Published in RNA on March 01, 2001
Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Nucleic Acids Res (2005) 2.55
A computational scan for U12-dependent introns in the human genome sequence. Nucleic Acids Res (2001) 2.21
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA (2004) 1.67
Identification, characterization and molecular phylogeny of U12-dependent introns in the Arabidopsis thaliana genome. Nucleic Acids Res (2003) 1.57
Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions. Mol Cell Biol (2002) 1.49
RNA splicing capability of live neuronal dendrites. Proc Natl Acad Sci U S A (2005) 1.46
The significant other: splicing by the minor spliceosome. Wiley Interdiscip Rev RNA (2012) 1.40
Evolutionary conservation of minor U12-type spliceosome between plants and humans. RNA (2005) 1.29
Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). PLoS One (2007) 1.28
The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing. Genes Dev (2010) 1.26
Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J Biol Chem (2003) 1.22
Minor spliceosome components are predominantly localized in the nucleus. Proc Natl Acad Sci U S A (2008) 1.16
A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. Hum Mol Genet (2010) 1.15
The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein. EMBO J (2005) 1.11
Where in the cell is the minor spliceosome? Proc Natl Acad Sci U S A (2008) 1.03
The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein. Mol Cell Biol (2008) 1.02
The abundance of the spliceosomal snRNPs is not limiting the splicing of U12-type introns. RNA (2006) 1.01
Mitogen-activated protein kinase phosphorylation of splicing factor 45 (SPF45) regulates SPF45 alternative splicing site utilization, proliferation, and cell adhesion. Mol Cell Biol (2012) 0.93
Branchpoint selection in the splicing of U12-dependent introns in vitro. RNA (2002) 0.92
Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers. RNA (2001) 0.88
Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assembly. Mol Cell Biol (2005) 0.87
Both U2 snRNA and U12 snRNA are required for accurate splicing of exon 5 of the rat calcitonin/CGRP gene. RNA (2004) 0.84
Targeting SR proteins improves SMN expression in spinal muscular atrophy cells. PLoS One (2014) 0.83
Thymosin β10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS production. PLoS One (2012) 0.83
Mutational analysis of the U12-dependent branch site consensus sequence. RNA (2008) 0.81
Evolutionarily conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11-48K and U11/U12-65K genes. RNA Biol (2015) 0.77
Dephosphorylated NSSR1 is induced by androgen in mouse epididymis and phosphorylated NSSR1 is increased during sperm maturation. PLoS One (2011) 0.75
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem Sci (2000) 10.77
Sorting out the complexity of SR protein functions. RNA (2000) 9.25
Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol Cell Biol (1990) 8.17
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature (1994) 6.97
Evolutionary fates and origins of U12-type introns. Mol Cell (1998) 6.25
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res (1993) 6.15
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell (1990) 5.67
Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes Dev (1990) 5.36
Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor. Proc Natl Acad Sci U S A (1989) 5.11
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol Cell Biol (1999) 4.87
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell (1993) 4.82
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J (1995) 4.66
Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell (1997) 3.85
Functional recognition of the 3' splice site AG by the splicing factor U2AF35. Nature (1999) 3.72
The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev (1996) 3.63
Requirement of U12 snRNA for in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns. Science (1996) 3.61
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro. Cell (1996) 3.55
Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns. Science (1996) 3.44
A coactivator of pre-mRNA splicing. Genes Dev (1998) 3.04
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon. Genes Dev (1992) 2.91
Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc. Proc Natl Acad Sci U S A (1988) 2.26
Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. EMBO J (1999) 2.20
SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. RNA (1995) 2.02
Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol Biol (1999) 2.02
Identification of both shared and distinct proteins in the major and minor spliceosomes. Science (1999) 1.96
The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. RNA (1999) 1.81
Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions. Genes Dev (1999) 1.78
U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science (1996) 1.74
Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome. Mol Cell (2001) 1.66
Analysis of splicing complexes and small nuclear ribonucleoprotein particles by native gel electrophoresis. Methods Enzymol (1989) 1.65
New proteins related to the Ser-Arg family of splicing factors. RNA (1995) 1.62
The function of multisite splicing enhancers. Mol Cell (1998) 1.60
Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps. Proc Natl Acad Sci U S A (1995) 1.58
