Published in Nature on December 24, 2006
Ion channel voltage sensors: structure, function, and pathophysiology. Neuron (2010) 3.16
Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc Natl Acad Sci U S A (2007) 2.85
Portability of paddle motif function and pharmacology in voltage sensors. Nature (2007) 2.43
Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel. Proc Natl Acad Sci U S A (2008) 2.39
The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26
Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment. Biophys J (2007) 2.10
Multimeric nature of voltage-gated proton channels. Proc Natl Acad Sci U S A (2008) 2.00
Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J (2010) 1.87
Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci U S A (2009) 1.79
Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann Neurol (2012) 1.76
Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A (2011) 1.68
Extent of voltage sensor movement during gating of shaker K+ channels. Neuron (2008) 1.42
In search of a consensus model of the resting state of a voltage-sensing domain. Neuron (2011) 1.36
Contributions of counter-charge in a potassium channel voltage-sensor domain. Nat Chem Biol (2011) 1.32
X-ray crystal structure of voltage-gated proton channel. Nat Struct Mol Biol (2014) 1.28
Lipid-dependent gating of a voltage-gated potassium channel. Nat Commun (2011) 1.22
Voltage-gated proton channels: what's next? J Physiol (2008) 1.21
Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations. J Gen Physiol (2010) 1.20
Water wires in atomistic models of the Hv1 proton channel. Biochim Biophys Acta (2011) 1.07
Voltage-gated proton channels. Cell Mol Life Sci (2008) 1.06
Down-state model of the voltage-sensing domain of a potassium channel. Biophys J (2010) 1.06
Models of voltage-dependent conformational changes in NaChBac channels. Biophys J (2008) 1.05
Molecular dynamics investigation of the ω-current in the Kv1.2 voltage sensor domains. Biophys J (2012) 1.03
Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains. Neuron (2013) 1.03
Evolutionary imprint of activation: the design principles of VSDs. J Gen Physiol (2014) 1.02
Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structure. J Gen Physiol (2008) 1.02
Hydrophobic plug functions as a gate in voltage-gated proton channels. Proc Natl Acad Sci U S A (2013) 1.01
The pore of the voltage-gated proton channel. Neuron (2011) 1.01
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Cell Res (2013) 1.00
Do hyperpolarization-induced proton currents contribute to the pathogenesis of hypokalemic periodic paralysis, a voltage sensor channelopathy? J Gen Physiol (2007) 0.97
Mapping the membrane-aqueous border for the voltage-sensing domain of a potassium channel. J Biol Chem (2007) 0.97
Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element. J Biol Chem (2010) 0.95
Channelopathies of skeletal muscle excitability. Compr Physiol (2015) 0.94
S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels. PLoS One (2008) 0.94
MLKL forms cation channels. Cell Res (2016) 0.92
Architecture and gating of Hv1 proton channels. J Physiol (2009) 0.91
Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac. Biophys J (2010) 0.89
Molecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation. Front Pharmacol (2012) 0.87
Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating. Biophys J (2010) 0.87
The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants. Front Pharmacol (2011) 0.87
Biophysics, pathophysiology, and pharmacology of ion channel gating pores. Front Pharmacol (2014) 0.87
Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy. J Gen Physiol (2015) 0.86
Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cations. J Biol Chem (2015) 0.86
Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins. Mol Pharmacol (2014) 0.84
Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP. Biochemistry (2012) 0.84
Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron (2013) 0.84
Divalent cations slow activation of EAG family K+ channels through direct binding to S4. Biophys J (2009) 0.83
A naturally occurring omega current in a Kv3 family potassium channel from a platyhelminth. BMC Neurosci (2008) 0.83
Voltage-dependent gating in a "voltage sensor-less" ion channel. PLoS Biol (2010) 0.82
Coupling between the voltage-sensing and pore domains in a voltage-gated potassium channel. Biochim Biophys Acta (2012) 0.82
Voltage Sensing in Membranes: From Macroscopic Currents to Molecular Motions. J Membr Biol (2015) 0.80
Pore size matters for potassium channel conductance. J Gen Physiol (2016) 0.80
A novel current pathway parallel to the central pore in a mutant voltage-gated potassium channel. J Biol Chem (2011) 0.80
Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating. PLoS One (2008) 0.79
Voltage gated ion channel function: gating, conduction, and the role of water and protons. Int J Mol Sci (2012) 0.79
