Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas.

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Published in Oncogene on June 04, 2007

Authors

H Jin1, X Wang, J Ying, A H Y Wong, H Li, K Y Lee, G Srivastava, A T C Chan, W Yeo, B B Y Ma, T C Putti, M L Lung, Z-Y Shen, L-Y Xu, C Langford, Q Tao

Author Affiliations

1: Cancer Epigenetics Laboratory, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Chinese University of Hong Kong, China.

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell (1998) 13.87

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Notch signalling controls pancreatic cell differentiation. Nature (1999) 7.18

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Building a dictionary for genomes: identification of presumptive regulatory sites by statistical analysis. Proc Natl Acad Sci U S A (2000) 3.18

Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14

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Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem (1994) 3.09

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Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J Biol Chem (1993) 3.04

Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering. Prog Biophys Mol Biol (2000) 3.00

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Nucleotide sequence of the 3' end of MCF 247 murine leukemia virus. J Virol (1983) 2.87

Identification of coryneform bacterial isolates by ribosomal DNA sequence analysis. J Clin Microbiol (2000) 2.87

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest (1999) 2.77

Validation of near-infrared spectroscopy in humans. J Appl Physiol (1985) (1994) 2.77

tRNA splicing. J Biol Chem (1998) 2.77

Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature (2001) 2.76

Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children's Cancer Group trial no. CCG-945. J Neurosurg (1998) 2.75

Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol (2000) 2.74

Radiofrequency catheter ablation of idiopathic left ventricular tachycardia guided by a Purkinje potential. Circulation (1993) 2.71

Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science (2000) 2.70

Invitro formation of assimilatory reduced nicotinamide adenine dinucleotide phosphate: nitrate reductase from a Neurospora mutant and a component of molybdenum-enzymes. Proc Natl Acad Sci U S A (1971) 2.69

Feasibility of a high-speed gamma-camera design using the high-yield-pileup-event-recovery method. J Nucl Med (2001) 2.69

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest (2001) 2.67

A systematic review and economic evaluation of statins for the prevention of coronary events. Health Technol Assess (2007) 2.62