Published in Neuron on May 24, 2007
Genetic dissection of neural circuits. Neuron (2008) 7.97
Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature (2009) 6.74
Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophys J (2009) 4.75
Bi-stable neural state switches. Nat Neurosci (2008) 4.69
Neural syntax: cell assemblies, synapsembles, and readers. Neuron (2010) 3.75
Electrophysiology in the age of light. Nature (2009) 2.90
Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans. Nat Methods (2011) 2.80
Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr Biol (2008) 2.69
Functional architecture of olfactory ionotropic glutamate receptors. Neuron (2011) 2.67
Remote control of neuronal signaling. Pharmacol Rev (2011) 2.66
Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature (2009) 2.61
Holographic photolysis of caged neurotransmitters. Nat Methods (2008) 2.45
Photochemical control of endogenous ion channels and cellular excitability. Nat Methods (2008) 2.30
Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans. Nat Methods (2011) 2.19
Optical control of zebrafish behavior with halorhodopsin. Proc Natl Acad Sci U S A (2009) 2.07
Homeostatic regulation of AMPA receptor trafficking and degradation by light-controlled single-synaptic activation. Neuron (2011) 2.01
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88
Spatial organization and signal transduction at intercellular junctions. Nat Rev Mol Cell Biol (2010) 1.72
Genetic control of neuronal activity in mice conditionally expressing TRPV1. Nat Methods (2008) 1.70
Rapid adaptive optical recovery of optimal resolution over large volumes. Nat Methods (2014) 1.69
LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther (2011) 1.53
New photochemical tools for controlling neuronal activity. Curr Opin Neurobiol (2009) 1.48
Focusing on optic tectum circuitry through the lens of genetics. BMC Biol (2010) 1.40
Optogenetic control of cells and circuits. Annu Rev Cell Dev Biol (2011) 1.40
Tuning photochromic ion channel blockers. ACS Chem Neurosci (2011) 1.39
The cellular architecture of the larval zebrafish tectum, as revealed by gal4 enhancer trap lines. Front Neural Circuits (2009) 1.34
Optogenetic pharmacology for control of native neuronal signaling proteins. Nat Neurosci (2013) 1.34
Optogenetic manipulation of neural circuitry in vivo. Curr Opin Neurobiol (2011) 1.29
Zebrafish and motor control over the last decade. Brain Res Rev (2007) 1.27
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nat Neurosci (2010) 1.25
Controlling the enzymatic activity of a restriction enzyme by light. Proc Natl Acad Sci U S A (2009) 1.25
Cardiac optogenetics. Am J Physiol Heart Circ Physiol (2013) 1.24
Predicting visual sensitivity in retinal prosthesis patients. Invest Ophthalmol Vis Sci (2008) 1.21
Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nat Chem (2012) 1.21
Genetic and optical targeting of neural circuits and behavior--zebrafish in the spotlight. Curr Opin Neurobiol (2009) 1.19
Using retroviruses as a mutagenesis tool to explore the zebrafish genome. Brief Funct Genomic Proteomic (2008) 1.15
High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device. Nat Protoc (2012) 1.14
Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR. Proc Natl Acad Sci U S A (2009) 1.13
Holographic optogenetic stimulation of patterned neuronal activity for vision restoration. Nat Commun (2013) 1.12
Colloid-guided assembly of oriented 3D neuronal networks. Nat Methods (2008) 1.11
Holographic photolysis for multiple cell stimulation in mouse hippocampal slices. PLoS One (2010) 1.11
Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol (2013) 1.09
Using imaging and genetics in zebrafish to study developing spinal circuits in vivo. Dev Neurobiol (2008) 1.07
AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades. Neural Plast (2012) 1.07
Movement, technology and discovery in the zebrafish. Curr Opin Neurobiol (2010) 1.00
Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release. J Physiol (2012) 1.00
Inducible control of gene expression with destabilized Cre. Nat Methods (2013) 0.98
A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor. J Am Chem Soc (2013) 0.98
Azo-propofols: photochromic potentiators of GABA(A) receptors. Angew Chem Int Ed Engl (2012) 0.95
Optogenetic investigation of neural circuits in vivo. Trends Mol Med (2011) 0.94
Regulating enzymatic activity with a photoswitchable affinity label. Chembiochem (2008) 0.91
Temporal interactions during paired-electrode stimulation in two retinal prosthesis subjects. Invest Ophthalmol Vis Sci (2011) 0.90
AMPA receptors and synaptic plasticity: a chemist's perspective. Nat Chem Biol (2010) 0.89
Light at the end of the channel: optical manipulation of intrinsic neuronal excitability with chemical photoswitches. Front Mol Neurosci (2013) 0.88
Two-photon neuronal and astrocytic stimulation with azobenzene-based photoswitches. J Am Chem Soc (2014) 0.88
Remote switching of cellular activity and cell signaling using light in conjunction with quantum dots. Biomed Opt Express (2012) 0.88