Voltage-dependent conformational changes of KVAP S4 segment in bacterial membrane environment. Channels (Austin) (2009) 0.79
Effect of verapamil on the action of methanethiosulfonate reagents on human voltage-gated K(v)1.3 channels: implications for the C-type inactivated state. Br J Pharmacol (2011) 0.79
Autonomous transmembrane segment S4 of the voltage sensor domain partitions into the lipid membrane. Biochim Biophys Acta (2012) 0.78
Functional extension of amino acid triads from the fourth transmembrane segment (S4) into its external linker in Shaker K(+) channels. J Biol Chem (2011) 0.77
Mechanisms of activation of voltage-gated potassium channels. Acta Naturae (2014) 0.77
TRPM3 in temperature sensing and beyond. Temperature (Austin) (2015) 0.76
The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel. Elife (2016) 0.76
Functional diversity of potassium channel voltage-sensing domains. Channels (Austin) (2016) 0.75
S0, where is it? J Gen Physiol (2008) 0.75
Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation. Sci Rep (2016) 0.75
Voltage sensor of ion channels and enzymes. Biophys Rev (2011) 0.75
Observation of σ-pore currents in mutant hKv1.2_V370C potassium channels. PLoS One (2017) 0.75
Proton currents constrain structural models of voltage sensor activation. Elife (2016) 0.75
bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles. J Gen Physiol (2016) 0.75
Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains. Biophys J (2017) 0.75
Atomistic Modeling of Ion Conduction Through the Voltage-Sensing Domain of the Shaker K(+) Ion Channel. J Phys Chem B (2017) 0.75
Subunit counting in membrane-bound proteins. Nat Methods (2007) 5.75
Closing in on the resting state of the Shaker K(+) channel. Neuron (2007) 3.49
Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature (2006) 3.47
Remote control of neuronal activity with a light-gated glutamate receptor. Neuron (2007) 3.45
Allosteric control of an ionotropic glutamate receptor with an optical switch. Nat Chem Biol (2005) 3.23
Molecular imaging of hydrogen peroxide produced for cell signaling. Nat Chem Biol (2007) 3.19
In vivo performance of genetically encoded indicators of neural activity in flies. J Neurosci (2005) 3.11
How does voltage open an ion channel? Annu Rev Cell Dev Biol (2006) 3.05
Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron (2005) 2.94
Functional architecture of olfactory ionotropic glutamate receptors. Neuron (2011) 2.67
Subunit organization and functional transitions in Ci-VSP. Nat Struct Mol Biol (2007) 2.64
Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature (2009) 2.61
Scanless two-photon excitation of channelrhodopsin-2. Nat Methods (2010) 2.60
The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26
Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells. Proc Natl Acad Sci U S A (2008) 2.15
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc (2005) 2.11
A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J Am Chem Soc (2004) 2.08
Optical switches for remote and noninvasive control of cell signaling. Science (2008) 2.02
The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron (2003) 1.96
Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron (2002) 1.95
Structural rearrangements in single ion channels detected optically in living cells. Proc Natl Acad Sci U S A (2002) 1.85
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84
Emergence of patterned activity in the developing zebrafish spinal cord. Curr Biol (2011) 1.76
Filtering of visual information in the tectum by an identified neural circuit. Science (2010) 1.73
A selective turn-on fluorescent sensor for imaging copper in living cells. J Am Chem Soc (2006) 1.72
Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor. Proc Natl Acad Sci U S A (2007) 1.62
How far will you go to sense voltage? Neuron (2005) 1.61
Rules of engagement for NMDA receptor subunits. Proc Natl Acad Sci U S A (2008) 1.60
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proc Natl Acad Sci U S A (2010) 1.54
LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther (2011) 1.53
Molecular models of voltage sensing. J Gen Physiol (2002) 1.53
All optical interface for parallel, remote, and spatiotemporal control of neuronal activity. Nano Lett (2007) 1.49
Optical control of metabotropic glutamate receptors. Nat Neurosci (2013) 1.45
The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol (2009) 1.40
Heterogeneity in synaptic transmission along a Drosophila larval motor axon. Nat Neurosci (2005) 1.40
Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors. J Am Chem Soc (2007) 1.35
Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons. Nat Neurosci (2011) 1.34
Control of neurotransmitter release by an internal gel matrix in synaptic vesicles. Proc Natl Acad Sci U S A (2003) 1.29
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nat Neurosci (2010) 1.25
Optical control of neuronal activity. Annu Rev Biophys (2010) 1.19
A fluorescent probe designed for studying protein conformational change. Proc Natl Acad Sci U S A (2005) 1.17
