Published in ChemMedChem on July 01, 2015
Inflammation and Immune Regulation as Potential Drug Targets in Antidepressant Treatment. Curr Neuropharmacol (2016) 0.75
Phenolic 1,3-diketones attenuate lipopolysaccharide-induced inflammatory response by an alternative magnesium-mediated mechanism. Br J Pharmacol (2017) 0.75
Peripheral Blood Monocyte Tolerance Alleviates Intraperitoneal Lipopolysaccharides-Induced Neuroinflammation in Rats Via Upregulating the CD200R Expression. Neurochem Res (2017) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A (2000) 9.67
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med (1999) 9.23
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain (1992) 9.17
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature (2009) 8.99
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature (1999) 8.50
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2003) 8.34
Native protein sequences are close to optimal for their structures. Proc Natl Acad Sci U S A (2000) 7.99
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem (1999) 7.81
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol (2000) 7.78
Structure and function of lipopolysaccharide binding protein. Science (1990) 7.76
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell (2007) 6.84
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol (2000) 6.57
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem (2002) 6.16
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med (2002) 5.70
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48
Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry (1976) 5.43
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol (2006) 5.35
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 5.26
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol (2004) 5.15
Inflammatory caspases are innate immune receptors for intracellular LPS. Nature (2014) 4.88
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol (1999) 4.77
The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem (2001) 4.74
Toll-like receptors stimulate human neutrophil function. Blood (2003) 4.29
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol (2001) 4.13
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem (2002) 4.03
Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science (2007) 4.01
Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol (2001) 3.76
Algorithm discovery by protein folding game players. Proc Natl Acad Sci U S A (2011) 3.74
The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A (2005) 3.59
Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun (2001) 3.55
Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol (2002) 3.53
Inflammation after trauma: microglial activation and traumatic brain injury. Ann Neurol (2011) 3.42
Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol (2002) 3.32
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem (2001) 3.16
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol (2005) 2.94
Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J Virol (2005) 2.90
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med (2005) 2.89
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin Immunol (2007) 2.89
Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect Immun (1995) 2.87
Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J Immunol (2001) 2.86
Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci U S A (2002) 2.70
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science (2012) 2.66
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43
Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. Neuroscientist (2004) 2.40
Characterization of heme as activator of Toll-like receptor 4. J Biol Chem (2007) 2.38
The role of synovitis in osteoarthritis pathogenesis. Bone (2012) 2.37
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31
RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum (2005) 2.07
Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol (2002) 2.00
Differential activation of astrocytes by innate and adaptive immune stimuli. Glia (2005) 1.99
A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock (2005) 1.97
Binding of bacterial peptidoglycan to CD14. J Biol Chem (1998) 1.97
TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol (2009) 1.87
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol (2002) 1.82
Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
Structural biology of the LPS recognition. Int J Med Microbiol (2007) 1.73
Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators. Glia (2006) 1.72
Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem (2005) 1.70
Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66
TLR4 as the mammalian endotoxin sensor. Curr Top Microbiol Immunol (2002) 1.65
LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria. J Clin Invest (1998) 1.62
Emerging role of Toll-like receptors in the control of pain and itch. Neurosci Bull (2012) 1.60
Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci U S A (2010) 1.51
Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein. J Immunol (2000) 1.51
Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation. J Biol Chem (2001) 1.49
Immune-neural connections: how the immune system's response to infectious agents influences behavior. J Exp Biol (2013) 1.48
Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus peptidoglycan but not intact bacteria by microglia. Glia (2005) 1.46
Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria. Biochem Soc Trans (2003) 1.44
Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Glia (2008) 1.44
Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. J Endotoxin Res (2001) 1.39
Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol (2009) 1.30
Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. J Immunol (2011) 1.24
Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun (2005) 1.23
Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect Immun (2003) 1.18
An essential role for albumin in the interaction of endotoxin with lipopolysaccharide-binding protein and sCD14 and resultant cell activation. J Biol Chem (2002) 1.16
Toll-like receptors and inflammation in the CNS. Curr Drug Targets Inflamm Allergy (2002) 1.15
Human granulocytes express a 55-kDa lipopolysaccharide-binding protein on the cell surface that is identical to the bactericidal/permeability-increasing protein. J Immunol (1993) 1.15
A peptide antagonist of the TLR4-MD2 interaction. Chembiochem (2009) 1.12
Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists. Biotechnol Adv (2011) 1.11
Exploring the LPS/TLR4 signal pathway with small molecules. Biochem Soc Trans (2010) 1.10
Sequence specific detection of bacterial 23S ribosomal RNA by TLR13. Elife (2012) 1.09
Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience (2010) 1.07
Antibacterial proteins of granulocytes differ in interaction with endotoxin. Comparison of bactericidal/permeability-increasing protein, p15s, and defensins. J Immunol (1995) 1.05
Small-molecule inhibitors of the TLR3/dsRNA complex. J Am Chem Soc (2011) 1.04
The clinical characteristics of Chinese Takayasu's arteritis patients: a retrospective study of 411 patients over 24 years. Arthritis Res Ther (2017) 0.75
Development of Antibacterial Drugs by Targeting Toll-Like Receptors. Curr Top Med Chem (2017) 0.75