Published in PLoS One on June 20, 2007
Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis. PLoS One (2010) 1.60
Regulation of alternative splicing by the core spliceosomal machinery. Genes Dev (2011) 1.60
Cotranscriptional exon skipping in the genotoxic stress response. Nat Struct Mol Biol (2010) 1.39
Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome. Nat Struct Mol Biol (2014) 1.20
A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. Hum Mol Genet (2010) 1.15
Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Mol Cell (2012) 1.14
SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant. Am J Hum Genet (2013) 1.09
The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution. PLoS Genet (2009) 1.07
PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Hum Mol Genet (2011) 1.04
Identification of motifs that function in the splicing of non-canonical introns. Genome Biol (2008) 1.02
Spatial mapping of splicing factor complexes involved in exon and intron definition. J Cell Biol (2008) 1.01
Concerted perturbation observed in a hub network in Alzheimer's disease. PLoS One (2012) 1.00
Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing. Nucleic Acids Res (2010) 0.99
Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. RNA (2009) 0.99
A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast. Nucleic Acids Res (2008) 0.96
A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. PLoS Biol (2014) 0.95
Allele-specific recognition of the 3' splice site of INS intron 1. Hum Genet (2010) 0.94
Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins. J Biol Chem (2009) 0.91
New Arabidopsis thaliana cytochrome c partners: a look into the elusive role of cytochrome c in programmed cell death in plants. Mol Cell Proteomics (2013) 0.90
Thioredoxin as a fusion tag for carrier-driven crystallization. Protein Sci (2008) 0.87
A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res (2013) 0.85
Features generated for computational splice-site prediction correspond to functional elements. BMC Bioinformatics (2007) 0.85
Cancer-relevant splicing factor CAPERα engages the essential splicing factor SF3b155 in a specific ternary complex. J Biol Chem (2014) 0.85
The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA. J Biol Chem (2014) 0.84
Dominant variants in the splicing factor PUF60 cause a recognizable syndrome with intellectual disability, heart defects and short stature. Eur J Hum Genet (2016) 0.84
Targeting SR proteins improves SMN expression in spinal muscular atrophy cells. PLoS One (2014) 0.83
A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing. RNA (2008) 0.83
Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3' splice-site organization and activity of U2AF-related proteins. Nucleic Acids Res (2015) 0.82
Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome. Oncotarget (2015) 0.82
PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome. Ann Rheum Dis (2015) 0.78
Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2. RNA Biol (2013) 0.77
Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise. RNA (2016) 0.76
A Broad Set of Chromatin Factors Influences Splicing. PLoS Genet (2016) 0.75
PUF60 variants cause a syndrome of ID, short stature, microcephaly, coloboma, craniofacial, cardiac, renal and spinal features. Eur J Hum Genet (2017) 0.75
JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner. Nucleic Acids Res (2016) 0.75
Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons. Nucleic Acids Res (2016) 0.75
Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression. Sci Rep (2017) 0.75
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
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Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature (2002) 7.60
Comprehensive proteomic analysis of the human spliceosome. Nature (2002) 6.85
High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Res (2002) 6.64
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A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell (1988) 6.16
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Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes Dev (1990) 5.36
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A computational analysis of sequence features involved in recognition of short introns. Proc Natl Acad Sci U S A (2001) 4.68
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Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med (2005) 4.34
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Functional recognition of the 3' splice site AG by the splicing factor U2AF35. Nature (1999) 3.72
The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Cell (1997) 3.68
Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A (2004) 3.58
Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution. EMBO J (1991) 3.54
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol Cell Biol (2001) 3.31
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Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG. Nature (1999) 2.87
Both subunits of U2AF recognize the 3' splice site in Caenorhabditis elegans. Nature (1999) 2.65
A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. Genes Dev (1998) 2.64
A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. Mol Cell Biol (1998) 2.62
Splicing regulation in neurologic disease. Neuron (2006) 2.46
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J (2002) 2.39
U2AF homology motifs: protein recognition in the RRM world. Genes Dev (2004) 2.34
Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. Am J Hum Genet (2005) 2.29
Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assembly. Mol Cell Biol (1994) 2.03
Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol Biol (1999) 2.02
Common themes in the function of transcription and splicing enhancers. Curr Opin Cell Biol (1997) 1.92
The role of U2AF35 and U2AF65 in enhancer-dependent splicing. RNA (2001) 1.76
Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. Mol Cell (2005) 1.66
Intrinsic differences between authentic and cryptic 5' splice sites. Nucleic Acids Res (2003) 1.66
Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma. J Clin Invest (1993) 1.66
Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo. Mol Biol Cell (2005) 1.65
The FBP interacting repressor targets TFIIH to inhibit activated transcription. Mol Cell (2000) 1.63
Trans splicing of nematode pre-messenger RNA in vitro. Cell (1990) 1.62
PUF60: a novel U2AF65-related splicing activity. RNA (1999) 1.59
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Modulation of survival motor neuron pre-mRNA splicing by inhibition of alternative 3' splice site pairing. J Biol Chem (2001) 1.56
Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. Biochim Biophys Acta (2005) 1.52
Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA. EMBO J (2004) 1.50
The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes Dev (1999) 1.49
Methods for studying pro- and antiapoptotic genes in nonimmortal cells. Methods Cell Biol (2001) 1.46
Identification and analysis of all components of a gel retardation assay by combination with immunoblotting. Proc Natl Acad Sci U S A (1993) 1.45
UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. RNA (2003) 1.45
Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA (2001) 1.42
Insights into the mechanisms of splicing: more lessons from the ribosome. Genes Dev (2005) 1.41
Half pint regulates alternative splice site selection in Drosophila. Dev Cell (2002) 1.29
The Ro 60 kDa autoantigen: insights into cellular function and role in autoimmunity. J Mol Med (Berl) (2004) 1.25
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing. Mol Cell Biol (2001) 1.21
A primate virus generates transformed human cells by fusion. J Cell Biol (2005) 1.17
A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol Cell Biol (2005) 1.17
RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Mol Cell Biol (1998) 1.15
SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract. Proc Natl Acad Sci U S A (1997) 1.12
Biased exon/intron distribution of cryptic and de novo 3' splice sites. Nucleic Acids Res (2005) 1.08
In vitro splicing of a chicken delta-crystallin pre-mRNA in a mammalian nuclear extract. J Biochem (1987) 1.08
Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features. Clin Cancer Res (2003) 1.00
Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. RNA (2000) 0.99
A trans-acting factor, isolated by the three-hybrid system, that influences alternative splicing of the amyloid precursor protein minigene. Eur J Biochem (2000) 0.93
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Substrate-dependent differences in U2AF requirement for splicing in adenovirus-infected cell extracts. J Biol Chem (2005) 0.85
Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet (2002) 16.29
ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Res (2003) 12.81
The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol (2007) 6.16
Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. Nat Genet (2002) 5.80
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell (2006) 4.74
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev (2003) 4.73
Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell (2003) 4.63
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60
An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Hum Mol Genet (2006) 4.56
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev (2008) 4.24
Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature (2011) 4.04
Correction of disease-associated exon skipping by synthetic exon-specific activators. Nat Struct Biol (2003) 3.75
RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat Rev Drug Discov (2012) 3.70
Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One (2010) 3.50
Comprehensive splice-site analysis using comparative genomics. Nucleic Acids Res (2006) 3.30
Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice. Am J Hum Genet (2008) 3.24
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A (2010) 3.08
SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Mol Cell (2007) 3.04
Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes Dev (2010) 3.02
Plasma components affect accuracy of circulating cancer-related microRNA quantitation. J Mol Diagn (2011) 2.57
Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy. Sci Transl Med (2011) 2.56
Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biol (2007) 2.29
Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. Am J Hum Genet (2005) 2.29
Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem (2004) 2.26
Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Mol Cell Proteomics (2008) 2.24
Nuclear export and retention signals in the RS domain of SR proteins. Mol Cell Biol (2002) 2.04
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. J Biol Chem (2006) 1.90
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol (2012) 1.88
Involvement of SR proteins in mRNA surveillance. Mol Cell (2004) 1.84
BRCA2 T2722R is a deleterious allele that causes exon skipping. Am J Hum Genet (2002) 1.80
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nat Struct Mol Biol (2010) 1.78