Novel interfaces for light directed neuronal stimulation: advances and challenges. Int J Nanomedicine (2014) 0.87
Synaptic patterning of left-right alternation in a computational model of the rodent hindlimb central pattern generator. J Comput Neurosci (2010) 0.87
Optical control of an ion channel gate. Proc Natl Acad Sci U S A (2013) 0.87
Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish. Front Pharmacol (2014) 0.86
Investigating the genetics of visual processing, function and behaviour in zebrafish. Neurogenetics (2011) 0.86
Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential. Curr Opin Pharmacol (2015) 0.86
Integrating anatomy and function for zebrafish circuit analysis. Front Neural Circuits (2013) 0.86
Learning and memory in zebrafish larvae. Front Neural Circuits (2013) 0.85
Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner. BMC Biol (2012) 0.85
A fully genetically encoded protein architecture for optical control of peptide ligand concentration. Nat Commun (2014) 0.84
Automated identification of neurons in 3D confocal datasets from zebrafish brainstem. J Microsc (2009) 0.84
Regulation of zebrafish sleep and arousal states: current and prospective approaches. Front Neural Circuits (2013) 0.84
Engineering a light-regulated GABAA receptor for optical control of neural inhibition. ACS Chem Biol (2014) 0.84
Scalable fluidic injector arrays for viral targeting of intact 3-D brain circuits. J Vis Exp (2010) 0.83
New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish. Zebrafish (2013) 0.83
Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons. PLoS One (2009) 0.83
Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proc Natl Acad Sci U S A (2015) 0.82
How to understand and outwit adaptation. Dev Cell (2014) 0.82
Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR. Front Mol Neurosci (2013) 0.81
High-resolution analysis of central nervous system expression patterns in zebrafish Gal4 enhancer-trap lines. Dev Dyn (2015) 0.81
Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging. Nat Methods (2015) 0.81
Cellular dissection of the spinal cord motor column by BAC transgenesis and gene trapping in zebrafish. Front Neural Circuits (2013) 0.81
Fish in the matrix: motor learning in a virtual world. Front Neural Circuits (2013) 0.80
Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. ACS Cent Sci (2015) 0.80
Optogenetic activation of zebrafish somatosensory neurons using ChEF-tdTomato. J Vis Exp (2013) 0.79
Visualization and manipulation of neural activity in the developing vertebrate nervous system. Front Mol Neurosci (2011) 0.78
Colloids as mobile substrates for the implantation and integration of differentiated neurons into the mammalian brain. PLoS One (2012) 0.78
Proceedings of the First International Optogenetic Therapies for Vision Symposium. Transl Vis Sci Technol (2013) 0.78
Switching on the lights: the use of optogenetics to advance retinal gene therapy. Mol Ther (2011) 0.77
Optogenetic perturbations reveal the dynamics of an oculomotor integrator. Front Neural Circuits (2014) 0.77
A zebrafish model of hyperammonemia. Mol Genet Metab (2014) 0.77
Optical triggered seizures using a caged 4-Aminopyridine. Front Neurosci (2015) 0.77
A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors. Front Mol Neurosci (2016) 0.77
Genetic Analysis of the Touch Response in Zebrafish (Danio rerio). Int J Comp Psychol (2010) 0.76
Input-specific homeostatic regulation of AMPA receptor accumulation at central synapses. Commun Integr Biol (2012) 0.76
Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO). Chem Sci (2015) 0.75
The age of enlightenment: evolving opportunities in brain research through optical manipulation of neuronal activity. Front Syst Neurosci (2011) 0.75
Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters. Exp Neurobiol (2016) 0.75
Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner. Sci Rep (2015) 0.75
A family of photoswitchable NMDA receptors. Elife (2016) 0.75
Photochemical approaches to vision restoration. Vision Res (2015) 0.75
Neuroscience: Optical control of reward. Nature (2009) 0.75
The 64th Symposium of the Society for General Physiologists: optogenetics and superresolution microscopy take center stage. J Gen Physiol (2011) 0.75
Light-activated ion channels for remote control of neural activity. Methods Cell Biol (2008) 0.75
Optical sectioning deep inside live embryos by selective plane illumination microscopy. Science (2004) 13.77
Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci (2012) 6.09
Subunit counting in membrane-bound proteins. Nat Methods (2007) 5.75
Light-activated ion channels for remote control of neuronal firing. Nat Neurosci (2004) 4.42
Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron (2006) 3.85
Closing in on the resting state of the Shaker K(+) channel. Neuron (2007) 3.49
Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature (2006) 3.47
Allosteric control of an ionotropic glutamate receptor with an optical switch. Nat Chem Biol (2005) 3.23
Molecular imaging of hydrogen peroxide produced for cell signaling. Nat Chem Biol (2007) 3.19
