Published in Proc Natl Acad Sci U S A on November 12, 2008
Fast, background-free, 3D super-resolution optical fluctuation imaging (SOFI). Proc Natl Acad Sci U S A (2009) 3.17
Single-molecule spectroscopy and imaging of biomolecules in living cells. Anal Chem (2010) 1.78
Fluorescence nanoscopy by polarization modulation and polarization angle narrowing. Nat Methods (2014) 1.66
Optically modulated fluorophores for selective fluorescence signal recovery. J Am Chem Soc (2009) 1.35
Engineering of bacterial phytochromes for near-infrared imaging, sensing, and light-control in mammals. Chem Soc Rev (2013) 1.31
Live-imaging fluorescent proteins in mouse embryos: multi-dimensional, multi-spectral perspectives. Trends Biotechnol (2009) 1.25
Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. J Am Chem Soc (2012) 1.22
Genetic and optical targeting of neural circuits and behavior--zebrafish in the spotlight. Curr Opin Neurobiol (2009) 1.19
A unique series of reversibly switchable fluorescent proteins with beneficial properties for various applications. Proc Natl Acad Sci U S A (2012) 1.16
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Fluorescence applications in molecular neurobiology. Neuron (2010) 1.13
Synchronously amplified fluorescence image recovery (SAFIRe). J Phys Chem B (2010) 1.08
Optically enhanced, near-IR, silver cluster emission altered by single base changes in the DNA template. J Phys Chem B (2011) 1.04
Electron transfer-induced blinking in Ag nanodot fluorescence. J Phys Chem C Nanomater Interfaces (2009) 1.00
Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci U S A (2013) 0.99
Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2012) 0.97
Phosphine quenching of cyanine dyes as a versatile tool for fluorescence microscopy. J Am Chem Soc (2013) 0.94
Optical modulation and selective recovery of Cy5 fluorescence. Chemphyschem (2011) 0.94
Signal Discrimination Between Fluorescent Proteins in Live Cells by Long-wavelength Optical Modulation. J Phys Chem Lett (2012) 0.94
The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins. Trends Biochem Sci (2016) 0.93
Rational design, synthesis, and characterization of highly fluorescent optical switches for high-contrast optical lock-in detection (OLID) imaging microscopy in living cells. Bioorg Med Chem (2010) 0.93
Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator. J Am Chem Soc (2010) 0.93
Optically modulated fluorescence bioimaging: visualizing obscured fluorophores in high background. Acc Chem Res (2014) 0.92
Optically modulatable blue fluorescent proteins. J Am Chem Soc (2013) 0.92
FRET-enabled optical modulation for high sensitivity fluorescence imaging. J Am Chem Soc (2010) 0.90
Photoactivatable fluorophores and techniques for biological imaging applications. Photochem Photobiol Sci (2012) 0.89
All-optical fluorescence image recovery using modulated Stimulated Emission Depletion. Chem Sci (2011) 0.87
Characterization of the thermal and photoinduced reactions of photochromic spiropyrans in aqueous solution. J Phys Chem B (2013) 0.86
Optical imaging with dynamic contrast agents. Chemistry (2011) 0.86
Photomodulatable fluorescent proteins for imaging cell dynamics and cell fate. Organogenesis (2009) 0.84
Phototransformable fluorescent proteins: which one for which application? Histochem Cell Biol (2014) 0.84
Modulated fluorophore signal recovery buried within tissue mimicking phantoms. J Phys Chem A (2013) 0.82
Small-molecule labeling of live cell surfaces for three-dimensional super-resolution microscopy. J Am Chem Soc (2014) 0.81
Focal switching of photochromic fluorescent proteins enables multiphoton microscopy with superior image contrast. Biomed Opt Express (2012) 0.81
The synthesis-diffusion-degradation model explains Bicoid gradient formation in unfertilized eggs. Phys Biol (2012) 0.80
High-Resolution Ultrasound-Switchable Fluorescence Imaging in Centimeter-Deep Tissue Phantoms with High Signal-To-Noise Ratio and High Sensitivity via Novel Contrast Agents. PLoS One (2016) 0.80
Reversible optical control of cyanine fluorescence in fixed and living cells: optical lock-in detection immunofluorescence imaging microscopy. Philos Trans R Soc Lond B Biol Sci (2012) 0.79
