The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway.

PubWeight™: 2.77‹?› | Rank: Top 1%

🔗 View Article (PMC 481052)

Published in J Clin Invest on October 01, 1999

Authors

R M Lawn1, D P Wade, M R Garvin, X Wang, K Schwartz, J G Porter, J J Seilhamer, A M Vaughan, J F Oram

Author Affiliations

1: CV Therapeutics Inc., Palo Alto, California 94304, USA. lawn@cvt.com

Articles citing this

(truncated to the top 100)

The role of apolipoprotein E in Alzheimer's disease. Neuron (2009) 5.55

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci U S A (2000) 4.58

Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 3.63

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A (2001) 3.29

Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol (2002) 3.02

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A (2002) 2.55

The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci (2011) 2.44

The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci U S A (2004) 2.39

Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol Cell Biol (2003) 2.10

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest (2008) 2.01

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes. J Clin Invest (2000) 1.98

Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels. J Clin Invest (2001) 1.72

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc Natl Acad Sci U S A (2001) 1.61

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest (2001) 1.61

Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency. Am J Pathol (2000) 1.50

Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly. Structure (2015) 1.43

ABC transporters, atherosclerosis and inflammation. Atherosclerosis (2010) 1.41

Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells. Infect Immun (2002) 1.40

Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A (2000) 1.26

The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses. Biochemistry (2008) 1.24

Disruption of cholesterol homeostasis by plant sterols. J Clin Invest (2004) 1.22

Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase. Circ Res (2014) 1.21

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem (2008) 1.21

ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse. J Lipid Res (2009) 1.14

ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport. Mol Med (2010) 1.10

Statistical power of expression quantitative trait loci for mapping of complex trait loci in natural populations. Genetics (2008) 1.09

Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells. Biochim Biophys Acta (2011) 1.09

A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS. Nephrol Dial Transplant (2008) 1.08

Role of the C terminus of the photoreceptor ABCA4 transporter in protein folding, function, and retinal degenerative diseases. J Biol Chem (2008) 1.06

Searching for osteoporosis genes in the post-genome era: progress and challenges. Osteoporos Int (2003) 1.05

DNA microarrays in medical practice. BMJ (2001) 1.05

Rapid transbilayer movement of the fluorescent sterol dehydroergosterol in lipid membranes. Biophys J (2002) 1.04

More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron (2014) 1.04

Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse. Atherosclerosis (2008) 1.03

ABC1: connecting yellow tonsils, neuropathy, and very low HDL. J Clin Invest (1999) 1.03

A general framework for association tests with multivariate traits in large-scale genomics studies. Genet Epidemiol (2013) 1.03

Type 2 diabetes is associated with reduced ATP-binding cassette transporter A1 gene expression, protein and function. PLoS One (2011) 1.02

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry (2008) 1.01

ABCA1 gene variants regulate postprandial lipid metabolism in healthy men. Arterioscler Thromb Vasc Biol (2010) 0.99

PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1. Nucl Recept Signal (2010) 0.98

Monogenic dyslipidemias: window on determinants of plasma lipoprotein metabolism. Am J Hum Genet (2001) 0.97

Influence of C-terminal α-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality. Biochim Biophys Acta (2011) 0.96

The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Structure (2012) 0.95

Causes of dysregulation of lipid metabolism in chronic renal failure. Semin Dial (2009) 0.94

MicroRNA control of high-density lipoprotein metabolism and function. Circ Res (2014) 0.93

Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23. Am J Hum Genet (2000) 0.93

A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis. J Lipid Res (2014) 0.92

Reverse cholesterol transport pathway in experimental chronic renal failure. Am J Nephrol (2009) 0.92

LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PLoS One (2009) 0.92

Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging. Aging (Albany NY) (2009) 0.92

Microdomains, Inflammation, and Atherosclerosis. Circ Res (2016) 0.91

SAA does not induce cytokine production in physiological conditions. Cytokine (2012) 0.91

Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia (2014) 0.91

Integrated gene expression profiling and linkage analysis in the rat. Mamm Genome (2006) 0.90

Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes. J Biol Chem (2009) 0.90

A-Subclass ATP-Binding Cassette Proteins in Brain Lipid Homeostasis and Neurodegeneration. Front Psychiatry (2012) 0.89