Mammalian in vitro splicing assays. Methods Mol Biol (1999) 1.57
The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes Dev (1999) 1.49
Evidence for substrate-specific requirement of the splicing factor U2AF(35) and for its function after polypyrimidine tract recognition by U2AF(65). Mol Cell Biol (1999) 1.35
Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. RNA (1997) 1.27
Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing. Proc Natl Acad Sci U S A (1999) 1.21
Purification of SR protein splicing factors. Methods Mol Biol (1999) 1.11
Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. RNA (1998) 1.05
Insulin antibodies in diabetic pregnancy. Lancet (1974) 0.86
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (1994) 7.09
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res (1993) 6.15
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nat Genet (2001) 5.02
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol Cell Biol (1999) 4.87
Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol (2001) 4.64
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev (1993) 4.40
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev (1998) 4.19
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA (1998) 4.05
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J Cell Biol (1997) 3.95
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J (1994) 3.35
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol (2000) 3.34
Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Mol Cell (2001) 3.34
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol (1993) 3.16
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J (1993) 3.11
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev (1999) 3.08
hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO J (1999) 3.04
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proc Natl Acad Sci U S A (1992) 2.66
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol (1998) 2.60
Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. Trends Genet (1994) 2.54
Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol (2000) 2.22
Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. EMBO J (1999) 2.20
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol (1994) 2.12
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Mol Cell Biol (1999) 2.05
Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol Biol (1999) 2.02
The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem (1999) 1.90
Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc Natl Acad Sci U S A (1999) 1.86
atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes Dev (1999) 1.82
U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science (1996) 1.74
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proc Natl Acad Sci U S A (1997) 1.72
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Res (1993) 1.57
Mammalian in vitro splicing assays. Methods Mol Biol (1999) 1.57
The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes Dev (1999) 1.49
A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. RNA (1997) 1.43
RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. J Virol (2001) 1.41
The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Mol Cell Biol (1997) 1.41
Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proc Natl Acad Sci U S A (1992) 1.40
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure (1997) 1.40
A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes Dev (1997) 1.36
The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. EMBO J (2001) 1.36
Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. RNA (1997) 1.27
Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. Proc Natl Acad Sci U S A (1996) 1.26
The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. Mol Cell Biol (1994) 1.25
Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc Natl Acad Sci U S A (1999) 1.23
Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1. RNA (1998) 1.18
Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5' splice-site disruption. Hum Mutat (2007) 1.17
NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. J Biol Chem (2000) 1.15
Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proc Natl Acad Sci U S A (1999) 1.14
The U6 small nuclear RNA from Trypanosoma brucei. Nucleic Acids Res (1988) 1.14
Human p32: a coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication. Virology (2000) 1.10
Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. RNA (1998) 1.05
Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins. Mol Biochem Parasitol (1999) 0.95
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Mol Cell Biol (1989) 0.94
Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo. J Clin Endocrinol Metab (2000) 0.89
A putative homolog of U2AF65 in S. cerevisiae. Nucleic Acids Res (1992) 0.88
Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer. J Biol Chem (2000) 0.84
Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. Acta Crystallogr D Biol Crystallogr (1997) 0.81
RCC1 and nuclear organization. Mol Biol Cell (1997) 0.79
Non-radioactive detection of m3G capped RNAs by immunoblotting. Nucleic Acids Res (1994) 0.75
A putative homology of U2AF65 in S. cerevisiae. Nucleic Acids Res (1993) 0.75
Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation. Biotechniques (1991) 0.75