad Sci U S A (2004) 3.18
The mechanical hierarchies of fibronectin observed with single-molecule AFM. J Mol Biol (2002) 3.09
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Role of the active-site solvent in the thermodynamics of factor Xa ligand binding. J Am Chem Soc (2008) 2.81
Structure and mechanism of the reversible photoswitch of a fluorescent protein. Proc Natl Acad Sci U S A (2005) 2.21
Probing the chemistry of thioredoxin catalysis with force. Nature (2007) 2.17
Mechanoenzymatics of titin kinase. Proc Natl Acad Sci U S A (2008) 2.17
Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Proc Natl Acad Sci U S A (2006) 1.95
Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophys J (2006) 1.82
Mechanical unfolding intermediates observed by single-molecule force spectroscopy in a fibronectin type III module. J Mol Biol (2005) 1.79
Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field. J Am Chem Soc (2015) 1.76
Force-clamp spectroscopy of single-protein monomers reveals the individual unfolding and folding pathways of I27 and ubiquitin. Biophys J (2007) 1.63
PEVK domain of titin: an entropic spring with actin-binding properties. J Struct Biol (2002) 1.49
Importance of accurate charges in molecular docking: quantum mechanical/molecular mechanical (QM/MM) approach. J Comput Chem (2005) 1.48
Mechanical design of the first proximal Ig domain of human cardiac titin revealed by single molecule force spectroscopy. J Mol Biol (2003) 1.39
Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes. J Biol Chem (2010) 1.38
Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin. Proc Natl Acad Sci U S A (2009) 1.35
Ligand binding modulates the mechanical stability of dihydrofolate reductase. Biophys J (2005) 1.35
Mechanical unfolding pathways of the enhanced yellow fluorescent protein revealed by single molecule force spectroscopy. J Biol Chem (2006) 1.35
Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nat Struct Mol Biol (2011) 1.32
Simultaneous atomic force microscope and fluorescence measurements of protein unfolding using a calibrated evanescent wave. Proc Natl Acad Sci U S A (2004) 1.30
Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM. Proc Natl Acad Sci U S A (2002) 1.27
Single homopolypeptide chains collapse into mechanically rigid conformations. Proc Natl Acad Sci U S A (2009) 1.25
Mechanical network in titin immunoglobulin from force distribution analysis. PLoS Comput Biol (2009) 1.25
Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. J Am Chem Soc (2008) 1.22
Nanoscale dewetting transition in protein complex folding. J Phys Chem B (2007) 1.22
Mechanical characterization of protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry. Biophys J (2009) 1.22
Mechanical response of silk crystalline units from force-distribution analysis. Biophys J (2009) 1.21
Dynamic allostery in the methionine repressor revealed by force distribution analysis. PLoS Comput Biol (2009) 1.21
Stepwise unfolding of ankyrin repeats in a single protein revealed by atomic force microscopy. Biophys J (2005) 1.20
Protein folding drives disulfide formation. Cell (2012) 1.18
Dwell-time distribution analysis of polyprotein unfolding using force-clamp spectroscopy. Biophys J (2007) 1.17
Collapse dynamics of single proteins extended by force. Biophys J (2010) 1.16
The elasticity of individual titin PEVK exons measured by single molecule atomic force microscopy. J Biol Chem (2005) 1.16
Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence. Biophys J (2009) 1.15
Retracted Solvent molecules bridge the mechanical unfolding transition state of a protein. Proc Natl Acad Sci U S A (2008) 1.14
Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nat Struct Mol Biol (2009) 1.11
Excess entropy in alcohol-water solutions: a simple clustering explanation. J Phys Chem B (2006) 1.08
Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. Nat Protoc (2013) 1.08
A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13. Blood (2011) 1.06
Drying and hydrophobic collapse of paraffin plates. J Phys Chem B (2005) 1.06
Destruction of long-range interactions by a single mutation in lysozyme. Proc Natl Acad Sci U S A (2007) 1.04