Reversibly switchable fluorescence microscopy with enhanced resolution and image contrast. J Biomed Opt (2014) 0.79
Reversible fluorescence photoswitching in DNA. J Phys Chem B (2012) 0.79
Optically Modulated Photoswitchable Fluorescent Proteins Yield Improved Biological Imaging Sensitivity. J Am Chem Soc (2015) 0.78
Wide-field in vivo background free imaging by selective magnetic modulation of nanodiamond fluorescence. Biomed Opt Express (2014) 0.78
Synthesis and spectroscopic characterization of red-shifted spironaphthoxazine based optical switch probes. Tetrahedron Lett (2010) 0.78
Time-lapse imaging of neural development: zebrafish lead the way into the fourth dimension. Genesis (2011) 0.75
High-contrast fluorescence imaging in fixed and living cells using optimized optical switches. PLoS One (2013) 0.75
Photoswitchable Spiropyran Dyads for Biological Imaging. Org Lett (2016) 0.75
Modulated-alignment dual-axis (MAD) confocal microscopy optimized for speed and contrast. IEEE Trans Biomed Eng (2015) 0.75
Preparation, Characterization and Application of Optical Switch Probes. Curr Protoc Chem Biol (2010) 0.75
Improved Fluorescent Protein Contrast and Discrimination by Optically Controlling Dark State Lifetimes. J Phys Chem Lett (2017) 0.75
Expanding discriminative dimensions for analysis and imaging. Chem Sci (2015) 0.75
Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations. Nat Commun (2017) 0.75
Reduced Fluorescent Protein Switching Fatigue by Binding-Induced Emissive State Stabilization. Int J Mol Sci (2017) 0.75
Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR. Angew Chem Int Ed Engl (2017) 0.75
Dynamic multicolor protein labeling in living cells. Chem Sci (2017) 0.75
Modulated-alignment dual-axis (MAD) confocal microscopy optimized for speed and contrast. IEEE Trans Biomed Eng (2015) 0.75
Imaging intracellular fluorescent proteins at nanometer resolution. Science (2006) 38.97
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat Methods (2006) 30.70
Ultra-high resolution imaging by fluorescence photoactivation localization microscopy. Biophys J (2006) 19.98
Creating new fluorescent probes for cell biology. Nat Rev Mol Cell Biol (2002) 9.25
Multicolor super-resolution imaging with photo-switchable fluorescent probes. Science (2007) 9.00
Breaking the diffraction barrier in fluorescence microscopy at low light intensities by using reversibly photoswitchable proteins. Proc Natl Acad Sci U S A (2005) 6.65
Direct physical measure of conformational rearrangement underlying potassium channel gating. Science (1996) 6.31
Autofluorescence of viable cultured mammalian cells. J Histochem Cytochem (1979) 3.41
Targeting neural circuitry in zebrafish using GAL4 enhancer trapping. Nat Methods (2007) 3.00
Total internal reflection fluorescence microscopy in cell biology. Methods Enzymol (2003) 2.67
Microfilament dynamics during cell movement and chemotaxis monitored using a GFP-actin fusion protein. Curr Biol (1997) 2.57
Fluorescence imaging for monitoring the colocalization of two single molecules in living cells. Biophys J (2004) 1.99
Analysis of protein interactions using fluorescence technologies. Curr Opin Chem Biol (2003) 1.91
Concepts for nanoscale resolution in fluorescence microscopy. Curr Opin Neurobiol (2004) 1.75
Diheteroarylethenes as thermally stable photoswitchable acceptors in photochromic fluorescence resonance energy transfer (pcFRET). J Am Chem Soc (2002) 1.60
Family of site-selective molecular optical switches. J Org Chem (2005) 1.41
Highlighted generation of fluorescence signals using simultaneous two-color irradiation on Dronpa mutants. Biophys J (2007) 1.32
Optical switching of dipolar interactions on proteins. Proc Natl Acad Sci U S A (2005) 1.28
Two-Photon deep tissue ex vivo imaging of mouse dermal and subcutaneous structures. Opt Express (1998) 1.28
Working with Xenopus spinal neurons in live cell culture. Methods Cell Biol (2003) 1.20
Pressure-jump study of the kinetics of ethidium bromide binding to DNA. Biochemistry (1985) 1.11