ABCA1, from pathology to membrane function. Pflugers Arch (2006) 0.89

Site-specific oxidation of apolipoprotein A-I impairs cholesterol export by ABCA1, a key cardioprotective function of HDL. Biochim Biophys Acta (2011) 0.89

Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene. J Biol Chem (2012) 0.89

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour. Nature (2015) 0.88

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling. Mol Neurodegener (2012) 0.88

ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid-bile acid conjugates (FABACs). Biochem J (2006) 0.87

Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo. Am J Physiol Heart Circ Physiol (2009) 0.87

ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore. Hum Genet (2003) 0.87

The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells. Glia (2008) 0.86

Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. J Neurosci Res (2009) 0.86

Whole-genome survey of the putative ATP-binding cassette transporter family genes in Vitis vinifera. PLoS One (2013) 0.85

Pharmacogenetics of lipid diseases. Hum Genomics (2004) 0.85

Markers of increased cardiovascular risk in patients with chronic kidney disease. Lipids Health Dis (2014) 0.84

Down-regulation of lipoprotein lipase increases ABCA1-mediated cholesterol efflux in THP-1 macrophages. Biochem Biophys Res Commun (2014) 0.84

Origins of intestinal ABCA1-mediated HDL-cholesterol. J Lipid Res (2008) 0.83

Dysfunctional HDL containing L159R ApoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice. Biochim Biophys Acta (2011) 0.83

Reverse cholesterol transport is regulated by varying fatty acyl chain saturation and sphingomyelin content in reconstituted high-density lipoproteins. Metabolism (2007) 0.83

ABC Transporters and the Alzheimer's Disease Enigma. Front Psychiatry (2012) 0.83

Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages. PLoS One (2014) 0.82

Rosiglitazone enhances apolipoprotein M (Apom) expression in rat's liver. Int J Med Sci (2014) 0.81

microRNAs in lipoprotein metabolism and cardiometabolic disorders. Atherosclerosis (2016) 0.81

Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells. J Gen Virol (2008) 0.81

Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Acta Pharmacol Sin (2010) 0.81

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway. J Lipid Res (2015) 0.80

Polarized cholesterol and phospholipid efflux in cultured gall-bladder epithelial cells: evidence for an ABCA1-mediated pathway. Biochem J (2002) 0.80

ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Mol Biol (2007) 0.80

Enhanced placental cholesterol efflux by fetal HDL in Smith-Lemli-Opitz syndrome. Mol Genet Metab (2008) 0.80

Fermentation of soy milk via Lactobacillus plantarum improves dysregulated lipid metabolism in rats on a high cholesterol diet. PLoS One (2014) 0.80

High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk. BBA Clin (2015) 0.79

PPAR Medicines and Human Disease: The ABCs of It All. PPAR Res (2012) 0.79

Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II. J Lipid Res (2013) 0.79

Genetic variation and atherosclerosis. Curr Genomics (2008) 0.79

Placental ABC Transporters: Biological Impact and Pharmaceutical Significance. Pharm Res (2016) 0.79

Regulation of foam cells by adenosine. Arterioscler Thromb Vasc Biol (2012) 0.78

Blasts from the past. J Clin Invest (2004) 0.78

Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet. Lipids (2010) 0.77

Cholesterol Transporters ABCA1 and ABCG1 Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Metabolic Syndrome. Cholesterol (2015) 0.77

The effect of PPARalpha and PPARgamma ligands on inflammation and ABCA1 expression in cultured gallbladder epithelial cells. Dig Dis Sci (2008) 0.77

Distribution of brevetoxin (PbTx-3) in mouse plasma: association with high-density lipoproteins. Environ Health Perspect (2005) 0.77

High-density lipoprotein and atherosclerosis: Roles of lipid transporters. World J Cardiol (2014) 0.77

New Insights into the High-Density Lipoprotein Dilemma. Trends Endocrinol Metab (2015) 0.76

A genetical genomics approach to genome scans increases power for QTL mapping. Genetics (2010) 0.76

EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. Arterioscler Thromb Vasc Biol (2017) 0.76

