Published in J Biol Chem on May 14, 2007
Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages. J Leukoc Biol (2009) 2.45
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood (2012) 2.10
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood (2013) 2.05
The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica (2012) 1.72
Extracellular hemin crisis triggers acute chest syndrome in sickle mice. J Clin Invest (2013) 1.58
Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota. PLoS Pathog (2011) 1.57
Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood (2008) 1.55
Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant? Infect Immun (2007) 1.50
Molecular mediators of liver ischemia and reperfusion injury: a brief review. Mol Med (2008) 1.43
Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation (2012) 1.40
Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell (2017) 1.40
Intruders below the radar: molecular pathogenesis of Bartonella spp. Clin Microbiol Rev (2012) 1.33
Free hemoglobin concentration in severe sepsis: methods of measurement and prediction of outcome. Crit Care (2012) 1.33
Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol (2009) 1.31
Heme, a plastid-derived regulator of nuclear gene expression in Chlamydomonas. Plant Cell (2008) 1.28
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood (2012) 1.28
Hemolysis-induced lethality involves inflammasome activation by heme. Proc Natl Acad Sci U S A (2014) 1.20
Heme on innate immunity and inflammation. Front Pharmacol (2014) 1.15
Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Br J Pharmacol (2008) 1.14
Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin. J Infect Dis (2010) 1.14
Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury. J Neuroinflammation (2013) 1.14
Interplay between coagulation and vascular inflammation in sickle cell disease. Br J Haematol (2013) 1.12
Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage. Ann Neurol (2011) 1.11
Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development. Front Physiol (2014) 1.10
Oxidative stress fuels Trypanosoma cruzi infection in mice. J Clin Invest (2012) 1.08
The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage. J Neuroinflammation (2013) 1.07
Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive Care Med (2010) 1.07
A comparative review of toll-like receptor 4 expression and functionality in different animal species. Front Immunol (2014) 1.05
TLR9 and MyD88 are crucial for the development of protective immunity to malaria. J Immunol (2012) 1.04
Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation. J Biol Chem (2010) 1.04
The mononuclear phagocyte system in homeostasis and disease: a role for heme oxygenase-1. Antioxid Redox Signal (2014) 1.01
Heme Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock. J Clin Biochem Nutr (2008) 1.01
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J (2013) 0.99
Blood substitutes: why haven't we been more successful? Trends Biotechnol (2014) 0.98
Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway. J Biol Chem (2010) 0.98
Damage control in host-pathogen interactions. Proc Natl Acad Sci U S A (2009) 0.97
Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly? Front Pharmacol (2012) 0.97
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Blood (2013) 0.95
Methemoglobin-induced signaling and chemokine responses in human alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol (2013) 0.95
Heme oxygenase system in hepatic ischemia-reperfusion injury. World J Gastroenterol (2010) 0.94
Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation. J Neuroinflammation (2013) 0.94
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front Pharmacol (2012) 0.94
Targeting Toll-like receptors with small molecule agents. Chem Soc Rev (2013) 0.93
Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes. Fertil Steril (2007) 0.92
Toll-like receptors of the ascidian Ciona intestinalis: prototypes with hybrid functionalities of vertebrate Toll-like receptors. J Biol Chem (2009) 0.92
Elevation of high-mobility group protein box-1 in serum correlates with severity of acute intracerebral hemorrhage. Mediators Inflamm (2010) 0.92
Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J Clin Invest (2015) 0.92
Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis. BMC Immunol (2011) 0.92
Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract. World J Gastroenterol (2010) 0.91
