Published in J Biol Chem on June 24, 2008
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Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev Cell (2004) 1.87
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem (2001) 1.84
Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays (2006) 1.83
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The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J Cell Biol (2002) 1.67
Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal (2008) 1.67
Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. Clin Cancer Res (2008) 1.62
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood (2008) 1.62
Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins. J Biol Chem (2008) 1.60
A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol (2002) 1.58
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol (2004) 1.57
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem (2007) 1.41
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The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J (2002) 1.30
Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. J Biol Chem (2002) 1.28
Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica (2009) 1.27
The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment. Biochem J (2010) 1.27
Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem (2004) 1.27
The renal cortical fibroblast in renal tubulointerstitial fibrosis. Int J Biochem Cell Biol (2005) 1.27
Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts. J Am Soc Nephrol (2005) 1.26
Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression. J Biol Chem (2008) 1.25
Transforming growth factor-beta/connective tissue growth factor axis in the kidney. Int J Biochem Cell Biol (2007) 1.23
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proc Natl Acad Sci U S A (2004) 1.23
The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol (2006) 1.22
Structure of the Drosophila apoptosome at 6.9 å resolution. Structure (2011) 1.22
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem (2004) 1.21
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. EMBO J (2003) 1.21
N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J Cell Sci (2004) 1.20
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci U S A (2009) 1.20
Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination. Mol Cancer Res (2009) 1.18
Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Pharmacogenet Genomics (2005) 1.18
Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. J Biol Chem (2007) 1.15
Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex. J Cell Biol (2002) 1.15
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Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol (2012) 1.13
Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun (2011) 1.13
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. J Clin Invest (2013) 1.13
Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP. J Biol Chem (2007) 1.13
Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues. J Cell Biol (2004) 1.12
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The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. J Biol Chem (2009) 1.11
Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury. J Neurosci (2006) 1.10
Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thromb Haemost (2003) 1.08
ClC-5: role in endocytosis in the proximal tubule. Am J Physiol Renal Physiol (2005) 1.07
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Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem (2004) 1.06
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells. J Biol Chem (2005) 1.06
Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron. Int J Biochem Cell Biol (2012) 1.03
Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chem Biol (2009) 1.03
Albumin transport and processing by the proximal tubule: physiology and pathophysiology. Curr Opin Nephrol Hypertens (2007) 1.03
In vivo visualization of albumin degradation in the proximal tubule. Kidney Int (2008) 1.01
Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma. J Immunol (2012) 1.01
PKC-alpha-mediated remodeling of the actin cytoskeleton is involved in constitutive albumin uptake by proximal tubule cells. Am J Physiol Renal Physiol (2005) 1.01
Adipokines as a link between obesity and chronic kidney disease. Am J Physiol Renal Physiol (2013) 1.01
ClC-5: a chloride channel with multiple roles in renal tubular albumin uptake. Int J Biochem Cell Biol (2005) 0.99
The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. Int J Biochem Cell Biol (2005) 0.98
Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines. J Biol Chem (2003) 0.97
Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734. J Biol Chem (2011) 0.97
Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy. Autophagy (2010) 0.97
dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. J Cell Biol (2008) 0.95
High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule. Kidney Int (2005) 0.95
Molecular changes in proximal tubule function in diabetes mellitus. Clin Exp Pharmacol Physiol (2004) 0.95
The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. Biol Reprod (2009) 0.94
An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells. J Biol Chem (2004) 0.94
NEDD1: function in microtubule nucleation, spindle assembly and beyond. Int J Biochem Cell Biol (2006) 0.93
Role of Bcl-2 family of proteins in malignancy. Hematol Oncol (2002) 0.92
Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood (2010) 0.92
Prevalence of ocular signs and subclinical vitamin A deficiency and its determinants among rural pre-school children in India. Public Health Nutr (2011) 0.91
A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABAA receptor chloride channels. Neurosci Lett (2005) 0.91
Na+-H+ exchanger regulatory factor 1 is a PDZ scaffold for the astroglial glutamate transporter GLAST. Glia (2007) 0.91
Methods and protocols for studying cell death in Drosophila. Methods Enzymol (2008) 0.91
PKC alpha is activated but not required during glucose-induced insulin secretion from rat pancreatic islets. Diabetes (2004) 0.91
Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases. Cells Tissues Organs (2007) 0.90
Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs). Biol Chem (2008) 0.90
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Muscarinic-induced recruitment of plasma membrane Ca2+-ATPase involves PSD-95/Dlg/Zo-1-mediated interactions. J Biol Chem (2008) 0.89
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Thrombin stimulates proinflammatory and proliferative responses in primary cultures of human proximal tubule cells. Kidney Int (2005) 0.89