Increased serum triglyceride clearance and elevated high-density lipoprotein 2 and 3 cholesterol during treatment of primary hypertriglyceridemia with bezafibrate. Curr Ther Res Clin Exp (2003) 0.75

Articles cited by this

Exploring the metabolic and genetic control of gene expression on a genomic scale. Science (1997) 60.15

ABC transporters: from microorganisms to man. Annu Rev Cell Biol (1992) 19.49

A receptor-mediated pathway for cholesterol homeostasis. Science (1986) 19.28

The plasma lecithins:cholesterol acyltransferase reaction. J Lipid Res (1968) 8.11

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem (1983) 7.70

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet (1999) 7.30

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet (1999) 7.04

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet (1999) 6.92

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature (1990) 6.41

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell (1993) 4.76

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet (1998) 3.33

Cell cholesterol efflux: integration of old and new observations provides new insights. J Lipid Res (1999) 2.61

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. J Clin Invest (1995) 2.20

Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun (1999) 2.08

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet (1996) 1.90

Intracellular cholesterol transport. J Lipid Res (1997) 1.86

Apolipoprotein-mediated removal of cellular cholesterol and phospholipids. J Lipid Res (1996) 1.73

Evolution of ATP-binding cassette transporter genes. Curr Opin Genet Dev (1995) 1.72

Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1. Blood (1997) 1.67

Plasma membrane caveolae mediate the efflux of cellular free cholesterol. Biochemistry (1995) 1.67

Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics (1994) 1.63

Homozygous Tangier disease and cardiovascular disease. Atherosclerosis (1994) 1.48

THE INHERITANCE OF HIGH DENSITY LIPOPROTEIN DEFICIENCY (TANGIER DISEASE). J Clin Invest (1964) 1.43

Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol. J Clin Invest (1993) 1.37

Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux. Arterioscler Thromb Vasc Biol (1997) 1.32

Cyclic AMP induces apolipoprotein E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors. J Biol Chem (1996) 1.24

Atheroprotective mechanisms of HDL. Atherosclerosis (1999) 1.16

HDL-mediated efflux of intracellular cholesterol is impaired in fibroblasts from Tangier disease patients. Arterioscler Thromb Vasc Biol (1995) 1.12

Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion. J Lipid Res (1997) 1.12

ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes. J Biol Chem (1997) 1.11

The high density lipoprotein- and apolipoprotein A-I-induced mobilization of cellular cholesterol is impaired in fibroblasts from Tangier disease subjects. Biochem Biophys Res Commun (1994) 1.10

High density lipoprotein apolipoproteins mediate removal of sterol from intracellular pools but not from plasma membranes of cholesterol-loaded fibroblasts. Arterioscler Thromb (1991) 1.07

Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus. J Lipid Res (1996) 1.00

Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategy. Nat Genet (1998) 0.93

Reduction in apolipoprotein-mediated removal of cellular lipids by immortalization of human fibroblasts and its reversion by cAMP: lack of effect with Tangier disease cells. J Lipid Res (1999) 0.93

Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. J Biol Chem (1993) 0.89

The adenosine 5',5"',P1,P4-tetraphosphate receptor is at the cell surface of heart cells. Biochemistry (1993) 0.89

Articles by these authors

The sequence of the human genome. Science (2001) 101.55

The genome sequence of Drosophila melanogaster. Science (2000) 74.32

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell (1998) 13.87

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83

Orchestrated transcription of key pathways in Arabidopsis by the circadian clock. Science (2000) 12.35

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med (2000) 11.35

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature (2000) 9.80

Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol (1999) 8.21

Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation (2001) 7.47

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell (1993) 6.95

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88

HOLE: a program for the analysis of the pore dimensions of ion channel structural models. J Mol Graph (1996) 6.48

Endonuclease G is an apoptotic DNase when released from mitochondria. Nature (2001) 6.20

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell (1997) 5.95

Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids. Insect Mol Biol (2000) 5.81

Speech recognition in noise as a function of the number of spectral channels: comparison of acoustic hearing and cochlear implants. J Acoust Soc Am (2001) 5.75

The Ebola virus VP35 protein functions as a type I IFN antagonist. Proc Natl Acad Sci U S A (2000) 5.46