Fungal glycans and the innate immune recognition. Front Cell Infect Microbiol (2014) 0.91
Iron is essential for oligodendrocyte genesis following intraspinal macrophage activation. Exp Neurol (2009) 0.91
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation. Transl Res (2015) 0.90
Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. Drug Metab Rev (2010) 0.90
Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1. Exp Parasitol (2011) 0.90
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood (2015) 0.90
Vasculotoxic and Proinflammatory Effects of Plasma Heme: Cell Signaling and Cytoprotective Responses. ISRN Oxidative Med (2013) 0.87
Atherogenesis and iron: from epidemiology to cellular level. Front Pharmacol (2014) 0.87
Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets. Innate Immun (2010) 0.87
Macrophages and Iron Metabolism. Immunity (2016) 0.86
Transfusion-Related Acute Lung Injury: The Work of DAMPs. Transfus Med Hemother (2013) 0.86
Heme oxygenase-1 regulates dendritic cell function through modulation of p38 MAPK-CREB/ATF1 signaling. J Biol Chem (2014) 0.86
The Iron age of host-microbe interactions. EMBO Rep (2015) 0.85
Toll-like receptor 7 mediates early innate immune responses to malaria. Infect Immun (2013) 0.85
Red blood cell, hemoglobin and heme in the progression of atherosclerosis. Front Physiol (2014) 0.85
Toll-like receptors of deuterostome invertebrates. Front Immunol (2012) 0.85
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders. Front Physiol (2015) 0.85
Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response. Cell Death Dis (2016) 0.84
Fungal surface and innate immune recognition of filamentous fungi. Front Microbiol (2011) 0.84
Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasis. Oxid Med Cell Longev (2013) 0.84
Extracellular hemoglobin - mediator of inflammation and cell death in the choroid plexus following preterm intraventricular hemorrhage. J Neuroinflammation (2014) 0.84
Role of heme in cardiovascular physiology and disease. J Am Heart Assoc (2015) 0.82
Telomere length correlates with disease severity and inflammation in sickle cell disease. Rev Bras Hematol Hemoter (2017) 0.82
Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states. J Neurochem (2013) 0.80
Natural history of the bruise: formation, elimination, and biological effects of oxidized hemoglobin. Oxid Med Cell Longev (2013) 0.80
Pathophysiology and treatment of pulmonary hypertension in sickle cell disease. Blood (2016) 0.80
Plasmodium falciparum: differential merozoite dose requirements for maximal production of various inflammatory cytokines. Exp Parasitol (2010) 0.79
The sickle cell mouse lung: proinflammatory and primed for allergic inflammation. Transl Res (2015) 0.79
Pathways involved in the synergistic activation of macrophages by lipoteichoic acid and hemoglobin. PLoS One (2012) 0.79
Cell-free hemoglobin: a novel mediator of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2016) 0.79
Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review. Int J Mol Sci (2016) 0.79
Molecular, Cellular and Clinical Aspects of Intracerebral Hemorrhage: Are the Enemies Within? Curr Neuropharmacol (2016) 0.79
Heme reversibly damps PERIOD2 rhythms in mouse suprachiasmatic nucleus explants. Neuroscience (2009) 0.79
Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage. Int J Mol Sci (2015) 0.78
Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children. Malar J (2015) 0.78
Proinflammatory responses of heme in alveolar macrophages: repercussion in lung hemorrhagic episodes. Mediators Inflamm (2013) 0.77
Do you see what I see: Recognition of protozoan parasites by Toll-like receptors. Curr Immunol Rev (2013) 0.77
Oral anticoagulant-associated intracerebral hemorrhage. J Neurol (2011) 0.77
Altered heme-mediated modulation of dendritic cell function in sickle cell alloimmunization. Haematologica (2016) 0.77
Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation. ChemMedChem (2015) 0.77
Interferons and interferon regulatory factors in malaria. Mediators Inflamm (2014) 0.77
Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies. Sci Rep (2015) 0.77
Dietary iron intake and risk of endometrial cancer: a population-based case-control study in Shanghai, China. Nutr Cancer (2010) 0.76
Taking some of the mystery out of host: virus interactions. PLoS Pathog (2011) 0.76
Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond. Transfus Med Rev (2016) 0.76
Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease. Mol Med (2016) 0.76
A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages. PLoS One (2013) 0.75
Heme as a Target for Therapeutic Interventions. Front Pharmacol (2017) 0.75
Protein aggregation as a cellular response to oxidative stress induced by heme and iron. Proc Natl Acad Sci U S A (2016) 0.75
Purified and recombinant hemopexin: protease activity and effect on neutrophil chemotaxis. Mol Med (2016) 0.75
Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.75
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care (2007) 3.80
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21
Adaptations against heme toxicity in blood-feeding arthropods. Insect Biochem Mol Biol (2006) 2.03
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood (2013) 1.74
Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria. J Biol Chem (2004) 1.59
Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota. PLoS Pathog (2011) 1.57
Neutrophil activation by heme: implications for inflammatory processes. Blood (2002) 1.49
Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania. Nat Med (2013) 1.46
Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis. Shock (2004) 1.36
Bioenergetic failure of human peripheral blood monocytes in patients with septic shock is mediated by reduced F1Fo adenosine-5'-triphosphate synthase activity. Crit Care Med (2011) 1.33
Identification of the Aedes aegypti peritrophic matrix protein AeIMUCI as a heme-binding protein. Biochemistry (2006) 1.32
Nod1 participates in the innate immune response to Pseudomonas aeruginosa. J Biol Chem (2005) 1.29
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood (2012) 1.28
Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus. FEBS Lett (2005) 1.27
Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion. Insect Biochem Mol Biol (2002) 1.25
An alpha-glucan of Pseudallescheria boydii is involved in fungal phagocytosis and Toll-like receptor activation. J Biol Chem (2006) 1.24
Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors. J Biol Chem (2007) 1.22
Sepsis induces brain mitochondrial dysfunction. Crit Care Med (2008) 1.21
Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection. FASEB J (2009) 1.19
Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy. PLoS Pathog (2010) 1.18
Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia. Shock (2005) 1.14
The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction. Free Radic Biol Med (2009) 1.09
Oxidative stress fuels Trypanosoma cruzi infection in mice. J Clin Invest (2012) 1.08
Inhibition of heme aggregation by chloroquine reduces Schistosoma mansoni infection. J Infect Dis (2004) 1.08
A new intracellular pathway of haem detoxification in the midgut of the cattle tick Boophilus microplus: aggregation inside a specialized organelle, the hemosome. J Exp Biol (2003) 1.07
Heme inhibits human neutrophil apoptosis: involvement of phosphoinositide 3-kinase, MAPK, and NF-kappaB. J Immunol (2004) 1.06
Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity. J Biol Chem (2006) 1.06
Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. PLoS Negl Trop Dis (2009) 1.06
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin. J Immunol (2003) 1.05
Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation. J Biol Chem (2010) 1.04
Extracellular lipid droplets promote hemozoin crystallization in the gut of the blood fluke Schistosoma mansoni. FEBS Lett (2007) 1.01
A heme-degradation pathway in a blood-sucking insect. Proc Natl Acad Sci U S A (2006) 1.01
Trypanosoma cruzi infection is enhanced by vector saliva through immunosuppressant mechanisms mediated by lysophosphatidylcholine. Infect Immun (2008) 1.00
Soluble factors released by Toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration. Infect Immun (2003) 0.99
Heme impairs prostaglandin E2 and TGF-beta production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria. J Immunol (2010) 0.99
Blood-feeding induces reversible functional changes in flight muscle mitochondria of Aedes aegypti mosquito. PLoS One (2009) 0.98
Changes in salivary nitrophorin profile during the life cycle of the blood-sucking bug Rhodnius prolixus. Insect Biochem Mol Biol (2003) 0.98
Heme oxygenase-1 promotes the persistence of Leishmania chagasi infection. J Immunol (2012) 0.96
Energy metabolism affects susceptibility of Anopheles gambiae mosquitoes to Plasmodium infection. Insect Biochem Mol Biol (2011) 0.96
Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells. PLoS One (2010) 0.95
Are reactive oxygen species always detrimental to pathogens? Antioxid Redox Signal (2013) 0.95
Oxidative stress impairs heme detoxification in the midgut of the cattle tick, Rhipicephalus (Boophilus) microplus. Mol Biochem Parasitol (2006) 0.95
Bacterial clearance in septic mice is modulated by MCP-1/CCL2 and nitric oxide. Shock (2013) 0.94
Azathioprine inhibits vaccinia virus replication in both BSC-40 and RAG cell lines acting on different stages of virus cycle. Virology (2002) 0.93
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein. J Immunol (2002) 0.92
CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection. J Leukoc Biol (2009) 0.92
Leukotriene B4 mediates neutrophil migration induced by heme. J Immunol (2011) 0.91
On the fate of extracellular hemoglobin and heme in brain. J Cereb Blood Flow Metab (2009) 0.90
Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection. FASEB J (2008) 0.90
Heme crystallization in the midgut of triatomine insects. Comp Biochem Physiol C Toxicol Pharmacol (2006) 0.90
Biglutaminyl-biliverdin IX alpha as a heme degradation product in the dengue fever insect-vector Aedes aegypti. Biochemistry (2007) 0.89
Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production. Clin Vaccine Immunol (2006) 0.89
Effects of retinoids and juvenoids on moult and on phenoloxidase activity in the blood-sucking insect Rhodnius prolixus. Acta Trop (2007) 0.89
Schistosomal‐derived lysophosphatidylcholine are involved in eosinophil activation and recruitment through Toll‐like receptor-2-dependent mechanisms. J Infect Dis (2010) 0.89
Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication. Virology (2010) 0.89
Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi. Antimicrob Agents Chemother (2002) 0.89
Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies. Am J Respir Cell Mol Biol (2010) 0.88
Reactive oxygen species generation is modulated by mitochondrial kinases: correlation with mitochondrial antioxidant peroxidases in rat tissues. Biochimie (2008) 0.88
Vampires, Pasteur and reactive oxygen species. Is the switch from aerobic to anaerobic metabolism a preventive antioxidant defence in blood-feeding parasites? FEBS Lett (2002) 0.88
HeLp, a heme-transporting lipoprotein with an antioxidant role. Insect Biochem Mol Biol (2004) 0.87
On the physico-chemical and physiological requirements of hemozoin formation promoted by perimicrovillar membranes in Rhodnius prolixus midgut. Insect Biochem Mol Biol (2010) 0.87
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Eur J Immunol (2007) 0.87
On the mechanisms involved in biological heme crystallization. J Bioenerg Biomembr (2011) 0.87
Vaccination of bovines with recombinant Boophilus Yolk pro-Cathepsin. Vet Immunol Immunopathol (2006) 0.87
On the pro-oxidant effects of haemozoin. FEBS Lett (2002) 0.87
Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab (2009) 0.87
The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal. PLoS One (2012) 0.86
Pro-inflammatory response resulting from sindbis virus infection of human macrophages: implications for the pathogenesis of viral arthritis. J Med Virol (2010) 0.86
TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection. Microbes Infect (2009) 0.86
Mitochondrial reactive oxygen species modulate mosquito susceptibility to Plasmodium infection. PLoS One (2012) 0.86
Nandrolone decanoate impairs exercise-induced cardioprotection: role of antioxidant enzymes. J Steroid Biochem Mol Biol (2006) 0.85
Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: a role for increased macrophage reactivity. Eur J Immunol (2007) 0.85
The role of reactive oxygen species in Anopheles aquasalis response to Plasmodium vivax infection. PLoS One (2013) 0.85
Alpha-tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-alpha-mediated downregulation in human smooth muscle cells. Circ Res (2003) 0.85
Fungal surface and innate immune recognition of filamentous fungi. Front Microbiol (2011) 0.84
Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS. PLoS One (2011) 0.84
Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. PLoS One (2011) 0.84
In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping. Free Radic Biol Med (2013) 0.83
MIF participates in Toxoplasma gondii-induced pathology following oral infection. PLoS One (2011) 0.82