Fast and reversible photoswitching of the fluorescent protein dronpa as evidenced by fluorescence correlation spectroscopy. Biophys J (2006) 1.04
Imaging calcium dynamics in developing neurons. Methods Enzymol (2003) 0.83
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Subunit counting in membrane-bound proteins. Nat Methods (2007) 5.75
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
ProServer: a simple, extensible Perl DAS server. Bioinformatics (2007) 4.16
Closing in on the resting state of the Shaker K(+) channel. Neuron (2007) 3.49
Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature (2006) 3.47
Remote control of neuronal activity with a light-gated glutamate receptor. Neuron (2007) 3.45
Allosteric control of an ionotropic glutamate receptor with an optical switch. Nat Chem Biol (2005) 3.23
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
Molecular imaging of hydrogen peroxide produced for cell signaling. Nat Chem Biol (2007) 3.19
In vivo performance of genetically encoded indicators of neural activity in flies. J Neurosci (2005) 3.11
How does voltage open an ion channel? Annu Rev Cell Dev Biol (2006) 3.05
Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron (2005) 2.94
Functional architecture of olfactory ionotropic glutamate receptors. Neuron (2011) 2.67
Subunit organization and functional transitions in Ci-VSP. Nat Struct Mol Biol (2007) 2.64
Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature (2009) 2.61
Scanless two-photon excitation of channelrhodopsin-2. Nat Methods (2010) 2.60
The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc (2005) 2.11
The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature (2006) 2.10
A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J Am Chem Soc (2004) 2.08
Optical switches for remote and noninvasive control of cell signaling. Science (2008) 2.02
The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron (2003) 1.96
Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron (2002) 1.95
Structural rearrangements in single ion channels detected optically in living cells. Proc Natl Acad Sci U S A (2002) 1.85
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84
Emergence of patterned activity in the developing zebrafish spinal cord. Curr Biol (2011) 1.76
Filtering of visual information in the tectum by an identified neural circuit. Science (2010) 1.73
A selective turn-on fluorescent sensor for imaging copper in living cells. J Am Chem Soc (2006) 1.72
Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor. Proc Natl Acad Sci U S A (2007) 1.62
How far will you go to sense voltage? Neuron (2005) 1.61
Rules of engagement for NMDA receptor subunits. Proc Natl Acad Sci U S A (2008) 1.60
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proc Natl Acad Sci U S A (2010) 1.54
Molecular models of voltage sensing. J Gen Physiol (2002) 1.53
LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther (2011) 1.53
Optical lock-in detection of FRET using synthetic and genetically encoded optical switches. Biophys J (2008) 1.50
All optical interface for parallel, remote, and spatiotemporal control of neuronal activity. Nano Lett (2007) 1.49
Optical control of metabotropic glutamate receptors. Nat Neurosci (2013) 1.45
A method of extending the depth of focus of the high-resolution X-ray imaging system employing optical lens and scintillator: a phantom study. Biomed Eng Online (2015) 1.43
Family of site-selective molecular optical switches. J Org Chem (2005) 1.41
The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol (2009) 1.40
Heterogeneity in synaptic transmission along a Drosophila larval motor axon. Nat Neurosci (2005) 1.40
Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors. J Am Chem Soc (2007) 1.35
Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons. Nat Neurosci (2011) 1.34
Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides. Proc Natl Acad Sci U S A (2003) 1.33
Optical switching of dipolar interactions on proteins. Proc Natl Acad Sci U S A (2005) 1.28
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nat Neurosci (2010) 1.25
Scheloribatid mites as the source of pumiliotoxins in dendrobatid frogs. J Chem Ecol (2005) 1.22