Tuning FlaSh: redesign of the dynamics, voltage range, and color of the genetically encoded optical sensor of membrane potential. Biophys J (2002) 1.16
Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR. Proc Natl Acad Sci U S A (2009) 1.13
Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J (2010) 1.13
Colloid-guided assembly of oriented 3D neuronal networks. Nat Methods (2008) 1.11
Molecular recognition and self-assembly special feature: Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels. Proc Natl Acad Sci U S A (2009) 1.09
Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron (2012) 1.09
A glutamate switch controls voltage-sensitive phosphatase function. Nat Struct Mol Biol (2012) 1.06
Collective behaviour in two-dimensional cobalt nanoparticle assemblies observed by magnetic force microscopy. Nat Mater (2004) 1.05
Shedding light on membrane proteins. Trends Neurosci (2005) 1.04
Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains. Neuron (2013) 1.03
Preparation of reliable probes for electrochemical tunneling spectroscopy. Anal Chem (2004) 1.02
Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers. Nat Chem Biol (2005) 1.02
Protein surface recognition by rational design: nanomolar ligands for potassium channels. J Am Chem Soc (2003) 1.02
The pore of the voltage-gated proton channel. Neuron (2011) 1.01
Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release. J Physiol (2012) 1.00
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun (2012) 0.98
Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex. Cell Rep (2012) 0.98
A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor. J Am Chem Soc (2013) 0.98
AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting. Proc Natl Acad Sci U S A (2013) 0.97
Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. Proc Natl Acad Sci U S A (2011) 0.96
Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element. J Biol Chem (2010) 0.95
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc Natl Acad Sci U S A (2011) 0.94
Architecture and gating of Hv1 proton channels. J Physiol (2009) 0.91
A robust molecular platform for non-volatile memory devices with optical and magnetic responses. Nat Chem (2011) 0.91
Two-photon imaging of calcium in virally transfected striate cortical neurons of behaving monkey. PLoS One (2010) 0.90
Supramolecular properties of the proline-rich gamma-Zein N-terminal domain. Biophys J (2002) 0.89
Two-photon scanning microscopy of in vivo sensory responses of cortical neurons genetically encoded with a fluorescent voltage sensor in rat. Front Neural Circuits (2012) 0.88
The Brain Prize 2013: the optogenetics revolution. Trends Neurosci (2013) 0.88
Two-photon neuronal and astrocytic stimulation with azobenzene-based photoswitches. J Am Chem Soc (2014) 0.88
Nanoengineering ion channels for optical control. Physiology (Bethesda) (2008) 0.87
Optical control of calcium-regulated exocytosis. Biochim Biophys Acta (2013) 0.85
Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis. Angew Chem Int Ed Engl (2013) 0.84
Stoichiometry and specific assembly of Best ion channels. Proc Natl Acad Sci U S A (2014) 0.83
Rapid feedback regulation of synaptic efficacy during high-frequency activity at the Drosophila larval neuromuscular junction. Proc Natl Acad Sci U S A (2013) 0.82
Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR. Front Mol Neurosci (2013) 0.81
Photoswitching of cell surface receptors using tethered ligands. Methods Mol Biol (2014) 0.79
Titration force microscopy on supported lipid bilayers. Anal Chem (2006) 0.78
Colloids as mobile substrates for the implantation and integration of differentiated neurons into the mammalian brain. PLoS One (2012) 0.78
Green fluorescent proteins (GFPs) for measuring voltage. Cold Spring Harb Protoc (2010) 0.77
Current-voltage characteristics and transition voltage spectroscopy of individual redox proteins. J Am Chem Soc (2012) 0.77
Measuring membrane voltage with fluorescent proteins. Cold Spring Harb Protoc (2013) 0.77
Conductance switching in single wired redox proteins. Small (2014) 0.77
Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective. Curr Neuropharmacol (2016) 0.77
Molecular handles for the mechanical manipulation of single-membrane proteins in living cells. IEEE Trans Nanobioscience (2005) 0.76
Transistor-like behavior of single metalloprotein junctions. Nano Lett (2011) 0.76
Nanomechanics of silicon surfaces with atomic force microscopy: an insight to the first stages of plastic deformation. J Chem Phys (2005) 0.76
Direct measurement of electron transfer distance decay constants of single redox proteins by electrochemical tunneling spectroscopy. ACS Nano (2011) 0.76
New GABA amides activating GABAA-receptors. Beilstein J Org Chem (2013) 0.75
Dynamic aspects of functioning membrane proteins. J Physiol (2009) 0.75
To dislodge an enzyme from an ion channel, try steroids. Nat Chem Biol (2008) 0.75