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Proc Natl Acad Sci U S A (2000) 5.38

DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide. J Bacteriol (2001) 5.35

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Nat Genet (1999) 5.04

Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci (2001) 4.99

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci U S A (1993) 4.61

POWER_SAGE: comparing statistical tests for SAGE experiments. Bioinformatics (2000) 4.56

Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett (1997) 4.48

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res (1999) 4.23

Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol (1996) 4.11

Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem (1998) 4.02

Treatment of supraventricular tachycardia due to atrioventricular nodal reentry, by radiofrequency catheter ablation of slow-pathway conduction. N Engl J Med (1992) 3.95

Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci (2000) 3.95

Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors. Proc Natl Acad Sci U S A (1998) 3.94

Multiple transcription-factor genes are early targets of phytochrome A signaling. Proc Natl Acad Sci U S A (2001) 3.91

Language comprehension in language-learning impaired children improved with acoustically modified speech. Science (1996) 3.84

The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci U S A (1998) 3.83

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat Genet (1997) 3.79

Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements. Nat Photonics (2012) 3.68

Structural basis of IAP recognition by Smac/DIABLO. Nature (2001) 3.66

Temporal and rate representations of time-varying signals in the auditory cortex of awake primates. Nat Neurosci (2001) 3.62

Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature (2000) 3.54

Apoptosis of T cells mediated by galectin-1. Nature (1995) 3.54

Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest (1998) 3.51

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol (1999) 3.45

Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell (1999) 3.45

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell (2000) 3.39

Myocyte death in the failing human heart is gender dependent. Circ Res (1999) 3.38

The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem (1996) 3.38

Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology (1993) 3.37

Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium. Proc Natl Acad Sci U S A (2000) 3.32

Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology (1995) 3.26

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem (1994) 3.09

Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Nat Genet (1995) 3.05

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J Biol Chem (1993) 3.04

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93

Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J Dent Res (2013) 2.89

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell (1998) 2.89

Myosin isoenzyme redistribution in chronic heart overload. Nature (1979) 2.89

Three myosin heavy-chain isozymes appear sequentially in rat muscle development. Nature (1981) 2.88

Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J (1995) 2.87

ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem (2000) 2.82

Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature (2001) 2.76

Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol (2000) 2.74

Myoblast transplantation for heart failure. Lancet (2001) 2.71

Radiofrequency catheter ablation of idiopathic left ventricular tachycardia guided by a Purkinje potential. Circulation (1993) 2.71

Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science (2000) 2.70

Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA (1986) 2.70

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest (2001) 2.67

Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders. Am J Med (1984) 2.60

Development and validation of an ECG algorithm for identifying accessory pathway ablation site in Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol (1998) 2.59

Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res (2001) 2.56

Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res (2001) 2.55

Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Hum Mol Genet (2000) 2.52

Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation. Blood (2001) 2.52

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52

Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy. Nat Genet (1995) 2.52

Effects of noise and spectral resolution on vowel and consonant recognition: acoustic and electric hearing. J Acoust Soc Am (1998) 2.46

Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol (2000) 2.46

Relation between sexual practices and T-cell subsets in homosexually active men. Lancet (1983) 2.46

Comparison of in vivo tissue temperature profile and lesion geometry for radiofrequency ablation with a saline-irrigated electrode versus temperature control in a canine thigh muscle preparation. Circulation (1995) 2.45

Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci U S A (1997) 2.44

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J Biol Chem (2000) 2.42

Long-term outcomes in nondiabetic chronic kidney disease. Kidney Int (2008) 2.41

The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway. J Clin Invest (1996) 2.39

Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort study. Arch Environ Health (1996) 2.39

Consonant recordings for speech testing. J Acoust Soc Am (1999) 2.38

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A (1998) 2.38

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest (1987) 2.37

A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum (2001) 2.37

IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. Neurology (2010) 2.36

Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Biochem J (2001) 2.35

CD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testing. J Virol (2001) 2.34

Torque generation in the flagellar motor of Escherichia coli: evidence of a direct role for FliG but not for FliM or FliN. J Bacteriol (1996) 2.32

Effects of cigarette smoking on lung function in adolescent boys and girls. N Engl J Med (1996) 2.31

Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron (2001) 2.29