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev (2010) 1.77
Aberrant 5' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization. Nucleic Acids Res (2007) 1.71
A positive modifier of spinal muscular atrophy in the SMN2 gene. Am J Hum Genet (2009) 1.70
Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Res (2005) 1.70
Determinants of the inherent strength of human 5' splice sites. RNA (2005) 1.69
Intrinsic differences between authentic and cryptic 5' splice sites. Nucleic Acids Res (2003) 1.66
Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proc Natl Acad Sci U S A (2005) 1.65
Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Mol Cell Biol (2002) 1.55
A splicing-independent function of SF2/ASF in microRNA processing. Mol Cell (2010) 1.55
hnRNP A1 associates with telomere ends and stimulates telomerase activity. RNA (2006) 1.50
Glioma cells display complex cell surface topographies that resist the actions of cytolytic effector lymphocytes. J Immunol (2010) 1.50
Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer. Am J Hum Genet (2007) 1.50
Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. J Biol Chem (2002) 1.50
RNA landscape of evolution for optimal exon and intron discrimination. Proc Natl Acad Sci U S A (2008) 1.45
HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS Biol (2004) 1.44
MicroRNAs are exported from malignant cells in customized particles. Nucleic Acids Res (2012) 1.43
The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proc Natl Acad Sci U S A (2008) 1.42
Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci U S A (2011) 1.42
An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor. Endocrinology (2002) 1.42
SpliceTrap: a method to quantify alternative splicing under single cellular conditions. Bioinformatics (2011) 1.42
OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucleic Acids Res (2013) 1.41
Pick one, but be quick: 5' splice sites and the problems of too many choices. Genes Dev (2013) 1.39
Biogenesis of mammalian microRNAs by a non-canonical processing pathway. Nucleic Acids Res (2012) 1.37
Cooperative-binding and splicing-repressive properties of hnRNP A1. Mol Cell Biol (2009) 1.37
Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. Cell Rep (2012) 1.36
Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1. Hum Mutat (2004) 1.35
A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. J Cell Biol (2006) 1.34
An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites. Nat Struct Mol Biol (2004) 1.33
Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Sci Transl Med (2009) 1.30
Antisense-based therapy for the treatment of spinal muscular atrophy. J Cell Biol (2012) 1.25
Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components. Proc Natl Acad Sci U S A (2007) 1.24
Human papillomavirus L2 facilitates viral escape from late endosomes via sorting nexin 17. Traffic (2012) 1.23
Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing. Nat Chem Biol (2012) 1.22
Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. Mol Cell Proteomics (2010) 1.22
Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1. Nat Struct Mol Biol (2007) 1.21
Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness. Nat Med (2013) 1.20
Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. EMBO J (2002) 1.19
Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions. J Biol Chem (2003) 1.19
Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. J Biol Chem (2007) 1.18
A primate virus generates transformed human cells by fusion. J Cell Biol (2005) 1.17
Targeting RNA splicing for disease therapy. Wiley Interdiscip Rev RNA (2013) 1.17
Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics. Genome Res (2007) 1.16
A generalizable pre-clinical research approach for orphan disease therapy. Orphanet J Rare Dis (2012) 1.16
Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA. Nat Struct Mol Biol (2009) 1.16
A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. Hum Mol Genet (2010) 1.15
Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site. J Biol Chem (2002) 1.14
Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts. Mol Cell Biol (2003) 1.14
Dual-specificity splice sites function alternatively as 5' and 3' splice sites. Proc Natl Acad Sci U S A (2007) 1.10
Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Mol Cell (2013) 1.10
Identification of synaptic targets of Drosophila pumilio. PLoS Comput Biol (2008) 1.10
Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function. Retrovirology (2011) 1.08
Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. RNA (2011) 1.08
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. J Mol Cell Biol (2011) 1.07
Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies. Int Immunopharmacol (2008) 1.07
Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. Structure (2006) 1.05
Where in the cell is the minor spliceosome? Proc Natl Acad Sci U S A (2008) 1.03
Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF. Mol Cell Biol (2010) 1.03
Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a. Hum Mutat (2005) 1.01
Functional analysis of the protein phosphatase activity of PTEN. Biochem J (2012) 1.01
Inhibition of PP1 phosphatase activity by HBx: a mechanism for the activation of hepatitis B virus transcription. Sci Signal (2012) 1.00
Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. RNA (2009) 0.99
Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB. BMC Mol Biol (2007) 0.99
Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides. Genes Dev (2012) 0.98