Comparison of the protein-unfolding pathways between mitochondrial protein import and atomic-force microscopy measurements. Proc Natl Acad Sci U S A (2005) 1.04
Nanomechanics of HaloTag tethers. J Am Chem Soc (2013) 1.03
Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy. Proc Natl Acad Sci U S A (2010) 1.02
A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding. J Am Chem Soc (2007) 1.01
Atomistic evidence of how force dynamically regulates thiol/disulfide exchange. J Am Chem Soc (2010) 1.00
Ultra-high vacuum scanning tunneling microscopy and theoretical studies of 1-halohexane monolayers on graphite. Proc Natl Acad Sci U S A (2005) 0.96
Self-assembly of small polycyclic aromatic hydrocarbons on graphite: a combined scanning tunneling microscopy and theoretical approach. J Phys Chem B (2005) 0.96
Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium. J Muscle Res Cell Motil (2002) 0.96
Rate limit of protein elastic response is tether dependent. Proc Natl Acad Sci U S A (2012) 0.94
Elasticity, structure, and relaxation of extended proteins under force. Proc Natl Acad Sci U S A (2013) 0.94
How sequence determines elasticity of disordered proteins. Biophys J (2010) 0.94
Water's role in the force-induced unfolding of ubiquitin. Proc Natl Acad Sci U S A (2010) 0.93
Dynamic prestress in a globular protein. PLoS Comput Biol (2012) 0.93
Single molecule force spectroscopy using polyproteins. Chem Soc Rev (2012) 0.92
Force distribution reveals signal transduction in E. coli Hsp90. Biophys J (2012) 0.92
Possible pathway(s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation. Drug Metab Dispos (2005) 0.91
What happens to the structure of water in cryoprotectant solutions? Faraday Discuss (2013) 0.91
How force unfolding differs from chemical denaturation. Proc Natl Acad Sci U S A (2014) 0.91
Dwell time analysis of a single-molecule mechanochemical reaction. Langmuir (2007) 0.91
The calculation of transport properties in quantum liquids using the maximum entropy numerical analytic continuation method: application to liquid para-hydrogen. Proc Natl Acad Sci U S A (2002) 0.90
Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin. Proc Natl Acad Sci U S A (2011) 0.89
A single-molecule perspective on the role of solvent hydrogen bonds in protein folding and chemical reactions. Chemphyschem (2008) 0.89
Osmolyte-induced separation of the mechanical folding phases of ubiquitin. Proc Natl Acad Sci U S A (2009) 0.89
The mechanical fingerprint of a parallel polyprotein dimer. Biophys J (2006) 0.89
Why is the partial molar volume of CO2 so small when dissolved in a room temperature ionic liquid? Structure and dynamics of CO2 dissolved in [Bmim+] [PF6(-)]. J Am Chem Soc (2005) 0.88
Towards design principles for determining the mechanical stability of proteins. Phys Chem Chem Phys (2013) 0.88
The force-driven conformations of heparin studied with single molecule force microscopy. Biophys J (2003) 0.88
An experimental and theoretical study of the formation of nanostructures of self-assembled cyanuric acid through hydrogen bond networks on graphite. J Phys Chem B (2007) 0.87
Conservation of protein structure over four billion years. Structure (2013) 0.87
Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. J Biol Chem (2008) 0.87
Mechanical force can fine-tune redox potentials of disulfide bonds. Biophys J (2012) 0.87
Evolutionary optimization of protein folding. PLoS Comput Biol (2013) 0.86
Silk fiber mechanics from multiscale force distribution analysis. Biophys J (2011) 0.86
Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins. J Cell Sci (2012) 0.84
Isopeptide bonds mechanically stabilize spy0128 in bacterial pili. Biophys J (2013) 0.84
Single-molecule force spectroscopy approach to enzyme catalysis. J Biol Chem (2010) 0.83
Tandem repeating modular proteins avoid aggregation in single molecule force spectroscopy experiments. J Phys Chem A (2007) 0.82
Base-catalyzed peptide hydrolysis is insensitive to mechanical stress. J Phys Chem B (2011) 0.81
Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments. Rev Sci Instrum (2009) 0.80
Role of conservative mutations in protein multi-property adaptation. Biochem J (2010) 0.80