Optical control of neuronal activity. Annu Rev Biophys (2010) 1.19
A fluorescent probe designed for studying protein conformational change. Proc Natl Acad Sci U S A (2005) 1.17
Tuning FlaSh: redesign of the dynamics, voltage range, and color of the genetically encoded optical sensor of membrane potential. Biophys J (2002) 1.16
Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR. Proc Natl Acad Sci U S A (2009) 1.13
Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J (2010) 1.13
Colloid-guided assembly of oriented 3D neuronal networks. Nat Methods (2008) 1.11
Molecular recognition and self-assembly special feature: Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels. Proc Natl Acad Sci U S A (2009) 1.09
Geranial: the alarm pheromone in the nymphal stage of the oribatid mite, Nothrus palustris. J Chem Ecol (2002) 1.09
Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron (2012) 1.09
Optically switchable chelates: optical control and sensing of metal ions. J Org Chem (2007) 1.09
A glutamate switch controls voltage-sensitive phosphatase function. Nat Struct Mol Biol (2012) 1.06
Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis. BMC Med Genomics (2008) 1.04
Shedding light on membrane proteins. Trends Neurosci (2005) 1.04
Fluorescent kabiramides: new probes to quantify actin in vitro and in vivo. Bioconjug Chem (2005) 1.03
Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers. Nat Chem Biol (2005) 1.02
Protein surface recognition by rational design: nanomolar ligands for potassium channels. J Am Chem Soc (2003) 1.02
The pore of the voltage-gated proton channel. Neuron (2011) 1.01
Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release. J Physiol (2012) 1.00
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun (2012) 0.98
A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor. J Am Chem Soc (2013) 0.98
Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex. Cell Rep (2012) 0.98
AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting. Proc Natl Acad Sci U S A (2013) 0.97
Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. Proc Natl Acad Sci U S A (2011) 0.96
Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element. J Biol Chem (2010) 0.95
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc Natl Acad Sci U S A (2011) 0.94
Optical switch probes and optical lock-in detection (OLID) imaging microscopy: high-contrast fluorescence imaging within living systems. Biochem J (2011) 0.94
Rational design, synthesis, and characterization of highly fluorescent optical switches for high-contrast optical lock-in detection (OLID) imaging microscopy in living cells. Bioorg Med Chem (2010) 0.93
Architecture and gating of Hv1 proton channels. J Physiol (2009) 0.91
Two-photon imaging of calcium in virally transfected striate cortical neurons of behaving monkey. PLoS One (2010) 0.90
Investigation of voice initiation and voice offset characteristics with high-speed digital imaging. Logoped Phoniatr Vocol (2006) 0.89
The Brain Prize 2013: the optogenetics revolution. Trends Neurosci (2013) 0.88
Two-photon scanning microscopy of in vivo sensory responses of cortical neurons genetically encoded with a fluorescent voltage sensor in rat. Front Neural Circuits (2012) 0.88
Nanoengineering ion channels for optical control. Physiology (Bethesda) (2008) 0.87
Tropomyosin dynamics in cardiac thin filaments: a multisite forster resonance energy transfer and anisotropy study. Biophys J (2008) 0.85
The effect of intermittent hypoxia on bodyweight, serum glucose and cholesterol in obesity mice. Pak J Biol Sci (2008) 0.85
Cell-based optimization of novel benzamides as potential antimalarial leads. Bioorg Med Chem Lett (2009) 0.85
Stoichiometry and specific assembly of Best ion channels. Proc Natl Acad Sci U S A (2014) 0.83
Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials. Bioorg Med Chem Lett (2010) 0.82
Rapid feedback regulation of synaptic efficacy during high-frequency activity at the Drosophila larval neuromuscular junction. Proc Natl Acad Sci U S A (2013) 0.82
Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues. ChemMedChem (2014) 0.81