Sensitive detection of DNA methylation.

Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res (2007) 2.69

Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. Clin Cancer Res (2007) 2.02

A real-time PCR assay for DNA-methylation using methylation-specific blockers. Nucleic Acids Res (2004) 1.63

Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection. Nucleic Acids Res (2008) 1.57

Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling. PLoS One (2008) 1.46

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res (2008) 1.42

Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. BMC Cancer (2006) 1.34

KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. Int J Cancer (2010) 1.26

Methods in DNA methylation profiling. Epigenomics (2009) 1.25

MSRE-PCR for analysis of gene-specific DNA methylation. Nucleic Acids Res (2005) 1.21

Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas. Oncogene (2007) 1.21

Promoter methylation and the detection of breast cancer. Cancer Causes Control (2009) 1.18

Control of carry-over contamination for PCR-based DNA methylation quantification using bisulfite treated DNA. Nucleic Acids Res (2006) 1.17

Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival. Clin Cancer Res (2011) 1.15

Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. Genome Res (2005) 1.02

DNA methylation pattern as important epigenetic criterion in cancer. Genet Res Int (2013) 1.00

Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. PLoS One (2012) 0.99

DNA methylation in pre-diagnostic serum samples of breast cancer cases: results of a nested case-control study. Cancer Epidemiol (2010) 0.98

Aberrant methylation in non-small cell lung cancer. Surg Today (2010) 0.96

Promoter hypermethylation in Indian primary oral squamous cell carcinoma. Int J Cancer (2010) 0.92

Epigenomics and ovarian carcinoma. Biomark Med (2010) 0.91

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes. Oncotarget (2012) 0.91

Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma. Chin J Cancer (2011) 0.86

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. Sci Rep (2014) 0.85

Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma. Chin J Cancer (2012) 0.85

MALDI-TOF MS in Prenatal Genomics. Transfus Med Hemother (2009) 0.84

Identification of guanine nucleotide-binding protein γ-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling. Int J Oncol (2013) 0.81

Quantitative assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens. Virchows Arch (2010) 0.80

A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation. Epigenetics Chromatin (2010) 0.79

DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis. PLoS One (2015) 0.79

What will it take to obtain DNA methylation markers for early cervical cancer detection? Gynecol Oncol (2009) 0.78

Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of Patients with Gastric Cancer. Dis Markers (2016) 0.77

Detecting Chemically Modified DNA Bases Using Surface Enhanced Raman Spectroscopy. J Phys Chem Lett (2011) 0.77

Hypermethylated SFRP1, but none of other nine genes "informative" for western countries, is valuable for bladder cancer detection in Mainland China. J Cancer Res Clin Oncol (2009) 0.77

High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method. BMC Med Genomics (2012) 0.76

Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer. Oncol Rep (2013) 0.76

Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma. BMC Cancer (2017) 0.75

Gene promoter hypermethylation in tumors and plasma of breast cancer patients. Cancer Res Treat (2005) 0.75

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12

Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87

Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62

Pan-cancer patterns of somatic copy number alteration. Nat Genet (2013) 7.73

Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res (2005) 6.49

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet (2011) 5.70

Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res (2011) 4.84

Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn (2006) 4.68

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97

Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol (2002) 3.79

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30

Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res (2004) 3.23

Interplay between the cancer genome and epigenome. Cell (2013) 3.05

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00

Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun (2013) 2.94

Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85

Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst (2010) 2.38

Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res (2013) 2.19

Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev (2008) 2.12

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila) (2008) 2.04

DNA methylation as a biomarker for cardiovascular disease risk. PLoS One (2010) 2.04

Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. Genome Biol (2012) 2.02

Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res (2006) 1.99

Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog (2010) 1.94

A comparison of cluster analysis methods using DNA methylation data. Bioinformatics (2004) 1.94

Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PLoS One (2009) 1.90

DNA hypomethylation and ovarian cancer biology. Cancer Res (2004) 1.75

Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res (2002) 1.73

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73

The landscape of microsatellite instability in colorectal and endometrial cancer genomes. Cell (2013) 1.68

DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines. PLoS One (2010) 1.65

Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene (2002) 1.59

Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology (2007) 1.56

Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One (2007) 1.55

Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res (2006) 1.52

Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells (2010) 1.50

Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res (2010) 1.47

Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47

Discovery of multi-dimensional modules by integrative analysis of cancer genomic data. Nucleic Acids Res (2012) 1.46

MethyLight. Methods Mol Biol (2009) 1.45

Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget (2013) 1.44

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res (2008) 1.42

An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst (2013) 1.42

Distinct methylation profiles of glioma subtypes. Int J Cancer (2003) 1.38

Hierarchical clustering of lung cancer cell lines using DNA methylation markers. Cancer Epidemiol Biomarkers Prev (2002) 1.38

Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res (2008) 1.36

Sex differential in methylation patterns of selected genes in Singapore Chinese. Hum Genet (2005) 1.35

DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis. Lab Invest (2007) 1.34

Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation (2002) 1.32

Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. Am J Surg Pathol (2006) 1.29

Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer (2008) 1.24

Combined bisulfite restriction analysis (COBRA). Methods Mol Biol (2002) 1.20

Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. Hum Genet (2002) 1.19

DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol (2002) 1.18

Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res (2004) 1.17

Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. PLoS One (2012) 1.14

The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer (2009) 1.14

Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer (2007) 1.14

DNA methylation profile of 28 potential marker loci in malignant mesothelioma. Lung Cancer (2007) 1.11

Ovarian cancer early detection claims are biased. Clin Cancer Res (2008) 1.10

The role of DNA methylation in the development and progression of lung adenocarcinoma. Dis Markers (2007) 1.09

The mutagenic potential of duodenoesophageal reflux. Ann Surg (2005) 1.08

Rapid and quantitative method of allele-specific DNA methylation analysis. Biotechniques (2006) 1.08

Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung. Lung Cancer (2005) 1.06

Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. J Nutr (2007) 1.04

DNA hypermethylation of ESR1 and PGR in breast cancer: pathologic and epidemiologic associations. Cancer Epidemiol Biomarkers Prev (2009) 1.04

Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases. J Mol Diagn (2010) 1.04

Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study. Nutr Cancer (2012) 1.03

Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial. Cancer Epidemiol Biomarkers Prev (2005) 1.01

Analysis of complex methylation data. Methods (2002) 1.00

Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. Neoplasia (2010) 0.99

Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women. Gastroenterology (2013) 0.98

Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer. PLoS One (2010) 0.95

Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women. Gut (2011) 0.94

In epigenetic therapy, less is more. Cell Stem Cell (2012) 0.93

Hormone therapy, DNA methylation and colon cancer. Carcinogenesis (2010) 0.91

Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis (2002) 0.89

Sensitivity and reproducibility of standardized-competitive RT-PCR for transcript quantification and its comparison with real time RT-PCR. Mol Cancer (2004) 0.89

Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women. Cancer Prev Res (Phila) (2011) 0.88

Gene dysregulation by histone variant H2A.Z in bladder cancer. Epigenetics Chromatin (2013) 0.88

Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Cancer Epidemiol Biomarkers Prev (2007) 0.88

Locking in on the human methylome. Nat Biotechnol (2009) 0.88

Clinical applications of DNA methylation biomarkers in colorectal cancer. Epigenomics (2013) 0.88

Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry. Cancer Prev Res (Phila) (2011) 0.88

2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1. Cancer Lett (2008) 0.88

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force. Cancer Res (2012) 0.87

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. PLoS One (2011) 0.87

Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer Prev Res (Phila) (2011) 0.87

Tumor Budding in Colorectal Carcinoma: Confirmation of Prognostic Significance and Histologic Cutoff in a Population-based Cohort. Am J Surg Pathol (2015) 0.84

Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors. PLoS One (2011) 0.80

Cluster analysis for DNA methylation profiles having a detection threshold. BMC Bioinformatics (2006) 0.80

Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis (2011) 0.80

Promoter hypermethylation: a new therapeutic target emerges in urothelial cancer. J Clin Oncol (2005) 0.79