In vivo performance of genetically encoded indicators of neural activity in flies. J Neurosci (2005) 3.11
How does voltage open an ion channel? Annu Rev Cell Dev Biol (2006) 3.05
Targeting neural circuitry in zebrafish using GAL4 enhancer trapping. Nat Methods (2007) 3.00
Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. Cell (2008) 2.97
Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron (2005) 2.94
Regulation of axon growth in vivo by activity-based competition. Nature (2005) 2.73
The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis A list of abbreviations can be found at the end of the article. Angew Chem Int Ed Engl (2001) 2.69
Visual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum. J Neurosci (2005) 2.68
Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons. J Biol Rhythms (2004) 2.67
Functional architecture of olfactory ionotropic glutamate receptors. Neuron (2011) 2.67
Subunit organization and functional transitions in Ci-VSP. Nat Struct Mol Biol (2007) 2.64
Optogenetic control of cardiac function. Science (2010) 2.63
Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Dev Biol (2007) 2.62
Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature (2009) 2.61
Scanless two-photon excitation of channelrhodopsin-2. Nat Methods (2010) 2.60
Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res (2013) 2.60
A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection. Development (2005) 2.57
In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells. Neuron (2006) 2.54
Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (2005) 2.32
Photochemical control of endogenous ion channels and cellular excitability. Nat Methods (2008) 2.30
The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26
Photochemical restoration of visual responses in blind mice. Neuron (2012) 2.16
Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells. Proc Natl Acad Sci U S A (2008) 2.15
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc (2005) 2.11
The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature (2006) 2.10
Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol (2008) 2.08
A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J Am Chem Soc (2004) 2.08
Optical control of zebrafish behavior with halorhodopsin. Proc Natl Acad Sci U S A (2009) 2.07
Optical switches for remote and noninvasive control of cell signaling. Science (2008) 2.02
Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish. Neuron (2007) 1.96
The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron (2003) 1.96
Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron (2002) 1.95
Structural rearrangements in single ion channels detected optically in living cells. Proc Natl Acad Sci U S A (2002) 1.85
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84
Visuomotor behaviors in larval zebrafish after GFP-guided laser ablation of the optic tectum. J Neurosci (2003) 1.80
Emergence of patterned activity in the developing zebrafish spinal cord. Curr Biol (2011) 1.76
Filtering of visual information in the tectum by an identified neural circuit. Science (2010) 1.73
Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Mol Ther (2009) 1.73
A selective turn-on fluorescent sensor for imaging copper in living cells. J Am Chem Soc (2006) 1.72
Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval. Nature (2008) 1.71
The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev Cell (2007) 1.68
A positive feedback synapse from retinal horizontal cells to cone photoreceptors. PLoS Biol (2011) 1.65
A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol (2007) 1.65
A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mech Dev (2004) 1.65
Catalysis of 6pi electrocyclizations. Angew Chem Int Ed Engl (2008) 1.62
Forward genetic analysis of visual behavior in zebrafish. PLoS Genet (2005) 1.62
Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor. Proc Natl Acad Sci U S A (2007) 1.62
Optochemical genetics. Angew Chem Int Ed Engl (2011) 1.61
How far will you go to sense voltage? Neuron (2005) 1.61
Rules of engagement for NMDA receptor subunits. Proc Natl Acad Sci U S A (2008) 1.60
A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem (2005) 1.60
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
Role of the synaptic ribbon in transmitting the cone light response. Nat Neurosci (2009) 1.58
The chemistry of marine furanocembranoids, pseudopteranes, gersolanes, and related natural products. Nat Prod Rep (2008) 1.57
Optogenetic localization and genetic perturbation of saccade-generating neurons in zebrafish. J Neurosci (2010) 1.54
Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proc Natl Acad Sci U S A (2010) 1.54
LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther (2011) 1.53
Molecular models of voltage sensing. J Gen Physiol (2002) 1.53
Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. Development (2005) 1.50
All optical interface for parallel, remote, and spatiotemporal control of neuronal activity. Nano Lett (2007) 1.49
New photochemical tools for controlling neuronal activity. Curr Opin Neurobiol (2009) 1.48